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CDC25B Gene

protein-coding GIFtS: 67

GC20P003771

cell division cycle 25 homolog B (S. pombe)
(Previous names: cell division cycle 25B, cell division cycle 25 homolog B (S. cerevisiae) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cell division cycle 25 homolog B (S. pombe)¹ ²		M-phase inducer phosphatase 2²
cell division cycle 25B¹ ²		CDC25HU2³
Dual specificity phosphatase Cdc25B² ³		EC 3.1.3.48³
cell division cycle 25 homolog B (S. cerevisiae)¹

External Ids:	HGNC: 1726¹	Entrez Gene: 994²	Ensembl: ENSG00000101224⁷	UniProtKB: P30305³

Export aliases for CDC25B gene to outside databases

Previous GC identifers: GC20P003765 GC20P003724

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDC25B:

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing

two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm

due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell

cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor

formation has not been determined. Multiple transcript variants for this gene exist. (provided by RefSeq)

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly

dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of

activity

summary for CDC25B:

Cdc25 is a dual specificity phosphatase with three isoforms in mammalian cells - cdc25A, B and C. Cdc25

activates cdk complexes that control progression through the cell cycle. Cdc25 is also involved in the DNA

damage checkpoints. Regulation of cdc25 occurs through a variety of mechanisms including phosphorylation,

interaction with 14.3.3 proteins, subcellular localization and protein degradation. Cdc25B is phosphorylated

and activated by aurora kinase A at the start of mitosis, and as mitosis progresses is then further

phosphorylated in an auto-amplification loop, along with cdc25C, by the CDK1/cyclin B complex. Cdc25C is

also phosphorylated during mitosis by PLK1, leading to greater activity of the CDK1/cyclin B complex.

Similarly, Cdc25A acts during the G1/S phase of the cell cycle in concert with the CDK2/cyclin E complex.

Both cdc25A and cdc25B can be activated by the DNA damage checkpoint kinase, Chk1 and thereby inhibit

mitosis.

Gene Wiki entry for CDC25B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDC25B gene promoter:
         GR-beta   GR-alpha   POU2F2C   oct-B2   Oct-B1   POU2F1   oct-B3   POU2F2B   POU2F2   POU2F2 (Oct-2.1)
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CDC25B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDC25B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

CDC25B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDC25B gene location

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P003771: view genomic region (about GC identifiers)

Start:	3,724,986 bp from pter
End:	3,735,364 bp from pter
Size:	10,379 bases
Orientation:	plus strand

1 alternative location:

Chr20+ 3,776,386-3,786,762

RefSeq DNA sequence:

NC_000020.10 NT_011387.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305 (See protein sequence)

Recommended Name: M-phase inducer phosphatase 2

Size: 580 amino acids; 64987 Da

Subcellular location: Cytoplasm, cytoskeleton, centrosome

PDB structures from and Proteopedia :

1CWR (3D)

1CWS (3D)

1CWT (3D)

1QB0 (3D)

1YM9 (3D)

1YMD (3D)

1YMK (3D)

1YML (3D)

1YS0 (3D)

2A2K (3D)

2IFD (3D)

2IFV (3D)

2UZQ (3D)

3FQT (3D)

3FQU (3D)

Secondary accessions: O43551 Q13971 Q5JX77 Q6RSS1 Q9BRA6

Alternative splicing: 4 isoforms: P30305-1 P30305-2 P30305-3 P30305-4

Explore the universe of human proteins at neXtProt for CDC25B: NX_P30305

Post-translational modifications:

Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_004349.1 NP_068658.1 NP_068659.1

ENSEMBL proteins:

