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COX8A Gene

protein-coding GIFtS: 49

GC11P060070

cytochrome c oxidase subunit VIIIA (ubiquitous)
(Previous names: cytochrome c oxidase subunit VIII, cytochrome c oxidase subunit 8A (ubiquitous) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: COX8)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cytochrome c oxidase subunit VIIIA (ubiquitous)¹ ²		cytochrome c oxidase subunit 8A (ubiquitous)¹ ²
COX8L¹ ² ³		cytochrome c oxidase subunit VIII¹ ²
COX8² ³ ⁵		VIII-L¹ ²
COX8-2¹ ²		Cytochrome c oxidase polypeptide VIII-liver/heart² ³
VIII¹ ²		Cytochrome c oxidase subunit 8-2² ³
COX¹ ²		cytochrome c oxidase subunit 8A, mitochondrial²

External Ids:	HGNC: 2294¹	Entrez Gene: 1351²	Ensembl: ENSG00000176340⁷	UniProtKB: P10176³

Export aliases for COX8A gene to outside databases

Previous GC identifers: GC11P063518 GC11P063498 GC11P063742

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COX8A:

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons

from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the

inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function,

the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in

mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic

function. This gene encodes one of the nuclear-encoded subunits. (provided by RefSeq)

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176

Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in

mitochondrial electron transport

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COX8A gene promoter:
         E2F-3a   E2F-5   E2F-4   E2F-2   E2F-1   E2F   YY1   STAT3   STAT1   STAT1alpha
         Other transcription factors

Search SABiosciences Chromatin IP Primers for COX8A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for COX8A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q12-q13

COX8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX8A gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P060070: view genomic region (about GC identifiers)

Start:	60,070,789 bp from pter
End:	60,072,725 bp from pter
Size:	1,937 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 63,742,079-63,744,014

RefSeq DNA sequence:

NC_000011.9 NT_167190.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176 (See protein sequence)

Recommended Name: Cytochrome c oxidase subunit 8A, mitochondrial precursor

Size: 69 amino acids; 7579 Da

Subcellular location: Mitochondrion inner membrane

Secondary accessions: P15955

Explore the universe of human proteins at neXtProt for COX8A: NX_P10176

REFSEQ proteins: NP_004065.1

ENSEMBL proteins:

ENSP00000321260

Human Recombinant Proteins

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	Novus Biologicals Protein for COX8A
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	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005743	mitochondrial inner membrane	TAS	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

COX8A for ontologies About GeneDecksing

Antibodies for COX8A:

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	Browse antibodies at Epitomics

Assays for COX8A:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COX8A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COX8A for domains About GeneDecksing

2 InterPro domains/families:

IPR003205 Cyt_c_oxidase_su8

IPR016070 Cyt_c_oxidase_su8/PSI_RC_su9

Graphical View of Domain Structure for InterPro Entry P10176

ProtoNet protein and cluster: P10176

1 Blocks protein family: IPB003205 Cytochrome oxidase c

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176

Similarity: Belongs to the cytochrome c oxidase VIII family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176

Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in

mitochondrial electron transport

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for COX8A Sigma-Aldrich shRNA for COX8A
		OriGene 29mer shRNA kits in GFP-retroviral vector: COX8A OriGene shRNA RFP: COX8A OriGene basic RS shRNA: COX8A OriGene siRNA: COX8A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of COX8A

miRNA:		Sigma-Aldrich microRNA Mimics for COX8A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of COX8A
		1 SABiosciences Assays for microRNA that regulate COX8A:
		hsa-miR-298

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: COX8A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: COX8A OriGene untagged cDNA clones in CMV expression vector: COX8A OriGene 3'-UTR clone: COX8A Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: COX8A
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for COX8A

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004129	cytochrome-c oxidase activity	IEA	--

About this table

COX8A for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

COX8A for pathways About GeneDecksing

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for COX8A

	Mitochondrial Dysfunction
	Oxidative Phosphorylation

5/6 Kegg Pathways (Kegg details for COX8A) (see all 6):

	hsa00190 Oxidative phosphorylation
	hsa01100 Metabolic pathways
	hsa04260 Cardiac muscle contraction
	hsa05010 Alzheimer's disease
	hsa05012 Parkinson's disease

SABiosciences Pathway-Focused PCR Arrays including COX8A: PAHS-008A PAHS-3401A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for COX8A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COX8A

5/31 Interacting proteins for COX8A (ENSP00000321260³) via UniProtKB, MINT, and/or STRING (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COX4I1	ENSP00000253452³	STRING: ENSP00000253452
COX5A	ENSP00000317780³	STRING: ENSP00000317780
COX5B	ENSP00000258424³	STRING: ENSP00000258424
COX6A1	ENSP00000229379³	STRING: ENSP00000229379
COX6B1	ENSP00000246554³	STRING: ENSP00000246554

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006091	generation of precursor metabolites and energy	TAS	2543673
GO:0022904	respiratory electron transport chain	TAS	--

