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CRK Gene

protein-coding   GIFtS: 63

GC17M001272
v-crk sarcoma virus CT10 oncogene homolog (avian)
(Previous name: v-crk avian sarcoma virus CT10 oncogene homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
v-crk sarcoma virus CT10 oncogene homolog (avian)1 2     CRKII2
v-crk avian sarcoma virus CT10 oncogene homolog1 2     adapter molecule crk2
Proto-oncogene c-Crk2 3     avian sarcoma virus CT10 (v-crk) oncogene homolog2
p382 3     

External Ids:    HGNC: 23621   Entrez Gene: 13982   Ensembl: ENSG000001671937   UniProtKB: P461083   

Export aliases for CRK gene to outside databases

Previous GC identifers: GC17M001318 GC17M001659 GC17M001533 GC17M001534


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRK:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The
product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling
pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.
The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal
SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different
isoforms with distinct biological activity have been described. (provided by RefSeq)

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108
Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than
Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent
manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4

Gene Wiki entry for CRK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRK gene promoter:
         AP-1   SRF   c-Fos   Max1   c-Myc   c-Jun   GR-alpha   GR-beta   Max   ISGF-3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CRK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

CRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRK gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001272:  view genomic region     (about GC identifiers)

Start:
1,226,186 bp from pter
End:
1,259,667 bp from pter
Size:
33,482 bases
Orientation:
minus strand

1 alternative location:
Chr17- 1,323,983-1,359,552     
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CRK_HUMAN, P46108 (See protein sequence)
Recommended Name: Adapter molecule crk  
Size: 304 amino acids; 33831 Da
Subunit: Interacts with ABL1, C3G, SOS, MAP4K1, MAPK8 and DOCK3 via its first SH3 domain. Interacts with BCAR1, CBL,
CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several
tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain (By similarity).
Interacts with DOCK1 and DOCK4. Interacts with SHB
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocated to the plasma
membrane upon cell adhesion (By similarity)
PDB structures from and Proteopedia :
1JU5 (3D)    2DVJ (3D)    2EYV (3D)    2EYW (3D)    2EYX (3D)    2EYY (3D)    2EYZ (3D)    
Secondary accessions: B0LPE8 Q96HJ0
Alternative splicing: 2 isoforms:  P46108-1   P46108-2   

Explore the universe of human proteins at neXtProt for CRK: NX_P46108 

Post-translational modifications:

  • Phosphorylation of Crk-II (40 kDa) gives rise to a 42 kDa form1
  • Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and
  • SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the
    SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_005197.3  NP_058431.2  


    ENSEMBL proteins: 
    ENSP00000300574 ENSP00000381942 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant CRK Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): CRK
    OriGene Protein Over-expression Lysate (see all 2): CRK
    GenScript Custom Purified and Recombinant Proteins Services for CRK 
    Novus Biologicals Proteins for CRK
    Novus Biologicals Lysates for CRK
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS10748058
    GO:0005737 cytoplasm IEA--
    GO:0005768 endosome TAS--
    GO:0005829 cytosol TAS--
    GO:0005886 plasma membrane IEA--
    About this table

    CRK for ontologies           About GeneDecksing



    Antibodies for CRK: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for CRK
    R&D Systems Antibodies for CRK
    Cell Signaling Technology (CST) Antibodies for CRK 
    OriGene Antibodies (see all 2): CRK
    GenScript Custom Superior Antibodies Services for CRK 
    Novus Biologicals Antibodies for CRK
    Epitomics antibodies for CRK

    Assays for CRK: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRK 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CRK 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CRK for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011511 SH3_2
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P46108

    ProtoNet protein and cluster: P46108

    3 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: CRK_HUMAN, P46108
    Domain: The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain
    appears to function as a positive regulator for transformation (By similarity)
    Domain: The SH2 domain mediates interaction with SHB
    Similarity: Belongs to the CRK family
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CRK_HUMAN, P46108
    Function: The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than
    Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent
    manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CRK
    Sigma-Aldrich shRNA for CRK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CRK
    OriGene shRNA RFP (see all 3): CRK
    OriGene basic RS shRNA (see all 3): CRK
    OriGene siRNA (see all 2): CRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRK 
    miRNA:Sigma-Aldrich microRNA Mimics for CRK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRK 
    8/16 SABiosciences Assays for microRNAs that regulate CRK (see all 16):
    hsa-miR-328 hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-93 hsa-miR-489 hsa-miR-325 hsa-miR-17

