CMTM8 Gene
protein-coding GIFtS: 49
GC03P032217
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CKLF-like MARVEL transmembrane domain containing 8
(Previous names: chemokine-like factor super family 8, chemokine-like factor superfamily 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CKLFSF8)
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Aliases &
Descriptions
for CMTM8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| CKLF-like MARVEL transmembrane domain containing 81 2 | | CKLFSF82 3 | | chemokine-like factor superfamily 81 2 | | CKLF-like MARVEL transmembrane domain-containing protein 82 | | chemokine-like factor super family 81 2 | | CKLFSF8-V22 | | Chemokine-like factor superfamily member 82 3 | | |
Export aliases for CMTM8 gene to outside databasesPrevious GC identifer: GC03P032256 |
Summaries
for CMTM8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CMTM8:
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine andthe transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster onchromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown.(provided by RefSeq)
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Genomic Views
for CMTM8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CMTM8 gene promoter:
CUTL1 STAT5B FOXC1 Bach1 STAT5A Nkx2-2 USF1 ATF6 NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CMTM8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CMTM8  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.3 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p22.2CMTM8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P032217: view genomic region
(about GC identifiers)
Start:
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32,215,225 bp from pter |
End:
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32,411,817 bp from pter |
Size:
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196,593 bases |
Orientation:
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plus strand |
RefSeq DNA sequence:- NC_000003.11 NT_022517.18
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Proteins
for CMTM8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2 (See
protein sequence)Recommended Name: CKLF-like MARVEL transmembrane domain-containing protein 8 Size: 173 amino acids; 19572 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q8IW01Explore the universe of human proteins at neXtProt for CMTM8: NX_Q8IZV2
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_849199.2
ENSEMBL proteins: ENSP00000307741 ENSP00000412934
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CMTM8 for ontologies About GeneDecksing
Antibodies for CMTM8:
Assays for CMTM8: |
Protein
Domains/
Families
for CMTM8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CMTM8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZV2ProtoNet protein and cluster: Q8IZV2 1 Blocks protein family: IPB008253 Marvel
UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2Similarity: Belongs to the chemokine-like factor familySimilarity: Contains 1 MARVEL domain |
Gene Function
for CMTM8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
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1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- |
About this table
CMTM8 for ontologies About GeneDecksing
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Pathways & Interactions
for CMTM8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
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SABiosciences Custom Pathway-Focused PCR Arrays for CMTM8
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CMTM8
1 Interacting protein for CMTM8 (Q8IZV22) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006935 | chemotaxis |
IEA | -- |
About this table
CMTM8 for ontologies About GeneDecksing
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Drugs & Compounds
for CMTM8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CMTM8
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Transcripts
for CMTM8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
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REFSEQ mRNAs for CMTM8 gene: NM_178868.3 Additional cDNA sequence: AF474370.2 AY598783.1 BC041390.2 3 DOTS entries: DT.100023114 DT.100023113 DT.100746081 24/45 AceView cDNA sequences (see all 45): BM785932 AW024144 CB070190 BQ224486 NM_178868 AF474370 AI197788 BF793712 BG216957 BG189930 BU075644 CB243247 BM554032 BU506617 BQ186760 BI791855 BM663331 BG213702 BC041390 AV660309 BE869501 BG182013 BG656425 BG193535
 highest scoring ESTs for CMTM8:AI693734 BM663331 BM785932 BU075644 CA775729 CB070190 AA523950 AI185475 AI197788 AI564525 Unigene Cluster for CMTM8: CKLF-like MARVEL transmembrane domain containing 8 Hs.154986 [show with all ESTs]Unigene Representative Sequence: NM_178868
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307526(uc003cex.2 uc010hfu.2) ENST00000458535
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Expression
for CMTM8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CMTM8 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CMTM8 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 83528_at2, 3
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U95-E |
1 |
0.69 |
1.00 |
1.00 |
1.00 |
AI693734 |
0.80 |
1.00 |
0.91 |
1 |
| 235099_at2, 3
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U133-B |
1 |
0.55 |
1.00 |
-- |
-- |
AW080832 |
0.60 |
1.00 |
0.82 |
1 |
| 235099_at2
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U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CMTM8 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.154986
UniProtKB/Swiss-Prot: CKLF8_HUMAN, Q8IZV2Tissue specificity: Highly expressed in liver and pancreas
SABiosciences Custom PCR Arrays for CMTM8
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Orthologs
for CMTM8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for CMTM8 gene from 5/8 species (see all 8)
About this table Species with no ortholog for CMTM8
ENSEMBL Gene Tree for CMTM8 (if available) |
Paralogs
for CMTM8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CMTM8 gene
- MAL2 MALL2 PLLP2
CMTM8 for paralogs About GeneDecksing
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Genomic Variants
for CMTM8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CMTM8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CMTM8
2 CNVs: 98277 6169
1 Indel: 63435 | | QIAGEN SeqTarget long-range PCR primers for resequencing CMTM8 |
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Disorders & Mutations
for CMTM8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CMTM8 for disorders About GeneDecksing
OMIM: 607891
Human Genome Epidemiology (HuGE) Navigator: CMTM8 (2 documents)
Export disorders and mutations for CMTM8 gene to outside databases
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Medical News
for CMTM8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CMTM8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for CMTM8 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with CMTM8)- Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. (PubMed id 12782130)1, 2, 7 Han W.... Ma D. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8. (PubMed id 16263120)1, 7 Jin C....Ma D. (2005)
- An alternative splice form of CMTM8 induces apoptosis. (PubMed id 17681841)1, 7 Li D....Wang Y. (2007)
- [Effect of novel human chemokine-like factor superfamily 8 on proliferation and EGFR expression of tumor cells] (PubMed id 16806010)1, 7 Huang Y.M. and Du Y. (2006)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1 Ollila H.M....Paunio T. (2009)
- Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1 Ferreira M.A....Craddock N. (2008)
- CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway. (PubMed id 17149703)1 Jin C....Ma D. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for CMTM8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CMTM8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CMTM8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CMTM8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for CMTM8 gene:
Search GeneIP for patents involving CMTM8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CMTM8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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