Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

CDC14B Gene

protein-coding GIFtS: 55

GC09M099252

CDC14 cell division cycle 14 homolog B (S. cerevisiae)
(Previous names: CDC14 (cell division cycle 14, S. cerevisiae) homolog B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
CDC14 cell division cycle 14 homolog B (S. cerevisiae)¹ ²		OTTHUMP00000215879²
Cdc14B1¹ ²		dual specificity protein phosphatase CDC14B²
CDC14B3¹ ²		OTTHUMP00000215878²
Cdc14B2¹ ²		CDC14 cell division cycle 14 homolog B³
hCDC14B¹ ²		EC 3.1.3.16³
CDC14 (cell division cycle 14, S. cerevisiae) homolog B¹		EC 3.1.3.48³
OTTHUMP00000021732²

External Ids:	HGNC: 1719¹	Entrez Gene: 8555²	Ensembl: ENSG00000081377⁷	UniProtKB: O60729³

Export aliases for CDC14B gene to outside databases

Previous GC identifers: GC09M090066 GC09M090996 GC09M092709 GC09M094632 GC09M096332 GC09M098292

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC14B:

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein

is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell

mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown

to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53.

Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. (provided by RefSeq)

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729

Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage

checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the

anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the

ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by

proline-directed kinases

Gene Wiki entry for CDC14B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC14B gene promoter:
         ATF-2   IRF-1   ATF   c-Jun   c-Myb   CREB   deltaCREB   Nkx6-1   Meis-1   HOXA9B
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CDC14B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDC14B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22.3

CDC14B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC14B gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M099252: view genomic region (about GC identifiers)

Start:	99,252,523 bp from pter
End:	99,382,112 bp from pter
Size:	129,590 bases
Orientation:	minus strand

1 alternative location:

Chr9- 68,873,293-68,940,865

RefSeq DNA sequence:

NC_000009.11 NT_008470.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729 (See protein sequence)

Recommended Name: Dual specificity protein phosphatase CDC14B

Size: 498 amino acids; 56802 Da

Subunit: Interacts with FZR1/CDH1

Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the

nucleolus to the nucleoplasm and interacts with FZR1/CDH1

Sequence caution: Sequence=CAI40539.1; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1OHC (3D)

1OHD (3D)

1OHE (3D)

Secondary accessions: A6N5X8 B1AL31 B1AL32 O43183 O60730 Q5JU08

Alternative splicing: 4 isoforms: O60729-1 O60729-2 O60729-3 O60729-4

Explore the universe of human proteins at neXtProt for CDC14B: NX_O60729

REFSEQ proteins (3 alternative transcripts):

NP_001070649.1 NP_003662.1 NP_201588.1

ENSEMBL proteins:

ENSP00000364385 ENSP00000396951 ENSP00000364384 ENSP00000392386 ENSP00000400480 ENSP00000364389

ENSP00000420572 ENSP00000417897 ENSP00000413940 ENSP00000265659 ENSP00000364388 ENSP00000364390

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for CDC14B
	Novus Biologicals Proteins for CDC14B
	Novus Biologicals Lysate for CDC14B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9367992
GO:0005654	nucleoplasm	IDA	18662541
GO:0005730	nucleolus	IDA	18662541

About this table

CDC14B for ontologies About GeneDecksing

Antibodies for CDC14B:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CDC14B
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CDC14B
	Novus Biologicals Antibodies for CDC14B
	Browse antibodies at Epitomics

Assays for CDC14B:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC14B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC14B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC14B for domains About GeneDecksing

4 InterPro domains/families:

IPR020422 Dual-sp_phosphatase_subgr_cat

IPR016130 Tyr_Pase_AS

IPR000387 Dual-sp/Tyr_phosphatase

IPR000340 Dual-sp_phosphatase_cat-dom

Graphical View of Domain Structure for InterPro Entry O60729

ProtoNet protein and cluster: O60729

1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729

Domain: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP)

fold

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CC14B_HUMAN, O60729

Function: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage

checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the

anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the

ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by

proline-directed kinases

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Enzyme Numbers (IUBMB): EC 3.1.3.16 EC 3.1.3.48

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for CDC14B Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC14B Sigma-Aldrich shRNA Panels and shRNA for CDC14B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC14B OriGene shRNA RFP (see all 5): CDC14B OriGene basic RS shRNA (see all 5): CDC14B OriGene siRNA (see all 4): CDC14B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC14B

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC14B
		8/32 SABiosciences Assays for microRNAs that regulate CDC14B (see all 32):
		hsa-miR-607 hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-508-3p hsa-miR-9 hsa-miR-424 hsa-miR-15b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC14B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC14B OriGene untagged cDNA clones in CMV expression vector (see all 4): CDC14B OriGene 3'-UTR clone (see all 3): CDC14B Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CDC14B
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CDC14B

