Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



CLEC7A Gene

protein-coding   GIFtS: 56

GC12M010012
C-type lectin domain family 7, member A
(Previous names: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CLECSF12)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
C-type lectin domain family 7, member A1 2     DC-associated C-type lectin 12 3
CLECSF122 3 5     C-type lectin superfamily member 122 3
DECTIN12 3 5     CANDF42 5
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily
member 121 2
     hDectin-11
dectin-11 2     dendritic cell-associated C-type lectin-12
Dendritic cell-associated C-type lectin 12 3     lectin-like receptor 12
Beta-glucan receptor2 3     C-type lectin domain family 7 member A2
BGR2 3     Dectin-13

External Ids:    HGNC: 145581   Entrez Gene: 645812   Ensembl: ENSG000001722437   UniProtKB: Q9BXN23   

Export aliases for CLEC7A gene to outside databases

Previous GC identifers: GC12M010161 GC12M010269


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CLEC7A:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded
glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a
cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition
receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this
way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,
have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the
natural killer gene complex region. (provided by RefSeq)

UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2
Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as
cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and
for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates
production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way
that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By
similarity)

Gene Wiki entry for CLEC7A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CLEC7A gene promoter:
         NF-kappaB1   POU3F2   AREB6   HOXA9B   Meis-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   NRSF form 1   NRSF form 2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CLEC7A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2-p12.3

CLEC7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CLEC7A gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010012:  view genomic region     (about GC identifiers)

Start:
10,012,523 bp from pter
End:
10,026,010 bp from pter
Size:
13,488 bases
Orientation:
minus strand

1 alternative location:
Chr12- 10,269,376-10,282,868     
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2 (See protein sequence)
Recommended Name: C-type lectin domain family 7 member A  
Size: 247 amino acids; 27627 Da
Subunit: Isoform 5 interacts with RANBP9
Subcellular location: Membrane; Single-pass type II membrane protein
Subcellular location: Isoform 5: Cytoplasm
Subcellular location: Isoform 6: Cytoplasm (Probable)
Subcellular location: Isoform 7: Cytoplasm (Probable)
Secondary accessions: B2R861 B7Z494 B7Z5A9 B7Z5B9 Q6IPS7 Q96DR9 Q96LD3 Q96PA5 Q96PA6 Q96PA7 Q96PA8
Q9H1K3
Alternative splicing: 8 isoforms:  Q9BXN2-1   Q9BXN2-2   Q9BXN2-3   Q9BXN2-4   Q9BXN2-5   Q9BXN2-6   Q9BXN2-7   Q9BXN2-8   

Explore the universe of human proteins at neXtProt for CLEC7A: NX_Q9BXN2 

Post-translational modifications:

  • Phosphorylated on tyrosine residues in response to glucan binding (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (6 alternative transcripts): 
    NP_072092.2  NP_922938.1  NP_922939.1  NP_922940.1  NP_922941.1  NP_922945.1  


    ENSEMBL proteins: 
    ENSP00000298523 ENSP00000344723 ENSP00000379743 ENSP00000379740 ENSP00000312089 ENSP00000395776 
    ENSP00000266456 ENSP00000302569 ENSP00000346758 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for CLEC7A (Dectin-1/CLEC7A)
    Enzo Life Sciences proteins for CLEC7A
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): CLEC7A
    GenScript Custom Purified and Recombinant Proteins Services for CLEC7A 
    Novus Biologicals Protein for CLEC7A
    Novus Biologicals Lysates for CLEC7A
    Sino Biological Recombinant Protein for CLEC7A
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0009897 external side of plasma membrane IEA--
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane TAS11567029
    About this table

    CLEC7A for ontologies           About GeneDecksing



    Antibodies for CLEC7A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for CLEC7A (Dectin-1/CLEC7A)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CLEC7A 
    Novus Biologicals Antibodies for CLEC7A
    Browse antibodies at Epitomics

    Assays for CLEC7A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CLEC7A 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CLEC7A 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CLEC7A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin
     IPR002353 AntifreezeII

    Graphical View of Domain Structure for InterPro Entry Q9BXN2

    ProtoNet protein and cluster: Q9BXN2

    1 Blocks protein family: IPB013600 Ly49-like N-terminal

    UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2
    Similarity: Contains 1 C-type lectin domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2
    Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as
    cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and
    for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates
    production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way
    that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By
    similarity)
    Induction: Up-regulated during differentiation from monocytes into dendritic cells

