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CRTAM Gene

protein-coding   GIFtS: 48

GC11P118652
cytotoxic and regulatory T cell molecule
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
cytotoxic and regulatory T cell molecule1 2
Class-I MHC-restricted T-cell-associated molecule2 3
cytotoxic and regulatory T-cell molecule2
class I MHC restricted T cell associated molecule2
class-I MHC-restricted T cell associated molecule2

External Ids:    HGNC: 243131   Entrez Gene: 562532   Ensembl: ENSG000001099437   UniProtKB: O957273   

Export aliases for CRTAM gene to outside databases

Previous GC identifers: GC11P124710 GC11P124222 GC11P122743 GC11P122246 GC11P122214


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRTAM:
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and
encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 (PubMed 18329370)).(supplied by
OMIM)

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRTAM gene promoter:
         c-Rel   NF-kappaB   NF-kappaB1   RelA   NF-kappaB2   RORalpha1   IRF-1   AML1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CRTAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

CRTAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRTAM gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118652:  view genomic region     (about GC identifiers)

Start:
118,652,105 bp from pter
End:
118,686,168 bp from pter
Size:
34,064 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 122,709,206-122,743,334     
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727 (See protein sequence)
Recommended Name: Cytotoxic and regulatory T-cell molecule precursor  
Size: 393 amino acids; 44641 Da
Subunit: Interacts with CADM1
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAD93067.1; Type=Erroneous initiation;
Secondary accessions: Q59EI1 Q6IRX2
Alternative splicing: 2 isoforms:  O95727-1   O95727-2   

Explore the universe of human proteins at neXtProt for CRTAM: NX_O95727 

REFSEQ proteins: NP_062550.2  

ENSEMBL proteins: 
ENSP00000227348 


Human Recombinant Proteins 
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OriGene Protein Over-expression Lysate: CRTAM
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Novus Biologicals Protein for CRTAM
Novus Biologicals Lysate for CRTAM
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Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS--
GO:0016021 integral to membrane IEA--
About this table

CRTAM for ontologies           About GeneDecksing



Antibodies for CRTAM: 
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Browse antibodies at Epitomics

Assays for CRTAM: 
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R&D Systems ELISAs for CRTAM
GenScript Custom Assay Services for CRTAM 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CRTAM 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CRTAM for domains           About GeneDecksing

5 InterPro domains/families:
 IPR007110 Ig-like
 IPR013162 CD80_C2-set
 IPR003599 Ig_sub
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry O95727

ProtoNet protein and cluster: O95727

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Similarity: Belongs to the nectin family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma)
secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRTAM
Sigma-Aldrich shRNA Panels and shRNA for CRTAM
OriGene 29mer shRNA kits in GFP-retroviral vector: CRTAM
OriGene shRNA RFP: CRTAM
OriGene basic RS shRNA: CRTAM
OriGene siRNA: CRTAM
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM 
miRNA:Sigma-Aldrich microRNA Mimics for CRTAM
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM 
6 SABiosciences Assays for microRNAs that regulate CRTAM:
hsa-miR-133a hsa-miR-539 hsa-miR-133b hsa-miR-33b hsa-miR-33a hsa-miR-504

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CRTAM
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CRTAM
OriGene untagged cDNA clones in CMV expression vector: CRTAM
OriGene 3'-UTR clone: CRTAM 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: CRTAM 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for CRTAM 

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005102 receptor binding IPI15811952
GO:0005515 protein binding ----
About this table

CRTAM for ontologies           About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Crtam):

hematopoietic systemimmune system

CRTAM for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for CRTAM 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CRTAM

1 Interacting protein for CRTAM (ENSP000002273483) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PVRL2ENSP000002524833STRING: ENSP00000252483
About this table

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

GO IDQualified GO termEvidencePubMed IDs
GO:0001913NOT T cell mediated cytotoxicity IDA15811952
GO:0002355 detection of tumor cell IDA15811952
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA15811952
GO:0008037 cell recognition IDA15811952
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA15811952
About this table