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004722	protein serine/threonine phosphatase activity	IDA	18662541
GO:0004725	protein tyrosine phosphatase activity	IDA	9367992
GO:0005515	protein binding	IPI	18662541
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

CDC14B for ontologies About GeneDecksing

Animal Models: 1 MGI phenotypic allele for Cdc14b (no phenotypes)

CDC14B for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CDC14B for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for CDC14B):

hsa04110 Cell cycle

SABiosciences Pathway-Focused PCR Arrays including CDC14B: PAHS-045A PAHS-093A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDC14B

5/17 Interacting proteins for CDC14B (ENSP00000364389³ O60729¹) via UniProtKB, MINT, and/or STRING (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FZR1	Q9UM11¹	STRING: ENSP00000221926 EBI-970231,EBI-724997
E2F1	ENSP00000345571³	STRING: ENSP00000345571
TFDP1	ENSP00000364519³	STRING: ENSP00000364519
CCNA1	ENSP00000255465³	STRING: ENSP00000255465
CCNE1	ENSP00000262643³	STRING: ENSP00000262643

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006470	protein dephosphorylation	NAS	9367992
GO:0016311	dephosphorylation	--	--
GO:0031572	G2/M transition DNA damage checkpoint	IDA	18662541
GO:0051488	activation of anaphase-promoting complex activity	IMP	18662541

About this table

CDC14B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDC14B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for CDC14B Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC14B Sigma-Aldrich shRNA Panels and shRNA for CDC14B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC14B OriGene shRNA RFP (see all 5): CDC14B OriGene basic RS shRNA (see all 5): CDC14B OriGene siRNA (see all 4): CDC14B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC14B

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC14B
		8/32 SABiosciences Assays for microRNAs that regulate CDC14B (see all 32):
		hsa-miR-607 hsa-miR-429 hsa-miR-513a-5p hsa-miR-15a hsa-miR-508-3p hsa-miR-9 hsa-miR-424 hsa-miR-15b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC14B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC14B OriGene untagged cDNA clones in CMV expression vector (see all 4): CDC14B OriGene 3'-UTR Clone (see all 3): CDC14B Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CDC14B

Primers:		OriGene genome-wide validated SYBR primer pairs: CDC14B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CDC14B: PPH08376A

REFSEQ mRNAs for CDC14B gene (3 alternative transcripts):

NM_001077181.1 NM_003671.3 NM_033331.2

Additional cDNA sequence:

AF064104.1 AK024886.1 AK126388.1 AK225361.1 BC050013.1 CR601692.1 EF611343.1

17 DOTS entries:

DT.454283 DT.91840499 DT.100739533 DT.100017203 DT.40112876 DT.40202717 DT.317227 DT.121174362

DT.91743831 DT.91909711 DT.92324051 DT.97790162 DT.100812802 DT.75105618 DT.102832313 DT.121174427

DT.91813544

24/173 AceView cDNA sequences (see all 173):

R17649 BE501717 BM679189 AA173406 BG058500 AI828647 AF064104 AI867161

AW293105 CB136222 CD105740 NM_033331 CR601692 BX480818 AI739548 BX641741

AI220354 BM772423 AK024886 AU119655 AW271614 NM_033332 AI280472 CF272197

highest scoring ESTs for CDC14B:

AA204912 AA305458 AF064104 AI280472 AI654054 AA037461 AA173406 AA173461 AA242742 AA242763

Unigene Cluster for CDC14B:

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

Hs.40582 [show with all ESTs]

Unigene Representative Sequence: NM_033331

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CDC14B

ExUns:	1	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:			-		-		-		-

About this scheme

ECgene alternative splicing isoforms for CDC14B
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375237 ENST00000481149 ENST00000496750 ENST00000480920 ENST00000452280

ENST00000463547 ENST00000484948 ENST00000375236 ENST00000437112(uc004awi.2)

ENST00000415608 ENST00000375241(uc004awj.2 uc004awk.2 uc004awl.2)

ENST00000463569 ENST00000474602 ENST00000412285 ENST00000265659 ENST00000375240

ENST00000375242

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CDC14B expression in normal and diseased human tissues

