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CREB5 Gene

protein-coding   GIFtS: 51

GC07P028305
cAMP responsive element binding protein 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cAMP responsive element binding protein 51 2     cAMP responsive element binding protein 5 isoform alpha2
H_GS165L15.11 2     cyclic AMP-responsive element-binding protein 52
CRE-BPA1 2     cAMP response element binding protein CRE-Bpa2
CREB-52 3     CREBPA3
cAMP-responsive element-binding protein 52 3     CRE-BPa3
cAMP response element-binding protein CRE-BPa2     

External Ids:    HGNC: 168441   Entrez Gene: 95862   Ensembl: ENSG000001465927   UniProtKB: Q029303   

Export aliases for CREB5 gene to outside databases

Previous GC identifers: GC07P028047 GC07P028194 GC07P028081 GC07P028112


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CREB5:
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family
contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a
heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript
variants encoding different isoforms have been identified. (provided by RefSeq)

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
Function: Binds to the cAMP response element and activates transcription

Gene Wiki entry for CREB5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CREB5 gene promoter:
         ATF-2   C/EBPalpha   POU3F1   Pbx1a   MRF-2   Meis-1   HOXA9B   CREB   deltaCREB   LUN-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CREB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.1   Ensembl cytogenetic band:  7p15.1   HGNC cytogenetic band: 7p15

CREB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CREB5 gene location

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P028305:  view genomic region     (about GC identifiers)

Start:
28,220,807 bp from pter
End:
28,865,511 bp from pter
Size:
644,705 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NT_079592.2  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930 (See protein sequence)
Recommended Name: Cyclic AMP-responsive element-binding protein 5  
Size: 508 amino acids; 56858 Da
Subunit: Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1
Subcellular location: Nucleus (Probable)
Secondary accessions: A8KA51 Q05886 Q06246 Q86UJ9
Alternative splicing: 4 isoforms:  Q02930-1   Q02930-2   Q02930-3   Q02930-4   

Explore the universe of human proteins at neXtProt for CREB5: NX_Q02930 

REFSEQ proteins (4 alternative transcripts): 
NP_001011666.1  NP_004895.2  NP_878901.2  NP_878902.2  


ENSEMBL proteins: 
ENSP00000394979 ENSP00000416198 ENSP00000387197 ENSP00000379594 ENSP00000351377 ENSP00000350359 
ENSP00000394088 ENSP00000379592 ENSP00000379593 ENSP00000391651 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: CREB5
GenScript Custom Purified and Recombinant Proteins Services for CREB5 
Novus Biologicals Proteins for CREB5
Novus Biologicals Lysates for CREB5
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
GO:0005634 nucleus IC8378084
About this table

CREB5 for ontologies           About GeneDecksing



Antibodies for CREB5: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for CREB5
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for CREB5 
Novus Biologicals Antibodies for CREB5
Browse antibodies at Epitomics

Assays for CREB5: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CREB5 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CREB5 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CREB5 for domains           About GeneDecksing

5/6 InterPro domains/families (see all 6):
 IPR004827 TF_bZIP
 IPR015880 Znf_C2H2-like
 IPR016378 TF_cAMP-dep
 IPR011616 bZIP_1
 IPR013087 Znf_C2H2/integrase_DNA-bd

Graphical View of Domain Structure for InterPro Entry Q02930

ProtoNet protein and cluster: Q02930

1 Blocks protein family: IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
Similarity: Belongs to the bZIP family
Similarity: Contains 1 bZIP domain
Similarity: Contains 1 C2H2-type zinc finger


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CREB5_HUMAN, Q02930
Function: Binds to the cAMP response element and activates transcription

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for CREB5
Sigma-Aldrich shRNA for CREB5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CREB5
OriGene shRNA RFP (see all 5): CREB5
OriGene basic RS shRNA (see all 5): CREB5
OriGene siRNA (see all 4): CREB5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CREB5 
miRNA:Sigma-Aldrich microRNA Mimics for CREB5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CREB5 
8/65 SABiosciences Assays for microRNAs that regulate CREB5 (see all 65):
hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-938 hsa-miR-374a hsa-miR-519a hsa-miR-93

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene untagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene 3'-UTR clone (see all 4): CREB5 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 4): CREB5 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CREB5 

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IDA8378084
GO:0005515 protein binding IPI8440710
GO:0008270 zinc ion binding IEA--
GO:0043565 sequence-specific DNA binding IEA--
GO:0046872 metal ion binding IEA--
About this table

CREB5 for ontologies           About GeneDecksing

Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Creb5):

adipose tissuebehavior/neurologicalcellulargrowth/sizehomeostasis/metabolism
lethality-prenatal/perinatal

