Aliases &
Descriptions
for COX6B2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cytochrome c oxidase subunit VIb polypeptide 2 (testis)1 2 | | FLJ328651 | | CT591 2 3 | | cytochrome c oxidase subunit 6B22 | | COXVIB21 2 | | cytochrome c oxidase subunit VIb, testes-specific2 | | Cytochrome c oxidase subunit VIb, testis-specific isoform2 3 | | MGC1190942 | | Cancer/testis antigen 592 3 | | cytochrome c oxidase subunit VIb, testes specific2 | | COX VIb-22 3 | | Cytochrome c oxidase subunit VIb isoform 23 |
Export aliases for COX6B2 gene to outside databasesPrevious GC identifers: GC19M060553 GC19M055861 |
Summaries
for COX6B2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2Function: Connects the two COX monomers into the physiological dimeric form (By similarity)
|
Genomic Views
for COX6B2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX6B2 gene promoter:
Egr-1 STAT3 STAT5A GATA-2 PPAR-gamma2 PPAR-gamma1 p53 deltaCREB CREB Nkx3-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX6B2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for COX6B2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42COX6B2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M052183: view genomic region
(about GC identifiers)
Start:
|
52,183,370 bp from pter |
End:
|
52,188,482 bp from pter |
Size:
|
5,113 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 55,861,076-55,866,182 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for COX6B2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2 (See
protein sequence)Recommended Name: Cytochrome c oxidase subunit 6B2 Size: 88 amino acids; 10529 Da
Subcellular location: Mitochondrion intermembrane space (By similarity)
Secondary accessions: Q7L1R4 Q96DL5Explore the universe of human proteins at neXtProt for COX6B2: NX_Q6YFQ2
REFSEQ proteins: NP_653214.2
ENSEMBL proteins: ENSP00000320672
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
COX6B2 for ontologies About GeneDecksing
Antibodies for COX6B2:
Assays for COX6B2: |
Protein
Domains/
Families
for COX6B2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX6B2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6YFQ2ProtoNet protein and cluster: Q6YFQ2 1 Blocks protein family: IPB003213 Cytochrome oxidase c
UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2Similarity: Belongs to the cytochrome c oxidase subunit 6B family |
Gene Function
for COX6B2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2Function: Connects the two COX monomers into the physiological dimeric form (By similarity)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004129 | cytochrome-c oxidase activity |
IEA | -- |
About this table
COX6B2 for ontologies About GeneDecksing
|
Pathways & Interactions
for COX6B2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
COX6B2 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for COX6B2
5/6  Kegg Pathways (Kegg details for COX6B2) (see all 6):
SABiosciences Pathway-Focused PCR Array including COX6B2: PAHS-008A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for COX6B2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX6B2
|
Drugs & Compounds
for COX6B2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for COX6B2
|
Transcripts
for COX6B2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for COX6B2 gene: NM_144613.4 Additional cDNA sequence: AK057427.1 AY152398.1 BC100899.2 BC100900.1 BC100901.1 BC100902.1 HM370404.1 4 DOTS entries: DT.101970804 DT.95258596 DT.91856314 DT.75139246 22 AceView cDNA sequences: NM_144613 AK057427 BC026123 AA878062 BC064548 AK127979 BM560283 AW194061 BC031875 AL834316 BG717038 BG717157 AY152398 BI827979 AK128284 BG716978 BG324185 AW087617 AW236235 BG324108 BG722806 BE063485
 highest scoring ESTs for COX6B2:AK057427 AY152398 BG716978 BG717038 BG717157 BG722806 BM560283 AA878062 AW194061 AW236235 Unigene Cluster for COX6B2: Cytochrome c oxidase subunit VIb polypeptide 2 (testis) Hs.550544 [show with all ESTs]Unigene Representative Sequence: AK057427
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for COX6B2
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000326529(uc002qkm.2 uc002qkn.2 uc002qko.2 uc002qkp.1)
|
Expression
for COX6B2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| COX6B2 expression in normal and diseased human tissues
1 / 2 1 probe-set matching COX6B2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1553367_a_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAAATATATA
SOURCE GeneReport for Unigene cluster: Hs.550544
UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines
SABiosciences Expression via Pathway-Focused PCR Array including COX6B2: PAHS-008A
|
Orthologs
for COX6B2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for COX6B2 gene from 3 species
About this table Species with no ortholog for COX6B2
ENSEMBL Gene Tree for COX6B2 (if available) |
Paralogs
for COX6B2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for COX6B2 gene
- COX6B12
COX6B2 for paralogs About GeneDecksing
|
Genomic Variants
for COX6B2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for COX6B2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COX6B2
1 CNV: 30085 | | QIAGEN SeqTarget long-range PCR primers for resequencing COX6B2 |
|
Disorders & Mutations
for COX6B2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for COX6B2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for COX6B2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
7 PubMed articles for COX6B2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with COX6B2)- Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb -- the counterpart to testes-specific cytochrome c? (PubMed id 12874793)1, 2, 3, 7 Huttemann M.... Grossman L.I. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)2 Chen Y.-T.... Simpson A.J.G. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues. (PubMed id 2172092)1 Taanman J.-W.... Agsteribbe E. (1990)
|
External Searches for COX6B2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX6B2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX6B2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX6B2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for COX6B2 gene:
Search GeneIP for patents involving COX6B2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX6B2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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