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CDT1 Gene

protein-coding   GIFtS: 58

GC16P074567
chromatin licensing and DNA replication factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
chromatin licensing and DNA replication factor 11 2
DUP1 2 3
RIS21 2
Double parked homolog2 3
DNA replication factor Cdt12
Double parked, Drosophila, homolog of2

External Ids:    HGNC: 245761   Entrez Gene: 816202   Ensembl: ENSG000001675137   UniProtKB: Q9H2113   

Export aliases for CDT1 gene to outside databases

Previous GC identifers: GC16M080446 GC16M090107 GC16P088573 GC16P088614 GC16P087397 GC16P088870


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form
the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and
conformation-independent manner. Potential oncogene

Gene Wiki entry for CDT1 (DNA replication factor CDT1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDT1 gene promoter:
         CUTL1   NF-kappaB1   Elk-1   CREB   deltaCREB   NF-kappaB   AhR   p53   p300   ATF   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CDT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDT1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDT1 gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P074567:  view genomic region     (about GC identifiers)

Start:
74,567,412 bp from pter
End:
74,572,892 bp from pter
Size:
5,481 bases
Orientation:
plus strand

1 alternative location:
Chr16+ 88,870,186-88,875,665     
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211 (See protein sequence)
Recommended Name: DNA replication factor Cdt1  
Size: 546 amino acids; 60390 Da
Subunit: Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding
activity. Interacts with PCNA
Subcellular location: Nucleus
Developmental stage: Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M
phases
Sequence caution: Sequence=AF070552; Type=Frameshift; Positions=278, 312;
PDB structures from and Proteopedia :
2WVR (3D)    
Secondary accessions: Q86XX9 Q96CJ5 Q96GK5 Q96H67 Q96HE6 Q9BWM0

Explore the universe of human proteins at neXtProt for CDT1: NX_Q9H211 

Post-translational modifications:

  • Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, in response to DNA damage, leading to its
  • degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is
    PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP
    box, recruit the DCX(DTL) complex, leading to its degradation. The interaction with GMNN protects it against
    ubiquitination1
  • Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and
  • subsequent degradation. Binding to GMNN is not affected by phosphorylation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_112190.2  

    ENSEMBL proteins: 
    ENSP00000301019 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CDT1
    OriGene Protein Over-expression Lysate: CDT1
    GenScript Custom Purified and Recombinant Proteins Services for CDT1 
    Novus Biologicals Lysate for CDT1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA11125146
    GO:0005654 nucleoplasm EXP11125146
    GO:0005829 cytosol TAS--
    About this table

    CDT1 for ontologies           About GeneDecksing



    Antibodies for CDT1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CDT1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CDT1 
    OriGene Antibodies (see all 2): CDT1
    GenScript Custom Superior Antibodies Services for CDT1 
    Novus Biologicals Antibodies for CDT1
    Epitomics antibodies for CDT1

    Assays for CDT1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDT1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDT1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDT1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR014939 DNA_replication_fac_CDT1-like

    Graphical View of Domain Structure for InterPro Entry Q9H211

    ProtoNet protein and cluster: Q9H211

    UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
    Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while
    the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its
    ubiquitination (By similarity)
    Similarity: Belongs to the Cdt1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
    Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form
    the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and
    conformation-independent manner. Potential oncogene

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CDT1
    Sigma-Aldrich shRNA for CDT1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CDT1
    OriGene shRNA RFP (see all 3): CDT1
    OriGene basic RS shRNA (see all 3): CDT1
    OriGene siRNA (see all 2): CDT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDT1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDT1 
    Search SABiosciences for Assays for microRNAs that regulate CDT1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CDT1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CDT1
    OriGene untagged cDNA clones in CMV expression vector: CDT1
    OriGene 3'-UTR clone: CDT1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDT1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CDT1 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ISS--
    GO:0005515 protein binding IPI15232106
    About this table

    CDT1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CDT1 for pathways           About GeneDecksing

    3 Millipore Pathways for CDT1
        Meiosis
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Role of SCF complex in cell cycle regulation

        SABiosciences Custom Pathway-Focused PCR Arrays for CDT1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDT1

