Aliases &
Descriptions
for COBL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cordon-bleu homolog (mouse)1 2 | | OTTHUMP000002090492 | | KIAA06331 2 3 | | DKFZp686G132272 | | protein cordon-bleu2 | | OTTHUMP000002090502 | | MGC1318932 | | |
Export aliases for COBL gene to outside databasesPrevious GC identifers: GC07M050548 GC07M050791 GC07M050825 GC07M050858 GC07M051051 |
Summaries
for COBL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for COBL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COBL gene promoter:
HNF-4alpha2 COUP-TF1 Fra-1 JunD AP-1 c-Fos JunB c-Jun ER-alpha TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for COBL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for COBL  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p12.1 Ensembl cytogenetic band: 7p12.1 HGNC cytogenetic band: 7p12.2-p12.1COBL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M050933: view genomic region
(about GC identifiers)
Start:
|
50,933,696 bp from pter |
End:
|
51,384,515 bp from pter |
Size:
|
450,820 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000007.13 NT_033968.6 NT_079592.2
|
Proteins
for COBL gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: COBL_HUMAN, O75128 (See
protein sequence)Recommended Name: Protein cordon-bleu Size: 1261 amino acids; 135617 Da
Sequence caution: Sequence=BAA31608.1; Type=Erroneous initiation;
Secondary accessions: A7E2B0 Q2T9J3 Q504Y4 Q86XA7 Q8N304Alternative splicing: 5 isoforms: O75128-1 O75128-2 O75128-3 O75128-4 O75128-5 Explore the universe of human proteins at neXtProt for COBL: NX_O75128
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056013.2
ENSEMBL proteins: ENSP00000378912 ENSP00000399500 ENSP00000408189 ENSP00000397300 ENSP00000378910 ENSP00000405059 ENSP00000401204 ENSP00000265136 ENSP00000416422 ENSP00000329919 ENSP00000391864 ENSP00000413498
Human Recombinant Proteins
Antibodies for COBL:
Assays for COBL: |
Protein
Domains/
Families
for COBL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COBL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75128ProtoNet protein and cluster: O75128 1 Blocks protein family: IPB003124 Actin-binding WH2
UniProtKB/Swiss-Prot: COBL_HUMAN, O75128Similarity: Contains 3 WH2 domains |
Gene Function
for COBL gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
About this table
COBL for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cobl):
COBL for phenotypes About GeneDecksing
|
Pathways & Interactions
for COBL gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for COBL
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COBL
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001843 | neural tube closure |
-- | -- |
About this table
COBL for ontologies About GeneDecksing
|
Drugs & Compounds
for COBL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for COBL
|
Transcripts
for COBL gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for COBL gene: NM_015198.3 Additional cDNA sequence: AB014533.1 AK293883.1 AK308718.1 AK309254.1 BC029275.1 BC045771.1 BC094695.1 BC111496.1 BC136441.1 BC144099.1 BC150263.1 CR595988.1 CR605312.1 CR936689.1 11 DOTS entries: DT.100772995 DT.414792 DT.432622 DT.75137259 DT.100692146 DT.121106097 DT.121106114 DT.95268905 DT.92424254 DT.95121391 DT.95296148 24/116 AceView cDNA sequences (see all 116): BU180194 CB215218 CD515180 CK819381 AA679276 AA447744 BM128673 NM_015198 C04829 AA629100 AI648364 H80622 BU736727 AA807916 AB014533 CR595988 BG236854 AV708581 BM128674 BX100753 AI277138 BM272305 BM263196 AI301180
 highest scoring ESTs for COBL:AB014533 BM543618 AA305226 AA322250 AA476314 AA476363 AA552402 AA594937 AA679276 AA701242 Unigene Cluster for COBL: Cordon-bleu homolog (mouse) Hs.99141 [show with all ESTs]Unigene Representative Sequence: NM_015198
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for COBL
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for COBL
13 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395542(uc003tpp.3 uc003tpq.3 uc003tpr.3 uc003tps.2 uc011kcl.1 uc010kzc.2)
ENST00000462395(uc003tpo.3) ENST00000441453(uc003tpt.2) ENST00000430962
ENST00000457306 ENST00000395540 ENST00000452534 ENST00000445054 ENST00000265136
ENST00000457460 ENST00000333663 ENST00000449281 ENST00000431948
|
Expression
for COBL gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| COBL expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching COBL gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35669_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.93 |
0.82 |
AB014533 |
1.00 |
1.00 |
1.00 |
1 |
| 68103_at2, 3
|
U95-D |
1 |
0.50 |
1.00 |
0.16 |
1.22 |
AI038604 |
0.60 |
1.00 |
0.82 |
1 |
| 213050_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AA594937 |
0.60 |
1.00 |
0.82 |
1 |
| 213050_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1552496_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
COBL for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGCCCAGTC
SOURCE GeneReport for Unigene cluster: Hs.99141
Expression variation in blood from EXPOLDB for COBL SABiosciences Custom PCR Arrays for COBL
|
Orthologs
for COBL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for COBL gene from 5/6 species (see all 6)
About this table Species with no ortholog for COBL
ENSEMBL Gene Tree for COBL (if available) |
Paralogs
for COBL gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for COBL gene
- COBLL12
COBL for paralogs About GeneDecksing
|
Genomic Variants
for COBL gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for COBL (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for COBL
1 CNV: 52244
2 Indels: 47364 12930 | | QIAGEN SeqTarget long-range PCR primers for resequencing COBL |
|
Disorders & Mutations
for COBL gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COBL for disorders About GeneDecksing
OMIM: 610317
Human Genome Epidemiology (HuGE) Navigator: COBL (3 documents)
Export disorders and mutations for COBL gene to outside databases
|
Medical News
for COBL gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for COBL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for COBL gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with COBL)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1 Barrett J.C....Rich S.S. (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1 de Krom M....van Ree J.M. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for COBL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COBL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COBL gene
(According to HUGE)
About This Section
| |
Specialized Databases showing COBL gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for COBL gene:
Search GeneIP for patents involving COBL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COBL gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for COBL |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for COBL |
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