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CLEC7A
    Sigma-Aldrich shRNA Panels and shRNA for CLEC7A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 10): CLEC7A
    OriGene shRNA RFP (see all 10): CLEC7A
    OriGene basic RS shRNA (see all 10): CLEC7A
    OriGene siRNA (see all 9): CLEC7A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLEC7A 
    miRNA:Sigma-Aldrich microRNA Mimics for CLEC7A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLEC7A 
    Search SABiosciences for Assays for microRNAs that regulate CLEC7A

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene untagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene 3'-UTR clone (see all 6): CLEC7A 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CLEC7A 
    Sino Biological Human cDNA Clone for CLEC7A

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CLEC7A 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001846 opsonin binding IEA--
    GO:0001872 zymosan binding ----
    GO:0001874 zymosan receptor activity IEA--
    GO:0005488 binding IEA--
    GO:0005529 sugar binding IDA11567029
    About this table

    CLEC7A for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Clec7a):

    digestive/alimentaryimmune systemlife span-post-weaning/agingrespiratory system

    CLEC7A for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CLEC7A for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  CLEC7A
        Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

    1 Kegg Pathway  (Kegg details for CLEC7A):
        hsa04145 Phagosome

        SABiosciences Pathway-Focused PCR Arrays including CLEC7A: PAHS-053A PAHS-073A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CLEC7A
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLEC7A

    5/15 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 15):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001878 response to yeast ----
    GO:0001879 detection of yeast IEA--
    GO:0002238 response to molecule of fungal origin IEA--
    GO:0002752 cell surface pattern recognition receptor signaling pathway IEA--
    GO:0006910 phagocytosis, recognition IDA11567029
    About this table

    CLEC7A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CLEC7A for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CLEC7A
    6 Novoseek chemical compound relationships for CLEC7A gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    laminarin 82.7 1 11424011 (1)
    zymosan 79.6 6 7543539 (2), 7530718 (1), 9916047 (1), 19811837 (1)
    mannose 73.3 12 7790075 (2), 1593222 (1), 8991539 (1), 18025938 (1) (see all 10)
    glucose 23.6 3 7505123 (1), 7641306 (1), 1334474 (1)
    tyrosine 19.1 1 11567029 (1)
    dexamethasone 1.94 2 7505123 (1), 8132226 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CLEC7A
    Sigma-Aldrich shRNA Panels and shRNA for CLEC7A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 10): CLEC7A
    OriGene shRNA RFP (see all 10): CLEC7A
    OriGene basic RS shRNA (see all 10): CLEC7A
    OriGene siRNA (see all 9): CLEC7A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLEC7A 
    miRNA: Sigma-Aldrich microRNA Mimics for CLEC7A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLEC7A 
    Search SABiosciences for Assays for microRNAs that regulate CLEC7A
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene untagged cDNA clones in CMV expression vector (see all 6): CLEC7A
    OriGene 3'-UTR Clone (see all 6): CLEC7A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CLEC7A 
    Primers: OriGene genome-wide validated SYBR primer pairs: CLEC7A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CLEC7A: PPH05563A

    REFSEQ mRNAs for CLEC7A gene (6 alternative transcripts): 

    NM_022570.4  NM_197947.2  NM_197948.2  NM_197949.2  NM_197950.2  NM_197954.2  

    Additional cDNA sequence: 

    AF313468.1 AF313469.1 AF400595.1 AF400596.1 AF400597.1 AF400598.1 AF400599.1 AJ312372.1 
    AJ312373.1 AK294111.1 AK295108.1 AK297028.1 AK298679.1 AK298724.1 AK313247.1 AY009090.2 
    AY026769.2 AY026770.2 AY026771.1 AY359002.1 BC013385.1 BC071746.1 BC093829.1 BC093831.1 

    10 DOTS entries:

    DT.430109  DT.92039763  DT.100815542  DT.101965064  DT.95272729  DT.95272734  DT.97838632  DT.40309927 
    DT.121180571  DT.92419093 

    24/66 AceView cDNA sequences (see all 66):

    AF400597 NM_197953 AY026769 AI708851 NM_197949 AY026770 AF400596 AJ312372 
    NM_197948 AF400602 AA535015 AY359002 NM_197950 NM_197947 NM_197952 NM_197951 
    AF400595 NM_022570 BM280423 AI209158 NM_197954 AY026771 BX479704 AF400601 

    highest scoring ESTs for CLEC7A:

