Aliases &
Descriptions
for CDKL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cyclin-dependent kinase-like 1 (CDC2-related kinase)1 2 | | serine/threonine protein kinase KKIALRE2 | | KKIALRE1 2 | | CDC2-related kinase 12 | | Serine/threonine-protein kinase KKIALRE2 3 | | OTTHUMP000001789692 | | Protein kinase p42 KKIALRE2 3 | | P422 | | cyclin-dependent kinase-like 12 | | EC 2.7.11.223 |
Export aliases for CDKL1 gene to outside databasesPrevious GC identifers: GC14M048118 GC14M044592 GC14M048786 GC14M049866 GC14M050796 |
Summaries
for CDKL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDKL1:
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulatesprimarily in the nucleus. Alternative splice variants encoding different protein isoforms have been described, buttheir full-length nature has not been determined. (provided by RefSeq)
|
Genomic Views
for CDKL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDKL1 gene promoter:
CUTL1 Pax-6 PPAR-gamma2 PPAR-gamma1 GR-beta GR-alpha RORalpha1 AREB6 ER-alpha STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKL1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDKL1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.3 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q21.3CDKL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M030921: view genomic region
(about GC identifiers)
Start:
|
30,921,968 bp from pter |
End:
|
30,987,930 bp from pter |
Size:
|
65,963 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr14- 50,796,310-50,883,179 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for CDKL1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532 (See
protein sequence)Recommended Name: Cyclin-dependent kinase-like 1 Size: 357 amino acids; 41671 Da
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAI04978.1; Type=Erroneous initiation; Sequence=AAS00095.1; Type=Erroneous initiation;Sequence=CAA47002.1; Type=Erroneous initiation;
Secondary accessions: Q2M3A4 Q6QUA0Explore the universe of human proteins at neXtProt for CDKL1: NX_Q00532
REFSEQ proteins: NP_004187.2
ENSEMBL proteins: ENSP00000348467 ENSP00000216378 ENSP00000379176
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CDKL1 for ontologies About GeneDecksing
Antibodies for CDKL1:
Assays for CDKL1: |
Protein
Domains/
Families
for CDKL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDKL1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q00532ProtoNet protein and cluster: Q00532 UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding regionSimilarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for CDKL1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.22
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004693 | cyclin-dependent protein kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
About this table
CDKL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CDKL1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including CDKL1: PAHS-057A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDKL1
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- | | GO:0007507 | heart development |
-- | -- |
About this table
CDKL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDKL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CDKL1 for compounds About GeneDecksing
 Browse Tocris compounds for CDKL1
1  Novoseek chemical compound relationship for CDKL1 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
21.6 |
3 |
7579336 (2), 17472728 (1) |
About this table
2 PharmGKB drug compound relationships for CDKL1 geneAbout this table
|
Transcripts
for CDKL1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CDKL1 gene: NM_004196.3 Additional cDNA sequence: AF390028.1 AK308732.1 BC104977.1 X66358.1 8 DOTS entries: DT.40131479 DT.100018854 DT.206768 DT.120765466 DT.40277908 DT.120765602 DT.40129014 DT.91653511 24/35 AceView cDNA sequences (see all 35): AF390028 NM_004196 BM700097 BF439746 AL047521 BE700389 BX099583 BP349057 CA334835 AI333007 BU737897 AW237555 AA334399 AL603471 AI632347 AA680410 AA927373 AK093741 CN478950 BE700387 BX498224 AA043556 BF507529 AI950480
 highest scoring ESTs for CDKL1:AF390028 X66358 AA680410 BE700387 BE700389 NM_004196 AA043555 AA043556 AA334399 AA742987 Unigene Cluster for CDKL1: Cyclin-dependent kinase-like 1 (CDC2-related kinase) Hs.679430 [show with all ESTs]Unigene Representative Sequence: AF390028
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CDKL1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CDKL1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356146(uc010anu.1) ENST00000216378 ENST00000395834(uc001wxz.2)
|
Expression
for CDKL1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CDKL1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching CDKL1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 796_i_at2, 3
|
U95-A |
1 |
0.86 |
1.00 |
0.68 |
1.15 |
X66358 |
0.80 |
1.00 |
0.91 |
1 |
| 795_s_at2, 3
|
U95-A |
1 |
0.62 |
1.00 |
0.79 |
0.71 |
X66358 |
0.80 |
1.00 |
0.91 |
1 |
| 82180_at*2, 3
|
U95-E |
1 |
0.50 |
1.00 |
0.83 |
1.16 |
AA742987 |
0.40 |
1.00 |
0.76 |
1 |
| 207766_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_004196 |
0.60 |
1.00 |
0.82 |
1 |
| 235512_at2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
AW976363 |
0.20 |
1.00 |
0.72 |
1 |
| 207766_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1555286_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 235512_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CDKL1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGAACAGCTG
SOURCE GeneReport for Unigene cluster: Hs.679430
Expression variation in blood from EXPOLDB for CDKL1 UniProtKB/Swiss-Prot: CDKL1_HUMAN, Q00532Tissue specificity: Highly expressed in kidney, and to a lower extent in ovary
SABiosciences Expression via Pathway-Focused PCR Array including CDKL1: PAHS-057A
|
Orthologs
for CDKL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDKL1 gene from 5/11 species (see all 11)
About this table Species with no ortholog for CDKL1
ENSEMBL Gene Tree for CDKL1 (if available) |
Paralogs
for CDKL1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CDKL1 gene
- RAGE2 CDKL22 CDKL52 CDKL32 MAK2 ICK2 CDKL42
CDKL1 for paralogs About GeneDecksing
|
Genomic Variants
for CDKL1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CDKL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CDKL1
2 CNVs: 58676 66642 | | QIAGEN SeqTarget long-range PCR primers for resequencing CDKL1 |
|
Disorders & Mutations
for CDKL1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDKL1 for disorders About GeneDecksing
OMIM: 603441
1 PharmGKB disease relationship for CDKL1 geneAbout this table
Human Genome Epidemiology (HuGE) Navigator: CDKL1 (1 document)
Export disorders and mutations for CDKL1 gene to outside databases
|
Medical News
for CDKL1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDKL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for CDKL1 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with CDKL1)- A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3 Meyerson M.... Tsai L.-H. (1992)
- Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PubMed id 9000130)1, 2, 7 Taglienti C.A.... Davis R.J. (1996)
- The distribution and biochemical properties of a Cdc2 -related kinase, KKIALRE, in normal and Alzheimer brains. (PubMed id 7595554)1, 3 Yen S.H....Dickson D.W. (1995)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1 Cirulli E.T....Goldstein D.B. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. (PubMed id 15499549)1 Tao J.... Kalscheuer V.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. (PubMed id 12704389)5 Cheok M.H....Evans W.E. (2003)
|
External Searches for CDKL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDKL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDKL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDKL1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/cdkl1/ |
|
| | |
About This Section
| Patent Information for CDKL1 gene:
Search GeneIP for patents involving CDKL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKL1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for CDKL1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CDKL1 |
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