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CRK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CRK
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CRK
    OriGene 3'-UTR clone (see all 2): CRK 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): CRK 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CRK 

    Genatlas biochemistry entry for CRK:
    avian sarcoma virus CT10 (v-crk) homolog

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070 SH3/SH2 adaptor activity IEA--
    GO:0005515 protein binding IPI11278465
    GO:0019904 protein domain specific binding ----
    GO:0030674 protein binding, bridging ----
    GO:0042169 SH2 domain binding IPI9472046
    About this table

    CRK for ontologies           About GeneDecksing

    Animal Models: 11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Crk):

    cardiovascular systemcraniofacialdigestive/alimentarygrowth/sizehomeostasis/metabolism
    lethality-postnatallethality-prenatal/perinatalmusclenervous systemnormal
    respiratory system

    CRK for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CRK for pathways           About GeneDecksing

    5/7 Millipore Pathways for CRK (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Development Angiopoietin - Tie2 signaling
    Chemotaxis CXCR4 signaling pathway
    Cytoskeleton remodeling FAK signaling
    Signal transduction JNK pathway

    5/19 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  CRK (see all 19)
        Ephrin Receptor Signaling
    PDGF Signaling
    Renal Cell Carcinoma Signaling
    Insulin Receptor Signaling
    SAPK/JNK Signaling

    4 Cell Signaling Technology (CST) Pathways for CRK
        Insulin Receptor Signaling
    Cytoskeletal Signaling
    MAPK/Erk in Growth and Differentiation
    SAPK/JNK Signaling Cascades

    5/13 Kegg Pathways  (Kegg details for CRK) (see all 13):
        hsa04010 MAPK signaling pathway
    hsa04012 ErbB signaling pathway
    hsa04062 Chemokine signaling pathway
    hsa04510 Focal adhesion
    hsa04666 Fc gamma R-mediated phagocytosis

        SABiosciences Pathway-Focused PCR Arrays including CRK: PAHS-039A PAHS-088A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CRK
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRK

    5/245 Interacting proteins for CRK (ENSP000003005743 P461081, 2) via UniProtKB, MINT, and/or STRING (see all 245)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL2P426841, 2STRING: ENSP00000356595 EBI-886,EBI-1102694 MINT-7254034 MINT-7254574 MINT-7254094
    BCAR1P569451, 2STRING: ENSP00000162330 EBI-886,EBI-702093 MINT-6763936 MINT-7104340 MINT-7104448
    RAPGEF1Q139051, 2STRING: ENSP00000338266 EBI-886,EBI-976876 MINT-7253914 MINT-7254430 MINT-15982
    ABL1P005191, 2STRING: ENSP00000361423 EBI-886,EBI-375543 MINT-7254106 MINT-8036825
    ASAP1Q9ULH11, 2STRING: ENSP00000344591 EBI-886,EBI-346622 MINT-7254202 MINT-7254166
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186 activation of MAPKK activity TAS--
    GO:0006357 regulation of transcription from RNA polymerase II promoter TAS10748058
    GO:0007165 signal transduction TAS10748058
    GO:0007596 blood coagulation TAS--
    GO:0008286 insulin receptor signaling pathway TAS--
    About this table

    CRK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CRK for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRK
    10/20 Novoseek chemical compound relationships for CRK gene (see all 20)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 78.3 147 12799422 (6), 9195921 (5), 18835194 (4), 8524328 (4) (see all 76)
    phosphotyrosine 62.8 2 11695992 (1), 15525532 (1)
    phosphatidylinositol 58.9 17 14640702 (2), 15581361 (2), 10531310 (1), 9837978 (1) (see all 13)
    thiosemicarbazide 48.1 3 7531694 (2)
    thiazolidinedione 38.8 2 15581362 (1), 14640702 (1)
    k252a 37.1 1 10850658 (1)
    guanine 36 7 18835194 (2), 10970810 (1), 7512734 (1), 8035825 (1)
    phenylalanine 31.4 4 9546424 (1), 12799422 (1), 11316748 (1), 9564038 (1)
    proline 25 4 11080615 (2), 12955086 (1)
    gtp 24.6 3 12054111 (1), 9268367 (1), 12198159 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CRK
    Sigma-Aldrich shRNA for CRK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): CRK
    OriGene shRNA RFP (see all 3): CRK
    OriGene basic RS shRNA (see all 3): CRK
    OriGene siRNA (see all 2): CRK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRK 
    miRNA: Sigma-Aldrich microRNA Mimics for CRK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRK 
    8/16 SABiosciences Assays for microRNAs that regulate CRK (see all 16):
    hsa-miR-328 hsa-miR-126 hsa-miR-300 hsa-miR-106a hsa-miR-93 hsa-miR-489 hsa-miR-325 hsa-miR-17
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): CRK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CRK
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CRK
    OriGene 3'-UTR Clone (see all 2): CRK 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): CRK 
    Primers: OriGene genome-wide validated SYBR primer pairs: CRK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CRK: PPH00731A

