Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



CDK10 Gene

protein-coding   GIFtS: 55

GC16P075448
cyclin-dependent kinase 10
(Previous name: cyclin-dependent kinase (CDC2-like) 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cyclin-dependent kinase 101 2     serine/threonine protein kinase PISSLRE2
PISSLRE1 2 5     cell division protein kinase 102
cyclin-dependent kinase (CDC2-like) 101 2     OTTHUMP000002178472
Serine/threonine-protein kinase PISSLRE2 3     cyclin-dependent kinase related protein2
CDC2-related protein kinase2     EC 2.7.11.223

External Ids:    HGNC: 17701   Entrez Gene: 85582   Ensembl: ENSG000001853247   UniProtKB: Q151313   

Export aliases for CDK10 gene to outside databases

Previous GC identifers: GC16P081075 GC16P090742 GC16P089455 GC16P089496 GC16P088280 GC16P089753


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK10:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily
members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be
essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its
function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq)

Gene Wiki entry for CDK10 (Cyclin-dependent kinase 10)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK10 gene promoter:
         c-Myb   Pax-2   GR-alpha   E47   AREB6   GCNF-2   GCNF-1   HSF1 (long)   GATA-1   STAT5A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CDK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDK10 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK10 gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P075448:  view genomic region     (about GC identifiers)

Start:
75,448,350 bp from pter
End:
75,458,046 bp from pter
Size:
9,697 bases
Orientation:
plus strand

1 alternative location:
Chr16+ 89,753,078-89,762,772     
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131 (See protein sequence)
Recommended Name: Cell division protein kinase 10  
Size: 360 amino acids; 41038 Da
Secondary accessions: A8MXU6 B7Z420 Q0VGZ7 Q15130 Q6PJC0
Alternative splicing: 4 isoforms:  Q15131-1   Q15131-2   Q15131-3   Q15131-4   

Explore the universe of human proteins at neXtProt for CDK10: NX_Q15131 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001092003.2  NP_001153839.1  NP_443713.2  NP_443714.3  


    ENSEMBL proteins: 
    ENSP00000426264 ENSP00000404540 ENSP00000338673 ENSP00000421597 ENSP00000423370 ENSP00000329957 
    ENSP00000376797 ENSP00000426102 ENSP00000424415 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CDK10 
    Novus Biologicals Protein for CDK10
    Novus Biologicals Lysate for CDK10
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for CDK10: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CDK10
    Browse R&D Systems for Antibodies
    OriGene Antibodies: CDK10
    GenScript Custom Superior Antibodies Services for CDK10 
    Novus Biologicals Antibody for CDK10
    Browse antibodies at Epitomics

    Assays for CDK10: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK10 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK10 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDK10 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15131

    ProtoNet protein and cluster: Q15131

    UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.22 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for CDK10
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDK10
    Sigma-Aldrich shRNA Panels and shRNA for CDK10
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): CDK10
    OriGene shRNA RFP (see all 7): CDK10
    OriGene basic RS shRNA (see all 7): CDK10
    OriGene siRNA (see all 7): CDK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDK10 
    miRNA:Sigma-Aldrich microRNA Mimics for CDK10
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDK10 
    Search SABiosciences for Assays for microRNAs that regulate CDK10

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene untagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene 3'-UTR clone (see all 4): CDK10 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDK10 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CDK10 

    Genatlas biochemistry entry for CDK10:
    cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex splicing,acting
    in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004693 cyclin-dependent protein kinase activity IEA--
    GO:0005515 protein binding IPI18242510
    About this table

    CDK10 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for CDK10 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK10

    1 Interacting protein for CDK10 (ENSP000003386733 Q151311) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS2P150361STRING: ENSP00000353344 EBI-1646959,EBI-1646991
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    GO:0007089 traversing start control point of mitotic cell cycle TAS8208557
    GO:0008285 negative regulation of cell proliferation TAS8208557
    About this table

    CDK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK10


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for CDK10
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDK10
    Sigma-Aldrich shRNA Panels and shRNA for CDK10
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): CDK10
    OriGene shRNA RFP (see all 7): CDK10
    OriGene basic RS shRNA (see all 7): CDK10
    OriGene siRNA (see all 7): CDK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDK10 
    miRNA: Sigma-Aldrich microRNA Mimics for CDK10
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDK10 
    Search SABiosciences for Assays for microRNAs that regulate CDK10
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene untagged cDNA clones in CMV expression vector (see all 4): CDK10
    OriGene 3'-UTR Clone (see all 4): CDK10 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDK10 
    Primers: OriGene genome-wide validated SYBR primer pairs: CDK10
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDK10: PPH05724A