CRTAM for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CRTAM


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRTAM
Sigma-Aldrich shRNA Panels and shRNA for CRTAM
OriGene 29mer shRNA kits in GFP-retroviral vector: CRTAM
OriGene shRNA RFP: CRTAM
OriGene basic RS shRNA: CRTAM
OriGene siRNA: CRTAM
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM 
miRNA: Sigma-Aldrich microRNA Mimics for CRTAM
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM 
6 SABiosciences Assays for microRNAs that regulate CRTAM:
hsa-miR-133a hsa-miR-539 hsa-miR-133b hsa-miR-33b hsa-miR-33a hsa-miR-504
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CRTAM
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CRTAM
OriGene untagged cDNA clones in CMV expression vector: CRTAM
OriGene 3'-UTR Clone: CRTAM 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: CRTAM 
Primers: OriGene genome-wide validated SYBR primer pairs: CRTAM
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CRTAM: PPH13174A

REFSEQ mRNAs for CRTAM gene: 

NM_019604.2  

Additional cDNA sequence: 

AB209830.1 AF001622.1 AK293470.1 AK313578.1 BC070266.1 

2 DOTS entries:

DT.424789  DT.100764176 

24/26 AceView cDNA sequences (see all 26):

AA322525 BM919441 BX118379 CA309993 NM_019604 BF434560 AA322787 AW137831 
CD640439 BF445107 CD641796 BX488905 CD639624 CD365583 BC070266 AF001622 
BG058725 BX488047 AI693616 CK004240 BG205621 BG231751 CD640427 CD642037 

highest scoring ESTs for CRTAM:

AF001622 AI693616 AW137831 BC070266 BF434560 BF445107 BG058725 BG205621 BG231751 BX118379 

Unigene Cluster for CRTAM:

Cytotoxic and regulatory T cell molecule
Hs.159523  [show with all ESTs]
Unigene Representative Sequence: BC070266


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000227348(uc001pyj.2 uc001pyk.2)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CRTAM expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching CRTAM gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
36389_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF001622 1.00 1.00 1.00 1
206914_at2, 3 U133-A 1 0.73 1.00 -- -- NM_019604 0.60 1.00 0.82 1
206914_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table

CRTAM for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CRTAM gene expression
CRTAM gene electronic northern expression
CRTAM gene sage expression
About these images

CGAP SAGE TAG: CCTTTCTTTT

SOURCE GeneReport for Unigene cluster: Hs.159523

Expression variation in blood from EXPOLDB for CRTAM

UniProtKB/Swiss-Prot: CRTAM_HUMAN, O95727
Tissue specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including
NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje
neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues

Primers: OriGene genome-wide validated SYBR primer pairs: CRTAM
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CRTAM: PPH13174A
    SABiosciences Custom PCR Arrays for CRTAM 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CRTAM gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
CRTAM1   -- cytotoxic and regulatory T cell molecule 83.63(n)
76.74(a)
610296  XM_847764.1  XP_852857.1 
chimpanzee
(Pan troglodytes)
CRTAM1   -- cytotoxic and regulatory T cell molecule 99.07(n)
98.98(a)
736196  XM_001136009.1  XP_001136009.1 
cow
(Bos taurus)
CRTAM1   -- cytotoxic and regulatory T cell molecule 81.87(n)
75(a)
781864  XM_001250376.1  XP_001250377.1 
rat
(Rattus norvegicus)
Crtam1   -- cytotoxic and regulatory T cell molecule 77.99(n)
71.74(a)
300649  XM_236103.4  XP_236103.4 
mouse
(Mus musculus)
Crtam1 , 5 9 (21.79 cM)5
cytotoxic and regulatory T cell molecule1, 5 77.63(n)1
72.54(a)1
546981  NM_019465.21  NP_062338.21 
 AF0011045  AK0057195  (see all 8)
About this table        Species with no ortholog for CRTAM

