CLVS2 Gene
protein-coding GIFtS: 38
GC06P120894
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clavesin 2
(Previous names: chromosome 6 open reading frame 212, chromosome 6 open reading frame 213, retinaldehyde binding protein 1-like 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C6orf212, C6orf213, RLBP1L2)
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Aliases &
Descriptions
for CLVS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
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| Aliases & Descriptions |
|---|
| clavesin 21 2 | | RLBP1L22 3 | | bA160A10.41 2 | | chromosome 6 open reading frame 2121 | | retinaldehyde binding protein 1-like 21 2 | | chromosome 6 open reading frame 2131 | | Retinaldehyde-binding protein 1-like 22 3 | | OTTHUMP000000171222 | | C6orf2122 3 | | clavesin-22 | | C6orf2132 3 | | MGC1205722 |
Export aliases for CLVS2 gene to outside databasesPrevious GC identifer: GC06P123360 |
Summaries
for CLVS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1Function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Bindsphosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
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Genomic Views
for CLVS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CLVS2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CLVS2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CLVS2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.31 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22.31CLVS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P120894: view genomic region
(about GC identifiers)
Start:
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120,894,951 bp from pter |
End:
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120,962,427 bp from pter |
Size:
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67,477 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr6+ 123,317,116-123,385,612 |
RefSeq DNA sequence:- NC_000006.11 NT_025741.15
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Proteins
for CLVS2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
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UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1 (See
protein sequence)Recommended Name: Clavesin-2 Size: 327 amino acids; 38000 Da
Subunit: Forms a complex with clathrin heavy chain and gamma-adaptin
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity).Cytoplasmic vesicle, clathrin-coated vesicle (By similarity). Early endosome membrane; Peripheral membrane protein
Miscellaneous: Binding to PtdIns(3,5)P2 is not required for localization (By similarity)
Secondary accessions: B3KTG5 B4DHL0 C8UZT4 Q5SYC0Alternative splicing: 2 isoforms: Q5SYC1-1 Q5SYC1-2 Explore the universe of human proteins at neXtProt for CLVS2: NX_Q5SYC1
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001010852.2
ENSEMBL proteins: ENSP00000275162 ENSP00000357423 ENSP00000357422 ENSP00000416047
Human Recombinant Proteins
5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8): About this table
CLVS2 for ontologies About GeneDecksing
Antibodies for CLVS2:
Assays for CLVS2: |
Protein
Domains/
Families
for CLVS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CLVS2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SYC1ProtoNet protein and cluster: Q5SYC1 2 Blocks protein families: IPB001071 Cellular retinaldehyde-binding protein signature IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1Domain: The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2Similarity: Contains 1 CRAL-TRIO domain |
Gene Function
for CLVS2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CLVS2_HUMAN, Q5SYC1Function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Bindsphosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CLVS2 for ontologies About GeneDecksing
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Pathways & Interactions
for CLVS2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CLVS2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CLVS2
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CLVS2 for ontologies About GeneDecksing
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Drugs & Compounds
for CLVS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CLVS2
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Transcripts
for CLVS2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
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REFSEQ mRNAs for CLVS2 gene: NM_001010852.2 Additional cDNA sequence: AK095527.1 AK295158.1 BC101376.1 BC101377.2 1 DOTS entry: DT.99936993 3 AceView cDNA sequences: AK095527 BE796967 BG899217 Unigene Cluster for CLVS2: Clavesin 2 Hs.486361 [show with all ESTs]Unigene Representative Sequence: AK095527
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000275162(uc003pzi.1) ENST00000368438 ENST00000368437 ENST00000412300
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Expression
for CLVS2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CLVS2 expression in normal and diseased human tissues
1 / 2 1 probe-set matching CLVS2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1562443_at2
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U133Plus2 |
2 |
1.00 |
0.64 |
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-- |
-- |
-- |
-- |
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About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTAATGTAGC
SOURCE GeneReport for Unigene cluster: Hs.486361
SABiosciences Custom PCR Arrays for CLVS2
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Orthologs
for CLVS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for CLVS2 gene from 5/8 species (see all 8)
About this table Species with no ortholog for CLVS2
ENSEMBL Gene Tree for CLVS2 (if available) |
Paralogs
for CLVS2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CLVS2 gene
- TTPAL2 RLBP12 CLVS12 TTPA2
CLVS2 for paralogs About GeneDecksing
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Genomic Variants
for CLVS2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CLVS2
2 Indels: 81573 93994 | | QIAGEN SeqTarget long-range PCR primers for resequencing CLVS2 |
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Disorders & Mutations
for CLVS2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Medical News
for CLVS2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications
for CLVS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
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5 PubMed articles for CLVS2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CLVS2)- The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. (PubMed id 19651769)1, 2, 3 Katoh Y....McPherson P.S. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CLVS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CLVS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing CLVS2 gene
(According to HUGE)
About This Section
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Specialized Databases showing CLVS2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for CLVS2 gene:
Search GeneIP for patents involving CLVS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CLVS2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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| |  | Search Tocris compounds for CLVS2 |
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 | | | ELISAs and CLIAs for CLVS2 |
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