Aliases &
Descriptions
for CDK16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cyclin-dependent kinase 161 2 | | Serine/threonine-protein kinase PCTAIRE-12 3 | | PCTK12 3 5 | | PCTAIRE-motif protein kinase 12 3 | | PCTGAIRE1 2 | | PCTAIRE protein kinase 11 | | PCTAIRE1 2 | | cell division protein kinase 162 | | PCTAIRE11 2 | | EC 2.7.11.223 | | FLJ166651 2 | | |
Export aliases for CDK16 gene to outside databasesPrevious GC identifers: GC0XP046963 GC0XP047078 |
Summaries
for CDK16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDK16:
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It mayplay a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport ofsecretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicingresults in multiple transcript variants encoding different isoforms. (provided by RefSeq)
UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536Function: May play a role in signal transduction cascades in terminally differentiated cells
Gene Wiki entry for CDK16 (PCTK1) |
Genomic Views
for CDK16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDK16
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDK16  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11CDK16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP044787: view genomic region
(about GC identifiers)
Start:
|
44,787,880 bp from pter |
End:
|
44,799,166 bp from pter |
Size:
|
11,287 bases |
Orientation:
|
plus strand |
1 alternative location:
| ChrX+ 47,077,259-47,089,396 |
RefSeq DNA sequence:- NC_000023.10 NT_079573.4
|
Proteins
for CDK16 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536 (See
protein sequence)Recommended Name: Cell division protein kinase 16 Size: 496 amino acids; 55716 Da
Subunit: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ (By similarity)
PDB structures from  and Proteopedia  :3MTL (3D)
Secondary accessions: A8K280Explore the universe of human proteins at neXtProt for CDK16: NX_Q00536
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001163931.1 NP_006192.1 NP_148978.2
ENSEMBL proteins: ENSP00000430988 ENSP00000429044 ENSP00000349762 ENSP00000428351 ENSP00000431085 ENSP00000429985 ENSP00000276052 ENSP00000429259 ENSP00000430824 ENSP00000430486 ENSP00000430966 ENSP00000405798 ENSP00000428349 ENSP00000429751
Human Recombinant Proteins
Antibodies for CDK16:
Assays for CDK16: |
Protein
Domains/
Families
for CDK16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK16 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q00536ProtoNet protein and cluster: Q00536 UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for CDK16 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536Function: May play a role in signal transduction cascades in terminally differentiated cellsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.22
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
CDK16 for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Cdk16 (no phenotypes)
CDK16 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDK16 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CDK16 for pathways About GeneDecksing
1  Millipore Pathway for CDK16
SABiosciences Custom Pathway-Focused PCR Arrays for CDK16
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK16
2 Interacting proteins for CDK16 (Q005361, 2) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- |
About this table
CDK16 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CDK16
|
Transcripts
for CDK16 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CDK16 gene (3 alternative transcripts): NM_001170460.1 NM_006201.4 NM_033018.3 Additional cDNA sequence: AB209465.1 AK096881.1 AK290145.1 AK301832.1 AK303849.1 BC001048.2 BC006190.2 BC009852.2 BC015607.2 BT006827.1 CR612039.1 CR620813.1 X66363.1 24/29 DOTS entries (see all 29): DT.100058938 DT.100640965 DT.95110942 DT.443184 DT.100818191 DT.99983136 DT.100818193 DT.100818189 DT.95076636 DT.97862739 DT.121295829 DT.95263149 DT.100818182 DT.121295863 DT.91798196 DT.95208593 DT.100731789 DT.121295816 DT.121295817 DT.121295845 DT.121295856 DT.121295865 DT.40220735 DT.91773109 24/464 AceView cDNA sequences (see all 464): F17521 BI964065 CB306800 H14264 AI144457 BU859301 AK131486 AI917446 BU184870 CN483617 AI051719 BM264559 BM973729 H02429 AI338323 BG490494 BQ945864 BC006190 AW241196 CA433645 BQ012947 CK903784 BI062181 BQ185403 Unigene Cluster for CDK16: Cyclin-dependent kinase 16 Hs.496068 [show with all ESTs]Unigene Representative Sequence: AB209465
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 (see all 21)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CDK16
18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000517997 ENST00000523699 ENST00000520141 ENST00000518391 ENST00000357227(uc004dho.2 uc011mlk.1)
ENST00000520893 ENST00000493213 ENST00000522234 ENST00000522883 ENST00000462483
ENST00000517426 ENST00000428400(uc011mlj.1) ENST00000276052 ENST00000519758
ENST00000523543 ENST00000462827 ENST00000523034 ENST00000520295
|
Expression
for CDK16 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CDK16 expression in normal and diseased human tissues
1 / 2 9 probe-sets matching CDK16 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39183_at2
|
U95-A |
1 |
1.00 |
1.00 |
0.98 |
0.99 |
-- |
-- |
-- |
-- |
-- |
| 1225_g_at2
|
U95-A |
1 |
1.00 |
1.00 |
0.98 |
1.07 |
-- |
-- |
-- |
-- |
-- |
| 1224_at2
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
0.94 |
-- |
-- |
-- |
-- |
-- |
| 207239_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208824_x_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208823_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 207239_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208824_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208823_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CDK16 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCACAGCCAC
SOURCE GeneReport for Unigene cluster: Hs.496068
SABiosciences Custom PCR Arrays for CDK16
|
Orthologs
for CDK16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDK16 gene from 5/7 species (see all 7)
About this table Species with no ortholog for CDK16
ENSEMBL Gene Tree for CDK16 (if available) |
Paralogs
for CDK16 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CDK16 gene
- CDK32 CDK182 CDK142 CDK52 CDK22 CDK172 CDK152 CDK12
CDK16 for paralogs About GeneDecksing
|
Genomic Variants
for CDK16 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CDK16 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CDK16
5 Indels: 96636 83489 83487 96635 83488 | | QIAGEN SeqTarget long-range PCR primers for resequencing CDK16 |
|
Disorders & Mutations
for CDK16 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK16 for disorders About GeneDecksing
OMIM: 311550
Locus Specific Mutation Databases (LSDB): CDK16
Export disorders and mutations for CDK16 gene to outside databases
|
Medical News
for CDK16 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDK16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/34 PubMed articles for CDK16 gene, integrated from 7 sources (see all 34):
(articles sorted by number of sources associating them with CDK16)- Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PubMed id 1437147)1, 3 Okuda T....Downing J.R. (1992)
- A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2 Meyerson M.... Tsai L.-H. (1992)
- Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. (PubMed id 12154078)1, 7 Graeser R....Hunt T. (2002)
- X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. (PubMed id 8852665)1, 7 Carrel L....Willard H.F. (1996)
|
External Searches for CDK16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDK16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK16 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDK16 gene:
Search GeneIP for patents involving CDK16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDK16 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for CDK16 (Pctaire1) |
| | | | Search Tocris compounds for CDK16 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CDK16 |
| |
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