About this table

COX8A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COX8A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for COX8A Sigma-Aldrich shRNA for COX8A
		OriGene 29mer shRNA kits in GFP-retroviral vector: COX8A OriGene shRNA RFP: COX8A OriGene basic RS shRNA: COX8A OriGene siRNA: COX8A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of COX8A

miRNA:		Sigma-Aldrich microRNA Mimics for COX8A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of COX8A
		1 SABiosciences Assays for microRNA that regulate COX8A:
		hsa-miR-298

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: COX8A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: COX8A OriGene untagged cDNA clones in CMV expression vector: COX8A OriGene 3'-UTR Clone: COX8A Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: COX8A

Primers:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for COX8A: PPH20233A

REFSEQ mRNAs for COX8A gene:

NM_004074.2

Additional cDNA sequence:

AK311934.1 BC063025.1 BT009803.1 CR407687.1 CR609784.1

24 DOTS entries:

DT.100886580 DT.101971358 DT.100045241 DT.120741946 DT.91673279 DT.100045240 DT.100886564 DT.219944

DT.100886572 DT.100886573 DT.100886558 DT.97824342 DT.100886562 DT.120741903 DT.120741959 DT.100673331

DT.40107023 DT.95149702 DT.95149708 DT.100044586 DT.100044589 DT.120741910 DT.95333829 DT.97856606

24/1333 AceView cDNA sequences (see all 1333):

BM926040 BQ927020 BI093185 BG828440 AY177200 CB121525 BI754560 BQ218109

CR617783 BM918158 BE045570 BQ926290 F30551 CB119220 BU785580 BM755291

BE877230 AI376960 BI113833 CR617727 BU169848 AI858087 T16501 AI280913

highest scoring ESTs for COX8A:

AI525665 AA040592 AA056340 AA078804 AA078805 AA079023 AA086414 AA088250 AA088649 AA099575

Unigene Cluster for COX8A:

Cytochrome c oxidase subunit VIIIA (ubiquitous)

Hs.433901 [show with all ESTs]

Unigene Representative Sequence: CD555987

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000314133(uc001nye.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

COX8A expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching COX8A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38080_at²^{, 3}	U95-A	1	0.50	1.00	1.00	1.00	AI525665	1.00	1.00	1.00	1
201119_s_at²^{, 3}	U133-A	1	0.46	1.00	--	--	NM_004074	0.60	1.00	0.82	1
201119_s_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

COX8A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

COX8A gene electronic northern expression

About these images

CGAP SAGE TAG: GTGACCTCCT

SOURCE GeneReport for Unigene cluster: Hs.433901

Expression variation in blood from EXPOLDB for COX8A

Primers:		Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for COX8A: PPH20233A

SABiosciences Expression via Pathway-Focused PCR Arrays including COX8A: PAHS-008A PAHS-3401A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for COX8A gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC476040¹	--	similar to Cytochrome c oxidase polypeptide VIII-liver, more	80.19(n) 69.57(a)	476040 XM_533249.2 XP_533249.2
chimpanzee (Pan troglodytes)	COX8A¹	--	cytochrome c oxidase subunit 8A (ubiquitous)	99.03(n) 98.55(a)	742828 XM_001163079.1 XP_001163079.1
cow (Bos taurus)	LOC783202¹	--	similar to Cytochrome c oxidase polypeptide VIII-liver, more	80.68(n) 73.91(a)	783202 XM_001251833.1 XP_001251834.1
rat (Rattus norvegicus)	Cox8a¹	--	cytochrome c oxidase, subunit VIIIa	76.81(n) 66.67(a)	171335 NM_134345.1 NP_599172.1
mouse (Mus musculus)	Cox8a^{1 , 5}	19 (5.28 cM)⁵	cytochrome c oxidase, subunit VIIIa^{1, 5}	78.74(n)¹ 68.12(a)¹	12868¹ NM_007750.2¹ NP_031776.1¹ AA060558⁵ AI326932⁵ (see all 14)

About this table Species with no ortholog for COX8A

ENSEMBL Gene Tree for COX8A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs8360^1,2	--	63743830(+)	`GACCAG/CCCCCA`	1	--	ut3¹ ese³		1		MN	184
rs1187867^1,2	--	63741209(+)	`caatcC/Tcggct`	1	--	ng5¹		0	--	--	--	--
rs1803315^1,2	--	63743846(+)	`CCATCC/TTGGTC`	1	--	ut3¹		0	--	--	--	--
rs7127354^1,2	C,F,	63744152(+)	`GTGCTT/GCTGTA`	1	--	ng3¹		6		NS EA WA	496
rs7129565^1,2	H	63742409(+)	`AGGGCG/TCGAAC`	1	--	int¹		4		NS EA	420
rs7130187^1,2	C,F,	63742174(+)	`CGCTGC/TTGCTG`	2	L	ref¹ syn¹ ese³		5		NS EA WA	420
rs7927429^1,2	A,H	63743525(+)	`CTGCTC/GTGTCT`	1	--	int¹		4		NS EA	416
rs9943682^1,2	C,A,	63744314(+)	`tgtgtG/CtgtCC`	1	--	ng3¹		3		NA EA	162
rs10531954^1,2	--	63744275(+)	`gtgtc-/TGTG tgtgt`	1	--	ng3¹		0	--	--	--	--
rs10751004^1,2	C,F,A,H,	63741510(+)	`ACCTCA/TGATGA`	1	--	ng5¹ tfbs³		5		EA NA	176

