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CENPB Gene

protein-coding   GIFtS: 53

GC20M003712
centromere protein B, 80kDa
(Previous name: centromere protein B (80kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
centromere protein B, 80kDa1 2
CENP-B2 3
centromere protein B (80kD)1
centromere autoantigen B2
major centromere autoantigen B2
Centromere protein B3

External Ids:    HGNC: 18521   Entrez Gene: 10592   Ensembl: ENSG000001258177   UniProtKB: P071993   

Export aliases for CENPB gene to outside databases

Previous GC identifers: GC20M003752 GC20M003759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPB:
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that
is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at
the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp
sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in
the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered
a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. (provided by RefSeq)

UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199
Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite
DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then
directs centromere formation and kinetochore assembly in mammalian chromosomes


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPB gene promoter:
         GR-alpha   GR-beta   POU2F2 (Oct-2.1)   POU2F1   oct-B2   Oct-B1   POU2F2B   oct-B3   POU2F2   POU2F2C   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CENPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CENPB 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CENPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPB gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003712:  view genomic region     (about GC identifiers)

Start:
3,713,053 bp from pter
End:
3,715,727 bp from pter
Size:
2,675 bases
Orientation:
minus strand

1 alternative location:
Chr20- 3,764,500-3,767,337     
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199 (See protein sequence)
Recommended Name: Major centromere autoantigen B  
Size: 599 amino acids; 65171 Da
Subunit: Homodimer. Interacts with CENPT
Subcellular location: Nucleus. Chromosome, centromere
PDB structures from and Proteopedia :
1BW6 (3D)    1HLV (3D)    1UFI (3D)    

Explore the universe of human proteins at neXtProt for CENPB: NX_P07199 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001801.1  

    ENSEMBL proteins: 
    ENSP00000369075 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CENPB 
    Novus Biologicals Lysate for CENPB
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CENPB

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775 chromosome, centromeric region IDA11682612
    GO:0005634 nucleus IEA--
    GO:0005694 chromosome ----
    About this table

    CENPB for ontologies           About GeneDecksing



    Antibodies for CENPB: 
    Millipore Mono- and Polyclonal Antibodies for the study of CENPB
    Sigma-Aldrich Antibodies for CENPB
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CENPB 
    Novus Biologicals Antibodies for CENPB
    Browse antibodies at Epitomics

    Assays for CENPB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CENPB 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CENPB 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CENPB for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR006600 Pogo/CenpB/PDC2_DNA-bd_HTH
     IPR004906 Pogo/CenpB/PDC2_subgr_DNA-bd
     IPR015115 Centromere_CenpB_dimerisation
     IPR012287 Homeodomain-rel
     IPR004875 DDE_SF_endonuclease_CENPB-like

    Graphical View of Domain Structure for InterPro Entry P07199

    ProtoNet protein and cluster: P07199

    2 Blocks protein families:
    IPB004875 CENP-B protein
    IPB006695 CENP-B


    UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199
    Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite
    DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then
    directs centromere formation and kinetochore assembly in mammalian chromosomes

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for CENPB
    Sigma-Aldrich shRNA for CENPB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CENPB
    OriGene shRNA RFP (see all 2): CENPB
    OriGene basic RS shRNA (see all 2): CENPB
    OriGene siRNA: CENPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CENPB 
    miRNA:Sigma-Aldrich microRNA Mimics for CENPB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CENPB 
    2 SABiosciences Assays for microRNAs that regulate CENPB:
    hsa-miR-485-5p hsa-miR-615-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CENPB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CENPB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): CENPB
    OriGene 3'-UTR clone: CENPB 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CENPB 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CENPB 

    Genatlas biochemistry entry for CENPB:
    centromere protein B (80kDa),associated with most human centromeres,function unknown

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding ----
    GO:0003677 DNA binding ----
    GO:0003682 chromatin binding NAS1893793
    GO:0003696 satellite DNA binding NAS1893793
    GO:0005515 protein binding IEA--
    About this table

    CENPB for ontologies           About GeneDecksing

    Animal Models: 5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cenpb):

    cellularendocrine/exocrine glandgrowth/sizenormalreproductive system

    CENPB for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for CENPB 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CENPB

