Aliases &
Descriptions
for CD109 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
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|
| Aliases & Descriptions |
|---|
| CD109 molecule1 2 | | p1802 3 | | CPAMD71 2 3 | | r1502 3 | | FLJ385691 2 | | CD109 antigen (Gov platelet alloantigens)1 | | DKFZp762L11111 2 | | Gov platelet alloantigens2 | | Platelet-specific Gov antigen2 3 | | RP11-525G3.12 | | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 72 3 | | FLJ419662 | | 150 kDa TGF-beta-1-binding protein2 3 | | activated T-cell marker CD1092 | | CD109 antigen2 3 | | |
Export aliases for CD109 gene to outside databasesPrevious GC identifers: GC06P074364 GC06P074401 GC06P074462 |
Summaries
for CD109 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD109:
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein isfound on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negativelyregulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding differentisoforms have been found for this gene.
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3Function: Modulates negatively TGFB1 signaling in keratinocytes
Gene Wiki entry for CD109 |
Genomic Views
for CD109 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD109 gene promoter:
GR-beta GR-alpha FOXJ2 (long isoform) Pax-6 AP-1 c-Fos Fra-1 JunB JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD109
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CD109  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q13 Ensembl cytogenetic band: 6q13 HGNC cytogenetic band: 6q14.1CD109 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P071605: view genomic region
(about GC identifiers)
Start:
|
71,605,012 bp from pter |
End:
|
71,737,517 bp from pter |
Size:
|
132,506 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+ 74,405,514-74,538,040 |
RefSeq DNA sequence:- NC_000006.11 NT_007299.13
|
Proteins
for CD109 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3 (See
protein sequence)Recommended Name: CD109 antigen precursor Size: 1445 amino acids; 161689 Da
Subunit: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1,TGFBR2 and TGFBR3 in a ligand-independent manner
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence caution: Sequence=BAG53987.1; Type=Erroneous initiation; Sequence=CAE46045.1; Type=Erroneous initiation;Note=Translation N-terminally shortened; Sequence=CAE46045.1; Type=Frameshift; Positions=1282;
Secondary accessions: A5YKK4 B2R948 B3KW25 Q0P6K7 Q5SYA8 Q5XUM7 Q5XUM9 Q6MZI7 Q8N3A7 Q8N915 Q8TDJ2Q8TDJ3Alternative splicing: 4 isoforms: Q6YHK3-1 Q6YHK3-2 Q6YHK3-3 Q6YHK3-4 Explore the universe of human proteins at neXtProt for CD109: NX_Q6YHK3
Post-translational modifications:
N-glycosylated1
2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001153059.1 NP_001153060.1 NP_598000.2
ENSEMBL proteins: ENSP00000287097 ENSP00000404475 ENSP00000388062
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CD109 for ontologies About GeneDecksing
Antibodies for CD109:
Assays for CD109: |
Protein
Domains/
Families
for CD109 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD109 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q6YHK3ProtoNet protein and cluster: Q6YHK3 2 Blocks protein families: IPB001599 Alpha-2-macroglobulin IPB002890 Alpha-2-macroglobulin
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family |
Gene Function
for CD109 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3Function: Modulates negatively TGFB1 signaling in keratinocytes
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004866 | endopeptidase inhibitor activity |
-- | -- | | GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- |
About this table
CD109 for ontologies About GeneDecksing
|
Pathways & Interactions
for CD109 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CD109
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD109
|
Drugs & Compounds
for CD109 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CD109
|
Transcripts
for CD109 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CD109 gene (3 alternative transcripts): NM_001159587.1 NM_001159588.1 NM_133493.3 Additional cDNA sequence: AF410459.1 AK095888.1 AK123960.1 AK130104.1 AK313636.1 AL110152.1 AL834478.1 AY149920.1 AY374441.2 AY374442.1 AY788891.1 BX641095.1 CR599670.1 EF553520.1 5 DOTS entries: DT.411247 DT.101961256 DT.100786952 DT.117452 DT.40115866 24/182 AceView cDNA sequences (see all 182): BQ775821 AK130104 AA843263 AA411010 AA479110 AI206246 N35347 BF434900 BP351431 AI382712 AL110152 BG032261 BX646244 AA418644 CA420610 AI275388 BM981498 AA479261 BU688056 AI026963 AA844126 CR599670 AI378219 BU687393
