Aliases &
Descriptions
for CD99L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| CD99 molecule-like 21 2 | | CD99 antigen-like 21 | | MIC2 like 11 2 | | OTTHUMP000000260602 | | CD99B1 2 | | CD99 antigen-like protein 22 | | MIC2-like protein 12 3 | | DKFZp761H20242 | | MIC2L12 3 | | CD99 antigen3 |
Export aliases for CD99L2 gene to outside databasesPrevious GC identifers: GC0XM146617 GC0XM147705 GC0XM148576 GC0XM148577 GC0XM149605 GC0XM149934 |
Summaries
for CD99L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD99L2:
This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesionmolecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. (provided byRefSeq)
UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2Function: May function as a homophilic adhesion molecule. Functions in leukocyte-endothelial cell interactions duringleukocyte extravasation, and in particular, at the diapedesis step. Does not seem to be involved in docking ofleukocytes to the vessel wall or in lymphocyte diapedesis (By similarity)
Gene Wiki entry for CD99L2 |
Genomic Views
for CD99L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD99L2 gene promoter:
RORalpha1 POU2F1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 POU2F2 (Oct-2.1) oct-B2 POU2F2C oct-B3 POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD99L2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CD99L2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28CD99L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM138794: view genomic region
(about GC identifiers)
Start:
|
138,794,255 bp from pter |
End:
|
138,859,221 bp from pter |
Size:
|
64,967 bases |
Orientation:
|
minus strand |
1 alternative location:
| ChrX- 149,934,810-150,067,179 |
RefSeq DNA sequence:- NC_000023.10 NT_167198.1
|
Proteins
for CD99L2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2 (See
protein sequence)Recommended Name: CD99 antigen-like protein 2 precursor Size: 262 amino acids; 27986 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity). Celljunction (By similarity)
Sequence caution: Sequence=CAB66515.1; Type=Frameshift; Positions=156;
Secondary accessions: A8K2D5 A8K5R0 Q8TAW2 Q8TCZ0 Q8TCZ1 Q9BQG9Alternative splicing: 4 isoforms: Q8TCZ2-1 Q8TCZ2-2 Q8TCZ2-3 Q8TCZ2-4 Explore the universe of human proteins at neXtProt for CD99L2: NX_Q8TCZ2
Post-translational modifications:
O-glycosylated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001171737.1 NP_113650.2 NP_604394.1 NP_604395.1
ENSEMBL proteins: ENSP00000347275 ENSP00000392637 ENSP00000325449 ENSP00000406629 ENSP00000417697 ENSP00000359403 ENSP00000391821 ENSP00000394858 ENSP00000347487
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CD99L2 for ontologies About GeneDecksing
Antibodies for CD99L2:
Assays for CD99L2: |
Protein
Domains/
Families
for CD99L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD99L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCZ2ProtoNet protein and cluster: Q8TCZ2 UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2Similarity: Belongs to the CD99 family |
Gene Function
for CD99L2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2Function: May function as a homophilic adhesion molecule. Functions in leukocyte-endothelial cell interactions duringleukocyte extravasation, and in particular, at the diapedesis step. Does not seem to be involved in docking ofleukocytes to the vessel wall or in lymphocyte diapedesis (By similarity)
|
Pathways & Interactions
for CD99L2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CD99L2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD99L2
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- |
About this table
CD99L2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CD99L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CD99L2
|
Transcripts
for CD99L2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CD99L2 gene (4 alternative transcripts): NM_001184808.1 NM_031462.3 NM_134445.3 NM_134446.3 Additional cDNA sequence: AK023776.1 AK024278.1 AK098810.1 AK125020.1 AK290200.1 AK291375.1 AK293244.1 AK295217.1 AL136580.1 AY078165.1 AY078166.1 AY078167.1 AY358837.1 BC007569.1 BC013029.2 BC019857.1 BC025729.1 BC030536.1 CR610005.1 CR611984.1 23 DOTS entries: DT.100660224 DT.75156472 DT.95342521 DT.95181825 DT.100809899 DT.100809907 DT.95088176 DT.95202844 DT.100809910 DT.95202833 DT.97815480 DT.121317136 DT.121317137 DT.121317146 DT.121317160 DT.121317163 DT.121317169 DT.121317238 DT.121317244 DT.40122837 DT.92460392 DT.95242155 DT.121317234 24/305 AceView cDNA sequences (see all 305): AL137989 CD675789 BQ889880 AY078166 BX508041 BC019857 NM_134445 NM_031462 AI720278 AI753385 AA426346 AI872067 BM722283 BE792355 BC025729 NM_134446 AL136580 AW074581 AL533048 AL569970 AA599761 AW297248 AY358837 AA323297
 highest scoring ESTs for CD99L2:AL136580 AL523721 AL555937 AU279604 AY078165 AY078166 AY078167 AY358837 BC025729 BC030536 Unigene Cluster for CD99L2: CD99 molecule-like 2 Hs.522805 [show with all ESTs]Unigene Representative Sequence: BC025729
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD99L2 (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CD99L2
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355149 ENST00000438086(uc004fek.2) ENST00000320893 ENST00000419771
ENST00000466436 ENST00000370377(uc004fel.2 uc004fem.2 uc004fen.2 uc011myb.1)
ENST00000418547 ENST00000437787 ENST00000355330 ENST00000346693(uc004feo.2)
ENST00000491877
|
Expression
for CD99L2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CD99L2 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching CD99L2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 44733_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
W95046 |
0.80 |
1.00 |
0.91 |
1 |
| 223041_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL136580 |
0.80 |
1.00 |
0.91 |
1 |
| 233825_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AU158444 |
0.20 |
1.00 |
0.72 |
1 |
| 223041_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 233825_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1554758_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CD99L2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGGGTGAAG
SOURCE GeneReport for Unigene cluster: Hs.522805
UniProtKB/Swiss-Prot: C99L2_HUMAN, Q8TCZ2Tissue specificity: Expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle,ovary, thymus, testis and uterus. Lower expression seen in thymus. Expressed in E18 uterus and placenta
SABiosciences Custom PCR Arrays for CD99L2
|
Orthologs
for CD99L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD99L2 gene from 5 species
About this table Species with no ortholog for CD99L2
ENSEMBL Gene Tree for CD99L2 (if available) |
Paralogs
for CD99L2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CD99L2 gene
- CD992
CD99L2 for paralogs About GeneDecksing
|
Genomic Variants
for CD99L2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CD99L2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CD99L2
2 CNVs: 97078 83839
1 Indel: 29287 | | QIAGEN SeqTarget long-range PCR primers for resequencing CD99L2 |
|
Disorders & Mutations
for CD99L2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for CD99L2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CD99L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for CD99L2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CD99L2)- Cloning, genomic organization, alternative transcripts and expression analysis of CD99L2, a novel paralog of human CD99, and identification of evolutionary conserved motifs. (PubMed id 12706889)1, 2, 7 Suh Y.H.... Park S.H. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. (PubMed id 18163232)1 Schenkel A.R....Muller W.A. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
|
External Searches for CD99L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD99L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD99L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD99L2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CD99L2 gene:
Search GeneIP for patents involving CD99L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD99L2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for CD99L2 |
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