    5/83 Interacting proteins for CDT1 (Q9H2111, 2 ENSP000003010193) via UniProtKB, MINT, and/or STRING (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GMNNO754961, 2, ENSP000003489023EBI-456953,EBI-371669 MINT-1955603 MINT-4508837 MINT-50424 MINT-4508819 STRING: ENSP00000348902
    CDC6Q997411, 2, ENSP000002097283EBI-456953,EBI-374862 MINT-50423 STRING: ENSP00000209728
    ORC1Q134151, 2, ENSP000003606213EBI-456953,EBI-374847 MINT-50425 STRING: ENSP00000360621
    ORC2Q134161, 2, ENSP000002342963EBI-456953,EBI-374957 MINT-50426 STRING: ENSP00000234296
    PCNAP120042, ENSP000003684383MINT-1955576 MINT-1955474 STRING: ENSP00000368438
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076 DNA replication checkpoint IDA14672932
    GO:0000082 G1/S transition of mitotic cell cycle TAS--
    GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle TAS--
    GO:0000084 S phase of mitotic cell cycle TAS--
    GO:0000216 M/G1 transition of mitotic cell cycle TAS--
    About this table

    CDT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CDT1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDT1
    1 Novoseek chemical compound relationship for CDT1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 18.6 6 16387651 (2), 11741544 (1), 11737877 (1), 16428461 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CDT1
    Sigma-Aldrich shRNA for CDT1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CDT1
    OriGene shRNA RFP (see all 3): CDT1
    OriGene basic RS shRNA (see all 3): CDT1
    OriGene siRNA (see all 2): CDT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CDT1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CDT1 
    Search SABiosciences for Assays for microRNAs that regulate CDT1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CDT1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CDT1
    OriGene untagged cDNA clones in CMV expression vector: CDT1
    OriGene 3'-UTR Clone: CDT1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CDT1 
    Primers: OriGene genome-wide validated SYBR primer pairs: CDT1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDT1: PPH11604A

    REFSEQ mRNAs for CDT1 gene: 

    NM_030928.3  

    Additional cDNA sequence: 

    AB053172.1 AF070552.1 AF321125.1 BC000137.2 BC008676.1 BC008860.2 BC009410.1 BC014202.2 
    BC021126.1 BC049205.1 CR596577.1 CR597956.1 CR598796.1 CR600099.1 CR603023.1 CR609788.1 
    CR610728.1 CR613412.1 CR613446.1 CR614189.1 CR625627.1 

    11 DOTS entries:

    DT.455965  DT.100786092  DT.100759637  DT.121641720  DT.91874678  DT.97848222  DT.100837111  DT.100029168 
    DT.100786083  DT.121207297  DT.422791 

    24/235 AceView cDNA sequences (see all 235):

    CR609788 BE301693 CA432508 CR598796 BM927844 AI872096 CR603023 CA422735 
    CR613446 BM783379 BX421258 BU629552 CR613412 BM783362 BM758710 CR597956 
    CR614189 CR600099 BM783501 BE018212 BU164161 BM450908 BQ053454 BU522023 

    highest scoring ESTs for CDT1:

    AF070552 AA159048 AA768390 AA806956 AB053172 AF321125 AI275191 AI692892 AI739449 AI872096 

    Unigene Cluster for CDT1:

    Chromatin licensing and DNA replication factor 1
    Hs.122908  [show with all ESTs]
    Unigene Representative Sequence: AB053172


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDT1

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                                              
    SP2:                                                  -                           

    About this scheme

    ECgene alternative splicing isoforms for CDT1
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301019(uc002flu.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CDT1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching CDT1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34510_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF070552 1.00 1.00 1.00 1
    209832_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF321125 0.80 1.00 0.91 1
    228868_x_at2, 3 U133-B 10 0.46 0.83 -- -- AW075105 0.20 1.00 0.72 1
    209832_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    228868_x_at2 U133Plus2 10 0.46 0.83 -- -- -- -- -- -- --
    About this table

    CDT1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CDT1 gene expression
    CDT1 gene electronic northern expression
    CDT1 gene sage expression
    About these images