CREB5 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


CREB5 for pathways           About GeneDecksing

5/28 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  CREB5 (see all 28)
    CREB Signaling in Neurons
Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
p38 MAPK Signaling
Neurotrophin/TRK Signaling
Melanocyte Development and Pigmentation Signaling

3 Kegg Pathways  (Kegg details for CREB5):
    hsa04962 Vasopressin-regulated water reabsorption
hsa05016 Huntington's disease
hsa05215 Prostate cancer

    SABiosciences Custom Pathway-Focused PCR Arrays for CREB5 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CREB5
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CREB5

5/10 Interacting proteins for CREB5 (ENSP000003503593) via UniProtKB, MINT, and/or STRING (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
ATF4ENSP000003367903STRING: ENSP00000336790
CREB1ENSP000002369963STRING: ENSP00000236996
CREB3L1ENSP000002884003STRING: ENSP00000288400
CREB3L2ENSP000003291403STRING: ENSP00000329140
CREB3L3ENSP000003713693STRING: ENSP00000371369
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent ----
GO:0006366 transcription from RNA polymerase II promoter TAS8378084
GO:0045893 positive regulation of transcription, DNA-dependent IDA8378084
About this table

CREB5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CREB5


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for CREB5
Sigma-Aldrich shRNA for CREB5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CREB5
OriGene shRNA RFP (see all 5): CREB5
OriGene basic RS shRNA (see all 5): CREB5
OriGene siRNA (see all 4): CREB5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CREB5 
miRNA: Sigma-Aldrich microRNA Mimics for CREB5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CREB5 
8/65 SABiosciences Assays for microRNAs that regulate CREB5 (see all 65):
hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-938 hsa-miR-374a hsa-miR-519a hsa-miR-93
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene untagged cDNA clones in CMV expression vector (see all 4): CREB5
OriGene 3'-UTR Clone (see all 4): CREB5 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 4): CREB5 
Primers: OriGene genome-wide validated SYBR primer pairs: CREB5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CREB5: PPH06982A

REFSEQ mRNAs for CREB5 gene (4 alternative transcripts): 

NM_001011666.1  NM_004904.2  NM_182898.2  NM_182899.3  

Additional cDNA sequence: 

AB209262.1 AB451409.1 AK021493.1 AK057151.1 AK292916.1 AK298121.1 AK300455.1 AK316187.1 
BC059400.1 BC087859.1 L05515.1 L05911.1 L05912.1 L05913.1 

15 DOTS entries:

DT.91750301  DT.100812990  DT.95374150  DT.100812991  DT.95098526  DT.97828917  DT.121057467  DT.87014787 
DT.95209779  DT.40225961  DT.97825503  DT.100747131  DT.121057538  DT.95225955  DT.438809 

24/78 AceView cDNA sequences (see all 78):

BX279704 AL706583 AV754746 BM468660 AA581655 BC059400 BP345509 AL706571 
AA700776 CB149302 AA582287 CK820213 AW024551 AW151127 AI609531 AA748577 
AU139456 BE620362 AW071804 BX099680 BX490928 BQ023803 AU119216 BX282747 

highest scoring ESTs for CREB5:

L05515 AA460982 AA748577 AI457917 AI819043 AI887077 AW024551 AW151127 AW469766 AW665405 

Unigene Cluster for CREB5:

CAMP responsive element binding protein 5
Hs.437075  [show with all ESTs]
Unigene Representative Sequence: NM_182898


GeneLoc Exon Structure

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000468391(uc011jzr.1) ENST00000426500 ENST00000482692 ENST00000484383
ENST00000432860(uc003szo.2 uc003szq.2 uc003szr.2 uc003szs.2)
ENST00000409603 ENST00000396300 ENST00000358569 ENST00000469531 ENST00000498316
ENST00000357727 ENST00000424599 ENST00000396298 ENST00000396299 ENST00000431246
ENST00000468813 ENST00000478078 ENST00000461921

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CREB5 expression in normal and diseased human tissues

1  / 2  / 3

13 probe-sets matching CREB5 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
670_s_at2, 3 U95-A 1 1.00 1.00 -0.06 0.33 L05515 1.00 0.90 0.95 1
59695_at2, 3 U95-B 1 0.75 1.00 0.89 1.25 AI819043 0.80 1.00 0.91 1
59808_at2, 3 U95-B 1 0.69 1.00 0.45 0.67 N98661 0.80 1.00 0.91 1
54744_at2, 3 U95-C 3 0.50 0.33 0.87 1.17 AA582287 0.40 0.50 0.45 1
67842_at*2, 3 U95-D 1 0.44 1.00 -0.32 0.37 AI609531 0.40 1.00 0.76 1
205931_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004904 0.60 1.00 0.82 1
229228_at2, 3 U133-B 1 0.82 1.00 -- -- AI819043 0.80 1.00 0.91 1
242329_at2, 3 U133-B 3 0.46 0.33 -- -- AW071804 0.40 0.67 0.55 1
232555_at*2, 3 U133-B 1 0.27 1.00 -- -- AI689210 0.40 1.00 0.76 1
205931_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
229228_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
242329_at2 U133Plus2 3 0.46 0.33 -- -- -- -- -- -- --
232555_at*2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
About this table