    1 Interacting protein for CENPB (P071992) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD92MINT-2857580
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045449 regulation of transcription IEA--
    About this table

    CENPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CENPB for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPB
    2 Novoseek chemical compound relationships for CENPB gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 20.8 5 2071944 (1), 9543016 (1), 8198697 (1), 1730770 (1)
    hydroxyurea 11.9 1 11129795 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for CENPB
    Sigma-Aldrich shRNA for CENPB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CENPB
    OriGene shRNA RFP (see all 2): CENPB
    OriGene basic RS shRNA (see all 2): CENPB
    OriGene siRNA: CENPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CENPB 
    miRNA: Sigma-Aldrich microRNA Mimics for CENPB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CENPB 
    2 SABiosciences Assays for microRNAs that regulate CENPB:
    hsa-miR-485-5p hsa-miR-615-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CENPB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CENPB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): CENPB
    OriGene 3'-UTR Clone: CENPB 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CENPB 
    Primers: OriGene genome-wide validated SYBR primer pairs: CENPB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CENPB: PPH10313A

    REFSEQ mRNAs for CENPB gene: 

    NM_001810.5  

    Additional cDNA sequence: 

    AF002714.1 BC003649.2 BC012297.1 BC021577.1 BC033658.1 BC040446.2 BC053847.1 CR591718.1 
    X05299.1 

    8 DOTS entries:

    DT.413828  DT.95204579  DT.97847830  DT.102825597  DT.92440831  DT.95204578  DT.95204582  DT.97847829 

    24/244 AceView cDNA sequences (see all 244):

    BQ446139 BQ224597 BQ677772 CK724874 BU541735 AI277571 BC012297 BU846455 
    BU729396 BU552634 BQ016707 BM716657 NM_001810 BC021577 AW068260 BU170013 
    BU855627 BQ428113 BE622329 BC053847 BM703471 BQ025796 BU517161 BQ433040 

    highest scoring ESTs for CENPB:

    X05299 AA324050 AA455552 AW016300 AW068260 AW245678 BC003649 BC012297 BC021577 BC040446 

    Unigene Cluster for CENPB:

    Centromere protein B, 80kDa
    Hs.516855  [show with all ESTs]
    Unigene Representative Sequence: NM_001810


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379751(uc002wjk.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CENPB expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching CENPB gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    63959_r_at2, 3 U95-C 1 0.88 1.00 0.96 1.05 AA639474 0.40 1.00 0.76 1
    37931_at2, 3 U95-A 1 0.75 1.00 0.94 0.89 X05299 1.00 1.00 1.00 1
    50959_at2, 3 U95-C 1 0.75 1.00 0.98 1.06 AW016300 0.80 1.00 0.91 1
    212437_at2 U133-A 1 0.82 1.00 -- -- -- -- -- -- --
    212437_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    CENPB for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CENPB gene expression
    CENPB gene electronic northern expression
    CENPB gene sage expression
    About these images

    CGAP SAGE TAG: CCTCTCCTCC

    SOURCE GeneReport for Unigene cluster: Hs.516855

    Expression variation in blood from EXPOLDB for CENPB

    Primers: OriGene genome-wide validated SYBR primer pairs: CENPB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CENPB: PPH10313A
        SABiosciences Custom PCR Arrays for CENPB 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CENPB gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CENPB1   -- centromere protein B, 80kDa 90.58(n)
    94.75(a)
    485791  XM_846313.1  XP_851406.1 
    chimpanzee
    (Pan troglodytes)
    CENPB1   -- centromere protein B, 80kDa 93.22(n)
    90.66(a)
    458446  XM_530325.2  XP_530325.2 
    cow
    (Bos taurus)
    CENPB1   -- centromere protein B, 80kDa 88.12(n)
    89.08(a)
    788381  XM_001255460.1  XP_001255461.1 
    rat
    (Rattus norvegicus)
    Cenpb1   -- centromere protein B 88.63(n)
    93.81(a)
    362217  XM_342521.3  XP_342522.1 
    mouse
    (Mus musculus)
    Cenpb1 , 5 2 (63.29 cM)5
    centromere protein B1, 5 87.98(n)1
    92.62(a)1
    126161  NM_007682.21  NP_031708.21 
     AK1588115  BC0066285  (see all 10)
    About this table        Species with no ortholog for CENPB

