Aliases &
Descriptions
for CD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| CD2 molecule1 2 | | LFA-3 receptor2 3 | | CD2 antigen (p50), sheep red blood cell receptor1 2 | | T-cell surface antigen CD22 | | Erythrocyte receptor2 3 | | lymphocyte-function antigen-22 | | Rosette receptor2 3 | | T112 | | LFA-22 3 | | FLJ460322 | | SRBC2 3 | | CD2 antigen3 | | T-cell surface antigen T11/Leu-52 3 | | |
Export aliases for CD2 gene to outside databasesPrevious GC identifers: GC01P117800 GC01P116179 GC01P116444 GC01P116643 GC01P117009 GC01P117098 GC01P117297 |
Summaries
for CD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD2:
CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells(summarized by Sewell et al., 1986 (PubMed 3490670)). It is one of the earliest T-cell markers, being present on morethan 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodiesdirected against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocytereceptor or is closely associated with it.(supplied by OMIM)
UniProtKB/Swiss-Prot: CD2_HUMAN, P06729Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion betweenT-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated inthe signaling function
Gene Wiki entry for CD2 |
Genomic Views
for CD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD2 gene promoter:
CREB deltaCREB STAT5A c-Myc Max1 IRF-1 AhR p53 FOXO3a FOXO3b
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.1 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13CD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P115156: view genomic region
(about GC identifiers)
Start:
|
115,156,224 bp from pter |
End:
|
115,170,989 bp from pter |
Size:
|
14,766 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 117,297,007-117,311,850 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for CD2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: CD2_HUMAN, P06729 (See
protein sequence)Recommended Name: T-cell surface antigen CD2 precursor Size: 351 amino acids; 39448 Da
Subunit: Interacts with CD2AP (By similarity). Interacts with PSTPIP1
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from  and Proteopedia  :1CDB (3D)
1GYA (3D)
1HNF (3D)
1L2Z (3D)
1QA9 (3D)
2J6O (3D)
2J7I (3D)
Secondary accessions: Q96TE5Explore the universe of human proteins at neXtProt for CD2: NX_P06729
REFSEQ proteins: NP_001758.2
ENSEMBL proteins: ENSP00000358490 ENSP00000358489
Human Recombinant Proteins
5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8): About this table
CD2 for ontologies About GeneDecksing
Antibodies for CD2:
Assays for CD2: |
Protein
Domains/
Families
for CD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P06729ProtoNet protein and cluster: P06729 1 Blocks protein family: IPB008424 T-cell surface antigen CD2
UniProtKB/Swiss-Prot: CD2_HUMAN, P06729Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Gene Function
for CD2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CD2_HUMAN, P06729Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion betweenT-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated inthe signaling function
Genatlas biochemistry entry for CD2:cell differentiation antigen CD2 (p50),50kDa,membrane glycoprotein,SRBC receptor,LFA3 receptor,identified by monoclonalantibodies 9.6,T11,35.1,M-T910,expressed on all T cells,thymocytes and NK cells,involved in antigen recognition viaits role in adhesion and signal transduction,interacting with CD58 prior antigen recognition by TCR,interacting withan adaptor protein (CDC2BP) to trigger cell adhesion,including a 3' locus control region LCR-CD24 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CD2 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Cd2):
CD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CD2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CD2 for pathways About GeneDecksing
2  Kegg Pathways (Kegg details for CD2):
SABiosciences Pathway-Focused PCR Arrays including CD2 (see all 5): PAHS-053A PAHS-054A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD2
5/35 Interacting proteins for CD2 (ENSP000003584903 P067292) via UniProtKB, MINT, and/or STRING (see all 35)About this table
5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11): About this table
CD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CD2 for compounds About GeneDecksing
 Browse Tocris compounds for CD2
10/15  Novoseek chemical compound relationships for CD2 gene (see all 15)
About this table
|
Transcripts
for CD2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CD2 gene: NM_001767.3 Additional cDNA sequence: AK127925.1 AK223393.1 AK301154.1 AK303367.1 AK310676.1 AK313614.1 BC033583.1 CR608242.1 M14362.1 M16336.1 M16445.1 5 DOTS entries: DT.111078 DT.86850751 DT.97835608 DT.97835609 DT.91664505 24/49 AceView cDNA sequences (see all 49): CR608242 BC033583 M16445 NM_001767 BX100790 BE503151 AI290326 BM821729 BQ028759 AA356532 AA927710 AW191960 AI358549 CA438480 CD691699 AL712654 CD709745 CD700090 AI702265 M16336 BM920483 BI833341 BX456944 M14362
 highest scoring ESTs for CD2:M16336 AA813618 AA927710 AA928888 AI131504 AI290326 AI358549 AI381022 AI702265 AI766734 Unigene Cluster for CD2: CD2 molecule Hs.523500 [show with all ESTs]Unigene Representative Sequence: AK127925
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CD2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CD2
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369478(uc010owz.1 uc010oxa.1 uc001egu.3) ENST00000369477
|
Expression
for CD2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CD2 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CD2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40738_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
M16336 |
1.00 |
1.00 |
1.00 |
1 |
| 205831_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_001767 |
0.60 |
1.00 |
0.82 |
1 |
| 205831_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CD2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGTAGATGCG
SOURCE GeneReport for Unigene cluster: Hs.523500
Expression variation in blood from EXPOLDB for CD2 SABiosciences Expression via Pathway-Focused PCR Arrays including CD2 (see all 5): PAHS-053A PAHS-054A
|
Orthologs
for CD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD2 gene from 5/6 species (see all 6)
About this table Species with no ortholog for CD2
ENSEMBL Gene Tree for CD2 (if available) |
Paralogs
for CD2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for CD2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD2
1 CNV: 4243 | | QIAGEN SeqTarget long-range PCR primers for resequencing CD2 |
|
Disorders & Mutations
for CD2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD2 for disorders About GeneDecksing
OMIM: 186990
10/18 Novoseek disease relationships for CD2 gene (see all 18)
About this table
Human Genome Epidemiology (HuGE) Navigator: CD2 (5 documents)
Export disorders and mutations for CD2 gene to outside databases
|
Medical News
for CD2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for CD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/296 PubMed articles for CD2 gene, integrated from 7 sources (see all 296):
(articles sorted by number of sources associating them with CD2)- Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. (PubMed id 2437578)1, 2, 3 Seed B. and Aruffo A. (1987)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion. (PubMed id 9857189)1, 2 Li J.... Reinherz E.L. (1998)
- Conformation and function of the N-linked glycan in the adhesion domain of human CD2. (PubMed id 7544493)1, 2 Wyss D.F.... Wagner G. (1995)
- Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution. (PubMed id 7994575)1, 2 Bodian D.L.... Davis S.J. (1994)
- Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2. (PubMed id 7915183)1, 2 Withka J.M....Recny M.A. (1993)
- Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. (PubMed id 1377404)1, 2 Hahn W.C.... Bierer B.E. (1992)
- Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. (PubMed id 2894031)1, 2 Diamond D.J.... Reinherz E.L. (1988)
- The structure of the human CD2 gene and its expression in transgenic mice. (PubMed id 2901953)1, 2 Lang G.... Kioussis D. (1988)
|
External Searches for CD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CD2 gene:
Search GeneIP for patents involving CD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for CD2 |
| |  |  |  |  | | | | | Antibodies for CD2 |
| | | Recombinant Protein for CD2 |
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