¹ / ² / ³

13 probe-sets matching CDC14B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40920_at²^{, 3}	U95-A	2	1.00	0.94	0.83	0.77	AF023158	0.40	1.00	0.76	1
57172_at²^{, 3}	U95-C	1	0.81	1.00	0.87	0.82	AA204912	0.80	1.00	0.91	1
60829_at²^{, 3}	U95-C	1	0.75	1.00	0.91	1.42	AI654054	0.80	1.00	0.91	1
221555_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AU145941	0.40	1.00	0.76	1
208022_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	NM_003671	0.40	1.00	0.76	1
211348_s_at²^{, 3}	U133-A	1	0.55	1.00	--	--	AF064105	0.40	1.00	0.76	1
221556_at²^{, 3}	U133-A	1	0.46	1.00	--	--	BF792631	0.40	1.00	0.76	1
211347_at²^{, 3}	U133-A	1	0.36	1.00	--	--	AF064105	0.40	1.00	0.76	1
221555_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
208022_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
211348_s_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
221556_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--
211347_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

About this table

CDC14B for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CDC14B gene electronic northern expression

About these images

CGAP SAGE TAG: TAATTAAAAG

SOURCE GeneReport for Unigene cluster: Hs.40582

Expression variation in blood from EXPOLDB for CDC14B

Primers:		OriGene genome-wide validated SYBR primer pairs: CDC14B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CDC14B: PPH08376A

SABiosciences Expression via Pathway-Focused PCR Arrays including CDC14B: PAHS-045A PAHS-093A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC14B gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDC14B¹	--	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	91.89(n) 90.85(a)	476294 XM_533499.2 XP_533499.2
chimpanzee (Pan troglodytes)	CDC14B¹	--	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	99.8(n) 100(a)	465251 XM_520708.2 XP_520708.2
cow (Bos taurus)	CDC14B¹	--	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	90.89(n) 88.87(a)	520428 XM_877619.2 XP_882712.1
rat (Rattus norvegicus)	Cdc14b¹	--	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	88.52(n) 89.71(a)	361195 XM_341478.3 XP_341479.3
mouse (Mus musculus)	Cdc14b^{1 , 5}	13 (33.26 cM)⁵	CDC14 cell division cycle 14 homolog B (S. cerevisiae)^{1, 5}	87.57(n)¹ 86.83(a)¹	218294¹ NM_172587.2¹ NP_766175.2¹ AA472821⁵ AA940114⁵ (see all 26)

About this table Species with no ortholog for CDC14B

ENSEMBL Gene Tree for CDC14B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDC14B gene

CDC14A² DUSP23²

CDC14B for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1058001^1,2		99265139(-)	`AAAAAA/TAGTTA`	2	--	ut3¹		1	MN	184
rs1411885^1,2	C,F,A,H,	99324377(+)	`CAAAGC/TACATT`	2	--	int¹		21	NA NS EA WA	1362
rs1974180^1,2	C,F,	99346916(-)	`ATTAAT/CTGCCA`	2	--	int¹		8	NS EA NA WA	608
rs2026929^1,2	C,F,A,	99313893(+)	`tacgaC/Tgcaca`	2	--	int¹		109	NS EA PA EU CA WA NA	7134
rs3087707^1,2	F,	99265138(+)	`GTAACT/ATTTTT`	2	--	ut3¹		1	MN	184
rs3174345^1,2	F,H	99276892(-)	`GAAAAA/GTTCCA`	2	--	int¹		5	MN NS EA	602
rs3739745^1,2	C,F,	99325282(-)	`CCCCTC/TCCCTC`	2	--	int¹ trp³		5	NS EA	506
rs3802442^1,2	C	99263535(+)	`AGCACC/TTAAAA`	2	--	ut3¹		4	NS EA	416
rs3802443^1,2	C,F,A,	99263580(+)	`GTCCCA/GGTGTA`	2	--	ut3¹ ese³		6	NA WA	218
rs3802444^1,2	H	99296873(+)	`CCCCAC/TAACCT`	2	--	int¹		4	NS EA	418

About this table

HapMap Linkage Disequilibrium images for CDC14B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CDC14B
1 CNV: 6700
2 Indels: 47756 60762

QIAGEN SeqTarget long-range PCR primers for resequencing CDC14B

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC14B for disorders About GeneDecksing

OMIM: 603505

Export disorders and mutations for CDC14B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/20 PubMed articles for CDC14B gene, integrated from 7 sources (see all 20):
(articles sorted by number of sources associating them with CDC14B)

