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CRTAM Gene

protein-coding GIFtS: 48

GC11P118652

cytotoxic and regulatory T cell molecule
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cytotoxic and regulatory T cell molecule¹ ²
Class-I MHC-restricted T-cell-associated molecule² ³
cytotoxic and regulatory T-cell molecule²
class I MHC restricted T cell associated molecule²
class-I MHC-restricted T cell associated molecule²

External Ids:	HGNC: 24313¹	Entrez Gene: 56253²	Ensembl: ENSG00000109943⁷	UniProtKB: O95727³

Export aliases for CRTAM gene to outside databases

Previous GC identifers: GC11P124710 GC11P124222 GC11P122743 GC11P122246 GC11P122214

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRTAM:

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and

encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 (PubMed 18329370)).(supplied by

OMIM)

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727

Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)

secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CRTAM gene promoter:
         c-Rel   NF-kappaB   NF-kappaB1   RelA   NF-kappaB2   RORalpha1   IRF-1   AML1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CRTAM

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1

CRTAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTAM gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P118652: view genomic region (about GC identifiers)

Start:	118,652,105 bp from pter
End:	118,686,168 bp from pter
Size:	34,064 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 122,709,206-122,743,334

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727 (See protein sequence)

Recommended Name: Cytotoxic and regulatory T-cell molecule precursor

Size: 393 amino acids; 44641 Da

Subunit: Interacts with CADM1

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=BAD93067.1; Type=Erroneous initiation;

Secondary accessions: Q59EI1 Q6IRX2

Alternative splicing: 2 isoforms: O95727-1 O95727-2

Explore the universe of human proteins at neXtProt for CRTAM: NX_O95727

REFSEQ proteins: NP_062550.2

ENSEMBL proteins:

ENSP00000227348

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

About this table

CRTAM for ontologies About GeneDecksing

Antibodies for CRTAM:

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Assays for CRTAM:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CRTAM

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRTAM for domains About GeneDecksing

5 InterPro domains/families:

IPR007110 Ig-like

IPR013162 CD80_C2-set

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry O95727

ProtoNet protein and cluster: O95727

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727

Similarity: Belongs to the nectin family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727

Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)

secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRTAM Sigma-Aldrich shRNA Panels and shRNA for CRTAM
		OriGene 29mer shRNA kits in GFP-retroviral vector: CRTAM OriGene shRNA RFP: CRTAM OriGene basic RS shRNA: CRTAM OriGene siRNA: CRTAM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM

miRNA:		Sigma-Aldrich microRNA Mimics for CRTAM Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM
		6 SABiosciences Assays for microRNAs that regulate CRTAM:
		hsa-miR-133a hsa-miR-539 hsa-miR-133b hsa-miR-33b hsa-miR-33a hsa-miR-504

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CRTAM OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CRTAM OriGene untagged cDNA clones in CMV expression vector: CRTAM OriGene 3'-UTR clone: CRTAM Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CRTAM
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CRTAM

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	15811952
GO:0005515	protein binding	--	--

About this table

CRTAM for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Crtam):

hematopoietic system

immune system

CRTAM for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for CRTAM

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CRTAM

1 Interacting protein for CRTAM (ENSP00000227348³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PVRL2	ENSP00000252483³	STRING: ENSP00000252483

About this table

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001913	NOT T cell mediated cytotoxicity	IDA	15811952
GO:0002355	detection of tumor cell	IDA	15811952
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA	15811952
GO:0008037	cell recognition	IDA	15811952
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IDA	15811952

About this table

CRTAM for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRTAM

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRTAM Sigma-Aldrich shRNA Panels and shRNA for CRTAM
		OriGene 29mer shRNA kits in GFP-retroviral vector: CRTAM OriGene shRNA RFP: CRTAM OriGene basic RS shRNA: CRTAM OriGene siRNA: CRTAM
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM

miRNA:		Sigma-Aldrich microRNA Mimics for CRTAM Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM
		6 SABiosciences Assays for microRNAs that regulate CRTAM:
		hsa-miR-133a hsa-miR-539 hsa-miR-133b hsa-miR-33b hsa-miR-33a hsa-miR-504

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CRTAM OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CRTAM OriGene untagged cDNA clones in CMV expression vector: CRTAM OriGene 3'-UTR Clone: CRTAM Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: CRTAM

Primers:		OriGene genome-wide validated SYBR primer pairs: CRTAM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CRTAM: PPH13174A

REFSEQ mRNAs for CRTAM gene:

