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CDC14B Gene

protein-coding   GIFtS: 55

GC09M099252
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
(Previous names: CDC14 (cell division cycle 14, S. cerevisiae) homolog B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
CDC14 cell division cycle 14 homolog B (S. cerevisiae)1 2     OTTHUMP000002158792
Cdc14B11 2     dual specificity protein phosphatase CDC14B2
CDC14B31 2     OTTHUMP000002158782
Cdc14B21 2     CDC14 cell division cycle 14 homolog B3
hCDC14B1 2     EC 3.1.3.163
CDC14 (cell division cycle 14, S. cerevisiae) homolog B1     EC 3.1.3.483
OTTHUMP000000217322     

External Ids:    HGNC: 17191   Entrez Gene: 85552   Ensembl: ENSG000000813777   UniProtKB: O607293   

Export aliases for CDC14B gene to outside databases

Previous GC identifers: GC09M090066 GC09M090996 GC09M092709 GC09M094632 GC09M096332 GC09M098292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC14B:
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein
is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell
mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown
to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53.
Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. (provided by RefSeq)

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729
Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage
checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the
anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the
ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by
proline-directed kinases

Gene Wiki entry for CDC14B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDC14B gene promoter:
         ATF-2   IRF-1   ATF   c-Jun   c-Myb   CREB   deltaCREB   Nkx6-1   Meis-1   HOXA9B   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CDC14B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDC14B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.3

CDC14B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14B gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099252:  view genomic region     (about GC identifiers)

Start:
99,252,523 bp from pter
End:
99,382,112 bp from pter
Size:
129,590 bases
Orientation:
minus strand

1 alternative location:
Chr9- 68,873,293-68,940,865     
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729 (See protein sequence)
Recommended Name: Dual specificity protein phosphatase CDC14B  
Size: 498 amino acids; 56802 Da
Subunit: Interacts with FZR1/CDH1
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the
nucleolus to the nucleoplasm and interacts with FZR1/CDH1
Sequence caution: Sequence=CAI40539.1; Type=Erroneous initiation;
PDB structures from and Proteopedia :
1OHC (3D)    1OHD (3D)    1OHE (3D)    
Secondary accessions: A6N5X8 B1AL31 B1AL32 O43183 O60730 Q5JU08
Alternative splicing: 4 isoforms:  O60729-1   O60729-2   O60729-3   O60729-4   

Explore the universe of human proteins at neXtProt for CDC14B: NX_O60729 

REFSEQ proteins (3 alternative transcripts): 
NP_001070649.1  NP_003662.1  NP_201588.1  


ENSEMBL proteins: 
ENSP00000364385 ENSP00000396951 ENSP00000364384 ENSP00000392386 ENSP00000400480 ENSP00000364389 
ENSP00000420572 ENSP00000417897 ENSP00000413940 ENSP00000265659 ENSP00000364388 ENSP00000364390 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for CDC14B 
Novus Biologicals Proteins for CDC14B
Novus Biologicals Lysate for CDC14B
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA9367992
GO:0005654 nucleoplasm IDA18662541
GO:0005730 nucleolus IDA18662541
About this table

CDC14B for ontologies           About GeneDecksing



Antibodies for CDC14B: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CDC14B
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for CDC14B 
Novus Biologicals Antibodies for CDC14B
Browse antibodies at Epitomics

Assays for CDC14B: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CDC14B 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CDC14B 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC14B for domains           About GeneDecksing

4 InterPro domains/families:
 IPR020422 Dual-sp_phosphatase_subgr_cat
 IPR016130 Tyr_Pase_AS
 IPR000387 Dual-sp/Tyr_phosphatase
 IPR000340 Dual-sp_phosphatase_cat-dom

Graphical View of Domain Structure for InterPro Entry O60729

ProtoNet protein and cluster: O60729

1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729
Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP)
fold
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729
Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage
checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the
anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the
ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by
proline-directed kinases
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
Enzyme Numbers (IUBMB): EC 3.1.3.16  EC 3.1.3.48 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Sigma-Aldrich Nano Scale siRNA for CDC14B
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC14B
Sigma-Aldrich shRNA Panels and shRNA for CDC14B
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC14B
OriGene shRNA RFP (see all 5): CDC14B
OriGene basic RS shRNA (see all 5): CDC14B
OriGene siRNA (see all 4): CDC14B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC14B 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC14B 
8/32 SABiosciences Assays for microRNAs that regulate CDC14B (see all 32):
hsa-miR-607 hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-508-3p hsa-miR-9 hsa-miR-424 hsa-miR-15b

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC14B
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC14B
OriGene untagged cDNA clones in CMV expression vector (see all 4): CDC14B
OriGene 3'-UTR clone (see all 3): CDC14B 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CDC14B 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CDC14B 

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IDA18662541
GO:0004725 protein tyrosine phosphatase activity IDA9367992
GO:0005515 protein binding IPI18662541
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA--
GO:0016787 hydrolase activity IEA--
About this table

CDC14B for ontologies           About GeneDecksing

Animal Models: 1 MGI phenotypic allele for Cdc14b (no phenotypes)


