Aliases &
Descriptions
for CNTFR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ciliary neurotrophic factor receptor1 2 | | ciliary neurotrophic factor receptor alpha2 | | CNTFR-alpha2 3 | | ciliary neurotrophic factor receptor subunit alpha2 | | CNTF receptor subunit alpha2 3 | | OTTHUMP000000212722 | | MGC17742 | | CNTFR alpha2 |
Export aliases for CNTFR gene to outside databasesPrevious GC identifers: GC09M034863 GC09M034720 |
Summaries
for CNTFR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CNTFR:
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. Theencoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex,which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositollinkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transductionrequires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to formthe tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in avariety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encodingthe same protein, have been identified. (provided by RefSeq)
UniProtKB/Swiss-Prot: CNTFR_HUMAN, P26992Function: Binds to CNTF. The alpha subunit provides the receptor specificity
|
Genomic Views
for CNTFR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CNTFR gene promoter:
STAT1alpha STAT1beta STAT1 STAT3 POU2F1 ATF-2 PPAR-gamma2 PPAR-gamma1 Oct-B1 POU2F2C
Other transcription factors
Search SABiosciences Chromatin IP Primers for CNTFR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CNTFR  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13CNTFR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M034541: view genomic region
(about GC identifiers)
Start:
|
34,505,792 bp from pter |
End:
|
34,540,343 bp from pter |
Size:
|
34,552 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr9- 34,551,430-34,590,121 |
RefSeq DNA sequence:- NC_000009.11 NT_008413.18
|
Proteins
for CNTFR gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CNTFR_HUMAN, P26992 (See
protein sequence)Recommended Name: Ciliary neurotrophic factor receptor subunit alpha precursor Size: 372 amino acids; 40633 Da
Subunit: Heterotrimer of the alpha subunit, LIFR and IL6ST
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
PDB structures from  and Proteopedia  :1UC6 (3D)
Explore the universe of human proteins at neXtProt for CNTFR: NX_P26992
REFSEQ proteins (2 alternative transcripts):
NP_001833.1 NP_671693.1
ENSEMBL proteins: ENSP00000242338 ENSP00000368265 ENSP00000388082
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CNTFR for ontologies About GeneDecksing
Antibodies for CNTFR:
Assays for CNTFR: |
Protein
Domains/
Families
for CNTFR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CNTFR for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P26992ProtoNet protein and cluster: P26992 2 Blocks protein families: IPB003530 Long hematopoietin receptor IPB003598 Immunoglobulin C-2 type
UniProtKB/Swiss-Prot: CNTFR_HUMAN, P26992Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellulartransport and cell-surface receptor bindingSimilarity: Belongs to the type I cytokine receptor family. Type 3 subfamilySimilarity: Contains 2 fibronectin type-III domainsSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Gene Function
for CNTFR gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CNTFR_HUMAN, P26992Function: Binds to CNTF. The alpha subunit provides the receptor specificity
Genatlas biochemistry entry for CNTFR:ciliary neurotrophic factor receptor,alpha5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CNTFR for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cntfr):
CNTFR for phenotypes About GeneDecksing
|
Pathways & Interactions
for CNTFR gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CNTFR for pathways About GeneDecksing
1  Millipore Pathway for CNTFR
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for CNTFR
2  Kegg Pathways (Kegg details for CNTFR):  | hsa04060 Cytokine-cytokine receptor interaction | | hsa04630 Jak-STAT signaling pathway |
SABiosciences Pathway-Focused PCR Arrays including CNTFR (see all 4): PAHS-017A PAHS-031A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CNTFR
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CNTFR
5/23 Interacting proteins for CNTFR (ENSP000002423383 P269921, 2) via UniProtKB, MINT, and/or STRING (see all 23)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CNTFR for ontologies About GeneDecksing
|
Drugs & Compounds
for CNTFR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CNTFR for compounds About GeneDecksing
 Browse Tocris compounds for CNTFR
4  Novoseek chemical compound relationships for CNTFR gene
About this table
|
Transcripts
