Aliases &
Descriptions
for CRYZ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| crystallin, zeta (quinone reductase)1 2 | | OTTHUMP000000112112 | | NADPH:quinone reductase2 3 | | OTTHUMP000000112122 | | DKFZp779E08342 | | FLJ414752 | | quinone oxidoreductase2 | | Zeta-crystallin3 | | zeta-crystallin2 | | EC 1.6.5.53 |
Export aliases for CRYZ gene to outside databasesPrevious GC identifers: GC01M075290 GC01M074149 GC01M074533 GC01M074541 GC01M074883 GC01M074943 GC01M075171 |
Summaries
for CRYZ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CRYZ:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes themajor proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The formerclass is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin proteinwhich has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcoholdehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenasefamily. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene. One pseudogene is known to exist. (provided by RefSeq)
UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act inthe detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding
Gene Wiki entry for CRYZ |
Genomic Views
for CRYZ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CRYZ gene promoter:
RP58 RFX1 HNF-1A CREB deltaCREB FOXO4 POU2F2C POU2F2B POU2F2 (Oct-2.1) POU2F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CRYZ
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31-p22 Ensembl cytogenetic band: 1p31.1 HGNC cytogenetic band: 1p31-p22CRYZ Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M073305: view genomic region
(about GC identifiers)
Start:
|
73,305,573 bp from pter |
End:
|
73,333,498 bp from pter |
Size:
|
27,926 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr1- 75,171,170-75,199,092 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for CRYZ gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257 (See
protein sequence)Recommended Name: Quinone oxidoreductase Size: 329 amino acids; 35207 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :1YB5 (3D)
Secondary accessions: Q53FT0 Q59EU7 Q6NSK9Explore the universe of human proteins at neXtProt for CRYZ: NX_Q08257
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001123514.1 NP_001123515.1 NP_001128231.1 NP_001880.2
ENSEMBL proteins: ENSP00000339399 ENSP00000359909 ENSP00000378494 ENSP00000404289 ENSP00000359907 ENSP00000399805 ENSP00000359908
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CRYZ for ontologies About GeneDecksing
Antibodies for CRYZ:
Assays for CRYZ: |
Protein
Domains/
Families
for CRYZ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CRYZ for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q08257ProtoNet protein and cluster: Q08257 2 Blocks protein families: IPB002364 Quinone oxidoreductase/zeta-crystallin IPB013154 Alcohol dehydrogenase GroES-like
UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily |
Gene Function
for CRYZ gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act inthe detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA bindingCatalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinoneEnzyme Number (IUBMB): EC 1.6.5.5
Genatlas biochemistry entry for CRYZ:crystallin,zeta polypeptide (quinone reductase)5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8): About this table
CRYZ for ontologies About GeneDecksing
|
Pathways & Interactions
for CRYZ gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CRYZ
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYZ
5/21 Interacting proteins for CRYZ (ENSP000003393993) via UniProtKB, MINT, and/or STRING (see all 21)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
CRYZ for ontologies About GeneDecksing
|
Drugs & Compounds
for CRYZ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CRYZ for compounds About GeneDecksing
 Browse Tocris compounds for CRYZ
2 PharmGKB drug compound relationships for CRYZ geneAbout this table
|
Transcripts
for CRYZ gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CRYZ gene (4 alternative transcripts): NM_001130042.1 NM_001130043.1 NM_001134759.1 NM_001889.3 Additional cDNA sequence: AB209714.1 AK123469.1 AK128794.1 AK223150.1 AK223201.1 AK314813.1 BC039578.1 BC070058.1 BX647883.1 BX649061.1 CR594192.1 CR595439.1 CR614503.1 CR620400.1 L13278.1 21 DOTS entries: DT.317064 DT.91958776 DT.451787 DT.40197655 DT.100795962 DT.121406059 DT.100795957 DT.121406041 DT.91760330 DT.100809052 DT.121406021 DT.121406038 DT.121406042 DT.121406070 DT.91760318 DT.91760321 DT.91760322 DT.91760323 DT.95170655 DT.95170662 DT.97813930 24/243 AceView cDNA sequences (see all 243): BM315099 BC039578 AW013953 BP362209 BQ772916 BE336715 CA446797 BX097794 BX445370 T28683 CA445304 CA430131 BG391747 BQ225733 BM315014 AA035180 CR594192 BM314808 AI978806 CA395829 BQ011562 AA948647 CR614503 CR620400
 highest scoring ESTs for CRYZ:AU100059 BM752407 AA442104 AK128794 AL535974 AU137029 AV645524 AV645598 AV655112 AV683636 Unigene Cluster for CRYZ: Crystallin, zeta (quinone reductase) Hs.83114 [show with all ESTs]Unigene Representative Sequence: BX649061
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ (see all 13)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CRYZ
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340866 ENST00000370872 ENST00000395054 ENST00000441120 ENST00000370870
ENST00000417775(uc001dgk.2 uc001dgj.2 uc001dgl.2 uc001dgm.2)
ENST00000370871 ENST00000492102
|
Expression
for CRYZ gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CRYZ expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CRYZ gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 37902_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
L13278 |
0.80 |
0.80 |
0.80 |
1 |
| 202950_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_001889 |
0.60 |
1.00 |
0.82 |
1 |
| 202950_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CRYZ for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACTGTATTGG
SOURCE GeneReport for Unigene cluster: Hs.83114
Expression variation in blood from EXPOLDB for CRYZ UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257Tissue specificity: Only very low amounts in the lens
SABiosciences Custom PCR Arrays for CRYZ
|
Orthologs
for CRYZ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CRYZ gene from 5/12 species (see all 12)
About this table Species with no ortholog for CRYZ
ENSEMBL Gene Tree for CRYZ (if available) |
Paralogs
for CRYZ gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CRYZ gene
- VAT12 ZADH22 VAT1L2 TP53I32
CRYZ for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for CRYZ gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CRYZ (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CRYZ
1 Indel: 68852 | | QIAGEN SeqTarget long-range PCR primers for resequencing CRYZ |
|
Disorders & Mutations
for CRYZ gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CRYZ for disorders About GeneDecksing
OMIM: 123691
1 PharmGKB disease relationship for CRYZ geneAbout this table
Genetic Association Database (GAD): CRYZ
Human Genome Epidemiology (HuGE) Navigator: CRYZ (1 document)
Export disorders and mutations for CRYZ gene to outside databases
|
Medical News
for CRYZ gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CRYZ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/20 PubMed articles for CRYZ gene, integrated from 7 sources (see all 20):
(articles sorted by number of sources associating them with CRYZ)- Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PubMed id 8088825)1, 2, 7 Gonzalez P.... Zigler J.S. Jr. (1994)
- {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PubMed id 20103721)1, 2 Lapucci A.... Capaccioli S. (2010)
- Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1, 2 Fernandez M.R.... Pares X. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease] (PubMed id 11295131)1, 4 Shao M....Chen B. (2001)
- Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. (PubMed id 8466529)1, 2 Gonzalez P.... Zigler J.S. Jr. (1993)
- Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. (PubMed id 7835889)1, 7 Heinzmann C....Bateman J.B. (1994)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CRYZ gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CRYZ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CRYZ gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CRYZ gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CRYZ gene:
Search GeneIP for patents involving CRYZ
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CRYZ gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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