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Aliases & Descriptionsfor CPA2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions carboxypeptidase A2 (pancreatic)1 2 carboxypeptidase A22 EC 3.4.17.153
Export aliases for CPA2 gene to outside databases Previous GC identifers: GC07P128383 GC07P129445 GC07P129459 GC07P129500 GC07P129693 GC07P129906
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Summariesfor CPA2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CPA2 : Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. (provided by RefSeq) Gene Wiki entry for CPA2 (Carboxypeptidase A2)
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Genomic Viewsfor CPA2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPA2 gene promoter: POU2F1 LUN-1 Lmo2 Max1 c-Myc SRF ATF USF1 CREB CUTL1 Other transcription factors Search SABiosciences Chromatin IP Primers for CPA2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32 CPA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P124269: view genomic region
(about GC identifiers )
Start:
124,269,090 bp from pter
End:
124,292,037 bp from pter
Size:
22,948 bases
Orientation:
plus strand
1 alternative location : Chr 7+ 129,906,667-129,929,638
RefSeq DNA sequence: NC_000007.13 NT_007933.15 NT_079596.2
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Proteinsfor CPA2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052 (See
protein sequence )Recommended Name: Carboxypeptidase A2 precursor Size : 419 amino acids; 47030 Da
Cofactor : Binds 1 zinc ion per subunit
Subcellular location : Secreted
Sequence caution : Sequence=AAA74425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH07009.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH14571.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH15140.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAL24092.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia : 1AYE (3D)
 1DTD (3D)
 1O6X (3D)
 
Secondary accessions : A4D1M4 C9JIK1 Q53XS1 Q96A12 Q96QN3 Q9UCF1Explore the universe of human proteins at neXtProt for CPA2: NX_P48052
REFSEQ proteins: NP_001860.2 ENSEMBL proteins: ENSP00000400218 ENSP00000222481 ENSP00000395582 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
About this table
CPA2 for ontologies About GeneDecksing Antibodies for CPA2: Assays for CPA2:
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Protein
Domains/ Familiesfor CPA2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CPA2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P48052 ProtoNet protein and cluster: P48052
2 Blocks protein families : IPB000834 Zinc carboxypeptidase A metalloprotease (M14) IPB003146 Carboxypeptidase activation peptide UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052 Similarity : Belongs to the peptidase M14 family
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Gene Functionfor CPA2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052 Catalytic activity : Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminalresidues Enzyme Number (IUBMB): EC 3.4.17.15
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):
About this table
CPA2 for ontologies About GeneDecksing
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Pathways & Interactionsfor CPA2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
CPA2 for pathways About GeneDecksing 2 Kegg Pathways (Kegg details for CPA2) : SABiosciences Custom Pathway-Focused PCR Arrays for CPA2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA2 1 Interacting protein for CPA2 (P48052 2 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
About this table
CPA2 for ontologies About GeneDecksing
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Drugs & Compoundsfor CPA2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for CPA2
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Transcriptsfor CPA2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for CPA2 gene: NM_001869.2
Additional cDNA sequence: AK293378.1 BC007009.1 BC014571.1 BC015140.1 BT007403.1 U19977.1
5 DOTS entries : DT.114086 DT.100780895 DT.121110016 DT.95070335 DT.86854275
24/99 AceView cDNA sequences (see all 99 ):
CK823467 AI961047 AA844831 AA294920 BM967213 CD613167 BC015140 AA366335 BQ777569 BQ478105 AA366648 AA363672 BC014571 BI766188 AI434875 BM924292 AA366154 AA835098 BX507148 AI937229 AA363706 BM142590 AA366803 BX498146
highest scoring ESTs for CPA2 :U19977 AA363637 AA363672 AA366154 AA366335 AA835098 AA835145 AA844831 AA845105 AI434875 Unigene Cluster for CPA2:
Carboxypeptidase A2 (pancreatic) Hs.490038 [show with all ESTs ] Unigene Representative Sequence: BC007009 GeneLoc Exon Structure 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000435170 (uc003vpq.2 ) ENST00000222481 ENST00000416698 ENST00000480781 ENST00000487259 (uc011kpc.1 )
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Expression for CPA2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section CPA2 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching CPA2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
40748_at2 , 3
U95-A
1
0.81
1.00
1.00
1.00
U19977
1.00
1.00
1.00
1
206212_at2 , 3
U133-A
1
0.64
1.00
--
--
NM_001869
0.60
1.00
0.82
1
206212_at2
U133Plus2
1
0.64
1.00
--
--
--
--
--
--
--
About this table
CPA2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGCGAGACCA SOURCE GeneReport for Unigene cluster: Hs.490038 Expression variation in blood from EXPOLDB for CPA2
SABiosciences Custom PCR Arrays for CPA2
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Orthologsfor CPA2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for CPA2 gene from 5/11 species (see all 11 )
About this table Species with no ortholog for CPA2 ENSEMBL Gene Tree for CPA2 (if available)
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Paralogsfor CPA2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for CPA2 gene CPO 2 CPA1 2 CPA5 2 CPA4 2
CPA2 for paralogs About GeneDecksing
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Genomic Variantsfor CPA2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 7 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for CPA2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CPA2: --
QIAGEN SeqTarget long-range PCR primers for resequencing CPA2
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Disorders & Mutationsfor CPA2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CPA2 for disorders About GeneDecksing
OMIM: 600688 Human Genome Epidemiology (HuGE) Navigator: CPA2 (2 documents) Export disorders and mutations for CPA2 gene to outside databases
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Medical Newsfor CPA2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor CPA2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/21 PubMed articles for CPA2 gene, integrated from 7 sources (see all 21 ): (articles sorted by number of sources associating them with CPA2) The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model. (PubMed id 7896805) 1 , 2 , 3, 7 Catasus L....Billeter M. (1995) Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. (PubMed id 10742178) 1 , 2 , 7 Reverter D.... Aviles F.X. (2000) Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2. (PubMed id 9450539) 1 , 2 , 7 Reverter D....Aviles F.X. (1997) Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PubMed id 8806703) 1 , 2 , 7 Laethem R.M.... Smith G.K. (1996) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) NMR solution structure of the activation domain of human procarboxypeptidase A2. (PubMed id 12538893) 1 , 2 Jimenez M.A.... Rico M. (2003) A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. (PubMed id 12948494) 1 , 2 Dantas G.... Baker D. (2003) Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668) 1 , 3 Hayashida S....Kishino T. (2000) The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen. (PubMed id 9384570) 1 , 2 Garcia-Saez I.... Coll M. (1997) Purification and properties of five different forms of human procarboxypeptidases. (PubMed id 2920728) 1 , 2 Pascual R.... Aviles F.X. (1989)
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External Searches for CPA2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CPA2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CPA2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CPA2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CPA2 gene: Search GeneIP for patents involving CPA2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CPA2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for CPA2
ELISAs and CLIAs for CPA2
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