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CDKN1B Gene

protein-coding   GIFtS: 67

GC12P012639
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cyclin-dependent kinase inhibitor 1B (p27, Kip1)1 2     cyclin-dependent kinase inhibitor 1B2
KIP11 2 3 5     MEN1B2
P27KIP11 2     OTTHUMP000001950992
MEN42 5     Cyclin-dependent kinase inhibitor p273
CDKN42 5     p27Kip13

External Ids:    HGNC: 17851   Entrez Gene: 10272   Ensembl: ENSG000001112767   UniProtKB: P465273   

Export aliases for CDKN1B gene to outside databases

Previous GC identifers: GC12P012597 GC12P013015 GC12P012768 GC12P012761


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDKN1B:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21.
The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus
controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent
phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from
quiescence to the proliferative state. (provided by RefSeq)

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation
and degradation events

Gene Wiki entry for CDKN1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDKN1B gene promoter:
         AP-1   Sp1   MyoD   GATA-1   GR-alpha   FOXO1a   GR-beta   p53   FOXO4   XBP-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CDKN1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDKN1B 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1-p12   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.1-p12

CDKN1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDKN1B gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P012639:  view genomic region     (about GC identifiers)

Start:
12,639,893 bp from pter
End:
12,644,900 bp from pter
Size:
5,008 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 12,867,992-12,875,305     
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See protein sequence)
Recommended Name: Cyclin-dependent kinase inhibitor 1B  
Size: 198 amino acids; 22073 Da
Subunit: Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated p27kip1.
Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to p27KIP degradation. Interacts
with SPDYA in the SPDYA/CDK2/p27kip1 complex. Interacts (Thr-198 phosphorylated-form) with 14-3-3 proteins, binds
strongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocation
to the cytoplasm. Interacts with AKT1, LYN and UHMK1; the interactions lead to cytoplasmic mislocation,
phosphorylation of p27kip1 and inhibition of cell cycle arrest. Interacts (unphosphorylated form) with CDK2. Interacts
(phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction induces nuclear translocation. Interacts with GRB2.
Interacts with PIM1 and CCND1. Identified in a complex with SKP1, SKP2 and CKS1B (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated
phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression.
Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle
progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of
Tyr-88 and Tyr-89
Miscellaneous: Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial
tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate
PDB structures from and Proteopedia :
1H27 (3D)    1JSU (3D)    2AST (3D)    
Secondary accessions: Q16307 Q5U0H2 Q9BUS6

Explore the universe of human proteins at neXtProt for CDKN1B: NX_P46527 

Post-translational modifications:

  • Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the
  • major site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability.
    Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines.
    The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction
    with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation.
    Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an
    inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is
    required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF1
  • Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by
  • SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like
    complex; leads to its degradation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004055.1  

    ENSEMBL proteins: 
    ENSP00000228872 ENSP00000379629 ENSP00000407597 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CDKN1B
    GenScript Custom Purified and Recombinant Proteins Services for CDKN1B 
    Novus Biologicals Proteins for CDKN1B
    Novus Biologicals Lysates for CDKN1B
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA11800646
    GO:0005654 nucleoplasm TAS--
    GO:0005737 cytoplasm IDA12093740
    GO:0005829 cytosol TAS--
    About this table

    CDKN1B for ontologies           About GeneDecksing



    Antibodies for CDKN1B: 
    Millipore Mono- and Polyclonal Antibodies for the study of CDKN1B
    Sigma-Aldrich Antibodies for CDKN1B
    R&D Systems Antibodies for CDKN1B (p27/Kip1)
    Cell Signaling Technology (CST) Antibodies for CDKN1B  (p27Kip1)
    OriGene Antibodies (see all 6): CDKN1B
    GenScript Custom Superior Antibodies Services for CDKN1B 
    Novus Biologicals Antibodies for CDKN1B
    Epitomics antibodies for CDKN1B

    Assays for CDKN1B: 
    Millipore Kits and Assays for the Analysis of CDKN1B
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for CDKN1B (p27/Kip1)
    GenScript CDKN1B-Activity-based Kinase Assay for Compound Screening 
    Enzo Life Sciences assays for CDKN1B
    Uscn ELISAs and CLIAs for CDKN1B 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDKN1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015456 Cyclin_inhib_p27
     IPR003175 CDI