A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. (PubMed id 9367992)^{1, 2, 3} Li L.... Dixon J.E. (1997)
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. (PubMed id 18662541)^{1, 2} Bassermann F....Pagano M. (2008)
The structure of the cell cycle protein Cdc14 reveals a proline- directed protein phosphatase. (PubMed id 12853468)^{1, 2} Gray C.H.... Barford D. (2003)
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. (PubMed id 11901424)^{1, 2} Mailand N.... Lukas J. (2002)
Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. (PubMed id 12134069)^{1, 2} Kaiser B.K.... Jackson P.K. (2002)
The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. (PubMed id 15899858)^{1, 7} Cho H.P....Wang Y. (2005)
Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. (PubMed id 18458157)^{1, 7} Wu J....Wang Y. (2008)
Functional homology among human and fission yeast Cdc14 phosphatases. (PubMed id 15911625)^{1, 7} Vazquez-Novelle M.D....Sacristan M.P. (2005)
The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. (PubMed id 10644693)^{1, 7} Li L....Dixon J.E. (2000)
Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. (PubMed id 20479464)¹ Mocciaro A....Schiebel E. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8555	HGNC: 1719	AceView: CDC14B	Ensembl:ENSG00000081377	euGenes: HUgn8555
ECgene: CDC14B	Kegg: 8555	H-InvDB: CDC14B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDC14B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc14b/

Intellectual Property for CDC14B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for CDC14B gene:
Search GeneIP for patents involving CDC14B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDC14B		Antibodies for CDC14B
	Super-pooled esiRNAs for CDC14B		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDC14B		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Nano Scale siRNA for CDC14B
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC14B
	SeqTarget long-range PCR primers for resequencing CDC14B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDC14B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC14B

	GenScript Custom Purified and Recombinant Proteins Services for CDC14B		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CDC14B
	GenScript Custom Assay Services for CDC14B		GenScript Custom Superior Antibodies Services for CDC14B
	GenScript Custom overexpressing Cell Line Services for CDC14B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CDC14B promoter
	Search Chromatin IP Primers for CDC14B
	RT² qPCR Primer Assay for CDC14B
	Search GNC Networks for CDC14B
	Assays for microRNAs that regulate CDC14B
	SABiosciences PCR Arrays including CDC14B

Search Tocris compounds for CDC14B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for CDC14B
	Proteins for CDC14B
	Lysates for CDC14B

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for CDC14B

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

CDC14B gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

CDC14B Gene

protein-coding GIFtS: 55

Aliases &
Descriptions
for CDC14B gene

Summaries
for CDC14B gene

Genomic Views
for CDC14B gene

Proteins
for CDC14B gene

Protein Domains/
Families
for CDC14B gene

Gene Function
for CDC14B gene

Pathways & Interactions
for CDC14B gene

Drugs & Compounds
for CDC14B gene

Transcripts
for CDC14B gene

Expression
for CDC14B gene

Orthologs
for CDC14B gene

Paralogs
for CDC14B gene

Genomic Variants
for CDC14B gene

Disorders & Mutations
for CDC14B gene

Medical News
for CDC14B gene

Publications
for CDC14B gene

External Searches for CDC14B gene

Genome Databases showing CDC14B gene

Other Databases showing CDC14B gene

Specialized Databases showing CDC14B gene

Intellectual Property
for CDC14B gene

Products
for CDC14B gene

View Random Gene

Advanced Search

Export list of displayed genes

CDC14B Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor CDC14B gene

Summariesfor CDC14B gene

Genomic Viewsfor CDC14B gene

Proteinsfor CDC14B gene

Protein Domains/Familiesfor CDC14B gene

Gene Functionfor CDC14B gene

Pathways & Interactionsfor CDC14B gene

Drugs & Compoundsfor CDC14B gene

Transcriptsfor CDC14B gene

Expression for CDC14B gene

Orthologsfor CDC14B gene

Paralogsfor CDC14B gene

Genomic Variantsfor CDC14B gene

Disorders & Mutationsfor CDC14B gene

Medical Newsfor CDC14B gene

Publicationsfor CDC14B gene

External Searches for CDC14B gene

Genome Databases showing CDC14B gene

Other Databases showing CDC14B gene

Specialized Databases showing CDC14B gene

Intellectual Propertyfor CDC14B gene

Productsfor CDC14B gene

View Random Gene

Aliases &
Descriptions
for CDC14B gene

Summaries
for CDC14B gene

Genomic Views
for CDC14B gene

Proteins
for CDC14B gene

Protein Domains/
Families
for CDC14B gene

Gene Function
for CDC14B gene

Pathways & Interactions
for CDC14B gene

Drugs & Compounds
for CDC14B gene

Transcripts
for CDC14B gene

Expression
for CDC14B gene

Orthologs
for CDC14B gene

Paralogs
for CDC14B gene

Genomic Variants
for CDC14B gene

Disorders & Mutations
for CDC14B gene

Medical News
for CDC14B gene

Publications
for CDC14B gene

Intellectual Property
for CDC14B gene

Products
for CDC14B gene