Aliases &
Descriptions
for CDKN1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cyclin-dependent kinase inhibitor 1B (p27, Kip1)1 2 | | cyclin-dependent kinase inhibitor 1B2 | | KIP11 2 3 5 | | MEN1B2 | | P27KIP11 2 | | OTTHUMP000001950992 | | MEN42 5 | | Cyclin-dependent kinase inhibitor p273 | | CDKN42 5 | | p27Kip13 |
Export aliases for CDKN1B gene to outside databasesPrevious GC identifers: GC12P012597 GC12P013015 GC12P012768 GC12P012761 |
Summaries
for CDKN1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDKN1B:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21.The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thuscontrols the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependentphosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition fromquiescence to the proliferative state. (provided by RefSeq)
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- andcyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylationand degradation events
Gene Wiki entry for CDKN1B |
Genomic Views
for CDKN1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDKN1B gene promoter:
AP-1 Sp1 MyoD GATA-1 GR-alpha FOXO1a GR-beta p53 FOXO4 XBP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDKN1B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDKN1B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.1-p12 Ensembl cytogenetic band: 12p13.1 HGNC cytogenetic band: 12p13.1-p12CDKN1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P012639: view genomic region
(about GC identifiers)
Start:
|
12,639,893 bp from pter |
End:
|
12,644,900 bp from pter |
Size:
|
5,008 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 12,867,992-12,875,305 |
RefSeq DNA sequence:- NC_000012.11 NT_009714.17
|
Proteins
for CDKN1B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527 (See
protein sequence)Recommended Name: Cyclin-dependent kinase inhibitor 1B Size: 198 amino acids; 22073 Da
Subunit: Interacts with NUP50; the interaction leads to nuclear import and degradation of phosphorylated p27kip1.Interacts with COPS5, subunit of the COP9 signalosome complex; the interaction leads to p27KIP degradation. Interactswith SPDYA in the SPDYA/CDK2/p27kip1 complex. Interacts (Thr-198 phosphorylated-form) with 14-3-3 proteins, bindsstrongly YWHAQ, weakly YWHAE and YWHAH, but not YWHAB nor YWHAZ; the interaction with YWHAQ results in translocationto the cytoplasm. Interacts with AKT1, LYN and UHMK1; the interactions lead to cytoplasmic mislocation,phosphorylation of p27kip1 and inhibition of cell cycle arrest. Interacts (unphosphorylated form) with CDK2. Interacts(phosphorylated on Tyr-88 and Tyr-89) with CDK4; the interaction induces nuclear translocation. Interacts with GRB2.Interacts with PIM1 and CCND1. Identified in a complex with SKP1, SKP2 and CKS1B (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediatedphosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression.Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycleprogression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation ofTyr-88 and Tyr-89
Miscellaneous: Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelialtumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate
PDB structures from  and Proteopedia  :1H27 (3D)
1JSU (3D)
2AST (3D)
Secondary accessions: Q16307 Q5U0H2 Q9BUS6Explore the universe of human proteins at neXtProt for CDKN1B: NX_P46527
Post-translational modifications:
Phosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is themajor site of phosphorylation in resting cells, takes place at the G(0)-G(1) phase and leads to protein stability.Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines.The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interactionwith 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation.Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, aninhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but isrequired for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF1
Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, bySCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-likecomplex; leads to its degradation1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004055.1
ENSEMBL proteins: ENSP00000228872 ENSP00000379629 ENSP00000407597
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CDKN1B for ontologies About GeneDecksing
Antibodies for CDKN1B:
Assays for CDKN1B: |
Protein
Domains/
Families
for CDKN1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDKN1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P46527ProtoNet protein and cluster: P46527 1 Blocks protein family: IPB003175 Cyclin-dependent kinase inhibitor
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527Domain: A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activitySimilarity: Belongs to the CDI family |
Gene Function
