Aliases &
Descriptions
for CDT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| chromatin licensing and DNA replication factor 11 2 | | DUP1 2 3 | | RIS21 2 | | Double parked homolog2 3 | | DNA replication factor Cdt12 | | Double parked, Drosophila, homolog of2 |
Export aliases for CDT1 gene to outside databasesPrevious GC identifers: GC16M080446 GC16M090107 GC16P088573 GC16P088614 GC16P087397 GC16P088870 |
Summaries
for CDT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to formthe pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, andconformation-independent manner. Potential oncogene
Gene Wiki entry for CDT1 (DNA replication factor CDT1) |
Genomic Views
for CDT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CDT1 gene promoter:
CUTL1 NF-kappaB1 Elk-1 CREB deltaCREB NF-kappaB AhR p53 p300 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDT1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CDT1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3CDT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P074567: view genomic region
(about GC identifiers)
Start:
|
74,567,412 bp from pter |
End:
|
74,572,892 bp from pter |
Size:
|
5,481 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 88,870,186-88,875,665 |
RefSeq DNA sequence:- NC_000016.9 NT_010542.15
|
Proteins
for CDT1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211 (See
protein sequence)Recommended Name: DNA replication factor Cdt1 Size: 546 amino acids; 60390 Da
Subunit: Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-bindingactivity. Interacts with PCNA
Subcellular location: Nucleus
Developmental stage: Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and Mphases
Sequence caution: Sequence=AF070552; Type=Frameshift; Positions=278, 312;
PDB structures from  and Proteopedia  :2WVR (3D)
Secondary accessions: Q86XX9 Q96CJ5 Q96GK5 Q96H67 Q96HE6 Q9BWM0Explore the universe of human proteins at neXtProt for CDT1: NX_Q9H211
Post-translational modifications:
Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, in response to DNA damage, leading to itsdegradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and isPCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIPbox, recruit the DCX(DTL) complex, leading to its degradation. The interaction with GMNN protects it againstubiquitination1
Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 andsubsequent degradation. Binding to GMNN is not affected by phosphorylation1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_112190.2
ENSEMBL proteins: ENSP00000301019
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CDT1 for ontologies About GeneDecksing
Antibodies for CDT1:
Assays for CDT1: |
Protein
Domains/
Families
for CDT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H211ProtoNet protein and cluster: Q9H211 UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: whilethe PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to itsubiquitination (By similarity)Similarity: Belongs to the Cdt1 family |
Gene Function
for CDT1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to formthe pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, andconformation-independent manner. Potential oncogene
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CDT1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CDT1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CDT1 for pathways About GeneDecksing
3  Millipore Pathways for CDT1
SABiosciences Custom Pathway-Focused PCR Arrays for CDT1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDT1
5/83 Interacting proteins for CDT1 (Q9H2111, 2 ENSP000003010193) via UniProtKB, MINT, and/or STRING (see all 83)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GMNN | O754961, 2, ENSP000003489023 | EBI-456953,EBI-371669 MINT-1955603 MINT-4508837 MINT-50424 MINT-4508819 STRING: ENSP00000348902 | | CDC6 | Q997411, 2, ENSP000002097283 | EBI-456953,EBI-374862 MINT-50423 STRING: ENSP00000209728 | | ORC1 | Q134151, 2, ENSP000003606213 | EBI-456953,EBI-374847 MINT-50425 STRING: ENSP00000360621 | | ORC2 | Q134161, 2, ENSP000002342963 | EBI-456953,EBI-374957 MINT-50426 STRING: ENSP00000234296 | | PCNA | P120042, ENSP000003684383 | MINT-1955576 MINT-1955474 STRING: ENSP00000368438 |
About this table
5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000076 | DNA replication checkpoint |
IDA | 14672932 | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000083 | regulation of transcription involved in G1/S phase of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- |
About this table
CDT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CDT1 for compounds About GeneDecksing