    ENSEMBL Gene Tree for CENPB (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CENPB gene
    TIGD72  JRKL2  TIGD22  TIGD12  TIGD52  TIGD32  TIGD62  TIGD42  

    CENPB for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/42 NCBI SNPs in CENPB are shown (see all 42)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10513491,2
    C,F,3764812(-) GCGGGC/TTCCTG 1 -- ut311Minor allele frequency- T:0.07MN 184
    rs10513681,2
    C,F,3764761(-) TCTGGC/TCCTGT 1 -- ut312Minor allele frequency- T:0.01MN NA 256
    rs10513721,2
    --3764697(-) CCCCCA/CCCGTG 1 -- ut31 ese30--------
    rs60520761,2
    C3765178(+) CGGCCG/AAGGTG 1 -- ut31 ese32Minor allele frequency- A:0.01EA NS 178
    rs60520771,2
    --3768035(+) tacacA/Gcttaa 1 -- ng510--------
    rs60844651,2
    --3765904(+) tcctcC/Ttcctc 2 E syn1 ref1 ese3 trp30--------
    rs61073451,2
    --3764407(+) CTTGCC/TTCCAT 1 -- ng310--------
    rs61160381,2
    C3764655(+) GGGGCC/TTGCAG 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 418
    rs61160391,2
    C3768789(+) aaaaaA/Gaaaga 1 -- ng51 trp30--------
    rs61160401,2
    C3769239(+) CTCAAG/AGTCCA 1 -- ng514Minor allele frequency- A:0.00NS EA 418
    About this table

    HapMap Linkage Disequilibrium images for CENPB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CENPB: --

    QIAGEN SeqTarget long-range PCR primers for resequencing CENPB 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CENPB for disorders           About GeneDecksing

    OMIM: 117140

    10/20 Novoseek disease relationships for CENPB gene (see all 20)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerodactyly 79.1 1 8129780 (1)
    crest syndrome 75.4 2 8198697 (1)
    raynauds phenomenon 67.9 1 8129780 (1)
    sclerosis systemic 66.2 7 8187334 (1), 19714638 (1), 10648030 (1), 16014550 (1) (see all 6)
    calcinosis 63.4 1 8129780 (1)
    telangiectasia 56.7 1 8129780 (1)
    raynauds syndrome 52.6 1 8129780 (1)
    connective tissue diseases 51.9 1 8129780 (1)
    esophageal motility disorders 51.6 1 8129780 (1)
    biliary cirrhosis primary 44.7 1 8527711 (1)
    About this table


    Export disorders and mutations for CENPB gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/149 PubMed articles for CENPB gene, integrated from 7 sources (see all 149):
    (articles sorted by number of sources associating them with CENPB)
    1. A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity. (PubMed id 1469042)1, 2, 7 Yoda K.... Okazaki T. (1992)
    2. CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins. (PubMed id 1893793)1, 2, 7 Sullivan K.F. and Glass C.A. (1991)
    3. A helix-turn-helix structure unit in human centromere protein B (CENP-B). (PubMed id 9451007)1, 2, 7 Iwahara J....Yokoyama S. (1998)
    4. CENP-A, -B, and -C chromatin complex that contains th e I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. (PubMed id 11884609)1, 3, 7 Ando S....Yoda K. (2002)
    5. Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. (PubMed id 18072184)1, 2, 7 Orthaus S....Diekmann S. (2008)
    6. Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B. (PubMed id 19412974)1, 2, 7 Hellwig D....Diekmann S. (2008)
    7. Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure. (PubMed id 8406460)1, 3, 7 Sugimoto K....Himeno M. (1993)
    8. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1, 2 Nousiainen M.... Koerner R. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1059 HGNC: 1852 AceView: CENPB Ensembl:ENSG00000125817 euGenes: HUgn1059
    ECgene: CENPB H-InvDB: CENPB

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CENPB gene:
    Search GeneIP for patents involving CENPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     ELISAs and CLIAs for CENPB
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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