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CEACAM16 Gene

protein-coding   GIFtS: 34

GC19P041634
carcinoembryonic antigen-related cell adhesion molecule 16
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
carcinoembryonic antigen-related cell adhesion molecule 161 2
Carcinoembryonic antigen-like 22 3
CEAL22 3
carcinoembryonic antigen like-2 protein2

External Ids:    HGNC: 319481   Entrez Gene: 3885512   Ensembl: ENSG000002138927   UniProtKB: Q2WEN93   

Export aliases for CEACAM16 gene to outside databases

Previous GC identifers: GC19P049893 GC19P045202


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM16 gene promoter:
         Bach2   Lmo2   AP-4   ER-alpha   NF-kappaB1   NF-kappaB   NF-kappaB2   GATA-1   Bach1   c-Jun   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CEACAM16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.31

CEACAM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM16 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041634:  view genomic region     (about GC identifiers)

Start:
41,634,688 bp from pter
End:
41,646,253 bp from pter
Size:
11,566 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 45,202,492-45,213,986     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 16 precursor  
Size: 484 amino acids; 52681 Da
Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for CEACAM16: NX_Q2WEN9 

REFSEQ proteins: NP_001034302.2  

ENSEMBL proteins: 
ENSP00000385576 ENSP00000379974 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

CEACAM16 for ontologies           About GeneDecksing



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Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEACAM16 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR003598 Ig_sub2
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like
 IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q2WEN9

ProtoNet protein and cluster: Q2WEN9

UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9
Similarity: Belongs to the immunoglobulin superfamily. CEA family
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for CEACAM16
Sigma-Aldrich shRNA for CEACAM16
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CEACAM16
OriGene shRNA RFP (see all 2): CEACAM16
OriGene basic RS shRNA (see all 2): CEACAM16
OriGene siRNA: CEACAM16
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CEACAM16 
miRNA:Sigma-Aldrich microRNA Mimics for CEACAM16
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CEACAM16 
Search SABiosciences for Assays for microRNAs that regulate CEACAM16

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CEACAM16
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CEACAM16
OriGene untagged cDNA clones in CMV expression vector: CEACAM16
Browse 3'-UTR reporter clones for miRNA target validation 
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Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CEACAM16 


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for CEACAM16 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM16

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEACAM16


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for CEACAM16
Sigma-Aldrich shRNA for CEACAM16
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CEACAM16
OriGene shRNA RFP (see all 2): CEACAM16
OriGene basic RS shRNA (see all 2): CEACAM16
OriGene siRNA: CEACAM16
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CEACAM16 
miRNA: Sigma-Aldrich microRNA Mimics for CEACAM16
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CEACAM16 
Search SABiosciences for Assays for microRNAs that regulate CEACAM16
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CEACAM16
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CEACAM16
OriGene untagged cDNA clones in CMV expression vector: CEACAM16
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for CEACAM16 
Primers: OriGene genome-wide validated SYBR primer pairs: CEACAM16
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CEACAM16: PPH22182A

REFSEQ mRNAs for CEACAM16 gene: 

NM_001039213.2  

Additional cDNA sequence: 

BC144608.1 EU021223.1 

1 DOTS entry:

DT.91787861 

1 AceView cDNA sequence:

BF589367 

highest scoring ESTs for CEACAM16:

BF589367 DV080601 DV080602 NM_001039213 

Unigene Cluster for CEACAM16:

Carcinoembryonic antigen-related cell adhesion molecule 16
Hs.456381  [show with all ESTs]
Unigene Representative Sequence: NM_001039213


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000405314(uc010xxd.1) ENST00000396750(uc002ozq.2)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CEACAM16 expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

CEACAM16 gene expression
CEACAM16 gene electronic northern expression
CEACAM16 gene sage expression
About these images