for CDKN1B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527Function: Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- andcyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylationand degradation eventsInduction: Maximal levels in quiescence cells and early G(1). Levels decrease after mitogen stimulation as cellsprogress toward S-phase
Genatlas biochemistry entry for CDKN1B:cyclin dependent kinases 2 and 4 (CDK2,CDK4) inhibitor,p27 (Kip1),involved in G1 phase arrest,and in the cellularresponse after DNA damage in cell cycle exit in megacaryocyte,regulator of cell cycle,critical terminal effector ofsignal transduction pathways that control cell differentiation,overexpressed with CCND3 in agressive B celllymphomas,underexpressed in the development and progression of oral squamous cell carcinoma and inthyroid,colon,breast,prostate and superficial bladder carcinomas,deleted in leukemias and other cancers with poorprognosis (pancreatic adenocarcinomas)degraded by proteasomes in gliomas5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
CDKN1B for ontologies About GeneDecksing
Animal Models: 15/26 MGI mutant phenotypes (inferred from 12 alleles ) (MGI details for Cdkn1b) (see all 26):
CDKN1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDKN1B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CDKN1B for pathways About GeneDecksing
5/8  Millipore Pathways for CDKN1B (see all 8)
5/17  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CDKN1B (see all 17)
2 
Cell Signaling Technology (CST) Pathways for CDKN1B
5/6  Kegg Pathways (Kegg details for CDKN1B) (see all 6):
SABiosciences Pathway-Focused PCR Arrays including CDKN1B (see all 11): PAHS-004A PAHS-005A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CDKN1B
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDKN1B
5/130 Interacting proteins for CDKN1B (ENSP000002288723 P465271, 2) via UniProtKB, MINT, and/or STRING (see all 130)About this table
5/42 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 42): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000075 | cell cycle checkpoint |
TAS | -- | | GO:0000079 | regulation of cyclin-dependent protein kinase activity |
TAS | 8033212 | | GO:0000080 | G1 phase of mitotic cell cycle |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- |
About this table
CDKN1B for ontologies About GeneDecksing
|
Drugs & Compounds
for CDKN1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CDKN1B for compounds About GeneDecksing
 Browse Tocris compounds for CDKN1B
10/102  Novoseek chemical compound relationships for CDKN1B gene (see all 102)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ly294002 |
55.1 |
8 |
15588951 (2), 12242656 (1), 19443725 (1), 11709727 (1) (see all 7) |
| leptomycin b |
50.2 |
9 |
15735731 (3), 16842750 (1), 11889117 (1) |
| eb 1089 |
49.4 |
6 |
12586749 (3), 16340750 (2), 10640426 (1) |
| 1,25 dihydroxy vitamin d3 |
44.6 |
17 |
9697881 (5), 9652739 (2), 16883603 (1), 16322758 (1) (see all 8) |
| mg 132 |
43.8 |
2 |
15173011 (1), 12646415 (1) |
| ciglitazone |
43.5 |
9 |
15763423 (6), 15951157 (1) |
| trastuzumab |
43.1 |
20 |
15611642 (6), 14648698 (3), 15173011 (2), 15642702 (1) (see all 7) |
| bromodeoxyuridine |
43 |
2 |
11738067 (1) |
| mimosine |
42.6 |
8 |
10623466 (4), 10530763 (1), 15855174 (1), 15923641 (1) |
| rapamycin |
41.5 |
14 |
20097763 (3), 8895523 (2), 12393532 (1), 16862180 (1) (see all 9) |
About this table
5 PharmGKB drug compound relationships for CDKN1B geneAbout this table
|
Transcripts
for CDKN1B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CDKN1B gene: NM_004064.3 Additional cDNA sequence: AB451291.1 AB451423.1 AF247551.1 AJ616234.1 AK298335.1 AK312461.1 AY004255.1 BC001971.1 BT019553.1 BT019554.1 CR457399.1 CR592928.1 U10906.1 13 DOTS entries: DT.417848 DT.91687599 DT.92038526 DT.100820961 DT.95238381 DT.95374074 DT.100820955 DT.100820956 DT.121171409 DT.121171413 DT.95374076 DT.101970489 DT.95374072 24/236 AceView cDNA sequences (see all 236): AW023852 AA897321 CB158193 AI380694 CR592928 BQ029289 BF221469 CB216548 AA563693 AA988214 H13167 AA749161 AI201163 AA737055 AW022687 U10906 NM_004064 R81658 AI093778 H88763 AI284117 BF061836 CA337570 BM055406
 highest scoring ESTs for CDKN1B:AI680672 AA062552 AA063159 AA128541 AA172029 AA172264 AA180797 AA180937 AA192725 AA206836 Unigene Cluster for CDKN1B: Cyclin-dependent kinase inhibitor 1B (p27, Kip1) Hs.238990 [show with all ESTs]Unigene Representative Sequence: NM_004064
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000228872(uc001rat.2) ENST00000396340 ENST00000477087 ENST00000442489
|
Expression
for CDKN1B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CDKN1B expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching CDKN1B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 2034_s_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.95 |
0.57 |
U10906 |
0.80 |
1.00 |
0.91 |
1 |
| 52535_s_at2, 3
|
U95-C |
1 |
0.88 |
1.00 |
0.87 |
1.46 |
AI680672 |
1.00 |
1.00 |
1.00 |
1 |