ENSEMBL Gene Tree for CRTAM (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/434 NCBI SNPs in CRTAM are shown (see all 434)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs18798821,2
C,F,O,122718690(+) GCAGCA/TGAGAG 1 -- int19Minor allele frequency- T:0.14MN NS EA NA 830
rs18798831,2
C,F,O,A,H,122710641(-) CCTTAC/TTAAGT 1 -- int113Minor allele frequency- N:0.00NS EA NA WA 842
rs18798841,2
C,F,A,H,122710561(-) ATGTAC/AAATAG 1 -- int113Minor allele frequency- A:0.49NS EA NA WA 986
rs19160361,2
C,F,A,122742028(+) AGAAGC/GAAAAA 2 A G ref1 mis111Minor allele frequency- G:0.12MN NS EA NA 1184
rs19160401,2
C,F,O,A,H,122733817(+) TTCCAG/ATTTTT 1 -- int125Minor allele frequency- A:0.31NS EA NA WA 1372
rs19160411,2
C,F,A,122737705(+) TTTTCA/GTTTTA 1 -- int11Minor allele frequency- G:0.28EA 88
rs19865541,2
C,122725871(-) ggttcG/Aagacc 1 -- int11Minor allele frequency- A:0.50WA 2
rs21401511,2
C,F,O,A,122736853(+) TCTGCC/AGTCTC 1 -- int115Minor allele frequency- A:0.49NS EA NA WA 782
rs21771941,2
C,F,O,122711989(-) TTAATT/GCTCAA 1 -- int112Minor allele frequency- G:0.15NS EA NA 1062
rs21771961,2
C,F,A,122732872(+) acagaG/Tggatt 1 -- int19Minor allele frequency- T:0.10NS EA NA WA 516
About this table

HapMap Linkage Disequilibrium images for CRTAM (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CRTAM: --

QIAGEN SeqTarget long-range PCR primers for resequencing CRTAM 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CRTAM for disorders           About GeneDecksing

OMIM: 612597


Export disorders and mutations for CRTAM gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

9 PubMed articles for CRTAM gene integrated from 7 sources:
(articles sorted by number of sources associating them with CRTAM)
  1. Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PubMed id 16300832)1, 2, 3 Patino-Lopez G.... Zlotnik A. (2006)
  2. A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PubMed id 10811014)1, 2, 3 Kennedy J.... Zlotnik A. (2000)
  3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. (PubMed id 15781451)1, 2 Galibert L.... Yan W. (2005)
  4. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PubMed id 15811952)1, 2 Boles K.S.... Colonna M. (2005)
  5. Characterization of CRTAM gene promoter: AP-1 transcr iption factor control its expression in human T CD8 lymphocytes. (PubMed id 19695707)1, 7 Valle-Rios R....Ortiz-Navarrete V. (2009)
  6. Regulation of a late phase of T cell polarity and effector functions by Crtam. (PubMed id 18329370)1 Yeh J.H....Chan A.C. (2008)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 56253 HGNC: 24313 AceView: CRTAM Ensembl:ENSG00000109943 euGenes: HUgn56253
ECgene: CRTAM H-InvDB: CRTAM

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CRTAM gene:
Search GeneIP for patents involving CRTAM

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services

 Predesigned and custom siRNAs for CRTAM Browse antibodies at Sigma-Aldrich
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 3' UTR Clones for miRNA Target Studies
 miRNA Expression Plasmids

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRTAM
 SeqTarget long-range PCR primers for resequencing CRTAM
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRTAM
 GenScript Custom Purified and Recombinant Proteins Services for CRTAM GenScript cDNA clones with any tag delivered in your preferred vector for CRTAM
 GenScript Custom Assay Services for CRTAM GenScript Custom Superior Antibodies Services for CRTAM
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 Regulatory tfbs in CRTAM promoter
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 GNC Network for CRTAM
 Assays for microRNAs that regulate CRTAM
 SABiosciences Custom PCR Arrays for CRTAM
 Search Tocris compounds for CRTAM
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological cDNA Clones
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 Antibodies for CRTAM
 Proteins for CRTAM
 Lysates for CRTAM
 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 ELISAs and CLIAs for CRTAM
       

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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