for CNTFR gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CNTFR gene (2 alternative transcripts): NM_001842.3 NM_147164.1 Additional cDNA sequence: AK127444.1 BC001492.2 BT019824.1 CR610538.1 CR615036.1 CR615362.1 CR621924.1 CR624688.1 M73238.1 4 DOTS entries: DT.409104 DT.100781270 DT.100719333 DT.95154739 24/94 AceView cDNA sequences (see all 94): BM714356 BX364435 NM_001842 M73238 CR624688 BC001492 AW950312 BX366394 F00357 AI934646 CR615036 AK127444 CR610538 NM_147164 BM710190 CR615362 BM719097 BG059668 BI917291 BX428112 AI039219 F16937 BX428111 BF315347
 highest scoring ESTs for CNTFR:M73238 AL528607 AL538308 BC001492 BE262541 BF311347 BF312992 BF315347 BG519609 BG911153 Unigene Cluster for CNTFR: Ciliary neurotrophic factor receptor Hs.129966 [show with all ESTs]Unigene Representative Sequence: AK127444
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CNTFR (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CNTFR
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000351266 ENST00000378980(uc003zup.1 uc003zuq.1) ENST00000417345
|
Expression
for CNTFR gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CNTFR expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching CNTFR gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32366_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.37 |
0.50 |
M73238 |
1.00 |
1.00 |
1.00 |
1 |
| 88926_at2, 3
|
U95-E |
1 |
0.75 |
1.00 |
0.80 |
1.54 |
AA029437 |
0.40 |
1.00 |
0.76 |
1 |
| 205723_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_001842 |
0.60 |
1.00 |
0.82 |
1 |
| 205723_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CNTFR for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CAGCTAACCC
SOURCE GeneReport for Unigene cluster: Hs.129966
Expression variation in blood from EXPOLDB for CNTFR UniProtKB/Swiss-Prot: CNTFR_HUMAN, P26992Tissue specificity: Nervous system and skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Arrays including CNTFR (see all 4): PAHS-017A PAHS-031A
|
Orthologs
for CNTFR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CNTFR gene from 5/7 species (see all 7)
About this table Species with no ortholog for CNTFR
ENSEMBL Gene Tree for CNTFR (if available) |
Paralogs
for CNTFR gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CNTFR gene
- IL11RA2 IL6R2 EBI32
CNTFR for paralogs About GeneDecksing
|
Genomic Variants
for CNTFR gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CNTFR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CNTFR
1 CNV: 9615 | | QIAGEN SeqTarget long-range PCR primers for resequencing CNTFR |
|
Disorders & Mutations
for CNTFR gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CNTFR for disorders About GeneDecksing
OMIM: 118946
5 Novoseek disease relationships for CNTFR gene
About this table
Genetic Association Database (GAD): CNTFR
Human Genome Epidemiology (HuGE) Navigator: CNTFR (10 documents)
Export disorders and mutations for CNTFR gene to outside databases
|
Medical News
for CNTFR gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CNTFR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/92 PubMed articles for CNTFR gene, integrated from 7 sources (see all 92):
(articles sorted by number of sources associating them with CNTFR)- The receptor for ciliary neurotrophic factor. (PubMed id 1648265)1, 2, 3 Davis S.... Yancopoulos G.D. (1991)
- Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. (PubMed id 12707266)1, 2, 7 Man D.... Ip N.Y. (2003)
- C174T polymorphism in the CNTF receptor gene is associated with fat-free mass in men and women. (PubMed id 12807897)1, 4, 7 Roth S.M....Ferrell R.E. (2003)
- Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. (PubMed id 7774913)1, 2, 7 Valenzuela D.M....Yancopoulos G.D. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. (PubMed id 11294841)1, 7 Lelievre E....Gascan H. (2001)
- Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9. (PubMed id 8244400)1, 7 Donaldson D.H....Patterson D. (1993)
- Humanin inhibits neuronal cell death by interacting w ith a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX- 1/gp130. (PubMed id 19386761)1, 7 Hashimoto Y....Matsuoka M. (2009)
- Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro. (PubMed id 11943154)1, 7 He W....Ip N.Y. (2002)
- Polymorphisms in the CNTF and CNTF receptor genes are associated with muscle strength in men and women. (PubMed id 17272411)1, 7 De Mars G....Thomis M.A. (2007)
|
External Searches for CNTFR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CNTFR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CNTFR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CNTFR gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CNTFR gene:
Search GeneIP for patents involving CNTFR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CNTFR gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for CNTFR |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for CNTFR |
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