About this table

HapMap Linkage Disequilibrium images for COX8A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COX8A: --

QIAGEN SeqTarget long-range PCR primers for resequencing COX8A

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COX8A for disorders About GeneDecksing

OMIM: 123870

Human Genome Epidemiology (HuGE) Navigator: COX8A (1 document)

Export disorders and mutations for COX8A gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/14 PubMed articles for COX8A gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with COX8A)

A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PubMed id 2543673)^{1, 2, 3} Rizzuto R.... Schon E.A. (1989)
Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PubMed id 2847943)^{1, 2, 3} van Kuilenburg A.B.P....van Beeumen J.J. (1988)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PubMed id 12909344)^{1, 7} Huettemann M.... Grossman L.I. (2003)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Peptide nucleic acid delivery to human mitochondria. (PubMed id 10637443)¹ Chinnery P.F....Lightowlers R.N. (1999)
Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates. (PubMed id 12716970)⁷ Goldberg A....Grossman L.I. (2003)
Sequence of the cDNA for the liver/non-muscle isoform of mouse cytochrome-c oxidase subunit VIII. (PubMed id 8809110)⁷ Makris G.J. and Lomax M.I. (1996)
Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII. (PubMed id 7766994)⁷ Lomax M.I....Womack J.E. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1351	HGNC: 2294	AceView: COX8AandOTUB1	Ensembl:ENSG00000176340	euGenes: HUgn1351
ECgene: COX8A	Kegg: 1351	H-InvDB: COX8A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for COX8A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for COX8A gene:
Search GeneIP for patents involving COX8A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for COX8A		Browse antibodies at Sigma-Aldrich
	Super-pooled esiRNAs for COX8A		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for COX8A		microRNA Mimics for COX8A
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of COX8A
	SeqTarget long-range PCR primers for resequencing COX8A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for COX8A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of COX8A

	GenScript Custom Purified and Recombinant Proteins Services for COX8A		GenScript cDNA clones with any tag delivered in your preferred vector for COX8A
	GenScript Custom Assay Services for COX8A		GenScript Custom Superior Antibodies Services for COX8A
	GenScript Custom overexpressing Cell Line Services for COX8A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in COX8A promoter
	Search Chromatin IP Primers for COX8A
	RT² qPCR Primer Assay for COX8A
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	SABiosciences PCR Arrays including COX8A

Search Tocris compounds for COX8A

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Proteins for COX8A

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

Browse ELISAs and CLIAs at Uscn

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

COX8A gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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COX8A Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for COX8A gene

Summaries
for COX8A gene

Genomic Views
for COX8A gene

Proteins
for COX8A gene

Protein Domains/
Families
for COX8A gene

Gene Function
for COX8A gene

Pathways & Interactions
for COX8A gene

Drugs & Compounds
for COX8A gene

Transcripts
for COX8A gene

Expression
for COX8A gene

Orthologs
for COX8A gene

Paralogs
for COX8A gene

Genomic Variants
for COX8A gene

Disorders & Mutations
for COX8A gene

Medical News
for COX8A gene

Publications
for COX8A gene

External Searches for COX8A gene

Genome Databases showing COX8A gene

Other Databases showing COX8A gene

Specialized Databases showing COX8A gene

Intellectual Property
for COX8A gene

Products
for COX8A gene

View Random Gene

Advanced Search

Export list of displayed genes

COX8A Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor COX8A gene

Summariesfor COX8A gene

Genomic Viewsfor COX8A gene

Proteinsfor COX8A gene

Protein Domains/Familiesfor COX8A gene

Gene Functionfor COX8A gene

Pathways & Interactionsfor COX8A gene

Drugs & Compoundsfor COX8A gene

Transcriptsfor COX8A gene

Expression for COX8A gene

Orthologsfor COX8A gene

Paralogsfor COX8A gene

Genomic Variantsfor COX8A gene

Disorders & Mutationsfor COX8A gene

Medical Newsfor COX8A gene

Publicationsfor COX8A gene

External Searches for COX8A gene

Genome Databases showing COX8A gene

Other Databases showing COX8A gene

Specialized Databases showing COX8A gene

Intellectual Propertyfor COX8A gene

Productsfor COX8A gene

View Random Gene

Aliases &
Descriptions
for COX8A gene

Summaries
for COX8A gene

Genomic Views
for COX8A gene

Proteins
for COX8A gene

Protein Domains/
Families
for COX8A gene

Gene Function
for COX8A gene

Pathways & Interactions
for COX8A gene

Drugs & Compounds
for COX8A gene

Transcripts
for COX8A gene

Expression
for COX8A gene

Orthologs
for COX8A gene

Paralogs
for COX8A gene

Genomic Variants
for COX8A gene

Disorders & Mutations
for COX8A gene

Medical News
for COX8A gene

Publications
for COX8A gene

Intellectual Property
for COX8A gene

Products
for COX8A gene