Aliases &
Descriptions
for COIL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| coilin1 2 | | CLN801 2 3 5 | | p80-coilin1 2 | | p802 3 | | coilin p802 |
Export aliases for COIL gene to outside databasesPrevious GC identifers: GC17M054752 GC17M057497 GC17M055357 GC17M055490 GC17M052370 GC17M055015 |
Summaries
for COIL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COIL:
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies arenuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification ofsmall nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization whilethe C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation andphosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly ofCajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. (provided by RefSeq)
UniProtKB/Swiss-Prot: COIL_HUMAN, P38432Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassemblyof nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80coilin
Gene Wiki entry for COIL (Coilin) |
Genomic Views
for COIL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COIL gene promoter:
AP-1 c-Jun c-Fos STAT5A TBP STAT5B TFIID Lmo2 Tal-1beta ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for COIL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for COIL  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22-q23 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q22-q23COIL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M050376: view genomic region
(about GC identifiers)
Start:
|
50,376,180 bp from pter |
End:
|
50,399,432 bp from pter |
Size:
|
23,253 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 55,015,563-55,038,411 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for COIL gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: COIL_HUMAN, P38432 (See
protein sequence)Recommended Name: Coilin Size: 576 amino acids; 62608 Da
Subunit: Interacts with ANKS1B
Subcellular location: Nucleus. Note=Nuclear coiled body located in the interchromatin space between the nucleolus andthe nucleus
Secondary accessions: B2R931Explore the universe of human proteins at neXtProt for COIL: NX_P38432
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004636.1
ENSEMBL proteins: ENSP00000240316
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
COIL for ontologies About GeneDecksing
Antibodies for COIL:
Assays for COIL: |
Protein
Domains/
Families
for COIL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P38432 UniProtKB/Swiss-Prot: COIL_HUMAN, P38432Similarity: Belongs to the coilin family |
Gene Function
for COIL gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: COIL_HUMAN, P38432Function: Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassemblyof nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80coilin
Genatlas biochemistry entry for COIL:coilin,protein of the non-capsular nuclear bodies (coiled bodies),in interphase cells,80kDa3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
COIL for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Coil):
COIL for phenotypes About GeneDecksing
|
Pathways & Interactions
for COIL gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for COIL
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COIL
5/59 Interacting proteins for COIL (ENSP000002403163 P384321, 2) via UniProtKB, MINT, and/or STRING (see all 59)About this table
|
Drugs & Compounds
for COIL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
COIL for compounds About GeneDecksing
 Browse Tocris compounds for COIL
8  Novoseek chemical compound relationships for COIL gene
About this table
|
Transcripts
for COIL gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for COIL gene: NM_004645.2 Additional cDNA sequence: AK313616.1 BC010385.1 CR594693.1 CR605137.1 CR610327.1 CR611341.1 M58411.1 U06632.1 9 DOTS entries: DT.117156 DT.100692058 DT.100714986 DT.100769597 DT.100806895 DT.100806898 DT.100806899 DT.120950534 DT.40106002 24/175 AceView cDNA sequences (see all 175): N58051 BU618421 BM799937 CB853192 BX365683 CR605137 BF939452 AI825820 BX377836 AW134642 BM479169 AA977067 CB215276 CR594693 BQ001448 BX379049 BF445836 CR611341 AI216471 AI458844 BM978288 AI650860 BM090923 R26308
 highest scoring ESTs for COIL:U06632 AA065045 AA333266 AA628380 AI205584 AI216471 AI337453 AI344290 AI637739 AI650860 Unigene Cluster for COIL: Coilin Hs.532795 [show with all ESTs]Unigene Representative Sequence: BC010385
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000240316(uc002iuu.2)
|
Expression
for COIL gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| COIL expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching COIL gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39153_r_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.69 |
0.52 |
U06632 |
1.00 |
1.00 |
1.00 |
1 |
| 39152_f_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.85 |
1.06 |
U06632 |
1.00 |
1.00 |
1.00 |
1 |
| 74817_at2, 3
|
U95-D |
1 |
0.62 |
1.00 |
0.79 |
1.43 |
AW021880 |
0.80 |
1.00 |
0.91 |
1 |
| 203654_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_004645 |
0.60 |
1.00 |
0.82 |
1 |
| 203653_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BG391060 |
0.80 |
1.00 |
0.91 |
1 |
| 203654_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 203653_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
COIL for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTATTTGACC
SOURCE GeneReport for Unigene cluster: Hs.532795
Expression variation in blood from EXPOLDB for COIL UniProtKB/Swiss-Prot: COIL_HUMAN, P38432Tissue specificity: Found in all the cell types examined
SABiosciences Custom PCR Arrays for COIL
|
Orthologs
for COIL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for COIL gene from 5/9 species (see all 9)
About this table Species with no ortholog for COIL
ENSEMBL Gene Tree for COIL (if available) |
Paralogs
for COIL gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Pseudogenes
- 2 related pseudogenes
|
Genomic Variants
for COIL gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for COIL (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COIL
1 CNV: 7166 | | QIAGEN SeqTarget long-range PCR primers for resequencing COIL |
|
Disorders & Mutations
for COIL gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COIL for disorders About GeneDecksing
OMIM: 600272
4 Novoseek disease relationships for COIL gene
About this table
Human Genome Epidemiology (HuGE) Navigator: COIL (15 documents)
Export disorders and mutations for COIL gene to outside databases
|
Medical News
for COIL gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for COIL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/132 PubMed articles for COIL gene, integrated from 7 sources (see all 132):
(articles sorted by number of sources associating them with COIL)- Structure, expression and chromosomal localization of human p80- coilin gene. (PubMed id 7971277)1, 2, 3, 7 Chan E.K.L.... Matera A.G. (1994)
- Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin. (PubMed id 2033369)1, 2, 7 Andrade L.E.C....Tan E.M. (1991)
- Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure. (PubMed id 7679389)1, 2, 7 Carmo-Fonseca M.... Lamond A.I. (1993)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1, 2 Nousiainen M.... Koerner R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. (PubMed id 15862129)1, 2 Xu H. and Hebert M.D. (2005)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coilin phosphorylation mediates interaction with SMN and SmB'. (PubMed id 19997741)1, 7 Toyota C.G....Hebert M.D. (2010)
|
External Searches for COIL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COIL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COIL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COIL gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for COIL gene:
Search GeneIP for patents involving COIL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COIL gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for COIL |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for COIL |
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