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CHRNA10 Gene

protein-coding   GIFtS: 51

GC11M003420
cholinergic receptor, nicotinic, alpha 10
(Previous names: cholinergic receptor, nicotinic, alpha polypeptide 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cholinergic receptor, nicotinic, alpha 101 2
cholinergic receptor, nicotinic, alpha polypeptide 101 2
Nicotinic acetylcholine receptor subunit alpha-102 3
NACHR alpha-102 3
neuronal acetylcholine receptor subunit alpha-102
NACHRA103

External Ids:    HGNC: 138001   Entrez Gene: 570532   Ensembl: ENSG000001297497   UniProtKB: Q9GZZ63   

Export aliases for CHRNA10 gene to outside databases

Previous GC identifers: GC11M004258 GC11M003952 GC11M003646 GC11M003651 GC11M003644 GC11M003645 GC11M003649 GC11M003654 GC11M003687


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an
extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across
the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which
may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in
basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.
This may protect against acoustic trauma

summary for CHRNA10:
Nicotinic receptors (nAChRs) are ligand-gated ion channels that modulate cell membrane potentials. Each
receptor is composed of pentameric combinations of subunits (alpha1-10, beta1-4, delta, epsilon and gamma).
Nicotinic receptors are generally divided into three functional classes: muscle subunits (alpha1, beta1,
delta, epsilon, gamma), standard neuronal subunits (alpha1-6 and beta2-4) that form in pairwise alphabeta
combinations, and subunits (alpha7-9) that can form homomeric nAChRs. Neuronal nicotinic receptors are found
in the central nervous system and in autonomic ganglia where they regulate processes such as transmitter
release, cell excitability and neuronal integration. Nicotinic receptors located at the neuromuscular
junctions of somatic muscles are responsible for muscular contraction.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRNA10 gene promoter:
         RP58   FOXF2   FOXO1a   Meis-1   HOXA9B   CUTL1   Arnt   AhR   POU3F2   GR-beta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CHRNA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5

CHRNA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRNA10 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M003420:  view genomic region     (about GC identifiers)

Start:
3,420,727 bp from pter
End:
3,426,524 bp from pter
Size:
5,798 bases
Orientation:
minus strand

1 alternative location:
Chr11- 3,686,818-3,692,614     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6 (See protein sequence)
Recommended Name: Neuronal acetylcholine receptor subunit alpha-10 precursor  
Size: 450 amino acids; 49705 Da
Subunit: Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be
composed of CHRNA9-CHRNA10 heterooligomers
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (Probable). Cell
membrane; Multi-pass membrane protein (Probable)
Miscellaneous: The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile,
binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic
acetylcholine receptor antagonist)

Explore the universe of human proteins at neXtProt for CHRNA10: NX_Q9GZZ6 

REFSEQ proteins: NP_065135.2  

ENSEMBL proteins: 
ENSP00000250699 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: CHRNA10
GenScript Custom Purified and Recombinant Proteins Services for CHRNA10 
Novus Biologicals Lysate for CHRNA10
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0005892 nicotinic acetylcholine-gated receptor-channel complex IEA--
GO:0016020 membrane TAS11350119
GO:0016021 integral to membrane IEA--
GO:0030054 cell junction IEA--
About this table

CHRNA10 for ontologies           About GeneDecksing



Antibodies for CHRNA10: 
Millipore Mono- and Polyclonal Antibodies for the study of CHRNA10
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for CHRNA10 
Novus Biologicals Antibody for CHRNA10
Browse antibodies at Epitomics

Assays for CHRNA10: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CHRNA10 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHRNA10 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR002394 Nicotinic_acetylcholine_rcpt
 IPR018000 Neurotransmitter_ion_chnl_CS
 IPR006201 Neur_channel
 IPR006202 Neur_chan_lig-bd
 IPR006029 Neurotrans-gated_channel_TM

Graphical View of Domain Structure for InterPro Entry Q9GZZ6

ProtoNet protein and cluster: Q9GZZ6

2 Blocks protein families:
IPB002394 Nicotinic acetylcholine receptor signature
IPB006201 Neurotransmitter-gated ion-channel


UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
Alpha-10/CHRNA10 sub-subfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an
extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across
the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which
may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in
basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.
This may protect against acoustic trauma

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and siRNA for CHRNA10
Sigma-Aldrich shRNA for CHRNA10
OriGene 29mer shRNA kits in GFP-retroviral vector: CHRNA10
OriGene shRNA RFP: CHRNA10
OriGene basic RS shRNA: CHRNA10
OriGene siRNA: CHRNA10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CHRNA10 
miRNA:Sigma-Aldrich microRNA Mimics for CHRNA10
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CHRNA10 
1 SABiosciences Assays for microRNA that regulate CHRNA10:
hsa-miR-1225-3p

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CHRNA10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CHRNA10
OriGene untagged cDNA clones in CMV expression vector: CHRNA10
OriGene 3'-UTR clone: CHRNA10 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: CHRNA10 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CHRNA10 