 highest scoring ESTs for CD109:AI948463 AL043807 AA132260 AA418546 AA418644 AA772347 AA844005 AA845494 AF410459 AI034454 Unigene Cluster for CD109: CD109 molecule Hs.399891 [show with all ESTs]Unigene Representative Sequence: NM_133493
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287097 ENST00000474094 ENST00000422508(uc010kaz.2 uc003phq.2 uc003php.2 uc010kba.2)
ENST00000437994
|
Expression
for CD109 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CD109 expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching CD109 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 46700_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.94 |
1.29 |
W55956 |
0.60 |
1.00 |
0.82 |
1 |
| 78575_at2, 3
|
U95-D |
1 |
0.88 |
1.00 |
0.54 |
0.92 |
AL043807 |
1.00 |
1.00 |
1.00 |
1 |
| 46118_at2, 3
|
U95-B |
1 |
0.75 |
1.00 |
0.87 |
0.82 |
AI948463 |
1.00 |
1.00 |
1.00 |
1 |
| 226545_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL110152 |
0.40 |
1.00 |
0.76 |
1 |
| 229900_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AL576908 |
0.80 |
1.00 |
0.91 |
1 |
| 239719_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
BF978262 |
0.60 |
1.00 |
0.82 |
1 |
| 226545_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 229900_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 239719_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CD109 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATTTATTAAT
SOURCE GeneReport for Unigene cluster: Hs.399891
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3Tissue specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetalheart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activatedT lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressedin keratinocytes and placenta
SABiosciences Custom PCR Arrays for CD109
|
Orthologs
for CD109 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD109 gene from 5/9 species (see all 9)
About this table Species with no ortholog for CD109
ENSEMBL Gene Tree for CD109 (if available) |
Paralogs
for CD109 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CD109 gene
- A2M2 A2ML12 PZP2 CPAMD82
CD109 for paralogs About GeneDecksing
|
Genomic Variants
for CD109 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
UniProtKB/Swiss-Prot: CD109_HUMAN, Q6YHK3Polymorphism: The Gov(b) variant in position 703 defines the Gov alloantigenic determinants
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CD109 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CD109
2 CNVs: 69558 99588
5 Indels: 28366 40882 47157 62533 12849 | | QIAGEN SeqTarget long-range PCR primers for resequencing CD109 |
|
Disorders & Mutations
for CD109 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD109 for disorders About GeneDecksing
OMIM: 608859
2  Novoseek disease relationships for CD109 gene
About this table
Human Gene Mutation Database (HGMD): CD109
Genetic Association Database (GAD): CD109
Human Genome Epidemiology (HuGE) Navigator: CD109 (7 documents)
Export disorders and mutations for CD109 gene to outside databases
|
Medical News
for CD109 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CD109 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/39 PubMed articles for CD109 gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with CD109)- A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. (PubMed id 11861285)1, 2, 3, 7 Schuh A.C.... Ouwehand W.H. (2002)
- Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins. (PubMed id 11861284)1, 2, 3 Lin M.... Schuh A.C. (2002)
- Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)1, 2 Sjoeblom T.... Velculescu V.E. (2006)
- Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes. (PubMed id 16754747)1, 2 Finnson K.W.... Philip A. (2006)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Gene frequencies of the HPA-15 (Gov) platelet alloantigen system in Brazilians. (PubMed id 15569238)1, 4 Cardone J.D....Bordin J.O. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- CD109 represents a novel branch of the alpha2- macroglobulin/complement gene family. (PubMed id 14980714)1, 2 Solomon K.R.... Finberg R.W. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
|
External Searches for CD109 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing CD109 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD109 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD109 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CD109 gene:
Search GeneIP for patents involving CD109
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD109 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for CD109 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CD109 |
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