    CGAP SAGE TAG: GGGCTCACCT

    SOURCE GeneReport for Unigene cluster: Hs.122908

    Expression variation in blood from EXPOLDB for CDT1

    Primers: OriGene genome-wide validated SYBR primer pairs: CDT1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CDT1: PPH11604A
        SABiosciences Custom PCR Arrays for CDT1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CDT1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CDT11   -- chromatin licensing and DNA replication factor 1 78.07(n)
    74.54(a)
    479616  XM_536753.2  XP_536753.2 
    cow
    (Bos taurus)
    CDT11   -- chromatin licensing and DNA replication factor 1 80.14(n)
    76.2(a)
    519016  XM_597224.3  XP_597224.3 
    rat
    (Rattus norvegicus)
    Cdt11   -- chromatin licensing and DNA replication factor 1 76.04(n)
    74.49(a)
    292071  XM_226545.4  XP_226545.4 
    mouse
    (Mus musculus)
    Cdt11 , 5 8 (71.91 cM)5
    chromatin licensing and DNA replication factor 11, 5 76.39(n)1
    76.26(a)1
    671771  NM_026014.31  NP_080290.31 
     AA6714295  AB0866555  (see all 33)
    zebrafish
    (Danio rerio)
    wu:fi38h091   -- wu:fi38h09 56.82(n)
    52.43(a)
    566787  XM_690072.3  XP_695164.3 
    About this table        Species with no ortholog for CDT1

    ENSEMBL Gene Tree for CDT1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/87 NCBI SNPs in CDT1 are shown (see all 87)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs158291,2
    C,F,A,H,88874778(+) TTTGGC/TCTTCC 1 -- ut31 trp313Minor allele frequency- N:0.00EA NA MN WA 680
    rs4756671,2
    C,F,A,88870967(+) CCCAGT/CACCCC 2 /S syn1 ref1 ese39Minor allele frequency- C:0.12MN NA NS EA WA 978
    rs4807271,2
    C,F,O,A,H,88872229(+) ATGGCG/ACCAGG 2 /T /A ref1 mis1 ese319Minor allele frequency- A:0.35MN EA NA NS 3202
    rs5073291,2
    C,H,88872145(+) AGGAGC/G/TGCAAT 3 R G C mis1 ref111MN NS EA NA WA 582
    rs5108621,2
    C,F,O,A,H,88872511(+) GAGCAC/TGTCAA 2 H syn1 ref1 ese313Minor allele frequency- T:0.15MN NS EA NA WA 1018
    rs5241901,2
    --88869502(+) ctggaA/Gtgcag 1 -- ng510--------
    rs5596781,2
    C88868866(+) CTCTAA/GGCCGT 1 -- ng51 tfbs30--------
    rs5652111,2
    C,F,A,88868252(+) ATCCCC/TTATAT 1 -- ng5113Minor allele frequency- T:0.40EA NA MN NS WA 1034
    rs5722751,2
    C,F,O,A,H,88874632(+) GACCTG/CGCCCA 2 /L ref1 syn1 ese311Minor allele frequency- C:0.45MN NA EA NS WA 884
    rs8377601,2
    88875370(+) ctgcaC/Tgcact 1 -- ut31 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for CDT1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CDT1
         5 CNVs: 59565 30015 59564 4976 4975

    QIAGEN SeqTarget long-range PCR primers for resequencing CDT1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDT1 for disorders           About GeneDecksing

    OMIM: 605525

    3 Novoseek disease relationships for CDT1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 23.3 16 19487297 (2), 16835273 (2), 18508524 (2), 15291814 (2) (see all 7)
    colon cancer 0 2 16273206 (2)
    tumors 0 3 18508524 (1), 8144677 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: CDT1 (1 document)

    Export disorders and mutations for CDT1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/150 PubMed articles for CDT1 gene, integrated from 7 sources (see all 150):
    (articles sorted by number of sources associating them with CDT1)
    1. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PubMed id 14993212)1, 2, 7 Sugimoto N.... Fujita M. (2004)
    2. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. (PubMed id 11125146)1, 2, 7 Wohlschlegel J.A....Dutta A. (2000)
    3. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PubMed id 15257290)1, 2, 7 Ballabeni A....Helin K. (2004)
    4. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PubMed id 11555648)1, 3, 7 Nishitani H....Nishimoto T. (2001)
    5. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2, 7 Jin J.... Walter J.C. (2006)
    6. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2 Higa L.A.... Zhang H. (2006)
    7. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)1, 2 Sansam C.L....Lees J.A. (2006)
    8. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. (PubMed id 14672932)1, 2 Cook J.G.... Nevins J.R. (2004)
    9. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81620 HGNC: 24576 AceView: CDT1 Ensembl:ENSG00000167513 euGenes: HUgn81620
    ECgene: CDT1 H-InvDB: CDT1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    (Patent information from GeneIP,
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