NM_019604.2

Additional cDNA sequence:

AB209830.1 AF001622.1 AK293470.1 AK313578.1 BC070266.1

2 DOTS entries:

DT.424789 DT.100764176

24/26 AceView cDNA sequences (see all 26):

AA322525 BM919441 BX118379 CA309993 NM_019604 BF434560 AA322787 AW137831

CD640439 BF445107 CD641796 BX488905 CD639624 CD365583 BC070266 AF001622

BG058725 BX488047 AI693616 CK004240 BG205621 BG231751 CD640427 CD642037

highest scoring ESTs for CRTAM:

AF001622 AI693616 AW137831 BC070266 BF434560 BF445107 BG058725 BG205621 BG231751 BX118379

Unigene Cluster for CRTAM:

Cytotoxic and regulatory T cell molecule

Hs.159523 [show with all ESTs]

Unigene Representative Sequence: BC070266

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000227348(uc001pyj.2 uc001pyk.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CRTAM expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching CRTAM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36389_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF001622	1.00	1.00	1.00	1
206914_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_019604	0.60	1.00	0.82	1
206914_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

CRTAM for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CRTAM gene electronic northern expression

About these images

CGAP SAGE TAG: CCTTTCTTTT

SOURCE GeneReport for Unigene cluster: Hs.159523

Expression variation in blood from EXPOLDB for CRTAM

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727

Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including

NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje

neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues

Primers:		OriGene genome-wide validated SYBR primer pairs: CRTAM Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CRTAM: PPH13174A

SABiosciences Custom PCR Arrays for CRTAM

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRTAM gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CRTAM¹	--	cytotoxic and regulatory T cell molecule	83.63(n) 76.74(a)	610296 XM_847764.1 XP_852857.1
chimpanzee (Pan troglodytes)	CRTAM¹	--	cytotoxic and regulatory T cell molecule	99.07(n) 98.98(a)	736196 XM_001136009.1 XP_001136009.1
cow (Bos taurus)	CRTAM¹	--	cytotoxic and regulatory T cell molecule	81.87(n) 75(a)	781864 XM_001250376.1 XP_001250377.1
rat (Rattus norvegicus)	Crtam¹	--	cytotoxic and regulatory T cell molecule	77.99(n) 71.74(a)	300649 XM_236103.4 XP_236103.4
mouse (Mus musculus)	Crtam^{1 , 5}	9 (21.79 cM)⁵	cytotoxic and regulatory T cell molecule^{1, 5}	77.63(n)¹ 72.54(a)¹	54698¹ NM_019465.2¹ NP_062338.2¹ AF001104⁵ AK005719⁵ (see all 8)

About this table Species with no ortholog for CRTAM

ENSEMBL Gene Tree for CRTAM (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1879882^1,2	C,F,O,	122718690(+)	`GCAGCA/TGAGAG`	1	--	int¹		9	MN NS EA NA	830
rs1879883^1,2	C,F,O,A,H,	122710641(-)	`CCTTAC/TTAAGT`	1	--	int¹		13	NS EA NA WA	842
rs1879884^1,2	C,F,A,H,	122710561(-)	`ATGTAC/AAATAG`	1	--	int¹		13	NS EA NA WA	986
rs1916036^1,2	C,F,A,	122742028(+)	`AGAAGC/GAAAAA`	2	A G	ref¹ mis¹		11	MN NS EA NA	1184
rs1916040^1,2	C,F,O,A,H,	122733817(+)	`TTCCAG/ATTTTT`	1	--	int¹		25	NS EA NA WA	1372
rs1916041^1,2	C,F,A,	122737705(+)	`TTTTCA/GTTTTA`	1	--	int¹		1	EA	88
rs1986554^1,2	C,	122725871(-)	`ggttcG/Aagacc`	1	--	int¹		1	WA	2
rs2140151^1,2	C,F,O,A,	122736853(+)	`TCTGCC/AGTCTC`	1	--	int¹		15	NS EA NA WA	782
rs2177194^1,2	C,F,O,	122711989(-)	`TTAATT/GCTCAA`	1	--	int¹		12	NS EA NA	1062
rs2177196^1,2	C,F,A,	122732872(+)	`acagaG/Tggatt`	1	--	int¹		9	NS EA NA WA	516

About this table

HapMap Linkage Disequilibrium images for CRTAM (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CRTAM: --

QIAGEN SeqTarget long-range PCR primers for resequencing CRTAM

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRTAM for disorders About GeneDecksing

