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CD2 Gene

protein-coding   GIFtS: 64

GC01P115156
CD2 molecule
(Previous names: CD2 antigen (p50), sheep red blood cell receptor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SRBC)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
CD2 molecule1 2     LFA-3 receptor2 3
CD2 antigen (p50), sheep red blood cell receptor1 2     T-cell surface antigen CD22
Erythrocyte receptor2 3     lymphocyte-function antigen-22
Rosette receptor2 3     T112
LFA-22 3     FLJ460322
SRBC2 3     CD2 antigen3
T-cell surface antigen T11/Leu-52 3     

External Ids:    HGNC: 16391   Entrez Gene: 9142   Ensembl: ENSG000001168247   UniProtKB: P067293   

Export aliases for CD2 gene to outside databases

Previous GC identifers: GC01P117800 GC01P116179 GC01P116444 GC01P116643 GC01P117009 GC01P117098 GC01P117297


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD2:
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells
(summarized by Sewell et al., 1986 (PubMed 3490670)). It is one of the earliest T-cell markers, being present on more
than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies
directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte
receptor or is closely associated with it.(supplied by OMIM)

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729
Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between
T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in
the signaling function

Gene Wiki entry for CD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD2 gene promoter:
         CREB   deltaCREB   STAT5A   c-Myc   Max1   IRF-1   AhR   p53   FOXO3a   FOXO3b   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

CD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD2 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P115156:  view genomic region     (about GC identifiers)

Start:
115,156,224 bp from pter
End:
115,170,989 bp from pter
Size:
14,766 bases
Orientation:
plus strand

1 alternative location:
Chr1+ 117,297,007-117,311,850     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729 (See protein sequence)
Recommended Name: T-cell surface antigen CD2 precursor  
Size: 351 amino acids; 39448 Da
Subunit: Interacts with CD2AP (By similarity). Interacts with PSTPIP1
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
1CDB (3D)    1GYA (3D)    1HNF (3D)    1L2Z (3D)    1QA9 (3D)    2J6O (3D)    2J7I (3D)    
Secondary accessions: Q96TE5

Explore the universe of human proteins at neXtProt for CD2: NX_P06729 

REFSEQ proteins: NP_001758.2  

ENSEMBL proteins: 
ENSP00000358490 ENSP00000358489 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: CD2
GenScript Custom Purified and Recombinant Proteins Services for CD2 
Novus Biologicals Proteins for CD2
Novus Biologicals Lysates for CD2
Sino Biological Recombinant Protein for CD2
ProSpec Recombinant Protein for CD2

5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005886 plasma membrane TAS--
GO:0005887 integral to plasma membrane NAS7544493
GO:0009897 external side of plasma membrane IEA--
GO:0009898 internal side of plasma membrane IEA--
About this table

CD2 for ontologies           About GeneDecksing



Antibodies for CD2: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CD2
R&D Systems Antibodies for CD2
OriGene Antibodies (see all 3): CD2
GenScript Superior Antibodies for CD2 
Novus Biologicals Antibodies for CD2
Epitomics antibodies for CD2

Assays for CD2: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CD2 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD2 for domains           About GeneDecksing

5/6 InterPro domains/families (see all 6):
 IPR015632 T-cell_sdhesion_molc_CD2
 IPR013285 Ag_CD2
 IPR008424 Ig_C2-set
 IPR015631 Signal_lymphocyte_activ_molc
 IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P06729

ProtoNet protein and cluster: P06729

1 Blocks protein family: IPB008424 T-cell surface antigen CD2

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CD2_HUMAN, P06729
Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between
T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in
the signaling function

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CD2
Sigma-Aldrich shRNA Panels and shRNA for CD2
OriGene 29mer shRNA kits in GFP-retroviral vector: CD2
OriGene shRNA RFP: CD2
OriGene basic RS shRNA: CD2
OriGene siRNA: CD2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD2 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD2 
Search SABiosciences for Assays for microRNAs that regulate CD2

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CD2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CD2
OriGene untagged cDNA clones in CMV expression vector: CD2
OriGene 3'-UTR clone: CD2 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CD2 
Sino Biological Human cDNA Clone for CD2

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CD2 

Genatlas biochemistry entry for CD2:
cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by monoclonal
antibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen recognition via
its role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by TCR,interacting with
an adaptor protein (CDC2BP) to trigger cell adhesion,including a 3' locus control region LCR-CD2

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity NAS7544493
GO:0005515 protein binding IPI12356317
GO:0042803 protein homodimerization activity IEA--
GO:0043499 eukaryotic cell surface binding IEA--
About this table

CD2 for ontologies           About GeneDecksing

Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cd2):

normal

CD2 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


CD2 for pathways           About GeneDecksing

2 Kegg Pathways  (Kegg details for CD2):
    hsa04514 Cell adhesion molecules (CAMs)
hsa04640 Hematopoietic cell lineage

    SABiosciences Pathway-Focused PCR Arrays including CD2 (see all 5): PAHS-053A PAHS-054A  