CGAP SAGE TAG: TATTGCGAAG

SOURCE GeneReport for Unigene cluster: Hs.456381
Primers: OriGene genome-wide validated SYBR primer pairs: CEACAM16
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CEACAM16: PPH22182A
    SABiosciences Custom PCR Arrays for CEACAM16 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CEACAM16 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CEACAM161   -- carcinoembryonic antigen-related cell adhesion molecule more 89.52(n)
91.02(a)
484457  XM_541572.2  XP_541572.2 
cow
(Bos taurus)
CEACAM161   -- carcinoembryonic antigen-related cell adhesion molecule more 88.26(n)
89.73(a)
614790  XM_866415.2  XP_871508.2 
rat
(Rattus norvegicus)
Ceacam161   -- carcinoembryonic antigen-related cell adhesion molecule more 84.24(n)
89.13(a)
292700  XM_214856.4  XP_214856.4 
mouse
(Mus musculus)
Ceacam161 , 5 7 (9.95 cM)5
carcinoembryonic antigen-related cell adhesion molecule more1, 5 83.29(n)1
89.83(a)1
3304831  NM_001033419.21  NP_001028591.21 
 AK1579055  BC1410875 
About this table        Species with no ortholog for CEACAM16

ENSEMBL Gene Tree for CEACAM16 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CEACAM16 gene
PSG92  PSG82  CEACAM42  CEACAM52  PSG112  CEACAM72  PSG32  CEACAM212  
PSG12  PSG52  PSG62  CEACAM12  CEACAM82  CEACAM62  PSG22  CEACAM182  
PSG42  CEACAM32  

CEACAM16 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/144 NCBI SNPs in CEACAM16 are shown (see all 144)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs8941891,2
C,F,O,A,45206695(-) ACCAGC/TGTGAC 4 T syn1 ref19Minor allele frequency- T:0.10NS EA NA 716
rs8941901,2
C,F,45205698(-) gtctaG/Accctc 1 -- int14Minor allele frequency- A:0.02NS EA 400
rs15302681,2
C,F,A,H,45204298(-) CTGCAC/ACTTTC 1 -- int16Minor allele frequency- A:0.04NS EA NA 512
rs21196601,2
C,F,A,45202640(-) ATGGAC/ATCTGC 3 /V /F int1 ref1 mis111Minor allele frequency- A:0.09NS EA NA WA 918
rs21655401,2
C,F,A,H,45202947(-) GCTCAC/Tggccg 1 -- int11Minor allele frequency- T:0.50NA 4
rs28603141,2
C,A45208026(+) acaaaC/Aaagaa 1 -- int11Minor allele frequency- A:0.50WA 2
rs29198471,2
C,A,H,45204322(-) AGGAAG/TAAAAT 1 -- int111Minor allele frequency- T:0.47NA EA WA 534
rs29198481,2
C,F,A,45203837(-) gtgcaC/Gtggct 1 -- int13Minor allele frequency- G:0.47NA WA 76
rs29198491,2
C,F,45201415(-) TCCCCG/AACTCC 1 -- ng514Minor allele frequency- A:0.12EA NS NA 338
rs29651631,2
C,F,A,H,45200526(+) GGCCCA/GGCACG 1 -- ng517Minor allele frequency- G:0.44NA 86
About this table

HapMap Linkage Disequilibrium images for CEACAM16 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CEACAM16
     2 CNVs: 0221 30910

QIAGEN SeqTarget long-range PCR primers for resequencing CEACAM16 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

2 PubMed articles for CEACAM16 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CEACAM16)
  1. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (2005)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388551 HGNC: 31948 AceView: LOC388551 Ensembl:ENSG00000213892 euGenes: HUgn388551
ECgene: CEACAM16 H-InvDB: CEACAM16

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CEACAM16 gene:
Search GeneIP for patents involving CEACAM16

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 SeqTarget long-range PCR primers for resequencing CEACAM16
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CEACAM16
 GenScript Custom Purified and Recombinant Proteins Services for CEACAM16 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CEACAM16
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