    REFSEQ mRNAs for CRK gene (2 alternative transcripts): 

    NM_005206.3  NM_016823.2  

    Additional cDNA sequence: 

    AK291060.1 BC001718.1 BC008506.1 BC009837.1 BT007277.1 CR590790.1 CR600568.1 D10656.1 

    10 DOTS entries:

    DT.450328  DT.100779280  DT.100721097  DT.95171032  DT.86849048  DT.120966123  DT.100716778  DT.91751135 
    DT.120966099  DT.91751133 

    24/68 AceView cDNA sequences (see all 68):

    BF794728 AI090527 BI862427 BM313846 AI203558 AV684422 BM005955 AA425067 
    BX116568 BU501498 BQ052326 AB067523 BQ653258 BM352339 AV700545 CK822353 
    AI141071 AI356364 AI190661 BM467173 AX747382 BQ643535 BM714209 BM676597 

    highest scoring ESTs for CRK:

    D10656 AA852942 AI085745 AL552288 AU116937 AU125411 AU135266 AU138629 BC001718 BC008506 

    Unigene Cluster for CRK:

    V-crk sarcoma virus CT10 oncogene homolog (avian)
    Hs.638121  [show with all ESTs]
    Unigene Representative Sequence: BC008506


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CRK

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b
    SP1:              -               
    SP2:                              

    About this scheme

    ECgene alternative splicing isoforms for CRK
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300574(uc002fsm.2 uc002fsl.2) ENST00000398970

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CRK expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching CRK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38219_at2, 3 U95-A 1 1.00 1.00 0.91 0.79 D10656 1.00 1.00 1.00 1
    772_at2, 3 U95-A 1 0.75 1.00 0.84 0.62 D10656 1.00 1.00 1.00 1
    49090_at2, 3 U95-C 1 0.50 1.00 0.54 1.62 AA197018 0.40 1.00 0.76 1
    202224_at2, 3 U133-A 1 1.00 1.00 -- -- BF304695 0.40 1.00 0.76 1
    202226_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_016823 0.60 1.00 0.82 1
    202225_at2, 3 U133-A 1 0.27 1.00 -- -- AW612311 0.40 1.00 0.76 1
    202224_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202226_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    202225_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    CRK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CRK gene expression
    CRK gene electronic northern expression
    CRK gene sage expression
    About these images

    CGAP SAGE TAG: AATTTGGGGT

    SOURCE GeneReport for Unigene cluster: Hs.638121
    Primers: OriGene genome-wide validated SYBR primer pairs: CRK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CRK: PPH00731A
        SABiosciences Expression via Pathway-Focused PCR Arrays including CRK: PAHS-039A PAHS-088A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CRK gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    CRK1   -- v-crk sarcoma virus CT10 oncogene homolog (avian) 99.56(n)
    99.32(a)
    747142  XM_001154201.1  XP_001154201.1 
    cow
    (Bos taurus)
    CRK1   -- v-crk sarcoma virus CT10 oncogene homolog (avian) 98.14(n)
    100(a)
    512841  XM_590426.3  XP_590426.3 
    rat
    (Rattus norvegicus)
    Crk1   -- v-crk sarcoma virus CT10 oncogene homolog (avian) 96.05(n)
    99.67(a)
    54245  NM_019302.1  NP_062175.1 
    mouse
    (Mus musculus)
    Crk1 , 5 11 (45.92 cM)5
    v-crk sarcoma virus CT10 oncogene homolog (avian)1, 5 96.16(n)1
    99.67(a)1
    129281  NM_133656.21  NP_598417.21 
     AF2396735  AK0284885  (see all 28)
    chicken
    (Gallus gallus)
    CRK1   -- v-crk sarcoma virus CT10 oncogene 83.99(n)
    85.2(a)
    417553  NM_001007846.1  NP_001007847.1 
    About this table        Species with no ortholog for CRK