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD2

5/35 Interacting proteins for CD2 (ENSP000003584903 P067292) via UniProtKB, MINT, and/or STRING (see all 35)
InteractantInteraction Details
GeneCardExternal ID(s)
CD2BP2O954002STRING: ENSP00000304903 MINT-50471 MINT-50457 MINT-15125 MINT-62665 MINT-50559 MINT-62656 MINT-62832 MINT-18223 MINT-62660 MINT-62648 MINT-62661 MINT-50473 MINT-62666 MINT-50470 MINT-50472 MINT-62819
FYNP062412STRING: ENSP00000357656 MINT-50661 MINT-50664 MINT-50663 MINT-50665
CD2APQ9Y5K62STRING: ENSP00000352264 MINT-51118 MINT-51119 MINT-7041387
LCKP062392STRING: ENSP00000328213 MINT-50662
PSTPIP1O435862MINT-51107 MINT-51108 MINT-16704 MINT-51111 MINT-51114
About this table

5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

GO IDQualified GO termEvidencePubMed IDs
GO:0001766 membrane raft polarization TAS11591762
GO:0006917 induction of apoptosis TAS9270771
GO:0007155 cell adhesion ----
GO:0007166 cell surface receptor linked signaling pathway TAS10575274
GO:0007596 blood coagulation TAS--
About this table

CD2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

CD2 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD2
10/15 Novoseek chemical compound relationships for CD2 gene (see all 15)
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
aerolysin 62.4 2 2158347 (1), 9282746 (1)
sialic acid 38.2 2 9584138 (1), 8557359 (1)
tyrosine 32.8 19 1372020 (2), 8557753 (2), 11166460 (1), 10580638 (1) (see all 12)
c-peptide 29.4 3 9670112 (1), 15247957 (1), 10631198 (1)
ionomycin 23.6 1 11123293 (1)
fructosamine 22.9 3 8755851 (3)
cyclosporin a 20.4 2 1676547 (1)
con a 16.3 1 7532641 (1)
wortmannin 12.4 4 8557753 (1), 11932928 (1)
proline 7.97 1 10430626 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CD2
Sigma-Aldrich shRNA Panels and shRNA for CD2
OriGene 29mer shRNA kits in GFP-retroviral vector: CD2
OriGene shRNA RFP: CD2
OriGene basic RS shRNA: CD2
OriGene siRNA: CD2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD2 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD2 
Search SABiosciences for Assays for microRNAs that regulate CD2
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CD2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CD2
OriGene untagged cDNA clones in CMV expression vector: CD2
OriGene 3'-UTR Clone: CD2 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CD2 
Primers: OriGene genome-wide validated SYBR primer pairs: CD2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CD2: PPH00832A

REFSEQ mRNAs for CD2 gene: 

NM_001767.3  

Additional cDNA sequence: 

AK127925.1 AK223393.1 AK301154.1 AK303367.1 AK310676.1 AK313614.1 BC033583.1 CR608242.1 
M14362.1 M16336.1 M16445.1 

5 DOTS entries:

DT.111078  DT.86850751  DT.97835608  DT.97835609  DT.91664505 

24/49 AceView cDNA sequences (see all 49):

CR608242 BC033583 M16445 NM_001767 BX100790 BE503151 AI290326 BM821729 
BQ028759 AA356532 AA927710 AW191960 AI358549 CA438480 CD691699 AL712654 
CD709745 CD700090 AI702265 M16336 BM920483 BI833341 BX456944 M14362 

highest scoring ESTs for CD2:

M16336 AA813618 AA927710 AA928888 AI131504 AI290326 AI358549 AI381022 AI702265 AI766734 

Unigene Cluster for CD2:

CD2 molecule
Hs.523500  [show with all ESTs]
Unigene Representative Sequence: AK127925


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CD2

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1:                                      -           -     -                     
SP2:                                      -           -                           
SP3:                                      -                                       
SP4:                                -     -           -     -                     
SP5:                                                                              

About this scheme

ECgene alternative splicing isoforms for CD2
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369478(uc010owz.1 uc010oxa.1 uc001egu.3) ENST00000369477


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CD2 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching CD2 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
40738_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M16336 1.00 1.00 1.00 1
205831_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001767 0.60 1.00 0.82 1
205831_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table

CD2 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CD2 gene expression
CD2 gene electronic northern expression
CD2 gene sage expression
About these images

CGAP SAGE TAG: TGTAGATGCG

SOURCE GeneReport for Unigene cluster: Hs.523500

Expression variation in blood from EXPOLDB for CD2

Primers: OriGene genome-wide validated SYBR primer pairs: CD2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CD2: PPH00832A
    SABiosciences Expression via Pathway-Focused PCR Arrays including CD2 (see all 5): PAHS-053A PAHS-054A  


