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CD53 Gene

protein-coding   GIFtS: 55

GC01P109285
CD53 molecule
(Previous name: CD53 antigen )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MOX44)
Products    

Aliases &
Descriptions
for CD53 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
CD53 molecule1 2     leukocyte surface antigen CD532
CD53 antigen1 2 3     tetraspanin-252
TSPAN251 2 3     cell surface antigen2
MOX442 3 5     transmembrane glycoprotein2
Cell surface glycoprotein CD532 3     antigen MOX44 identified by monoclonal antibody MRC-OX442
CD53 glycoprotein2     Tspan-253
tspan-252     Tetraspanin-253
CD53 tetraspan antigen2     

External Ids:    HGNC: 16861   Entrez Gene: 9632   Ensembl: ENSG000001431197   UniProtKB: P193973   

Export aliases for CD53 gene to outside databases

Previous GC identifers: GC01P111831 GC01P110282 GC01P110516 GC01P110714 GC01P111127 GC01P111413


Summaries
for CD53 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD53:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,
growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It
contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to
play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated
with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple
transcript variants encoding the same protein. (provided by RefSeq)

UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
Function: May be involved in growth regulation in hematopoietic cells

Gene Wiki entry for CD53

Genomic Views
for CD53 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD53 gene promoter:
         AP-1   Bach1   Pax-6   RORalpha2   ISGF-3   Bach2   c-Myb   STAT5B   CUTL1   STAT5A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CD53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

CD53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD53 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P109285:  view genomic region     (about GC identifiers)

Start:
 109,285,008 bp from pter
End:
 109,313,782 bp from pter
Size:
 28,775 bases
Orientation:
 plus strand

1 alternative location:
Chr1+ 111,415,722-111,442,558     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for CD53 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 (See protein sequence)
Recommended Name: Leukocyte surface antigen CD53  
Size: 219 amino acids; 24341 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R905 Q5U0D6

Explore the universe of human proteins at neXtProt for CD53: NX_P19397 

REFSEQ proteins (2 alternative transcripts): 
NP_000551.1  NP_001035122.1  


ENSEMBL proteins: 
ENSP00000412250 ENSP00000271324 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for CD53 
Novus Biologicals Protein for CD53
Novus Biologicals Lysate for CD53
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS8452817
GO:0009986 cell surface IEA--
GO:0016021 integral to membrane IEA--
About this table

CD53 for ontologies           About GeneDecksing



Antibodies for CD53: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for CD53
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for CD53 
Novus Biologicals Antibodies for CD53
Browse antibodies at Epitomics

Assays for CD53: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CD53 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 

Protein Domains/
Families
for CD53 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
CD53 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR018499 Tetraspanin
 IPR000301 Tetraspanin_sub
 IPR008952 Tetraspanin_EC2
 IPR018503 Tetraspanin_CS

Graphical View of Domain Structure for InterPro Entry P19397

ProtoNet protein and cluster: P19397

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
Similarity: Belongs to the tetraspanin (TM4SF) family


Gene Function
for CD53 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
Function: May be involved in growth regulation in hematopoietic cells

Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CD53
Sigma-Aldrich shRNA for CD53
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CD53
OriGene shRNA RFP (see all 2): CD53
OriGene basic RS shRNA (see all 2): CD53
OriGene siRNA (see all 2): CD53
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD53 
miRNA:Sigma-Aldrich microRNA Mimics for CD53
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD53 
3 SABiosciences Assays for microRNAs that regulate CD53:
hsa-miR-875-3p hsa-miR-431 hsa-miR-1299

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene untagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene 3'-UTR clone (see all 2): CD53 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CD53 
Sino Biological Human cDNA Clone for CD53

Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for CD53 

Genatlas biochemistry entry for CD53:
cell differentiation antigen 53,32-40kDa,single chain glycoprotein,identified by monoclonal antibodies
H129,H136,MEM-53,HD77,see MOX44

Pathways & Interactions
for CD53 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for CD53 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD53

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction NAS8404042
About this table

CD53 for ontologies           About GeneDecksing



Drugs & Compounds
for CD53 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD53