CDC14B for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


CDC14B for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for CDC14B):
    hsa04110 Cell cycle

    SABiosciences Pathway-Focused PCR Arrays including CDC14B: PAHS-045A PAHS-093A 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDC14B

5/17 Interacting proteins for CDC14B (ENSP000003643893 O607291) via UniProtKB, MINT, and/or STRING (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
FZR1Q9UM111STRING: ENSP00000221926 EBI-970231,EBI-724997
E2F1ENSP000003455713STRING: ENSP00000345571
TFDP1ENSP000003645193STRING: ENSP00000364519
CCNA1ENSP000002554653STRING: ENSP00000255465
CCNE1ENSP000002626433STRING: ENSP00000262643
About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006281 DNA repair IEA--
GO:0006470 protein dephosphorylation NAS9367992
GO:0016311 dephosphorylation ----
GO:0031572 G2/M transition DNA damage checkpoint IDA18662541
GO:0051488 activation of anaphase-promoting complex activity IMP18662541
About this table

CDC14B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC14B


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Sigma-Aldrich Nano Scale siRNA for CDC14B
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC14B
Sigma-Aldrich shRNA Panels and shRNA for CDC14B
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC14B
OriGene shRNA RFP (see all 5): CDC14B
OriGene basic RS shRNA (see all 5): CDC14B
OriGene siRNA (see all 4): CDC14B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC14B 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC14B 
8/32 SABiosciences Assays for microRNAs that regulate CDC14B (see all 32):
hsa-miR-607 hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-508-3p hsa-miR-9 hsa-miR-424 hsa-miR-15b
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC14B
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC14B
OriGene untagged cDNA clones in CMV expression vector (see all 4): CDC14B
OriGene 3'-UTR Clone (see all 3): CDC14B 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CDC14B 
Primers: OriGene genome-wide validated SYBR primer pairs: CDC14B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CDC14B: PPH08376A

REFSEQ mRNAs for CDC14B gene (3 alternative transcripts): 

NM_001077181.1  NM_003671.3  NM_033331.2  

Additional cDNA sequence: 

AF064104.1 AK024886.1 AK126388.1 AK225361.1 BC050013.1 CR601692.1 EF611343.1 

17 DOTS entries:

DT.454283  DT.91840499  DT.100739533  DT.100017203  DT.40112876  DT.40202717  DT.317227  DT.121174362 
DT.91743831  DT.91909711  DT.92324051  DT.97790162  DT.100812802  DT.75105618  DT.102832313  DT.121174427 
DT.91813544 

24/173 AceView cDNA sequences (see all 173):

R17649 BE501717 BM679189 AA173406 BG058500 AI828647 AF064104 AI867161 
AW293105 CB136222 CD105740 NM_033331 CR601692 BX480818 AI739548 BX641741 
AI220354 BM772423 AK024886 AU119655 AW271614 NM_033332 AI280472 CF272197 

highest scoring ESTs for CDC14B:

AA204912 AA305458 AF064104 AI280472 AI654054 AA037461 AA173406 AA173461 AA242742 AA242763 

Unigene Cluster for CDC14B:

CDC14 cell division cycle 14 homolog B (S. cerevisiae)
Hs.40582  [show with all ESTs]
Unigene Representative Sequence: NM_033331


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CDC14B

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:        -     -     -     -         

About this scheme

ECgene alternative splicing isoforms for CDC14B
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375237 ENST00000481149 ENST00000496750 ENST00000480920 ENST00000452280
ENST00000463547 ENST00000484948 ENST00000375236 ENST00000437112(uc004awi.2)
ENST00000415608 ENST00000375241(uc004awj.2 uc004awk.2 uc004awl.2)
ENST00000463569 ENST00000474602 ENST00000412285 ENST00000265659 ENST00000375240
ENST00000375242

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CDC14B expression in normal and diseased human tissues

1  / 2  / 3

13 probe-sets matching CDC14B gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
40920_at2, 3 U95-A 2 1.00 0.94 0.83 0.77 AF023158 0.40 1.00 0.76 1
57172_at2, 3 U95-C 1 0.81 1.00 0.87 0.82 AA204912 0.80 1.00 0.91 1
60829_at2, 3 U95-C 1 0.75 1.00 0.91 1.42 AI654054 0.80 1.00 0.91 1
221555_x_at2, 3 U133-A 2 1.00 0.95 -- -- AU145941 0.40 1.00 0.76 1
208022_s_at2, 3 U133-A 2 1.00 0.91 -- -- NM_003671 0.40 1.00 0.76 1
211348_s_at2, 3 U133-A 1 0.55 1.00 -- -- AF064105 0.40 1.00 0.76 1
221556_at2, 3 U133-A 1 0.46 1.00 -- -- BF792631 0.40 1.00 0.76 1
211347_at2, 3 U133-A 1 0.36 1.00 -- -- AF064105 0.40 1.00 0.76 1
221555_x_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
208022_s_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
211348_s_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
221556_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
211347_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
About this table

CDC14B for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CDC14B gene expression
CDC14B gene electronic northern expression
CDC14B gene sage expression
About these images