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD2 gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6074481   -- similar to T-cell surface antigen CD2 precursor (T-cell more 73.55(n)
60.48(a)
607448  XM_844126.1  XP_849219.1 
chimpanzee
(Pan troglodytes)
CD21   -- CD2 molecule 99.62(n)
99.43(a)
449512  XM_001146833.1  XP_001146833.1 
cow
(Bos taurus)
CD21   -- CD2 molecule 71.32(n)
54.9(a)
497022  NM_001011676.2  NP_001011676.2 
rat
(Rattus norvegicus)
Cd21   -- Cd2 molecule 69.44(n)
57.14(a)
497761  NM_012830.1  NP_036962.1 
mouse
(Mus musculus)
Cd21 , 5 3 (44.17 cM)5
CD2 antigen1, 5 67.25(n)1
52.65(a)1
124811  NM_013486.21  NP_038514.11 
 AF0659065  AF0659075  (see all 17)
About this table        Species with no ortholog for CD2

ENSEMBL Gene Tree for CD2 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD2
     1 CNV: 4243
QIAGEN SeqTarget long-range PCR primers for resequencing CD2 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD2 for disorders           About GeneDecksing

OMIM: 186990

10/18 Novoseek disease relationships for CD2 gene (see all 18)

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
malaria 45.4 9 7689250 (1), 17470537 (1), 19519483 (1), 9199449 (1) (see all 8)
mastocytosis 22.7 1 11919419 (1)
thymoma 19.2 1 1385156 (1)
necrosis 9.9 4 1359970 (2), 7488336 (1), 8095456 (1)
insulin resistance 8.78 2 10631198 (1), 9082345 (1)
skin lesion 0 1 7512116 (1)
lupus erythematosus systemic 0 2 1673843 (1), 10399227 (1)
leukemia 0 1 8350618 (1)
virus infection 0 1 7754234 (1)
essential hypertension 0 5 10697394 (3), 8807554 (2)
About this table

Human Genome Epidemiology (HuGE) Navigator: CD2 (5 documents)

Export disorders and mutations for CD2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/296 PubMed articles for CD2 gene, integrated from 7 sources (see all 296):
(articles sorted by number of sources associating them with CD2)
  1. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PubMed id 2437578)1, 2, 3 Seed B. and Aruffo A. (1987)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. (PubMed id 9857189)1, 2 Li J.... Reinherz E.L. (1998)
  5. Conformation and function of the N-linked glycan in the adhesion domain of human CD2. (PubMed id 7544493)1, 2 Wyss D.F.... Wagner G. (1995)
  6. Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution. (PubMed id 7994575)1, 2 Bodian D.L.... Davis S.J. (1994)
  7. Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. (PubMed id 7915183)1, 2 Withka J.M....Recny M.A. (1993)
  8. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. (PubMed id 1377404)1, 2 Hahn W.C.... Bierer B.E. (1992)
  9. Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (PubMed id 2894031)1, 2 Diamond D.J.... Reinherz E.L. (1988)
  10. The structure of the human CD2 gene and its expression in transgenic mice. (PubMed id 2901953)1, 2 Lang G.... Kioussis D. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 914 HGNC: 1639 AceView: CD2 Ensembl:ENSG00000116824 euGenes: HUgn914
ECgene: CD2 Kegg: 914 H-InvDB: CD2

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for CD2 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/CD2

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CD2 gene:
Search GeneIP for patents involving CD2

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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 Millipore Custom Antibody & Bulk Services
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 Predesigned and custom siRNAs for CD2 Antibodies for CD2
 Super-pooled esiRNAs for CD2 Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CD2 Browse microRNA Mimics at Sigma-Aldrich
 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 Antibodies for CD2 (CD2)   Cell Culture Products  
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 Primer Pairs   Kinase Activity Assays/Reagents  
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 Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
 DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
 Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
 Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Lysates
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 siRNA
 Custom Immunoassay Development
 Fluorogenic Cell Assay Kits
 miRNA Primers for qPCR Assays
 3' UTR Clones for miRNA Target Studies
 miRNA Expression Plasmids

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD2
 SeqTarget long-range PCR primers for resequencing CD2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD2
 GenScript Custom Purified and Recombinant Proteins Services for CD2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CD2
 GenScript Custom Assay Services for CD2 GenScript Superior Antibodies for CD2
 GenScript Custom overexpressing Cell Line Services for CD2 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in CD2 promoter
 Search Chromatin IP Primers for CD2
 RT2 qPCR Primer Assay for CD2
 GNC Network for CD2
 Search for Assays for microRNAs that regulate CD2
 SABiosciences PCR Arrays including CD2
 Search Tocris compounds for CD2
 Proteins and Antibodies for CD2
 cDNA Clones for CD2
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 Antibodies for CD2
 Proteins for CD2
 Lysates for CD2
 Antibodies for CD2
 Recombinant Protein for CD2

 Browse ELISAs and CLIAs at Uscn
       

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