Transcripts
for CD53 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CD53
Sigma-Aldrich shRNA for CD53
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CD53
OriGene shRNA RFP (see all 2): CD53
OriGene basic RS shRNA (see all 2): CD53
OriGene siRNA (see all 2): CD53
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD53 
miRNA: Sigma-Aldrich microRNA Mimics for CD53
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD53 
3 SABiosciences Assays for microRNAs that regulate CD53:
hsa-miR-875-3p hsa-miR-431 hsa-miR-1299
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene untagged cDNA clones in CMV expression vector (see all 2): CD53
OriGene 3'-UTR Clone (see all 2): CD53 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CD53 
Primers: OriGene genome-wide validated SYBR primer pairs: CD53
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CD53: PPH02885A

REFSEQ mRNAs for CD53 gene (2 alternative transcripts): 

NM_000560.3  NM_001040033.1  

Additional cDNA sequence: 

AK298723.1 AK313582.1 BC035456.1 BC040693.1 BT019643.1 CR592401.1 CR598355.1 CR605120.1 
CR609698.1 CR614019.1 CR619551.1 CR620545.1 M37033.1 M60871.1 

20 DOTS entries:

DT.92433604  DT.100819256  DT.100019308  DT.99943676  DT.121382896  DT.209137  DT.121382848  DT.92433596 
DT.95109186  DT.100026950  DT.100819258  DT.121382833  DT.121382890  DT.91819522  DT.100772197  DT.100819257 
DT.100819261  DT.75111548  DT.92433595  DT.95109190 

24/326 AceView cDNA sequences (see all 326):

CR620545 CD364590 H70124 CR605120 BM457687 BX381661 BP367968 AI022073 
CR592401 AI032692 H98696 BC035456 BI770932 AW575174 AI076089 AA383886 
BC040693 BX378202 BP338495 AA810480 AI040645 AA897735 CR609698 BU073271 

highest scoring ESTs for CD53:

M37033 AA362173 AA362399 AA362408 AA648126 AA770669 AA773833 AA872291 AA884893 AA894962 

Unigene Cluster for CD53:

CD53 molecule
Hs.443057  [show with all ESTs]
Unigene Representative Sequence: NM_001040033


GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CD53 (see all 10)

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1:        -                             -     -                             -           -                                       
SP2:                                      -     -                             -           -                                       
SP3:                                      -     -                             -           -     -                                 
SP4:        -                             -     -                 -     -     -     -     -     -     -     -                     
SP5:                                      -     -                             -                                                   

About this scheme

ECgene alternative splicing isoforms for CD53
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000476408 ENST00000429072(uc010owa.1) ENST00000464329 ENST00000271324(uc001dzw.2 uc001dzx.2 uc001dzy.2)
ENST00000468160 ENST00000497404 ENST00000471220

Expression
for CD53 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CD53 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching CD53 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38378_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M37033 1.00 1.00 1.00 1
203416_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000560 0.60 1.00 0.82 1
203416_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table

CD53 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CD53 gene expression
CD53 gene electronic northern expression
CD53 gene sage expression
About these images

CGAP SAGE TAG: AAGCCCTACA

SOURCE GeneReport for Unigene cluster: Hs.443057

Expression variation in blood from EXPOLDB for CD53

UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
Tissue specificity: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and
peripheral T-cells

Primers: OriGene genome-wide validated SYBR primer pairs: CD53
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CD53: PPH02885A
    SABiosciences Custom PCR Arrays for CD53 


Orthologs
for CD53 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for CD53 gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 CD531   -- CD53 molecule 87.6(n)
86.05(a)		 610454  XM_847399.1  XP_852492.1 
chimpanzee
(Pan troglodytes)		 CD531   -- CD53 molecule 99.85(n)
100(a)		 745007  XM_001162558.1  XP_001162558.1 
cow
(Bos taurus)		 CD531   -- CD53 molecule 87.52(n)
87.21(a)		 505040  NM_001034232.2  NP_001029404.1 
rat
(Rattus norvegicus)		 Cd531   -- Cd53 molecule 82.65(n)
81.28(a)		 24251  NM_012523.1  NP_036655.1 
mouse
(Mus musculus)		 Cd531 , 5 3 (46.53 cM)5
 CD53 antigen1, 5 82.95(n)1
83.11(a)1		 125081  NM_007651.21  NP_031677.11 
 AA1774095  AI3236595  (see all 20)
About this table        Species with no ortholog for CD53

ENSEMBL Gene Tree for CD53 (if available)

Paralogs
for CD53 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CD53 gene
TSPAN92  TSPAN182  TSPAN12  TSPAN42  