ENSP00000245960 ENSP00000339170 ENSP00000405972 ENSP00000368918 ENSP00000339125

Human Recombinant Proteins

	Millipore Purified and/or Recombinant CDC25B Protein
	Sigma-Aldrich Proteins for CDC25B
	R&D Systems Recombinant & Natural Proteins for CDC25B
	Enzo Life Sciences proteins for CDC25B
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): CDC25B
	GenScript Custom Purified and Recombinant Proteins Services for CDC25B
	Novus Biologicals Proteins for CDC25B
	Novus Biologicals Lysates for CDC25B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--
GO:0005815	microtubule organizing center	IEA	--
GO:0005829	cytosol	TAS	--

About this table

CDC25B for ontologies About GeneDecksing

Antibodies for CDC25B:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CDC25B
	R&D Systems Antibodies for CDC25B
	Cell Signaling Technology (CST) Antibodies for CDC25B
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CDC25B
	Novus Biologicals Antibodies for CDC25B
	Browse antibodies at Epitomics

Assays for CDC25B:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDC25B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDC25B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDC25B for domains About GeneDecksing

2 InterPro domains/families:

IPR001763 Rhodanese-like

IPR000751 MPI_Phosphatase

Graphical View of Domain Structure for InterPro Entry P30305

ProtoNet protein and cluster: P30305

2 Blocks protein families:

IPB000751 M-phase inducer phosphatase signature

IPB001763 Rhodanese-like

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305

Similarity: Belongs to the MPI phosphatase family

Similarity: Contains 1 rhodanese domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MPIP2_HUMAN, P30305

Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly

dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of

activity

Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

Enzyme regulation: Stimulated by B-type cyclins

Enzyme Number (IUBMB): EC 3.1.3.48

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC25B Sigma-Aldrich shRNA Panels and shRNA for CDC25B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC25B OriGene shRNA RFP (see all 5): CDC25B OriGene basic RS shRNA (see all 5): CDC25B OriGene siRNA (see all 4): CDC25B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC25B

miRNA:		Sigma-Aldrich microRNA Mimics for CDC25B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC25B
		2 SABiosciences Assays for microRNAs that regulate CDC25B:
		hsa-miR-141 hsa-miR-200a

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for CDC25B

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene untagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene 3'-UTR clone (see all 3): CDC25B Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): CDC25B
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CDC25B

Genatlas biochemistry entry for CDC25B:

cdc25 protein phosphatase,non receptor type,complexing with CDC2 (M phase promoting factor (MPF) component),form

B,regulator of the cell cycle

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004721	phosphoprotein phosphatase activity	TAS	--
GO:0004725	protein tyrosine phosphatase activity	TAS	9188863
GO:0005515	protein binding	IPI	7644510
GO:0016787	hydrolase activity	IEA	--

About this table

CDC25B for ontologies About GeneDecksing

Animal Models: 5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdc25b):

digestive/alimentary

endocrine/exocrine gland

growth/size

life span-post-weaning/aging

reproductive system

CDC25B for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CDC25B for pathways About GeneDecksing

2 Millipore Pathways for CDC25B

	Cell cycle Role of 14-3-3 proteins in cell cycle regulation
	Cell cycle Cell cycle (generic schema)

3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CDC25B

	Molecular Mechanisms of Cancer
	Mitotic Roles of Polo-Like Kinase
	Cell Cycle: G2/M DNA Damage Checkpoint Regulation

3 Kegg Pathways (Kegg details for CDC25B):

	hsa04010 MAPK signaling pathway
	hsa04110 Cell cycle
	hsa04914 Progesterone-mediated oocyte maturation

SABiosciences Pathway-Focused PCR Array including CDC25B: PAHS-045A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CDC25B