CREB5 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CREB5 gene expression
CREB5 gene electronic northern expression
CREB5 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.437075

Expression variation in blood from EXPOLDB for CREB5

Primers: OriGene genome-wide validated SYBR primer pairs: CREB5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CREB5: PPH06982A
    SABiosciences Custom PCR Arrays for CREB5 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CREB5 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CREB51   -- cAMP responsive element binding protein 5 93.9(n)
97.24(a)
475266  XM_532500.2  XP_532500.2 
chimpanzee
(Pan troglodytes)
CREB51   -- cAMP responsive element binding protein 5 99.61(n)
99.21(a)
463318  XM_519017.2  XP_519017.2 
cow
(Bos taurus)
CREB51   -- cAMP responsive element binding protein 5 93.61(n)
97.21(a)
534129  XM_865288.2  XP_870381.1 
rat
(Rattus norvegicus)
RGD15661071   -- similar to cAMP responsive element binding protein more 91.54(n)
97.64(a)
500131  XM_575483.2  XP_575483.2 
mouse
(Mus musculus)
Creb55 6 (25.90 cM) cAMP responsive element binding protein 5   -- BC098487 
About this table        Species with no ortholog for CREB5

ENSEMBL Gene Tree for CREB5 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CREB5 gene
ATF72  ATF22  

CREB5 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/5827 NCBI SNPs in CREB5 are shown (see all 5827)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs35931,2
--28865430(-) TCTTCT/ATGCTA 4 -- ut311Minor allele frequency- A:0.00MN 184
rs282341,2
C,F,28669836(+) CTCTTC/TTCCCA 3 -- int1 trp314Minor allele frequency- T:0.28NS EA NA WA 1010
rs285961,2
C,F,A,H,28446073(-) GAGTAC/TAGGCT 1 -- int116Minor allele frequency- T:0.37NA EA NS WA 846
rs412721,2
C,F,O,A,28644766(+) CTTACA/GTAGAG 3 -- int115Minor allele frequency- G:0.40NA PA NS EA WA 1022
rs412731,2
C,F,28644857(+) TGGTAG/AGTAAA 3 -- int17Minor allele frequency- A:0.13NS EA NA WA 628
rs412741,2
C,F,28647701(+) CATGCA/CTCTCT 3 -- int1 trp38Minor allele frequency- C:0.42NS EA NA WA 608
rs412751,2
C,F,O,28650054(+) TCAGCC/TTGGCC 3 -- int117Minor allele frequency- N:0.01NS EA NA WA 1266
rs412761,2
C,F,O,A,H,28650263(+) GGCCCA/GGTAAC 3 -- int18Minor allele frequency- G:0.36NS EA NA WA 616
rs412771,2
C,A,H,28650506(+) tgtgcA/Gtgtgt 3 -- int16Minor allele frequency- G:0.08NA 82
rs412781,2
C,H,28651542(+) AAAGCG/AACAAA 3 -- int17Minor allele frequency- A:0.15NA WA 132
About this table

HapMap Linkage Disequilibrium images for CREB5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CREB5
     3 CNVs: 64788 4529 99904
     3 Indels: 69839 43207 47332

QIAGEN SeqTarget long-range PCR primers for resequencing CREB5 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CREB5 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: CREB5 (5 documents)

Export disorders and mutations for CREB5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/14 PubMed articles for CREB5 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with CREB5)
  1. Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA. (PubMed id 8378084)1, 2, 3, 7 Zu Y.-L.... Ishii S. (1993)
  2. Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1. (PubMed id 8440710)1, 2, 3, 7 Nomura N....Ishii S. (1993)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  7. Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)1 Xu J....Isaacs W.B. (2010)
  8. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
  9. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1 Lesch K.P....Jacob C. (2008)
  10. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1 Uhl G.R....Lerman C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 9586 HGNC: 16844 AceView: CREB5 Ensembl:ENSG00000146592 euGenes: HUgn9586
ECgene: CREB5 Kegg: 9586 H-InvDB: CREB5

(According to HUGE)
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  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for CREB5 gene:
Search GeneIP for patents involving CREB5

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 ELISAs and CLIAs for CREB5
       

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