Aliases &
Descriptions
for CKMT1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| creatine kinase, mitochondrial 1A1 2 | | CKMT1B2 | | creatine kinase, mitochondrial 1 (ubiquitous)1 2 | | creatine kinase U-type, mitochondrial2 | | Ubiquitous mitochondrial creatine kinase2 3 | | FLJ509672 | | Acidic-type mitochondrial creatine kinase2 3 | | mia-CK2 | | U-MtCK2 3 | | EC 2.7.3.23 | | UMTCK2 | | CKMT3 | | CKMT12 | | Mia-CK3 |
Export aliases for CKMT1A gene to outside databasesPrevious GC identifers: GC15P041773 GC15U900516 GC15P043886 |
Summaries
for CKMT1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CKMT1A:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to thecytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two differentoligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; thismay be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrialcreatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes locatednear each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.(provided by RefSeq)
UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energydemands, such as skeletal muscle, heart, brain and spermatozoa
|
Genomic Views
for CKMT1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CKMT1A gene promoter:
FAC1 Pbx1a CUTL1 POU3F2 PPAR-gamma2 PPAR-gamma1 E2F-1 E2F Bach2 Lmo2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CKMT1A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15CKMT1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P020808: view genomic region
(about GC identifiers)
Start:
|
20,807,783 bp from pter |
End:
|
20,814,119 bp from pter |
Size:
|
6,337 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr15+ 43,886,225-43,991,420 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for CKMT1A gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532 (See
protein sequence)Recommended Name: Creatine kinase U-type, mitochondrial precursor Size: 417 amino acids; 47037 Da
Subunit: Exists as an octamer composed of four MTCK homodimers
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Miscellaneous: Mitochondrial creatine kinase binds cardiolipin
PDB structures from  and Proteopedia  :1QK1 (3D)
Secondary accessions: B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4Alternative splicing: 2 isoforms: P12532-1 P12532-2 Explore the universe of human proteins at neXtProt for CKMT1A: NX_P12532
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001015001.1
ENSEMBL proteins: ENSP00000413165 ENSP00000392779 ENSP00000401927 ENSP00000398973 ENSP00000406577 ENSP00000393792 ENSP00000371113 ENSP00000389806
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CKMT1A for ontologies About GeneDecksing
Antibodies for CKMT1A:
Assays for CKMT1A: |
Protein
Domains/
Families
for CKMT1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CKMT1A for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12532ProtoNet protein and cluster: P12532 1 Blocks protein family: IPB000749 ATP:guanido phosphotransferase
UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532Similarity: Belongs to the ATP:guanido phosphotransferase family |
Gene Function
for CKMT1A gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energydemands, such as skeletal muscle, heart, brain and spermatozoaCatalytic activity: ATP + creatine = ADP + phosphocreatineEnzyme Number (IUBMB): EC 2.7.3.2
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0004111 | creatine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- | | GO:0016301 | kinase activity |
-- | -- | | GO:0016772 | transferase activity, transferring phosphorus-containing groups |
-- | -- |
About this table
CKMT1A for ontologies About GeneDecksing
|
Pathways & Interactions
for CKMT1A gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CKMT1A for pathways About GeneDecksing
2  Kegg Pathways (Kegg details for CKMT1A):
SABiosciences Custom Pathway-Focused PCR Arrays for CKMT1A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CKMT1A
5/34 Interacting proteins for CKMT1A (P125322) via UniProtKB, MINT, and/or STRING (see all 34)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): About this table
CKMT1A for ontologies About GeneDecksing
|
Drugs & Compounds
for CKMT1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CKMT1A
|
Transcripts
for CKMT1A gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
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|
REFSEQ mRNAs for CKMT1A gene: NM_001015001.1 Additional cDNA sequence: AK316052.1 BT006628.1 11 DOTS entries: DT.315670 DT.100805678 DT.95261994 DT.97833511 DT.100813514 DT.100813509 DT.100813525 DT.121025328 DT.100813520 DT.100813526 DT.92046065
 highest scoring ESTs for CKMT1A:AA478264 AI940473 AW844855 BE407712 BE698210 BE775221 BE778933 BF364489 BF802451 BI551801 Unigene Cluster for CKMT1A: Creatine kinase, mitochondrial 1A Hs.654988 [show with all ESTs]Unigene Representative Sequence: BT006628
GeneLoc Exon Structure
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483604 ENST00000434505(uc001zsn.2 uc010uea.1) ENST00000424065
ENST00000415044 ENST00000411750 ENST00000413453(uc010ueb.1 uc010bdo.2 uc001zso.3)
ENST00000448957 ENST00000381694 ENST00000479938 ENST00000457648
|
Expression
for CKMT1A gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CKMT1A expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CKMT1A gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31887_at2, 3
|
U95-A |
2 |
1.00 |
0.50 |
1.00 |
1.00 |
J04469 |
0.20 |
0.33 |
0.27 |
1 |
| 202712_s_at2, 3
|
U133-A |
2 |
1.00 |
0.50 |
-- |
-- |
NM_020990 |
0.20 |
0.33 |
0.27 |
2 |
| 202712_s_at2
|
U133Plus2 |
2 |
1.00 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CKMT1A for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.654988
Expression variation in blood from EXPOLDB for CKMT1A SABiosciences Custom PCR Arrays for CKMT1A
|
Orthologs
for CKMT1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CKMT1A gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
zebrafish
(Danio rerio) |
ckmt11 |
-- |
creatine kinase, mitochondrial 1 |
72.44(n)
81.49(a) |
321892 NM_198801.1 NP_942096.1 |
About this table Species with no ortholog for CKMT1A
ENSEMBL Gene Tree for CKMT1A (if available) |
Paralogs
for CKMT1A gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CKMT1A gene
- CKMT1B1 2 CKB2 CKM2 CKMT22
CKMT1A for paralogs About GeneDecksing
|
Genomic Variants
for CKMT1A gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CKMT1A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for CKMT1A
7 CNVs: 3079 35315 87664 66782 7061 66780 3960
2 Indels: 33601 33285 | | QIAGEN SeqTarget long-range PCR primers for resequencing CKMT1A |
|
Disorders & Mutations
for CKMT1A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CKMT1A for disorders About GeneDecksing
OMIM: 613415
Human Genome Epidemiology (HuGE) Navigator: CKMT1A (1 document)
Export disorders and mutations for CKMT1A gene to outside databases
|
Medical News
for CKMT1A gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CKMT1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/29 PubMed articles for CKMT1A gene, integrated from 7 sources (see all 29):
(articles sorted by number of sources associating them with CKMT1A)- Crystal structure of human ubiquitous mitochondrial creatine kinase. (PubMed id 10737943)1, 2, 7 Eder M.... Schlattner U. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1, 2 Haas R.C....Strauss A.W. (1989)
- Ubiquitous mitochondrial creatine kinase is overexpre ssed in the conditioned medium and the extract of LNCaP lineaged androgen indep endent cell lines and facilitates prostate cancer progression. (PubMed id 19415690)1, 7 Pang B....Zhou J.G. (2009)
- ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PubMed id 20302626)1, 7 Kwon S....Kwon H.J. (2010)
- Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. (PubMed id 12401781)1, 7 Wendt S....Wallimann T. (2003)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)2 Heibeck T.H.... Qian W.-J. (2009)
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)2 Rikova K....Comb M.J. (2007)
- Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes. (PubMed id 17028143)1 Epand R.F....Epand R.M. (2007)
|
External Searches for CKMT1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CKMT1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CKMT1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CKMT1A gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CKMT1A gene:
Search GeneIP for patents involving CKMT1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CKMT1A gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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