    Graphical View of Domain Structure for InterPro Entry P46527

    ProtoNet protein and cluster: P46527

    1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity
    Similarity: Belongs to the CDI family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and
    cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation
    and degradation events
    Induction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cells
    progress toward S-phase

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of CDKN1B Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDKN1B
    Sigma-Aldrich shRNA Panels and shRNA for CDKN1B
    OriGene 29mer shRNA kits in GFP-retroviral vector: CDKN1B
    OriGene shRNA RFP: CDKN1B
    OriGene basic RS shRNA: CDKN1B
    OriGene siRNA: CDKN1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDKN1B 
    miRNA:Sigma-Aldrich microRNA Mimics for CDKN1B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDKN1B 
    8/10 SABiosciences Assays for microRNAs that regulate CDKN1B (see all 10):
    hsa-miR-502-5p hsa-miR-520f hsa-miR-222 hsa-miR-221 hsa-miR-105 hsa-miR-196a hsa-miR-196b hsa-miR-24

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for CDKN1B 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CDKN1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CDKN1B
    OriGene untagged cDNA clones in CMV expression vector: CDKN1B
    OriGene 3'-UTR clone: CDKN1B 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDKN1B 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CDKN1B 

    Genatlas biochemistry entry for CDKN1B:
    cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellular
    response after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector of
    signal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B cell
    lymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and in
    thyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poor
    prognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860 protein kinase inhibitor activity IEA--
    GO:0004861 cyclin-dependent protein kinase inhibitor activity TAS--
    GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity TAS8033212
    GO:0005515 protein binding IPI15890360
    GO:0019903 protein phosphatase binding IPI19838216
    About this table

    CDKN1B for ontologies           About GeneDecksing

    Animal Models: 15/26 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cdkn1b) (see all 26):

    adipose tissuebehavior/neurologicalcardiovascular systemcellularcraniofacial
    digestive/alimentaryendocrine/exocrine glandgrowth/sizehearing/vestibular/earhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aging

    CDKN1B for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CDKN1B for pathways           About GeneDecksing

    5/8 Millipore Pathways for CDKN1B (see all 8)
        Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle Role of SCF complex in cell cycle regulation
    Development Role of Activin A in cell differentiation and proliferation
    Development Thrombopoietin-regulated cell processes
    Cell cycle ESR1 regulation of G1/S transition

    5/17 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  CDKN1B (see all 17)
        Pancreatic Adenocarcinoma Signaling
    Antiproliferative Role of TOB in T Cell Signaling
    Chronic Myeloid Leukemia Signaling
    Cell Cycle: G1/S Checkpoint Regulation
    Aryl Hydrocarbon Receptor Signaling

    2 Cell Signaling Technology (CST) Pathways for CDKN1B
        Akt/PKB Signaling
    Cell Cycle Control: G1/S Checkpoint

    5/6 Kegg Pathways  (Kegg details for CDKN1B) (see all 6):
        hsa04012 ErbB signaling pathway
    hsa04110 Cell cycle
    hsa05200 Pathways in cancer
    hsa05215 Prostate cancer
    hsa05220 Chronic myeloid leukemia

        SABiosciences Pathway-Focused PCR Arrays including CDKN1B (see all 11): PAHS-004A PAHS-005A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CDKN1B
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN1B

    5/130 Interacting proteins for CDKN1B (ENSP000002288723 P465271, 2) via UniProtKB, MINT, and/or STRING (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249411, 2STRING: ENSP00000266970 EBI-519280,EBI-375096 MINT-3379700
    CDK4P118021, 2STRING: ENSP00000257904 EBI-519280,EBI-295644 MINT-3379718
    CCNA2P202481STRING: ENSP00000274026 EBI-519280,EBI-457097
    CCND1P243851STRING: ENSP00000227507 EBI-519280,EBI-375001
    CCNE1P248641STRING: ENSP00000262643 EBI-519280,EBI-519526
    About this table

    5/42 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 42):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000079 regulation of cyclin-dependent protein kinase activity TAS8033212
    GO:0000080 G1 phase of mitotic cell cycle TAS--
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    About this table