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004889 nicotinic acetylcholine-activated cation-selective channel activity IEA--
GO:0005102 receptor binding TAS11350119
GO:0005216 ion channel activity IEA--
GO:0005230 extracellular ligand-gated ion channel activity IEA--
About this table

CHRNA10 for ontologies           About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chrna10):

hearing/vestibular/earnervous system

CHRNA10 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


CHRNA10 for pathways           About GeneDecksing

1 Millipore Pathway for CHRNA10
    Calcium channels

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  CHRNA10
    Calcium Signaling
AMPK Signaling

1 Kegg Pathway  (Kegg details for CHRNA10):
    hsa04080 Neuroactive ligand-receptor interaction

    SABiosciences Custom Pathway-Focused PCR Arrays for CHRNA10 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CHRNA10
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHRNA10

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO IDQualified GO termEvidencePubMed IDs
GO:0006810 transport ----
GO:0006811 ion transport IEA--
GO:0006816 calcium ion transport IEA--
GO:0007204 elevation of cytosolic calcium ion concentration IGI18420419
GO:0007271 synaptic transmission, cholinergic TAS11350119
About this table

CHRNA10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Sigma-Aldrich Small Molecules for CHRNA10:
Small Molecule - Antagonist Small Molecule - Agonist Small Molecule - Blocker
Browse drugs & compounds from Enzo Life Sciences

Compounds for CHRNA10 available from Tocris Bioscience
CompoundAction CAS number
Mecamylamine hydrochlorideNon-competitive nicotinic receptor antagonist[826-39-1]
()-EpibatidineVery potent nicotinic agonist[140111-52-0]
ACV 1alpha9alpha10-selective antagonist[740980-24-9]
()-Anatoxin A fumarateNicotinic agonist[64285-06-9]
About this table




(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and siRNA for CHRNA10
Sigma-Aldrich shRNA for CHRNA10
OriGene 29mer shRNA kits in GFP-retroviral vector: CHRNA10
OriGene shRNA RFP: CHRNA10
OriGene basic RS shRNA: CHRNA10
OriGene siRNA: CHRNA10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CHRNA10 
miRNA: Sigma-Aldrich microRNA Mimics for CHRNA10
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CHRNA10 
1 SABiosciences Assays for microRNA that regulate CHRNA10:
hsa-miR-1225-3p
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CHRNA10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CHRNA10
OriGene untagged cDNA clones in CMV expression vector: CHRNA10
OriGene 3'-UTR Clone: CHRNA10 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: CHRNA10 
Primers: OriGene genome-wide validated SYBR primer pairs: CHRNA10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CHRNA10: PPH13064A

REFSEQ mRNAs for CHRNA10 gene: 

NM_020402.2  

Additional cDNA sequence: 

AF199235.2 AJ278118.1 AJ295237.1 BC033833.1 BC136250.1 BC143303.1 

4 DOTS entries:

DT.434596  DT.409305  DT.92418565  DT.75100915 

24/38 AceView cDNA sequences (see all 38):

AI673104 BQ010406 AI146549 BM665196 AA491394 AI939323 BF516446 AW207378 
AW135678 AI139700 BX096928 AJ295237 AI660069 BF343450 AJ278118 BF516351 
AA262389 BF345692 BF059093 BM702479 AF199235 NM_020402 BC033833 BF057531 

highest scoring ESTs for CHRNA10:

AF199235 AJ278118 AJ295237 AA243627 AA262389 AA937958 AI139700 AI660069 AI673104 AI939323 

Unigene Cluster for CHRNA10:

Cholinergic receptor, nicotinic, alpha 10
Hs.157714  [show with all ESTs]
Unigene Representative Sequence: NM_020402


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CHRNA10

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1:                    -           -               
SP2:                                                

About this scheme

ECgene alternative splicing isoforms for CHRNA10
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000250699(uc001lyf.2 uc010qxt.1 uc010qxu.1) ENST00000493827


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CHRNA10 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching CHRNA10 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
220210_at2, 3 U133-A 1 0.73 1.00 -- -- NM_020402 0.60 1.00 0.82 1
220210_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
CHRNA10 gene expression
CHRNA10 gene electronic northern expression
CHRNA10 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.157714

UniProtKB/Swiss-Prot: ACH10_HUMAN, Q9GZZ6
Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood
lymphocytes