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDC25B

5/29 Interacting proteins for CDC25B (P30305^{1, 2} ENSP00000245960³) via UniProtKB, MINT, and/or STRING (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946¹^,², ENSP00000361930³	EBI-1051746,EBI-359815 MINT-19327 MINT-8006726 MINT-51064 MINT-51065 MINT-8007484 MINT-25122 STRING: ENSP00000361930
YWHAE	P62258¹^,², ENSP00000264335³	EBI-1051746,EBI-356498 MINT-51066 MINT-25123 MINT-8004866 MINT-51067 STRING: ENSP00000264335
YWHAZ	P63104², ENSP00000309503³	MINT-19329 MINT-8006377 MINT-17849 MINT-17850 MINT-8006848 MINT-25121 MINT-8007512 STRING: ENSP00000309503
YWHAH	Q04917², ENSP00000248975³	MINT-8007505 MINT-25118 MINT-19328 MINT-19330 STRING: ENSP00000248975
SFN	P31947², ENSP00000340989³	MINT-51068 MINT-51069 MINT-51070 MINT-8007498 STRING: ENSP00000340989

About this table

5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000087	M phase of mitotic cell cycle	--	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0001556	oocyte maturation	--	--
GO:0006470	protein dephosphorylation	IEA	--

About this table

CDC25B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

CDC25B for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for CDC25B:

Small Molecule - Inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for CDC25B available from Tocris Bioscience

Compound	Action	CAS number
NSC 95397	Selective Cdc25 dual specificity phosphatase inhibitor	[93718-83-3]
NSC 663284	Potent, selective Cdc25 phosphatase inhibitor	[383907-43-5]

About this table

9 Novoseek chemical compound relationships for CDC25B gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leptomycin b	43.8	1	15003534 (1)
tyrosine	40.1	9	14767478 (2), 20025242 (1), 15498512 (1), 1836978 (1) (see all 6)
quinone	39.5	1	18802630 (1)
hydroxyurea	27.4	3	15556082 (1), 10392903 (1), 9281587 (1)
threonine	26.8	1	19075567 (1)
alanine	9.72	5	17003105 (1), 19638579 (1), 19276368 (1), 15173315 (1)
steroid	0	4	15193457 (3), 14559803 (1)
estrogen	0	2	15193457 (1), 14559803 (1)
cycloheximide	0	6	9281587 (2), 15456846 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDC25B Sigma-Aldrich shRNA Panels and shRNA for CDC25B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CDC25B OriGene shRNA RFP (see all 5): CDC25B OriGene basic RS shRNA (see all 5): CDC25B OriGene siRNA (see all 4): CDC25B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDC25B

miRNA:		Sigma-Aldrich microRNA Mimics for CDC25B Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDC25B
		2 SABiosciences Assays for microRNAs that regulate CDC25B:
		hsa-miR-141 hsa-miR-200a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene untagged cDNA clones in CMV expression vector (see all 3): CDC25B OriGene 3'-UTR Clone (see all 3): CDC25B Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): CDC25B

Primers:		OriGene genome-wide validated SYBR primer pairs: CDC25B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CDC25B: PPH01353A

REFSEQ mRNAs for CDC25B gene (3 alternative transcripts):

NM_004358.3 NM_021872.2 NM_021873.2

Additional cDNA sequence:

AK092713.1 AK295573.1 AK299028.1 AK299192.1 BC006395.2 BC009953.2 BC051711.1 BX640836.1

BX647988.1 CR591656.1 CR615304.1 CR620818.1 CR621743.1 M81934.1 S78187.1 Z68092.1

24/29 DOTS entries (see all 29):

DT.452676 DT.100812620 DT.100812628 DT.95244406 DT.101983619 DT.100812618 DT.100724666 DT.95244417

DT.100801781 DT.100812626 DT.97859977 DT.40116000 DT.100038305 DT.100812622 DT.95214264 DT.102822230

DT.120819392 DT.75117755 DT.95183579 DT.95244409 DT.100703642 DT.100738683 DT.120819356 DT.120819360

24/474 AceView cDNA sequences (see all 474):

CD051129 AI377984 R34850 BE394398 NM_021873 BU185973 T29904 CB127846

BQ961380 BM054792 AW245589 AI338486 AW295078 BF940005 AA402784 BM838191

BC011985 BQ225371 H20246 BE676194 CN484019 BM793120 BU507591 AK124284

highest scoring ESTs for CDC25B:

S78187 AA102013 AA306789 AA310302 AA311345 AA352638 AA357400 AA402262 AA448755 AA514594

Unigene Cluster for CDC25B:

Cell division cycle 25 homolog B (S. pombe)

Hs.153752 [show with all ESTs]

Unigene Representative Sequence: NM_021873

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CDC25B (see all 15)

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	·
SP1:							-		-		-		-		-						-				-		-						-														-		-
SP2:							-		-		-		-		-		-				-				-		-						-														-		-
SP3:															-						-				-		-						-														-		-
SP4:															-		-				-				-		-						-														-		-
SP5:															-						-				-		-						-		-		-										-		-

ExUns:	12c	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	·	20c
SP1:							-
SP2:							-
SP3:							-
SP4:							-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for CDC25B
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000245960(uc010zqk.1 uc010zql.1 uc010zqm.1 uc002wjl.2 uc002wjm.2 uc002wjn.2 uc002wjo.2 uc002wjp.2 uc002wjq.2 uc010gbc.2)

ENST00000340833 ENST00000495915 ENST00000468979 ENST00000439880 ENST00000379598

ENST00000480816 ENST00000467519 ENST00000344256

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CDC25B expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching CDC25B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1347_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	S78187	1.00	1.00	1.00	1
201853_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021873	0.60	1.00	0.82	1
201853_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

CDC25B for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CDC25B gene electronic northern expression

About these images

CGAP SAGE TAG: ACAGCCTGCA

SOURCE GeneReport for Unigene cluster: Hs.153752

Expression variation in blood from EXPOLDB for CDC25B

Primers:		OriGene genome-wide validated SYBR primer pairs: CDC25B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CDC25B: PPH01353A

SABiosciences Expression via Pathway-Focused PCR Array including CDC25B: PAHS-045A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDC25B gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDC25B¹	--	cell division cycle 25 homolog B (S. pombe)	86.45(n) 86.39(a)	485790 XM_845093.1 XP_850186.1
chimpanzee (Pan troglodytes)	CDC25B¹	--	cell division cycle 25 homolog B (S. pombe)	99.37(n) 99.31(a)	458064 XM_001162706.1 XP_001162706.1
cow (Bos taurus)	CDC25B¹	--	cell division cycle 25 homolog B (S. pombe)	87.78(n) 87.78(a)	505847 XM_866334.2 XP_871427.1
rat (Rattus norvegicus)	Cdc25b¹	--	cell division cycle 25 homolog B (S. pombe)	81.36(n) 80.66(a)	171103 NM_133572.1 NP_598256.1
mouse (Mus musculus)	Cdc25b^{1 , 5}	2 (63.29 cM)⁵	cell division cycle 25 homolog B (S. pombe)^{1, 5}	81.8(n)¹ 81.91(a)¹	12531¹ NM_023117.1¹ NP_075606.1¹ AA000325⁵ AA259306⁵ (see all 20)

About this table Species with no ortholog for CDC25B

ENSEMBL Gene Tree for CDC25B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDC25B gene

