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CKMT1A Gene

protein-coding   GIFtS: 47

GC15P020808
creatine kinase, mitochondrial 1A
(Previous names: creatine kinase, mitochondrial 1 (ubiquitous) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CKMT1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
creatine kinase, mitochondrial 1A1 2     CKMT1B2
creatine kinase, mitochondrial 1 (ubiquitous)1 2     creatine kinase U-type, mitochondrial2
Ubiquitous mitochondrial creatine kinase2 3     FLJ509672
Acidic-type mitochondrial creatine kinase2 3     mia-CK2
U-MtCK2 3     EC 2.7.3.23
UMTCK2     CKMT3
CKMT12     Mia-CK3

External Ids:    HGNC: 317361   Entrez Gene: 5485962   Ensembl: ENSG000002235727   UniProtKB: P125323   

Export aliases for CKMT1A gene to outside databases

Previous GC identifers: GC15P041773 GC15U900516 GC15P043886


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CKMT1A:
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the
cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes,
sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different
oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.
Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this
may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial
creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located
near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
(provided by RefSeq)

UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).
Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy
demands, such as skeletal muscle, heart, brain and spermatozoa


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CKMT1A gene promoter:
         FAC1   Pbx1a   CUTL1   POU3F2   PPAR-gamma2   PPAR-gamma1   E2F-1   E2F   Bach2   Lmo2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CKMT1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15

CKMT1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CKMT1A gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P020808:  view genomic region     (about GC identifiers)

Start:
20,807,783 bp from pter
End:
20,814,119 bp from pter
Size:
6,337 bases
Orientation:
plus strand

1 alternative location:
Chr15+ 43,886,225-43,991,420     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532 (See protein sequence)
Recommended Name: Creatine kinase U-type, mitochondrial precursor  
Size: 417 amino acids; 47037 Da
Subunit: Exists as an octamer composed of four MTCK homodimers
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
Miscellaneous: Mitochondrial creatine kinase binds cardiolipin
PDB structures from and Proteopedia :
1QK1 (3D)    
Secondary accessions: B4DIT8 B7ZA09 Q0VAM3 Q32NF6 Q53FC4
Alternative splicing: 2 isoforms:  P12532-1   P12532-2   

Explore the universe of human proteins at neXtProt for CKMT1A: NX_P12532 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001015001.1  

    ENSEMBL proteins: 
    ENSP00000413165 ENSP00000392779 ENSP00000401927 ENSP00000398973 ENSP00000406577 ENSP00000393792 
    ENSP00000371113 ENSP00000389806 


    Human Recombinant Proteins 
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    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739 mitochondrion IEA--
    GO:0005743 mitochondrial inner membrane TAS--
    GO:0016020 membrane IEA--
    About this table

    CKMT1A for ontologies           About GeneDecksing



    Antibodies for CKMT1A: 
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    Uscn ELISAs and CLIAs for CKMT1A 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CKMT1A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000749 ATP-guanido_PTrfase
     IPR014746 Gln_synth/guanido_kin_cat_dom
     IPR022413 ATP-guanido_PTrfase_N
     IPR022415 ATP-guanido_PTrfase_cat_AS
     IPR022414 ATP-guanido_PTrfase_cat

    Graphical View of Domain Structure for InterPro Entry P12532

    ProtoNet protein and cluster: P12532

    1 Blocks protein family: IPB000749 ATP:guanido phosphotransferase

    UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
    Similarity: Belongs to the ATP:guanido phosphotransferase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: KCRU_HUMAN, P12532
    Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate).
    Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy
    demands, such as skeletal muscle, heart, brain and spermatozoa
    Catalytic activity: ATP + creatine = ADP + phosphocreatine
    Enzyme Number (IUBMB): EC 2.7.3.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CKMT1A 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CKMT1A 
    Search SABiosciences for Assays for microRNAs that regulate CKMT1A

    Gene
    Editing:
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    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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    OriGene GFP tagged cDNA clones in CMV expression vector: CKMT1A
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CKMT1A 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004111 creatine kinase activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0016301 kinase activity ----
    GO:0016772 transferase activity, transferring phosphorus-containing groups ----
    About this table

    CKMT1A for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CKMT1A for pathways           About GeneDecksing

    2 Kegg Pathways  (Kegg details for CKMT1A):
        hsa00330 Arginine and proline metabolism
    hsa01100 Metabolic pathways

        SABiosciences Custom Pathway-Focused PCR Arrays for CKMT1A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CKMT1A

    5/34 Interacting proteins for CKMT1A (P125322) via UniProtKB, MINT, and/or STRING (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A2MP010232MINT-4054731
    ACTBP607092MINT-4054731
    ALPPP051872MINT-4054731
    APODP050902MINT-4054731
    ARL8BQ9NVJ22MINT-4054731
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006600 creatine metabolic process EXP10893433
    About this table

    CKMT1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CKMT1A


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    OriGene 29mer shRNA kits in GFP-retroviral vector: CKMT1A
    OriGene shRNA RFP: CKMT1A
    OriGene basic RS shRNA: CKMT1A
    OriGene siRNA: CKMT1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CKMT1A 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CKMT1A 
    Search SABiosciences for Assays for microRNAs that regulate CKMT1A
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CKMT1A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CKMT1A
    OriGene untagged cDNA clones in CMV expression vector: CKMT1A
    OriGene 3'-UTR Clone: CKMT1A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CKMT1A 
    Primers: OriGene genome-wide validated SYBR primer pairs: CKMT1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CKMT1A: PPH65966A