    REFSEQ mRNAs for CDK10 gene (4 alternative transcripts): 

    NM_001098533.2  NM_001160367.1  NM_052987.3  NM_052988.4  

    Additional cDNA sequence: 

    AK131531.1 AK290485.1 AK292351.1 AK295397.1 AK296631.1 AK298386.1 AK312016.1 BC017342.2 
    BC025301.1 CR595282.1 CR595651.1 CR599641.1 CR602954.1 CR612010.1 CR615113.1 CR617735.1 
    CR624710.1 L33264.1 

    24/29 DOTS entries (see all 29):

    DT.92413136  DT.120667672  DT.97847205  DT.100837924  DT.97847207  DT.100816583  DT.100816578  DT.86854973 
    DT.95252922  DT.120667665  DT.100816587  DT.95252931  DT.95306968  DT.99958417  DT.100836930  DT.100816593 
    DT.101984825  DT.95252941  DT.120667608  DT.120667648  DT.86854975  DT.102830992  DT.120667647  DT.120667667 

    24/255 AceView cDNA sequences (see all 255):

    BG676853 AI653574 AU107437 BQ184950 BM790720 BM924066 AW614035 NM_052988 
    F02549 BI823967 AI653044 CR602954 BM718757 BI917250 CR615113 CK819887 
    BQ214789 AK075036 AW473588 CR624710 BC025301 CR599641 BM773127 BX370771 

    highest scoring ESTs for CDK10:

    AA150212 AA548884 AA716692 AA805915 AA807211 AA947224 AI141781 AI183680 AI184032 AI215504 

    Unigene Cluster for CDK10:

    Cyclin-dependent kinase 10
    Hs.699177  [show with all ESTs]
    Unigene Representative Sequence: AK131531


    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 (see all 18)

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ·
    SP1:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP2:                                      -     -     -     -     -                                   -           -                 -     -     -     -         
    SP3:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP4:                                      -     -                 -                                   -           -                 -     -     -     -         
    SP5:                                -     -     -                 -                                   -           -                 -     -     -     -         

    ExUns: 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:        -     -     -                             -                           
    SP2:        -     -     -                                                         
    SP3:        -                                                                     
    SP4:                                                                              
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for CDK10
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512912 ENST00000437260(uc002fof.2) ENST00000353379(uc002fob.2 uc002foe.2 uc010cio.2 uc002fog.3 uc002foh.3 uc002foi.2)
    ENST00000502547 ENST00000514965 ENST00000507205 ENST00000503560 ENST00000378277
    ENST00000508723 ENST00000504473 ENST00000472018(uc010cip.2 uc010vpl.1)
    ENST00000331006(uc002fod.2) ENST00000510811(uc002foa.2) ENST00000393082
    ENST00000505733 ENST00000511415 ENST00000505473

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CDK10 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching CDK10 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1790_s_at2, 3 U95-A 1 1.00 1.00 0.70 1.15 HG3914-HT4184 0.20 1.00 0.72 1
    160024_at2, 3 U95-A 1 0.62 1.00 0.88 0.85 X78342 0.80 1.00 0.91 1
    203469_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003674 0.40 1.00 0.76 1
    210622_x_at2, 3 U133-A 1 1.00 1.00 -- -- AF153430 0.60 1.00 0.82 1
    203468_at2, 3 U133-A 1 0.91 1.00 -- -- NM_003674 0.40 1.00 0.76 1
    203469_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    210622_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    203468_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    CDK10 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CDK10 gene expression
    CDK10 gene electronic northern expression
    CDK10 gene sage expression
    About these images

    CGAP SAGE TAG: GAGGACCCAA

    SOURCE GeneReport for Unigene cluster: Hs.699177

    Expression variation in blood from EXPOLDB for CDK10

    Primers: OriGene genome-wide validated SYBR primer pairs: CDK10
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDK10: PPH05724A
        SABiosciences Custom PCR Arrays for CDK10 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CDK10 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CDK101   -- cyclin-dependent kinase 10 88.15(n)
    93.06(a)
    489655  XM_546775.2  XP_546775.1 
    cow
    (Bos taurus)
    CDK101   -- cyclin-dependent kinase 10 89.85(n)
    94.69(a)
    615171  NM_001038577.1  NP_001033666.1 
    rat
    (Rattus norvegicus)
    Cdk101   -- cyclin-dependent kinase 10 87.45(n)
    97.29(a)
    361434  NM_001025722.1  NP_001020893.1 
    mouse
    (Mus musculus)
    Cdk101 , 5 8 (72.09 cM)5
    cyclin-dependent kinase 105
    cyclin-dependent kinase (CDC2-like) 101
    87.04(n)1
    96.94(a)1
    2348541  NM_194446.11  NP_919428.11 
     AK1339185  AK1448015  (see all 16)
    chicken
    (Gallus gallus)
    CDK101   -- cyclin-dependent kinase 10 79.67(n)
    84.96(a)
    415840  XM_414201.2  XP_414201.1 
    About this table        Species with no ortholog for CDK10

