Aliases &
Descriptions
for CDK10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cyclin-dependent kinase 101 2 | | serine/threonine protein kinase PISSLRE2 | | PISSLRE1 2 5 | | cell division protein kinase 102 | | cyclin-dependent kinase (CDC2-like) 101 2 | | OTTHUMP000002178472 | | Serine/threonine-protein kinase PISSLRE2 3 | | cyclin-dependent kinase related protein2 | | CDC2-related protein kinase2 | | EC 2.7.11.223 |
Export aliases for CDK10 gene to outside databasesPrevious GC identifers: GC16P081075 GC16P090742 GC16P089455 GC16P089496 GC16P088280 GC16P089753 |
Summaries
for CDK10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDK10:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamilymembers are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to beessential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and itsfunction is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been foundfor this gene. (provided by RefSeq)
Gene Wiki entry for CDK10 (Cyclin-dependent kinase 10) |
Genomic Views
for CDK10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDK10 gene promoter:
c-Myb Pax-2 GR-alpha E47 AREB6 GCNF-2 GCNF-1 HSF1 (long) GATA-1 STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDK10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3CDK10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P075448: view genomic region
(about GC identifiers)
Start:
|
75,448,350 bp from pter |
End:
|
75,458,046 bp from pter |
Size:
|
9,697 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 89,753,078-89,762,772 |
RefSeq DNA sequence:- NC_000016.9 NT_010542.15
|
Proteins
for CDK10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131 (See
protein sequence)Recommended Name: Cell division protein kinase 10 Size: 360 amino acids; 41038 Da
Secondary accessions: A8MXU6 B7Z420 Q0VGZ7 Q15130 Q6PJC0Alternative splicing: 4 isoforms: Q15131-1 Q15131-2 Q15131-3 Q15131-4 Explore the universe of human proteins at neXtProt for CDK10: NX_Q15131
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001092003.2 NP_001153839.1 NP_443713.2 NP_443714.3
ENSEMBL proteins: ENSP00000426264 ENSP00000404540 ENSP00000338673 ENSP00000421597 ENSP00000423370 ENSP00000329957 ENSP00000376797 ENSP00000426102 ENSP00000424415
Human Recombinant Proteins
Antibodies for CDK10:
Assays for CDK10: |
Protein
Domains/
Families
for CDK10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK10 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q15131ProtoNet protein and cluster: Q15131 UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for CDK10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.22
Genatlas biochemistry entry for CDK10:cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex splicing,actingin G2 phase of the cell cycle,not deleted in sporadic breast carcinoma5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
CDK10 for ontologies About GeneDecksing
|
Pathways & Interactions
for CDK10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CDK10
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK10
1 Interacting protein for CDK10 (ENSP000003386733 Q151311) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CDK10 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CDK10
|
Transcripts
for CDK10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CDK10 gene (4 alternative transcripts): NM_001098533.2 NM_001160367.1 NM_052987.3 NM_052988.4 Additional cDNA sequence: AK131531.1 AK290485.1 AK292351.1 AK295397.1 AK296631.1 AK298386.1 AK312016.1 BC017342.2 BC025301.1 CR595282.1 CR595651.1 CR599641.1 CR602954.1 CR612010.1 CR615113.1 CR617735.1 CR624710.1 L33264.1 24/29 DOTS entries (see all 29): DT.92413136 DT.120667672 DT.97847205 DT.100837924 DT.97847207 DT.100816583 DT.100816578 DT.86854973 DT.95252922 DT.120667665 DT.100816587 DT.95252931 DT.95306968 DT.99958417 DT.100836930 DT.100816593 DT.101984825 DT.95252941 DT.120667608 DT.120667648 DT.86854975 DT.102830992 DT.120667647 DT.120667667 24/255 AceView cDNA sequences (see all 255): BG676853 AI653574 AU107437 BQ184950 BM790720 BM924066 AW614035 NM_052988 F02549 BI823967 AI653044 CR602954 BM718757 BI917250 CR615113 CK819887 BQ214789 AK075036 AW473588 CR624710 BC025301 CR599641 BM773127 BX370771
 highest scoring ESTs for CDK10:AA150212 AA548884 AA716692 AA805915 AA807211 AA947224 AI141781 AI183680 AI184032 AI215504 Unigene Cluster for CDK10: Cyclin-dependent kinase 10 Hs.699177 [show with all ESTs]Unigene Representative Sequence: AK131531
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 (see all 18)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | - | | - | | - | | - | | | |
| ExUns: | 11c | · | 11d | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CDK10
17 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000512912 ENST00000437260(uc002fof.2) ENST00000353379(uc002fob.2 uc002foe.2 uc010cio.2 uc002fog.3 uc002foh.3 uc002foi.2)
ENST00000502547 ENST00000514965 ENST00000507205 ENST00000503560 ENST00000378277
ENST00000508723 ENST00000504473 ENST00000472018(uc010cip.2 uc010vpl.1)
ENST00000331006(uc002fod.2) ENST00000510811(uc002foa.2) ENST00000393082
ENST00000505733 ENST00000511415 ENST00000505473
|
Expression
for CDK10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CDK10 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching CDK10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1790_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.70 |
1.15 |
HG3914-HT4184 |
0.20 |
1.00 |
0.72 |
1 |
| 160024_at2, 3
|
U95-A |
1 |
0.62 |
1.00 |
0.88 |
0.85 |
X78342 |
0.80 |
1.00 |
0.91 |
1 |
| 203469_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_003674 |
0.40 |
1.00 |
0.76 |
1 |
| 210622_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF153430 |
0.60 |
1.00 |
0.82 |
1 |
| 203468_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_003674 |
0.40 |
1.00 |
0.76 |
1 |
| 203469_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210622_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 203468_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CDK10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGGACCCAA
SOURCE GeneReport for Unigene cluster: Hs.699177
Expression variation in blood from EXPOLDB for CDK10 SABiosciences Custom PCR Arrays for CDK10
|
Orthologs
for CDK10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDK10 gene from 5/13 species (see all 13)
About this table Species with no ortholog for CDK10
ENSEMBL Gene Tree for CDK10 (if available) |
Paralogs
for CDK10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CDK10 gene
- CDK62 CDK11B2 CDK42
CDK10 for paralogs About GeneDecksing
|
Genomic Variants
for CDK10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CDK10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CDK10
2 CNVs: 49803 4977 |
Disorders & Mutations
for CDK10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK10 for disorders About GeneDecksing
OMIM: 603464
Export disorders and mutations for CDK10 gene to outside databases
|
Medical News
for CDK10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDK10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/29 PubMed articles for CDK10 gene, integrated from 7 sources (see all 29):
(articles sorted by number of sources associating them with CDK10)- Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PubMed id 8084611)1, 2, 3 Brambilla R. and Draetta G. (1994)
- PISSLRE, a human novel CDC2-related protein kinase. (PubMed id 8208557)1, 2, 3 Grana X.... Giordano A. (1994)
- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. (PubMed id 10036189)1, 2 Crawford J.... Savoia A. (1999)
- Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity. (PubMed id 11313931)1, 7 Kasten M. and Giordano A. (2001)
- Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 7 Bullrich F....Croce C.M. (1995)
- Human CDK10 gene isoforms. (PubMed id 11006117)1, 7 Sergere J.C.... Leteurtre F. (2000)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- CDK10 is not a target for aberrant DNA methylation in breast cancer. (PubMed id 19846932)1 Heller G....Filipits M. (2009)
|
External Searches for CDK10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDK10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDK10 gene:
Search GeneIP for patents involving CDK10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDK10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for CDK10 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CDK10 |
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