    ENSEMBL Gene Tree for CRK (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CRK gene
    CRKL2  

    CRK for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/464 NCBI SNPs in CRK are shown (see all 464)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10831,2
    C,F,H,1325297(-) AAGTAT/CGGAAT 2 -- ng31 ese318Minor allele frequency- C:0.16NS EA NA MN WA 998
    rs8810541,2
    C,A1331647(+) acttcG/Atgatc 2 -- int16Minor allele frequency- A:0.25NA WA 12
    rs10419671,2
    C,H1340365(-) CTATTT/GGGACA 4 /W /L mis1 ref19Minor allele frequency- G:0.00MN NS EA 996
    rs10419751,2
    --1326322(-) GGAGCA/GTGACC 2 -- ut311Minor allele frequency- G:0.00MN 184
    rs10419761,2
    --1326311(-) AGCGTG/ATGACT 2 -- ut311Minor allele frequency- A:0.00MN 184
    rs10604601,2
    --1339096(-) CTCACA/GCTTGT 2 -- int11Minor allele frequency- G:0.00MN 184
    rs11264571,2
    C,F,1325618(-) tagccC/Tggcgt 2 -- ut317Minor allele frequency- T:0.24NS NA WA 106
    rs18033251,2
    --1326479(-) GGAAGA/GAGTGT 2 -- ut310--------
    rs20481871,2
    C,F,A,1343158(+) gaaaaC/TGAATT 2 -- int19Minor allele frequency- T:0.50NA WA 262
    rs20631851,2
    C,F,A,H1348304(+) gggcaC/Tggtgg 2 -- int16Minor allele frequency- T:0.38NA WA 16
    About this table

    HapMap Linkage Disequilibrium images for CRK (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CRK: --

    QIAGEN SeqTarget long-range PCR primers for resequencing CRK 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CRK for disorders           About GeneDecksing

    OMIM: 164762

    9 Novoseek disease relationships for CRK gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 14.9 1 8524328 (1)
    carcinoma squamous cell 0 2 10595738 (1), 10970810 (1)
    inflammation 0 2 15031492 (1), 14610286 (1)
    breast cancer 0 4 20008144 (1), 12006644 (1)
    pheochromocytoma 0 1 8321240 (1)
    tumors 0 19 12970743 (4), 16491127 (1), 18602365 (1), 16849525 (1) (see all 5)
    carcinoma 0 3 12955086 (1), 10618718 (1)
    cancer 0 17 15831672 (3), 16491127 (2), 19350053 (2), 18602365 (1) (see all 7)
    sarcoma 0 2 19737974 (1), 17210721 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: CRK (1 document)
    Tumor Gene Database (TGDB): CRK

    Export disorders and mutations for CRK gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/315 PubMed articles for CRK gene, integrated from 7 sources (see all 315):
    (articles sorted by number of sources associating them with CRK)
    1. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 7 Koval A.P.... LeRoith D. (1998)
    2. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)1, 2, 7 Matsuda M.... Kurata T. (1996)
    3. Two species of human CRK cDNA encode proteins with distinct biological activities. (PubMed id 1630456)1, 2, 7 Matsuda M.... Shibuya M. (1992)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PubMed id 12628187)1, 2 Yajnik V....Haber D.A. (2003)
    7. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. (PubMed id 12384576)1, 2 Donaldson L.W.... Forman-Kay J.D. (2002)
    8. NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. (PubMed id 10964504)1, 2 Lu L.... Welsh M. (2000)
    9. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. (PubMed id 8657152)1, 2 Hasegawa H.... Matsuda M. (1996)
    10. CRK proto-oncogene maps to human chromosome band 17p13. (PubMed id 8378094)1, 2 Fioretos T.... Morris C. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1398 HGNC: 2362 AceView: CRK.1 Ensembl:ENSG00000167193 euGenes: HUgn1398
    ECgene: CRK Kegg: 1398 H-InvDB: CRK

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CRK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for CRK gene:
    Search GeneIP for patents involving CRK

    GeneCards and IP:
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