    CDKN1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CDKN1B for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for CDKN1B:
    Small Molecule - Inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDKN1B
    10/102 Novoseek chemical compound relationships for CDKN1B gene (see all 102)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ly294002 55.1 8 15588951 (2), 12242656 (1), 19443725 (1), 11709727 (1) (see all 7)
    leptomycin b 50.2 9 15735731 (3), 16842750 (1), 11889117 (1)
    eb 1089 49.4 6 12586749 (3), 16340750 (2), 10640426 (1)
    1,25 dihydroxy vitamin d3 44.6 17 9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8)
    mg 132 43.8 2 15173011 (1), 12646415 (1)
    ciglitazone 43.5 9 15763423 (6), 15951157 (1)
    trastuzumab 43.1 20 15611642 (6), 14648698 (3), 15173011 (2), 15642702 (1) (see all 7)
    bromodeoxyuridine 43 2 11738067 (1)
    mimosine 42.6 8 10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1)
    rapamycin 41.5 14 20097763 (3), 8895523 (2), 12393532 (1), 16862180 (1) (see all 9)
    About this table

    5 PharmGKB drug compound relationships for CDKN1B gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    docetaxelFA  14578462
    gemcitabineFA  14578462
    pravastatinFA  10477139
    tamoxifenFA  12907235
    trastuzumabFA  14578462
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of CDKN1B Gene knock-down
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CDKN1B
    Sigma-Aldrich shRNA Panels and shRNA for CDKN1B
    OriGene 29mer shRNA kits in GFP-retroviral vector: CDKN1B
    OriGene shRNA RFP: CDKN1B
    OriGene basic RS shRNA: CDKN1B
    OriGene siRNA: CDKN1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDKN1B 
    miRNA: Sigma-Aldrich microRNA Mimics for CDKN1B
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDKN1B 
    8/10 SABiosciences Assays for microRNAs that regulate CDKN1B (see all 10):
    hsa-miR-502-5p hsa-miR-520f hsa-miR-222 hsa-miR-221 hsa-miR-105 hsa-miR-196a hsa-miR-196b hsa-miR-24
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CDKN1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CDKN1B
    OriGene untagged cDNA clones in CMV expression vector: CDKN1B
    OriGene 3'-UTR Clone: CDKN1B 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDKN1B 
    Primers: OriGene genome-wide validated SYBR primer pairs: CDKN1B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDKN1B: PPH00212A

    REFSEQ mRNAs for CDKN1B gene: 

    NM_004064.3  

    Additional cDNA sequence: 

    AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1 
    BT019553.1 BT019554.1 CR457399.1 CR592928.1 U10906.1 

    13 DOTS entries:

    DT.417848  DT.91687599  DT.92038526  DT.100820961  DT.95238381  DT.95374074  DT.100820955  DT.100820956 
    DT.121171409  DT.121171413  DT.95374076  DT.101970489  DT.95374072 

    24/236 AceView cDNA sequences (see all 236):

    AW023852 AA897321 CB158193 AI380694 CR592928 BQ029289 BF221469 CB216548 
    AA563693 AA988214 H13167 AA749161 AI201163 AA737055 AW022687 U10906 
    NM_004064 R81658 AI093778 H88763 AI284117 BF061836 CA337570 BM055406 

    highest scoring ESTs for CDKN1B:

    AI680672 AA062552 AA063159 AA128541 AA172029 AA172264 AA180797 AA180937 AA192725 AA206836 

    Unigene Cluster for CDKN1B:

    Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
    Hs.238990  [show with all ESTs]
    Unigene Representative Sequence: NM_004064


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228872(uc001rat.2) ENST00000396340 ENST00000477087 ENST00000442489


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CDKN1B expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching CDKN1B gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    2034_s_at2, 3 U95-A 1 0.94 1.00 0.95 0.57 U10906 0.80 1.00 0.91 1
    52535_s_at2, 3 U95-C 1 0.88 1.00 0.87 1.46 AI680672 1.00 1.00 1.00 1
    33847_s_at2, 3 U95-A 1 0.88 1.00 0.93 1.19 U10906 0.80 1.00 0.91 1
    33848_r_at2, 3 U95-A 1 0.81 1.00 0.88 0.80 U10906 0.80 1.00 0.91 1
    209112_at2, 3 U133-A 1 0.73 1.00 -- -- BC001971 0.80 1.00 0.91 1
    209112_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    CDKN1B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CDKN1B gene expression
    CDKN1B gene electronic northern expression
    CDKN1B gene sage expression
    About these images