CGAP SAGE TAG: TAATTAAAAG

SOURCE GeneReport for Unigene cluster: Hs.40582

Expression variation in blood from EXPOLDB for CDC14B

Primers: OriGene genome-wide validated SYBR primer pairs: CDC14B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CDC14B: PPH08376A
    SABiosciences Expression via Pathway-Focused PCR Arrays including CDC14B: PAHS-045A PAHS-093A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC14B gene from 5/9 species (see all 9)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CDC14B1   -- CDC14 cell division cycle 14 homolog B (S. cerevisiae) 91.89(n)
90.85(a)
476294  XM_533499.2  XP_533499.2 
chimpanzee
(Pan troglodytes)
CDC14B1   -- CDC14 cell division cycle 14 homolog B (S. cerevisiae) 99.8(n)
100(a)
465251  XM_520708.2  XP_520708.2 
cow
(Bos taurus)
CDC14B1   -- CDC14 cell division cycle 14 homolog B (S. cerevisiae) 90.89(n)
88.87(a)
520428  XM_877619.2  XP_882712.1 
rat
(Rattus norvegicus)
Cdc14b1   -- CDC14 cell division cycle 14 homolog B (S. cerevisiae) 88.52(n)
89.71(a)
361195  XM_341478.3  XP_341479.3 
mouse
(Mus musculus)
Cdc14b1 , 5 13 (33.26 cM)5
CDC14 cell division cycle 14 homolog B (S. cerevisiae)1, 5 87.57(n)1
86.83(a)1
2182941  NM_172587.21  NP_766175.21 
 AA4728215  AA9401145  (see all 26)
About this table        Species with no ortholog for CDC14B

ENSEMBL Gene Tree for CDC14B (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CDC14B gene
CDC14A2  DUSP232  

CDC14B for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/1052 NCBI SNPs in CDC14B are shown (see all 1052)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs10580011,2
99265139(-) AAAAAA/TAGTTA 2 -- ut311Minor allele frequency- T:0.00MN 184
rs14118851,2
C,F,A,H,99324377(+) CAAAGC/TACATT 2 -- int121Minor allele frequency- N:0.00NA NS EA WA 1362
rs19741801,2
C,F,99346916(-) ATTAAT/CTGCCA 2 -- int18Minor allele frequency- C:0.07NS EA NA WA 608
rs20269291,2
C,F,A,99313893(+) tacgaC/Tgcaca 2 -- int1109Minor allele frequency- T:0.40NS EA PA EU CA WA NA 7134
rs30877071,2
F,99265138(+) GTAACT/ATTTTT 2 -- ut311Minor allele frequency- A:0.15MN 184
rs31743451,2
F,H99276892(-) GAAAAA/GTTCCA 2 -- int15Minor allele frequency- G:0.04MN NS EA 602
rs37397451,2
C,F,99325282(-) CCCCTC/TCCCTC 2 -- int1 trp35Minor allele frequency- T:0.01NS EA 506
rs38024421,2
C99263535(+) AGCACC/TTAAAA 2 -- ut314Minor allele frequency- T:0.00NS EA 416
rs38024431,2
C,F,A,99263580(+) GTCCCA/GGTGTA 2 -- ut31 ese36Minor allele frequency- G:0.14NA WA 218
rs38024441,2
H99296873(+) CCCCAC/TAACCT 2 -- int14Minor allele frequency- T:0.00NS EA 418
About this table

HapMap Linkage Disequilibrium images for CDC14B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CDC14B
     1 CNV: 6700
     2 Indels: 47756 60762

QIAGEN SeqTarget long-range PCR primers for resequencing CDC14B 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC14B for disorders           About GeneDecksing

OMIM: 603505


Export disorders and mutations for CDC14B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/20 PubMed articles for CDC14B gene, integrated from 7 sources (see all 20):
(articles sorted by number of sources associating them with CDC14B)
  1. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)1, 2, 3 Li L.... Dixon J.E. (1997)
  2. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)1, 2 Bassermann F....Pagano M. (2008)
  3. The structure of the cell cycle protein Cdc14 reveals a proline- directed protein phosphatase. (PubMed id 12853468)1, 2 Gray C.H.... Barford D. (2003)
  4. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)1, 2 Mailand N.... Lukas J. (2002)
  5. Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)1, 2 Kaiser B.K.... Jackson P.K. (2002)
  6. The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. (PubMed id 15899858)1, 7 Cho H.P....Wang Y. (2005)
  7. Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. (PubMed id 18458157)1, 7 Wu J....Wang Y. (2008)
  8. Functional homology among human and fission yeast Cdc14 phosphatases. (PubMed id 15911625)1, 7 Vazquez-Novelle M.D....Sacristan M.P. (2005)
  9. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. (PubMed id 10644693)1, 7 Li L....Dixon J.E. (2000)
  10. Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. (PubMed id 20479464)1 Mocciaro A....Schiebel E. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8555 HGNC: 1719 AceView: CDC14B Ensembl:ENSG00000081377 euGenes: HUgn8555
ECgene: CDC14B Kegg: 8555 H-InvDB: CDC14B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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NameDescription
ATLAS Chromosomes in Cancer entry for CDC14B Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc14b/

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