CD53 for paralogs           About GeneDecksing


Pseudogenes
1 related pseudogene



Genomic Variants
for CD53 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/288 NCBI SNPs in CD53 are shown (see all 288)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs4977591,2
C,F,H,111413750(-) TCAGCT/CGGCTA 2 -- ng5112Minor allele frequency- C:0.00MN NS EA NA WA 612
rs5740521,2
H111421308(+) GCTTAC/GAAAGG 2 -- int15Minor allele frequency- G:0.00MN NS EA 586
rs9315471,2
C,F,A,H,111417446(-) AAAAAA/CCCAAG 2 -- int111Minor allele frequency- C:0.22MN NS EA NA WA 732
rs9764391,2
H111419374(-) AATAAA/GTGATC 2 -- int15Minor allele frequency- G:0.00MN NS EA 552
rs9764401,2
H111419306(-) ATTCTA/TCAATA 2 -- int14Minor allele frequency- T:0.00NS EA 402
rs9764411,2
H111419273(-) ATGGAA/GTAATT 2 -- int14Minor allele frequency- G:0.00NS EA 406
rs11151321,2
C,F,A,111426508(-) TAGGAT/ATGAGA 2 -- int111Minor allele frequency- A:0.23NS EA NA 1002
rs13330591,2
H111422489(+) CGAGCC/TTGATC 2 -- int14Minor allele frequency- T:0.00NS EA 416
rs13330601,2
H111422520(+) CCAACC/TTTAAC 2 -- int14Minor allele frequency- T:0.00NS EA 416
rs13438171,2
C,F,O,A,H,111437129(+) ATAGAA/CATGAA 2 -- int1105Minor allele frequency- G:0.01NS MN NA EA PA EU CA WA 6702
About this table

HapMap Linkage Disequilibrium images for CD53 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CD53: --

QIAGEN SeqTarget long-range PCR primers for resequencing CD53 

Disorders & Mutations
for CD53 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
CD53 for disorders           About GeneDecksing

OMIM: 151525

1 Novoseek disease relationship for CD53 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 4 12606948 (2), 15931266 (1)
About this table

Human Genome Epidemiology (HuGE) Navigator: CD53 (3 documents)

Export disorders and mutations for CD53 gene to outside databases

Medical News
for CD53 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for CD53 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/59 PubMed articles for CD53 gene, integrated from 7 sources (see all 59):
(articles sorted by number of sources associating them with CD53)
  1. The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (PubMed id 1700763)1, 2, 7 Angelisova P.... Horejsi V. (1990)
  2. Genomic structure of the human CD53 gene. (PubMed id 8319976)1, 3, 7 Korinek V. and Horejsi V. (1993)
  3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Identification and analysis of cDNA clones encoding CD53. A pan- leukocyte antigen related to membrane transport proteins. (PubMed id 2258620)1, 2 Amiot M. (1990)
  6. Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. (PubMed id 8452817)1, 7 Wright M.D....Williams A.F. (1993)
  7. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. (PubMed id 8816400)1, 7 Szollosi J....Damjanovich S. (1996)
  8. Apoptosis protection and survival signal by the CD53 tetraspanin antigen. (PubMed id 12606948)1, 7 Yunta M. and Lazo P.A. (2003)
  9. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120)1, 7 Charrin S....Rubinstein E. (2002)
  10. Functional expression of transmembrane 4 superfamily molecules on human eosinophils. (PubMed id 10529602)1, 7 Matsumoto K....Kurashige T. (1999)

External Searches for CD53 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing CD53 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 963 HGNC: 1686 AceView: CD53 Ensembl:ENSG00000143119 euGenes: HUgn963
ECgene: CD53 H-InvDB: CD53

Other Databases showing CD53 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing CD53 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for CD53 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for CD53 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CD53 gene:
Search GeneIP for patents involving CD53

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for CD53 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 Millipore Custom Antibody & Bulk Services
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 Predesigned and custom siRNAs for CD53 Browse antibodies at Sigma-Aldrich
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 Lentivirus-delivered shRNAs for CD53 microRNA Mimics for CD53
 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 miRNA Expression Plasmids

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CD53
 SeqTarget long-range PCR primers for resequencing CD53
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CD53
 GenScript Custom Purified and Recombinant Proteins Services for CD53 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CD53
 GenScript Custom Assay Services for CD53 GenScript Custom Superior Antibodies Services for CD53
 GenScript Custom overexpressing Cell Line Services for CD53 CloneReady with Over 120,000 Genes
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 Regulatory tfbs in CD53 promoter
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 Lysates for CD53
 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 Browse ELISAs and CLIAs at Uscn
       

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