Primers: OriGene genome-wide validated SYBR primer pairs: CHRNA10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CHRNA10: PPH13064A
    SABiosciences Custom PCR Arrays for CHRNA10 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHRNA10 gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
CHRNA101   -- cholinergic receptor, nicotinic, alpha 10 99.33(n)
99.11(a)
743844  XM_001158734.1  XP_001158734.1 
cow
(Bos taurus)
CHRNA101   -- cholinergic receptor, nicotinic, alpha 10 90.42(n)
94.21(a)
539128  XM_585021.3  XP_585021.3 
rat
(Rattus norvegicus)
Chrna101   -- cholinergic receptor, nicotinic, alpha 10 85.16(n)
90.6(a)
64574  NM_022639.1  NP_072161.1 
mouse
(Mus musculus)
Chrna101 , 5 7 (54.71 cM)5
cholinergic receptor, nicotinic, alpha polypeptide more1, 5 86.06(n)1
91.95(a)1
5041861  NM_001081424.11  NP_001074893.11 
 AK0330685  BC1472455  (see all 8)
zebrafish
(Danio rerio)
si:dkey-24p1.31   -- si:dkey-24p1.3 60.74(n)
59.56(a)
556507  NM_001044804.1  NP_001038269.1 
About this table        Species with no ortholog for CHRNA10

ENSEMBL Gene Tree for CHRNA10 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CHRNA10 gene
CHRNA72  CHRFAM7A2  CHRNA92  

CHRNA10 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/106 NCBI SNPs in CHRNA10 are shown (see all 106)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs22315281,2
C,3693410(-) AGTCCC/TGCACT 1 -- ng514Minor allele frequency- T:0.00NS EA 416
rs22315291,2
C,F,O,3693253(-) CTGTAC/TTCTCC 1 -- ng5122Minor allele frequency- T:0.09NS EA NA WA 2708
rs22315301,2
C,3693184(-) TCAAGC/TCCCAG 1 -- ng511Minor allele frequency- T:0.02WA 50
rs22315311,2
H3693136(-) AGGCAC/TGGTGT 1 -- ng514Minor allele frequency- T:0.00NS EA 418
rs22315321,2
C,F,A,H,3693120(-) AGCTAA/GTGAAA 1 -- ng5118Minor allele frequency- G:0.49NS EA NA WA 1348
rs22315331,2
C,3692992(-) GGGGAA/GTGGAA 1 -- ng510--------
rs22315341,2
C,H,3692755(-) GTACTA/GAAATC 1 -- ng512Minor allele frequency- G:0.29WA NA 52
rs22315351,2
3692697(-) GGCTCA/GCTGGA 1 -- ng510--------
rs22315361,2
C,F,3692643(-) AGGTAC/ATGTCC 1 -- ng513Minor allele frequency- A:0.03EU EA WA 516
rs22315371,2
C,F,3692628(-) CATCCT/CTGCCA 1 -- ng511Minor allele frequency- C:0.18WA 50
About this table

HapMap Linkage Disequilibrium images for CHRNA10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CHRNA10
     1 CNV: 3833

Search QIAGEN SeqTarget long-range PCR primers for resequencing for CHRNA10 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHRNA10 for disorders           About GeneDecksing

OMIM: 606372

Human Genome Epidemiology (HuGE) Navigator: CHRNA10 (10 documents)

Export disorders and mutations for CHRNA10 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/13 PubMed articles for CHRNA10 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with CHRNA10)
  1. Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). (PubMed id 11350119)1, 2, 7 Lustig L.R.... Fuchs P.A. (2001)
  2. Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes. (PubMed id 15531379)1, 2 Peng H....Lustig L.R. (2004)
  3. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (PubMed id 11752216)1, 2 Sgard F.... Besnard F. (2002)
  4. Why do young women smoke? V. Role of direct and interactive effects of nicotinic cholinergic receptor gene variation on neurocognitive function. (PubMed id 17559419)1, 7 Rigbi A....Lerer B. (2008)
  5. Why do young women smoke? VI. A controlled study of n icotine effects on attention: pharmacogenetic interactions. (PubMed id 20231857)1 Rigbi A....Lerer B. (2010)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
  8. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. (PubMed id 20584212)1 Saccone N.L....Bierut L.J. (2010)
  9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
  10. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. (PubMed id 19259974)1 Saccone N.L....Bierut L.J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 57053 HGNC: 13800 AceView: CHRNA10 Ensembl:ENSG00000129749 euGenes: HUgn57053
ECgene: CHRNA10 Kegg: 57053 H-InvDB: CHRNA10

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CHRNA10 gene:
Search GeneIP for patents involving CHRNA10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 Millipore Custom Antibody & Bulk Services
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 Predesigned and custom siRNAs for CHRNA10 Browse antibodies at Sigma-Aldrich
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 Lentivirus-delivered shRNAs for CHRNA10 microRNA Mimics for CHRNA10
 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CHRNA10
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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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 GenScript Custom Purified and Recombinant Proteins Services for CHRNA10 GenScript cDNA clones with any tag delivered in your preferred vector for CHRNA10
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 Regulatory tfbs in CHRNA10 promoter
 Search Chromatin IP Primers for CHRNA10
 RT2 qPCR Primer Assay for CHRNA10
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 SABiosciences Custom PCR Arrays for CHRNA10
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 Antibodies for CHRNA10
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 Browse antibodies at Epitomics
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 Browse ELISAs and CLIAs at Uscn
       

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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