    ENSEMBL Gene Tree for CDK10 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CDK10 gene
    CDK62  CDK11B2  CDK42  

    CDK10 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/127 NCBI SNPs in CDK10 are shown (see all 127)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1647421,2
    C,F,A,H,89757725(-) GAGAAT/CTGGGG 3 -- int18Minor allele frequency- C:0.35NS EA NA WA 424
    rs1647431,2
    C,H89757431(-) CAGGCG/ATGAGC 3 -- int16Minor allele frequency- A:0.00NA WA 12
    rs1647441,2
    C,F,A,89756768(-) TCCTCA/CTTTGA 3 -- int111Minor allele frequency- C:0.31NS EA NA WA 636
    rs1872821,2
    C,F,89758973(-) AGAGTC/TAGGCC 3 -- int110Minor allele frequency- T:0.02MN NS EA NA 608
    rs2583211,2
    C,F,89756473(-) tttttT/Cgagac 3 -- int14Minor allele frequency- C:0.37NA WA 78
    rs2583221,2
    C,F,A,89755903(-) TACAAC/TGTTTG 3 -- int126Minor allele frequency- T:0.48EA NA NS WA 2832
    rs2583231,2
    C,F,A,89754694(-) actaaC/Gacggt 3 -- int15Minor allele frequency- G:0.03EA NS NA 298
    rs2583241,2
    C,F,O,H,89754255(-) CTCAAC/ACTCCC 3 -- int120Minor allele frequency- A:0.24NS EA NA WA 2678
    rs2583251,2
    C,F,H,89753971(-) aaaagG/AaaaGG 3 -- int1 trp311Minor allele frequency- A:0.01NS EA NA WA 432
    rs2583261,2
    C,89753474(-) GGAGCC/TTGCTC 3 -- int112Minor allele frequency- T:0.01MN NS EA NA WA 610
    About this table

    HapMap Linkage Disequilibrium images for CDK10 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CDK10
         2 CNVs: 49803 4977

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for CDK10 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDK10 for disorders           About GeneDecksing

    OMIM: 603464


    Export disorders and mutations for CDK10 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/29 PubMed articles for CDK10 gene, integrated from 7 sources (see all 29):
    (articles sorted by number of sources associating them with CDK10)
    1. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PubMed id 8084611)1, 2, 3 Brambilla R. and Draetta G. (1994)
    2. PISSLRE, a human novel CDC2-related protein kinase. (PubMed id 8208557)1, 2, 3 Grana X.... Giordano A. (1994)
    3. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. (PubMed id 10036189)1, 2 Crawford J.... Savoia A. (1999)
    6. Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity. (PubMed id 11313931)1, 7 Kasten M. and Giordano A. (2001)
    7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 7 Bullrich F....Croce C.M. (1995)
    8. Human CDK10 gene isoforms. (PubMed id 11006117)1, 7 Sergere J.C.... Leteurtre F. (2000)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. CDK10 is not a target for aberrant DNA methylation in breast cancer. (PubMed id 19846932)1 Heller G....Filipits M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8558 HGNC: 1770 AceView: CDK10 Ensembl:ENSG00000185324 euGenes: HUgn8558
    ECgene: CDK10 H-InvDB: CDK10

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CDK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CDK10 gene:
    Search GeneIP for patents involving CDK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for CDK10 Antibodies for CDK10
     Super-pooled esiRNAs for CDK10 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CDK10 microRNA Mimics for CDK10
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for CDK10
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDK10
     Search QIAGEN SeqTarget long-range PCR primers for resequencing for CDK10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDK10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDK10
     GenScript Custom Purified and Recombinant Proteins Services for CDK10 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CDK10
     GenScript Custom Assay Services for CDK10 GenScript Custom Superior Antibodies Services for CDK10
     GenScript Custom overexpressing Cell Line Services for CDK10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDK10 promoter
     Search Chromatin IP Primers for CDK10
     RT2 qPCR Primer Assay for CDK10
     GNC Network for CDK10
     Search for Assays for microRNAs that regulate CDK10
     SABiosciences Custom PCR Arrays for CDK10
     Search Tocris compounds for CDK10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for CDK10
     Proteins for CDK10
     Lysates for CDK10
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for CDK10
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    CDK10 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4