    CGAP SAGE TAG: TTTTGTGCAT

    SOURCE GeneReport for Unigene cluster: Hs.238990

    Expression variation in blood from EXPOLDB for CDKN1B

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
    Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: CDKN1B
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDKN1B: PPH00212A
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN1B (see all 11): PAHS-004A PAHS-005A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CDKN1B gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CDKN1B1   -- cyclin-dependent kinase inhibitor 1B (p27, Kip1) 89.56(n)
    90.4(a)
    403429  NM_001002957.1  NP_001002957.1 
    chimpanzee
    (Pan troglodytes)
    CDKN1B1   -- cyclin-dependent kinase inhibitor 1B (p27, Kip1) 99.38(n)
    99.38(a)
    466947  XM_522347.2  XP_522347.2 
    cow
    (Bos taurus)
    CDKN1B1   -- cyclin-dependent kinase inhibitor 1B (p27, Kip1) 90.24(n)
    90.91(a)
    512613  XM_590159.3  XP_590159.3 
    rat
    (Rattus norvegicus)
    Cdkn1b1   -- cyclin-dependent kinase inhibitor 1B 87.59(n)
    87.24(a)
    83571  NM_031762.2  NP_113950.2 
    mouse
    (Mus musculus)
    Cdkn1b1 , 5 6 (65.77 cM)5
    cyclin-dependent kinase inhibitor 1B1, 5 87.24(n)1
    87.76(a)1
    125761  NM_009875.31  NP_034005.21 
     AA4083295  AI8437865  (see all 20)
    About this table        Species with no ortholog for CDKN1B

    ENSEMBL Gene Tree for CDKN1B (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CDKN1B gene
    CDKN1C2  CDKN1A2  

    CDKN1B for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    QIAGEN SeqTarget long-range PCR primers for resequencing CDKN1B 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDKN1B for disorders           About GeneDecksing

    OMIM: 600778   disorders: 610755  

    UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527

  • Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine
  • neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic
    overlap of both MEN1 and MEN2

    10/96 Novoseek disease relationships for CDKN1B gene (see all 96)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 80.4 45 12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 40)
    tumors 68.8 455 12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99)
    cancer 61 123 9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 82)
    aggressiveness 56.8 15 19866239 (2), 10223564 (2), 9864434 (1), 10514396 (1) (see all 13)
    multiple endocrine neoplasia type 1 56 5 17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1)
    prostate cancer 52.5 71 15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 37)
    multiple endocrine neoplasia 51.8 8 17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5)
    carcinoma 51.7 63 18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 33)
    carcinoma squamous cell 51.2 35 11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28)
    lip squamous cell carcinoma 50.6 3 14662421 (2), 15743689 (1)
    About this table

    2 PharmGKB disease relationships for CDKN1B gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Breast NeoplasmsFA  14578462
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Gene Mutation Database (HGMD): CDKN1B
    Genetic Association Database (GAD): CDKN1B
    Human Genome Epidemiology (HuGE) Navigator: CDKN1B (57 documents)
    Tumor Gene Database (TGDB): CDKN1B

    Export disorders and mutations for CDKN1B gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/1419 PubMed articles for CDKN1B gene, integrated from 7 sources (see all 1419):
    (articles sorted by number of sources associating them with CDKN1B)
    1. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)1, 2, 3, 7 Polyak K.... Massague J. (1994)
    2. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2, 7 Fujita N.... Tsuruo T. (2002)
    3. The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)1, 4, 7 Schondorf T....Hoopmann M. (2004)
    4. A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction. (PubMed id 15061869)1, 4, 7 Gonzalez P....Andres V. (2004)
    5. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. (PubMed id 7882309)1, 2, 7 Pietenpol J.A.... Rowley J.D. (1995)
    6. Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2 Morishita D.... Fujita N. (2008)
    7. Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. (PubMed id 17254966)1, 2 Grimmler M.... Hengst L. (2007)
    8. Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. (PubMed id 17030811)1, 2 Pellegata N.S.... Atkinson M.J. (2006)
    9. Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. (PubMed id 16880511)1, 2 Sabile A....Krek W. (2006)
    10. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. (PubMed id 16209941)1, 2 Hao B....Pavletich N.P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1027 HGNC: 1785 AceView: CDKN1B Ensembl:ENSG00000111276 euGenes: HUgn1027
    ECgene: CDKN1B Kegg: 1027 H-InvDB: CDKN1B

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CDKN1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdkn1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CDKN1B gene:
    Search GeneIP for patents involving CDKN1B

    GeneCards and IP:
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