 Browse Tocris compounds for CDT1
1  Novoseek chemical compound relationship for CDT1 gene
About this table
|
Transcripts
for CDT1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CDT1 gene: NM_030928.3 Additional cDNA sequence: AB053172.1 AF070552.1 AF321125.1 BC000137.2 BC008676.1 BC008860.2 BC009410.1 BC014202.2 BC021126.1 BC049205.1 CR596577.1 CR597956.1 CR598796.1 CR600099.1 CR603023.1 CR609788.1 CR610728.1 CR613412.1 CR613446.1 CR614189.1 CR625627.1 11 DOTS entries: DT.455965 DT.100786092 DT.100759637 DT.121641720 DT.91874678 DT.97848222 DT.100837111 DT.100029168 DT.100786083 DT.121207297 DT.422791 24/235 AceView cDNA sequences (see all 235): CR609788 BE301693 CA432508 CR598796 BM927844 AI872096 CR603023 CA422735 CR613446 BM783379 BX421258 BU629552 CR613412 BM783362 BM758710 CR597956 CR614189 CR600099 BM783501 BE018212 BU164161 BM450908 BQ053454 BU522023
 highest scoring ESTs for CDT1:AF070552 AA159048 AA768390 AA806956 AB053172 AF321125 AI275191 AI692892 AI739449 AI872096 Unigene Cluster for CDT1: Chromatin licensing and DNA replication factor 1 Hs.122908 [show with all ESTs]Unigene Representative Sequence: AB053172
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CDT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CDT1
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000301019(uc002flu.2)
|
Expression
for CDT1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CDT1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching CDT1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 34510_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AF070552 |
1.00 |
1.00 |
1.00 |
1 |
| 209832_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF321125 |
0.80 |
1.00 |
0.91 |
1 |
| 228868_x_at2, 3
|
U133-B |
10 |
0.46 |
0.83 |
-- |
-- |
AW075105 |
0.20 |
1.00 |
0.72 |
1 |
| 209832_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 228868_x_at2
|
U133Plus2 |
10 |
0.46 |
0.83 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CDT1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGGCTCACCT
SOURCE GeneReport for Unigene cluster: Hs.122908
Expression variation in blood from EXPOLDB for CDT1 SABiosciences Custom PCR Arrays for CDT1
|
Orthologs
for CDT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CDT1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for CDT1
ENSEMBL Gene Tree for CDT1 (if available) |
Paralogs
for CDT1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for CDT1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CDT1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CDT1
5 CNVs: 59565 30015 59564 4976 4975 | | QIAGEN SeqTarget long-range PCR primers for resequencing CDT1 |
|
Disorders & Mutations
for CDT1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDT1 for disorders About GeneDecksing
OMIM: 605525
3 Novoseek disease relationships for CDT1 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: CDT1 (1 document)
Export disorders and mutations for CDT1 gene to outside databases
|
Medical News
for CDT1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CDT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/150 PubMed articles for CDT1 gene, integrated from 7 sources (see all 150):
(articles sorted by number of sources associating them with CDT1)- Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PubMed id 14993212)1, 2, 7 Sugimoto N.... Fujita M. (2004)
- Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. (PubMed id 11125146)1, 2, 7 Wohlschlegel J.A....Dutta A. (2000)
- Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PubMed id 15257290)1, 2, 7 Ballabeni A....Helin K. (2004)
- The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PubMed id 11555648)1, 3, 7 Nishitani H....Nishimoto T. (2001)
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2, 7 Jin J.... Walter J.C. (2006)
- L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2 Higa L.A.... Zhang H. (2006)
- DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)1, 2 Sansam C.L....Lees J.A. (2006)
- The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. (PubMed id 14672932)1, 2 Cook J.G.... Nevins J.R. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CDT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing CDT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDT1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CDT1 gene:
Search GeneIP for patents involving CDT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDT1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for CDT1 |
| | | | Search Tocris compounds for CDT1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CDT1 |
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