    AA535015 AA361063 AF313468 AF313469 AF400595 AF400596 AF400597 AF400598 AF400599 AJ312372 

    Unigene Cluster for CLEC7A:

    C-type lectin domain family 7, member A
    Hs.143929  [show with all ESTs]
    Unigene Representative Sequence: NM_197947


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CLEC7A (see all 9)

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                    -     -                 -     -     -                 -     -                                 
    SP2:                                            -     -     -                 -     -                                 
    SP3:                                            -     -     -     -           -     -                                 
    SP4:                                            -     -     -     -           -           -                           
    SP5:                                            -     -     -     -           -     -     -                           

    About this scheme

    ECgene alternative splicing isoforms for CLEC7A
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298523 ENST00000349926 ENST00000396484 ENST00000396480(uc001qxe.3 uc001qxf.2 uc001qxg.2 uc001qxh.2 uc001qxi.2 uc001qxj.2 uc001qxk.1)
    ENST00000310002(uc001qxn.2) ENST00000422474 ENST00000353231(uc009zhg.1)
    ENST00000465100(uc001qxl.1) ENST00000304084 ENST00000354721(uc010sgy.1 uc001qxm.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CLEC7A expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching CLEC7A gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    82013_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AA535015 1.00 1.00 1.00 1
    221698_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF313468 0.80 1.00 0.91 1
    221698_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555213_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1554406_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555214_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555756_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    CLEC7A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CLEC7A gene expression
    CLEC7A gene electronic northern expression
    CLEC7A gene sage expression
    About these images

    CGAP SAGE TAG: TGCTGATTTG

    SOURCE GeneReport for Unigene cluster: Hs.143929

    UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2
    Tissue specificity: Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone
    marrow, lung, muscle, stomach and placenta

    Primers: OriGene genome-wide validated SYBR primer pairs: CLEC7A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CLEC7A: PPH05563A
        SABiosciences Expression via Pathway-Focused PCR Arrays including CLEC7A: PAHS-053A PAHS-073A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CLEC7A gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CLEC7A1   -- C-type lectin domain family 7, member A 83.88(n)
    74.39(a)
    611385  XM_849050.1  XP_854143.1 
    chimpanzee
    (Pan troglodytes)
    CLEC7A1   -- C-type lectin domain family 7, member A 99.33(n)
    98.38(a)
    473361  XM_528732.2  XP_528732.2 
    cow
    (Bos taurus)
    CLEC7A1   -- C-type lectin domain family 7, member A 81.65(n)
    73.68(a)
    532865  NM_001031852.1  NP_001027022.1 
    rat
    (Rattus norvegicus)
    Clec7a1   -- C-type lectin domain family 7, member a 72.7(n)
    58.44(a)
    502902  XM_578404.2  XP_578404.2 
    mouse
    (Mus musculus)
    Clec7a1 , 5 6 (63.34 cM)5
    C-type lectin domain family 7, member a1, 5 73.11(n)1
    60.91(a)1
    566441  NM_020008.11  NP_064392.11 
     AA2406435  AF2629855  (see all 9)
    About this table        Species with no ortholog for CLEC7A

    ENSEMBL Gene Tree for CLEC7A (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CLEC7A gene
    OLR12  CLEC1B2  CLEC12A2  CLEC1A2  

    CLEC7A for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/248 NCBI SNPs in CLEC7A are shown (see all 248)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs20781781,2
    C,F,A,10276562(-) GACTGT/CCATCT 4 -- int118Minor allele frequency- C:0.35EA NA NS 1064
    rs30538171,2
    --10276649(-) AGTAC-/TTCTTAAC 4 -- int10--------
    rs39015321,2
    C,F,A,H,10277171(-) ACCCTG/ACTATC 4 -- int117Minor allele frequency- A:0.44MN NS EA NA WA 954
    rs39015331,2
    C,F,A,H,10277083(-) TAAATT/GCTATA 4 -- int116Minor allele frequency- G:0.45NS EA NA WA 770
    rs47634461,2
    C,F,H,10278567(+) TTGAAC/TTGAAA 4 -- int118Minor allele frequency- N:0.00EA NA NS WA 840
    rs47642711,2
    C,A10275336(+) ccgccG/Cacctg 4 -- int15Minor allele frequency- C:0.10NA 10
    rs47642721,2
    C,F,A,10275533(+) cGGGGG/AGTTAC 4 -- int112Minor allele frequency- A:0.42NA EA WA 358
    rs57963801,2
    C10276648(+) TTAAG-/AAGTACTT 4 -- int11Minor allele frequency- AAG:0.00NA 2
    rs57963811,2
    C10279526(+) aaaaaA/-gaaaa 5 -- int1 ng31 trp31Minor allele frequency- -:0.00NA 2
    rs64882631,2
    C,F,A,H,10277524(+) caagtG/Atggtg 4 -- int19Minor allele frequency- A:0.40NA EA WA 178
    About this table