| 33847_s_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.93 |
1.19 |
U10906 |
0.80 |
1.00 |
0.91 |
1 |
| 33848_r_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.88 |
0.80 |
U10906 |
0.80 |
1.00 |
0.91 |
1 |
| 209112_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
BC001971 |
0.80 |
1.00 |
0.91 |
1 |
| 209112_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CDKN1B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTTGTGCAT
SOURCE GeneReport for Unigene cluster: Hs.238990
Expression variation in blood from EXPOLDB for CDKN1B UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including CDKN1B (see all 11): PAHS-004A PAHS-005A
|
Orthologs
for CDKN1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDKN1B gene from 5/8 species (see all 8)
About this table Species with no ortholog for CDKN1B
ENSEMBL Gene Tree for CDKN1B (if available) |
Paralogs
for CDKN1B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CDKN1B gene
- CDKN1C2 CDKN1A2
CDKN1B for paralogs About GeneDecksing
|
Genomic Variants
for CDKN1B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing CDKN1B |
|
Disorders & Mutations
for CDKN1B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDKN1B for disorders About GeneDecksing
OMIM: 600778 disorders: 610755 UniProtKB/Swiss-Prot: CDN1B_HUMAN, P46527
Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrineneoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypicoverlap of both MEN1 and MEN2
10/96 Novoseek disease relationships for CDKN1B gene (see all 96)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| retinoblastoma |
80.4 |
45 |
12783864 (2), 9083081 (2), 16740772 (2), 8916935 (1) (see all 40) |
| tumors |
68.8 |
455 |
12605366 (8), 10329035 (6), 19293259 (5), 10559792 (5) (see all 99) |
| cancer |
61 |
123 |
9683802 (3), 11266285 (2), 19082479 (2), 10404130 (2) (see all 82) |
| aggressiveness |
56.8 |
15 |
19866239 (2), 10223564 (2), 9864434 (1), 10514396 (1) (see all 13) |
| multiple endocrine neoplasia type 1 |
56 |
5 |
17613552 (1), 18673462 (1), 17299066 (1), 17803708 (1) |
| prostate cancer |
52.5 |
71 |
15265403 (4), 14960249 (3), 17070313 (3), 9458103 (3) (see all 37) |
| multiple endocrine neoplasia |
51.8 |
8 |
17961654 (1), 18710468 (1), 17097557 (1), 17613552 (1) (see all 5) |
| carcinoma |
51.7 |
63 |
18036045 (5), 9426067 (5), 12150617 (3), 9466585 (3) (see all 33) |
| carcinoma squamous cell |
51.2 |
35 |
11854065 (2), 15645120 (2), 9683778 (2), 12530030 (2) (see all 28) |
| lip squamous cell carcinoma |
50.6 |
3 |
14662421 (2), 15743689 (1) |
About this table
2 PharmGKB disease relationships for CDKN1B geneAbout this table
Human Gene Mutation Database (HGMD): CDKN1B
Genetic Association Database (GAD): CDKN1B
Human Genome Epidemiology (HuGE) Navigator: CDKN1B (57 documents)
Tumor Gene Database (TGDB): CDKN1B
Export disorders and mutations for CDKN1B gene to outside databases
|
Medical News
for CDKN1B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDKN1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/1419 PubMed articles for CDKN1B gene, integrated from 7 sources (see all 1419):
(articles sorted by number of sources associating them with CDKN1B)- Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. (PubMed id 8033212)1, 2, 3, 7 Polyak K.... Massague J. (1994)
- Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. (PubMed id 12042314)1, 2, 7 Fujita N.... Tsuruo T. (2002)
- The V109G polymorphism of the p27 gene CDKN1B indicates a worse outcome in node-negative breast cancer patients. (PubMed id 15627896)1, 4, 7 Schondorf T....Hoopmann M. (2004)
- A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction. (PubMed id 15061869)1, 4, 7 Gonzalez P....Andres V. (2004)
- Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. (PubMed id 7882309)1, 2, 7 Pietenpol J.A.... Rowley J.D. (1995)
- Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. (PubMed id 18593906)1, 2 Morishita D.... Fujita N. (2008)
- Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. (PubMed id 17254966)1, 2 Grimmler M.... Hengst L. (2007)
- Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans. (PubMed id 17030811)1, 2 Pellegata N.S.... Atkinson M.J. (2006)
- Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. (PubMed id 16880511)1, 2 Sabile A....Krek W. (2006)
- Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. (PubMed id 16209941)1, 2 Hao B....Pavletich N.P. (2005)
|
External Searches for CDKN1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDKN1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDKN1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDKN1B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDKN1B gene:
Search GeneIP for patents involving CDKN1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDKN1B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for CDKN1B (p27Kip1) |
| | | | Search Tocris compounds for CDKN1B |
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