    REFSEQ mRNAs for CKMT1A gene: 

    NM_001015001.1  

    Additional cDNA sequence: 

    AK316052.1 BT006628.1 

    11 DOTS entries:

    DT.315670  DT.100805678  DT.95261994  DT.97833511  DT.100813514  DT.100813509  DT.100813525  DT.121025328 
    DT.100813520  DT.100813526  DT.92046065 

    highest scoring ESTs for CKMT1A:

    AA478264 AI940473 AW844855 BE407712 BE698210 BE775221 BE778933 BF364489 BF802451 BI551801 

    Unigene Cluster for CKMT1A:

    Creatine kinase, mitochondrial 1A
    Hs.654988  [show with all ESTs]
    Unigene Representative Sequence: BT006628


    GeneLoc Exon Structure

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483604 ENST00000434505(uc001zsn.2 uc010uea.1) ENST00000424065
    ENST00000415044 ENST00000411750 ENST00000413453(uc010ueb.1 uc010bdo.2 uc001zso.3)
    ENST00000448957 ENST00000381694 ENST00000479938 ENST00000457648

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CKMT1A expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching CKMT1A gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31887_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 J04469 0.20 0.33 0.27 1
    202712_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_020990 0.20 0.33 0.27 2
    202712_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
    About this table

    CKMT1A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CKMT1A gene expression
    CKMT1A gene electronic northern expression
    CKMT1A gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.654988

    Expression variation in blood from EXPOLDB for CKMT1A

    Primers: OriGene genome-wide validated SYBR primer pairs: CKMT1A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CKMT1A: PPH65966A
        SABiosciences Custom PCR Arrays for CKMT1A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CKMT1A gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    zebrafish
    (Danio rerio)
    ckmt11   -- creatine kinase, mitochondrial 1 72.44(n)
    81.49(a)
    321892  NM_198801.1  NP_942096.1 
    About this table        Species with no ortholog for CKMT1A

    ENSEMBL Gene Tree for CKMT1A (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CKMT1A gene
    CKMT1B1 2  CKB2  CKM2  CKMT22  

    CKMT1A for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/43 NCBI SNPs in CKMT1A are shown (see all 43)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs22367401,2
    C,H43990187(+) TTTTCA/G/TTTAAT 1 -- int11NA 2
    rs22599501,2
    A43988575(-) CTACAC/TAATCT 1 -- int10--------
    rs22599511,2
    C,A43988573(-) ACACAA/GTCTTC 1 -- int10--------
    rs24112681,2
    --43988696(-) GTCCTA/GGAGTG 1 -- int10--------
    rs24112691,2
    --43988682(-) CCTAGA/GTAGTC 1 -- int10--------
    rs24112701,2
    A43988668(-) TTTACC/TATCAG 1 -- int10--------
    rs24128071,2
    A43988655(+) ACCCAA/GGACAT 1 -- int10--------
    rs24128081,2
    A43988665(+) TGTCTG/TATGGT 1 -- int10--------
    rs24674261,2
    C,F,O,43989518(+) AGCACA/GTAAGA 1 -- int185Minor allele frequency- G:0.29NS EA PA EU CA WA 4340
    rs24674271,2
    --43989531(+) TCCCCG/TGTGGC 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for CKMT1A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for CKMT1A
         7 CNVs: 3079 35315 87664 66782 7061 66780 3960
         2 Indels: 33601 33285

    QIAGEN SeqTarget long-range PCR primers for resequencing CKMT1A 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CKMT1A for disorders           About GeneDecksing

    OMIM: 613415

    Human Genome Epidemiology (HuGE) Navigator: CKMT1A (1 document)

    Export disorders and mutations for CKMT1A gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/29 PubMed articles for CKMT1A gene, integrated from 7 sources (see all 29):
    (articles sorted by number of sources associating them with CKMT1A)
    1. Crystal structure of human ubiquitous mitochondrial creatine kinase. (PubMed id 10737943)1, 2, 7 Eder M.... Schlattner U. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase. (PubMed id 2914937)1, 2 Haas R.C....Strauss A.W. (1989)
    4. Ubiquitous mitochondrial creatine kinase is overexpre ssed in the conditioned medium and the extract of LNCaP lineaged androgen indep endent cell lines and facilitates prostate cancer progression. (PubMed id 19415690)1, 7 Pang B....Zhou J.G. (2009)
    5. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PubMed id 20302626)1, 7 Kwon S....Kwon H.J. (2010)
    6. Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues. (PubMed id 12401781)1, 7 Wendt S....Wallimann T. (2003)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    8. An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)2 Heibeck T.H.... Qian W.-J. (2009)
    9. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)2 Rikova K....Comb M.J. (2007)
    10. Novel lipid transfer property of two mitochondrial proteins that bridge the inner and outer membranes. (PubMed id 17028143)1 Epand R.F....Epand R.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 548596 HGNC: 31736 Ensembl:ENSG00000223572 euGenes: HUgn548596 ECgene: CKMT1A Kegg: 548596
    H-InvDB: CKMT1A

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CKMT1A gene:
    Search GeneIP for patents involving CKMT1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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