    HapMap Linkage Disequilibrium images for CLEC7A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CLEC7A: --

    QIAGEN SeqTarget long-range PCR primers for resequencing CLEC7A 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CLEC7A for disorders           About GeneDecksing

    OMIM: 606264   disorders: 613108  

    UniProtKB/Swiss-Prot: CLC7A_HUMAN, Q9BXN2

  • Defects in CLEC7A may be a cause of candidiasis familial type 4 (CANDF4) [MIM:613108]. It is a rare disorder
  • with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is
    characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of
    the genus Candida, mainly Candida albicans

    3 Novoseek disease relationships for CLEC7A gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 27.9 2 8751898 (1), 1334474 (1)
    tumors 1.3 2 8751898 (1), 1334474 (1)
    tuberculosis 0 1 2108212 (1)
    About this table

    Human Gene Mutation Database (HGMD): CLEC7A
    Human Genome Epidemiology (HuGE) Navigator: CLEC7A (6 documents)

    Export disorders and mutations for CLEC7A gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/92 PubMed articles for CLEC7A gene, integrated from 7 sources (see all 92):
    (articles sorted by number of sources associating them with CLEC7A)
    1. Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. (PubMed id 11567029)1, 2, 7 Willment J.A.... Brown G.D. (2001)
    2. Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. (PubMed id 11470510)1, 2, 7 Yokota K.... Ariizumi K. (2001)
    3. Human dectin-1 deficiency and mucocutaneous fungal in fections. (PubMed id 19864674)1, 2 Ferwerda B....Netea M.G. (2009)
    4. Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM. (PubMed id 16870151)1, 2 Xie J.... Gu J. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Molecular and functional characterization of human Dectin-1. (PubMed id 12423684)1, 2 Gruenebach F.... Brossart P. (2002)
    8. A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex. (PubMed id 11745369)1, 2 Sobanov Y.... Hofer E. (2001)
    9. Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. (PubMed id 11491532)1, 2 Hermanz-Falcon P.... Fernandez-Ruiz E. (2001)
    10. The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells. (PubMed id 15816015)1, 7 Willment J.A....Brown G.D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64581 HGNC: 14558 AceView: CLECSF12 Ensembl:ENSG00000172243 euGenes: HUgn64581
    ECgene: CLEC7A Kegg: 64581 H-InvDB: CLEC7A

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CLEC7A gene:
    Search GeneIP for patents involving CLEC7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for CLEC7A Browse antibodies at Sigma-Aldrich
     Super-pooled esiRNAs for CLEC7A Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CLEC7A microRNA Mimics for CLEC7A
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for CLEC7A (Dectin-1/CLEC7A)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CLEC7A (Dectin-1/CLEC7A)  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CLEC7A
     SeqTarget long-range PCR primers for resequencing CLEC7A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CLEC7A
     GenScript Custom Purified and Recombinant Proteins Services for CLEC7A GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CLEC7A
     GenScript Custom Assay Services for CLEC7A GenScript Custom Superior Antibodies Services for CLEC7A
     GenScript Custom overexpressing Cell Line Services for CLEC7A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CLEC7A promoter
     Search Chromatin IP Primers for CLEC7A
     RT2 qPCR Primer Assay for CLEC7A
     Search GNC Networks for CLEC7A
     Search for Assays for microRNAs that regulate CLEC7A
     SABiosciences PCR Arrays including CLEC7A
     Search Tocris compounds for CLEC7A
     Proteins and Antibodies for CLEC7A
     cDNA Clones for CLEC7A
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for CLEC7A
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for CLEC7A
     Proteins for CLEC7A
     Lysates for CLEC7A
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for CLEC7A
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    CLEC7A gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4