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Aliases & Descriptionsfor CNNM1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions cyclin M11 2 FLJ316322 ACDP12 3 5 ancient conserved domain protein 12 Ancient conserved domain-containing protein 12 3 cyclin-M12 metal transporter CNNM12 Cyclin-M13
Export aliases for CNNM1 gene to outside databases Previous GC identifers: GC10P099983 GC10P100323 GC10P101221 GC10P100754 GC10P101080
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Summariesfor CNNM1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CNNM1_HUMAN, Q9NRU3 Function : Probable metal transporter (By similarity)
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Genomic Viewsfor CNNM1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CNNM1 gene promoter: NF-1 LCR-F1 AhR Arnt Bach1 NF-E2 p45 NF-E2 Bach2 c-Myc Max1 Other transcription factors Search SABiosciences Chromatin IP Primers for CNNM1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CNNM1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q24.2 Ensembl cytogenetic band: 10q24.2 HGNC cytogenetic band: 10q23-q24 CNNM1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P094715: view genomic region
(about GC identifiers )
Start:
94,715,434 bp from pter
End:
94,780,724 bp from pter
Size:
65,291 bases
Orientation:
plus strand
1 alternative location : Chr 10+ 101,088,856-101,154,087
RefSeq DNA sequence: NC_000010.10 NT_030059.13
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Proteinsfor CNNM1 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: CNNM1_HUMAN, Q9NRU3 (See
protein sequence )Recommended Name: Metal transporter CNNM1 Size : 951 amino acids; 104351 Da
Subcellular location : Cell membrane; Multi-pass membrane protein (By similarity)
Miscellaneous : Shares weak sequence similarity with the cyclin family, explaining its name. However it has nocyclin-like function in vivo
Sequence caution : Sequence=AAF86357.1; Type=Erroneous initiation; Sequence=AAH98103.2; Type=Erroneous initiation;Sequence=AAH98279.2; Type=Erroneous initiation; Sequence=AAH98307.2; Type=Erroneous initiation; Sequence=CAB70798.1; Type=Frameshift; Positions=839, 874;
Secondary accessions : Q4QQG7 Q4QQH8 Q4QQP9 Q9NT45Alternative splicing : 2 isoforms : Q9NRU3-1 Q9NRU3-2 Explore the universe of human proteins at neXtProt for CNNM1: NX_Q9NRU3 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_065081.2 ENSEMBL proteins: ENSP00000406492 ENSP00000359559 ENSP00000349147 ENSP00000359565 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
CNNM1 for ontologies About GeneDecksing Antibodies for CNNM1: Assays for CNNM1:
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Protein
Domains/ Familiesfor CNNM1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CNNM1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NRU3 ProtoNet protein and cluster: Q9NRU3
1 Blocks protein family : IPB000644 CBS domain UniProtKB/Swiss-Prot: CNNM1_HUMAN, Q9NRU3 Similarity : Belongs to the ACDP familySimilarity : Contains 2 CBS domains
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Gene Functionfor CNNM1 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: CNNM1_HUMAN, Q9NRU3 Function : Probable metal transporter (By similarity)
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Pathways & Interactionsfor CNNM1 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for CNNM1 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CNNM1 1 Interacting protein for CNNM1 (ENSP00000349147 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006811 ion transport
IEA --
About this table
CNNM1 for ontologies About GeneDecksing
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Drugs & Compoundsfor CNNM1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for CNNM1
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Transcriptsfor CNNM1 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for CNNM1 gene: NM_020348.2
Additional cDNA sequence: AF169226.1 AK056194.1 AK296545.1 AK299346.1 AK308326.1 AK308618.1 AK310486.1 AL137536.1 BC098103.1 BC098134.1 BC098279.1 BC098307.1
4 DOTS entries : DT.308590 DT.100737928 DT.91748097 DT.91706557
24/35 AceView cDNA sequences (see all 35 ):
AF169226 NM_020348 AK056194 AW296465 BI870106 BG117179 BM709460 BM932302 BM692809 BM714452 AA399647 BU733423 BI868774 AL041768 AA326530 AA397733 BP369359 BE780768 AL137536 BM671372 CA420502 AL041769 BX329025 AA812661
highest scoring ESTs for CNNM1 :H20551 AA397733 AA399647 AA812661 AF169226 AL041768 AL041769 AL137536 AL530155 BE780768 Unigene Cluster for CNNM1:
Cyclin M1 Hs.274579 [show with all ESTs ] Unigene Representative Sequence: NM_020348 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CNNM1 (see all 7 ) ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b SP1 :       -   -   -             -       -             SP2 :       -   -   -             -       -     -         SP3 :         -   -             -                   SP4 :                                         SP5 :                                        
About this scheme ECgene alternative splicing isoforms for CNNM1 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000446890 ENST00000370528 ENST00000488090 ENST00000356713 ENST00000370534 (uc009xwe.2 uc001kpp.3 uc010qpi.1 uc009xwf.2 uc009xwg.2 )
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Expression for CNNM1 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section CNNM1 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching CNNM1 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
49882_at2 , 3
U95-B
1
1.00
1.00
1.00
1.00
H20551
1.00
1.00
1.00
1
220166_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_020348
0.60
1.00
0.82
1
220166_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
CNNM1 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAGGCTTCTT SOURCE GeneReport for Unigene cluster: Hs.274579 UniProtKB/Swiss-Prot: CNNM1_HUMAN, Q9NRU3 Tissue specificity : Restricted to brain and testis
SABiosciences Custom PCR Arrays for CNNM1
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Orthologsfor CNNM1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for CNNM1 gene from 5/7 species (see all 7 )
About this table Species with no ortholog for CNNM1 ENSEMBL Gene Tree for CNNM1 (if available)
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Paralogsfor CNNM1 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for CNNM1 gene CNNM3 2 CNNM2 2 CNNM4 2
CNNM1 for paralogs About GeneDecksing
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Genomic Variantsfor CNNM1 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 10 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for CNNM1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CNNM1: --
QIAGEN SeqTarget long-range PCR primers for resequencing CNNM1
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Disorders & Mutationsfor CNNM1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CNNM1 for disorders About GeneDecksing
OMIM: 607802 Human Genome Epidemiology (HuGE) Navigator: CNNM1 (2 documents) Export disorders and mutations for CNNM1 gene to outside databases
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Medical Newsfor CNNM1 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor CNNM1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/11 PubMed articles for CNNM1 gene, integrated from 7 sources (see all 11 ): (articles sorted by number of sources associating them with CNNM1) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). (PubMed id 12657465) 1 , 2 Wang C.-Y.... She J.-X. (2003) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451) 1 Grupe A....Goate A. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 2 Deloukas P.... Rogers J. (2004) Molecular cloning and characterization of the mouse Acdp gene family. (PubMed id 14723793) 1 Wang C.Y....She J.X. (2004) High resolution mapping and mutation analyses of candidate genes in the urofacial syndrome (UFS) critical region. (PubMed id 12707951) 2 Wang C.-Y.... She J.-X. (2003)
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External Searches for CNNM1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CNNM1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CNNM1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CNNM1 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CNNM1 gene: Search GeneIP for patents involving CNNM1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CNNM1 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for CNNM1
ELISAs and CLIAs for CNNM1
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