OMIM: 612597

Export disorders and mutations for CRTAM gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

9 PubMed articles for CRTAM gene integrated from 7 sources:
(articles sorted by number of sources associating them with CRTAM)

Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PubMed id 16300832)^{1, 2, 3} Patino-Lopez G.... Zlotnik A. (2006)
A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PubMed id 10811014)^{1, 2, 3} Kennedy J.... Zlotnik A. (2000)
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)^{1, 2} Galibert L.... Yan W. (2005)
The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)^{1, 2} Boles K.S.... Colonna M. (2005)
Characterization of CRTAM gene promoter: AP-1 transcr iption factor control its expression in human T CD8 lymphocytes. (PubMed id 19695707)^{1, 7} Valle-Rios R....Ortiz-Navarrete V. (2009)
Regulation of a late phase of T cell polarity and effector functions by Crtam. (PubMed id 18329370)¹ Yeh J.H....Chan A.C. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56253	HGNC: 24313	AceView: CRTAM	Ensembl:ENSG00000109943	euGenes: HUgn56253
ECgene: CRTAM	H-InvDB: CRTAM

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for CRTAM gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for CRTAM gene:
Search GeneIP for patents involving CRTAM

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM
	SeqTarget long-range PCR primers for resequencing CRTAM
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM

	GenScript Custom Purified and Recombinant Proteins Services for CRTAM		GenScript cDNA clones with any tag delivered in your preferred vector for CRTAM
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	Regulatory tfbs in CRTAM promoter
	Search Chromatin IP Primers for CRTAM
	RT² qPCR Primer Assay for CRTAM
	GNC Network for CRTAM
	Assays for microRNAs that regulate CRTAM
	SABiosciences Custom PCR Arrays for CRTAM

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GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

CRTAM gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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CRTAM Gene

protein-coding GIFtS: 48

Aliases &
Descriptions
for CRTAM gene

Summaries
for CRTAM gene

Genomic Views
for CRTAM gene

Proteins
for CRTAM gene

Protein Domains/
Families
for CRTAM gene

Gene Function
for CRTAM gene

Pathways & Interactions
for CRTAM gene

Drugs & Compounds
for CRTAM gene

Transcripts
for CRTAM gene

Expression
for CRTAM gene

Orthologs
for CRTAM gene

Paralogs
for CRTAM gene

Genomic Variants
for CRTAM gene

Disorders & Mutations
for CRTAM gene

Medical News
for CRTAM gene

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for CRTAM gene

External Searches for CRTAM gene

Genome Databases showing CRTAM gene

Other Databases showing CRTAM gene

Specialized Databases showing CRTAM gene

Intellectual Property
for CRTAM gene

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for CRTAM gene

View Random Gene

Advanced Search

Export list of displayed genes

CRTAM Gene

protein-coding GIFtS: 48

Aliases & Descriptionsfor CRTAM gene

Summariesfor CRTAM gene

Genomic Viewsfor CRTAM gene

Proteinsfor CRTAM gene

Protein Domains/Familiesfor CRTAM gene

Gene Functionfor CRTAM gene

Pathways & Interactionsfor CRTAM gene

Drugs & Compoundsfor CRTAM gene

Transcriptsfor CRTAM gene

Expression for CRTAM gene

Orthologsfor CRTAM gene

Paralogsfor CRTAM gene

Genomic Variantsfor CRTAM gene

Disorders & Mutationsfor CRTAM gene

Medical Newsfor CRTAM gene

Publicationsfor CRTAM gene

External Searches for CRTAM gene

Genome Databases showing CRTAM gene

Other Databases showing CRTAM gene

Specialized Databases showing CRTAM gene

Intellectual Propertyfor CRTAM gene

Productsfor CRTAM gene

View Random Gene

Aliases &
Descriptions
for CRTAM gene

Summaries
for CRTAM gene

Genomic Views
for CRTAM gene

Proteins
for CRTAM gene

Protein Domains/
Families
for CRTAM gene

Gene Function
for CRTAM gene

Pathways & Interactions
for CRTAM gene

Drugs & Compounds
for CRTAM gene

Transcripts
for CRTAM gene

Expression
for CRTAM gene

Orthologs
for CRTAM gene

Paralogs
for CRTAM gene

Genomic Variants
for CRTAM gene

Disorders & Mutations
for CRTAM gene

Medical News
for CRTAM gene

Publications
for CRTAM gene

Intellectual Property
for CRTAM gene

Products
for CRTAM gene