CDC25A² CDC25C²

CDC25B for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3516^1,2	C,F,	3786681(-)	`CCCCCA/GTCTTG`	3	--	ut3¹		12	NS MN EA	1242
rs8156^1,2	C,F,A,	3786637(+)	`AAGCAG/CCTAAA`	3	--	ut3¹ ese³		15	NS MN EA NA	1402
rs514521^1,2	--	3785572(-)	`CGCCGG/CCTCCG`	6	/S /R	ref¹ mis¹ ese³		1	MN	184
rs514523^1,2	--	3785571(-)	`GCCGGC/GTCCGC`	6	T S	mis¹ ref¹ ese³		1	MN	184
rs592687^1,2	C,	3783649(-)	`CAAATG/CTGCCT`	3	--	int¹		7	MN NA WA	196
rs932529^1,2	C,F,O,A,	3779629(-)	`CCTTGA/C/G/T AGAAA`	3	--	int¹		28	NA EA NS MN WA	1652
rs1010608^1,2	C,F,A,H,	3784593(-)	`AATAGC/TGACAG`	3	--	int¹		16	NS EA NA WA	1154
rs1056720^1,2	C,F,H,	3784110(+)	`CCCATC/TGCGCC`	6	I	ref¹ syn¹		25	MN EA NS NA WA	3432
rs1803263^1,2	C,F,A,	3786567(+)	`GTGTGC/TCTATT`	3	--	ut3¹ ese³		9	NS WA	698
rs2077151^1,2	C,F,H,	3786831(-)	`CTGTCC/TCCTAC`	3	--	ng3¹		8	NS NA EA	340

About this table

HapMap Linkage Disequilibrium images for CDC25B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDC25B: --

QIAGEN SeqTarget long-range PCR primers for resequencing CDC25B

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDC25B for disorders About GeneDecksing

OMIM: 116949

10/18 Novoseek disease relationships for CDC25B gene (see all 18)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	43.3	26	19276368 (3), 16818502 (2), 12801222 (1), 14712212 (1) (see all 20)
tumors	36.8	39	9563496 (5), 9751615 (4), 10850455 (3), 15193457 (2) (see all 23)
neoplastic transformation	30.7	1	17361412 (1)
carcinoma squamous cell	28.7	11	11487274 (2), 11972550 (2), 18722351 (1), 11489794 (1) (see all 7)
mammary tumor	23.4	2	10498865 (1), 10467401 (1)
primary tumor	23	5	18722351 (1), 11489794 (1), 17651784 (1), 10467401 (1)
neck cancer	14.8	3	14769838 (1), 9192810 (1), 9751615 (1)
breast cancer	7.98	1	7667636 (1)
nsclc	4.27	17	17651784 (6), 11597794 (4), 9751615 (3)
colorectal carcinoma	2.01	3	10850455 (2)

About this table

Human Genome Epidemiology (HuGE) Navigator: CDC25B (7 documents)
Tumor Gene Database (TGDB): CDC25B

Export disorders and mutations for CDC25B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/164 PubMed articles for CDC25B gene, integrated from 7 sources (see all 164):
(articles sorted by number of sources associating them with CDC25B)

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. (PubMed id 1836978)^{1, 2, 3, 7} Galaktionov K.I. and Beach D. (1991)
Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? (PubMed id 9188863)^{1, 2, 7} Baldin V.... Docommun B. (1997)
Centrosome-associated Chk1 prevents premature activation of cyclin-B- Cdk1 kinase. (PubMed id 15311285)^{1, 2} Kraemer A.... Lukas J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle. (PubMed id 10543950)^{1, 2} Reynolds R.A....Watenpaugh K.D. (1999)
An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. (PubMed id 1662986)^{1, 2} Nagata A.... Okayama H. (1991)
Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B. (PubMed id 15173315)^{1, 7} Uchida S....Yamashita K. (2004)
Coordinate expression of Cdc25B and ER-alpha is frequent in low-grade endometrioid endometrial carcinoma but uncommon in high-grade endometrioid and nonendometrioid carcinomas. (PubMed id 14559803)^{1, 7} Wu W....Lu K.H. (2003)
Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress. (PubMed id 15456846)^{1, 7} Lindqvist A....Karlsson Rosenthal C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 994	HGNC: 1726	AceView: CDC25BandC20orf29	Ensembl:ENSG00000101224	euGenes: HUgn994
ECgene: CDC25B	Kegg: 994	H-InvDB: CDC25B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDC25B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdc25b/

Intellectual Property for CDC25B gene
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Patent Information for CDC25B gene:
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Antibodies & Assays for CDC25B

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