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CRYZ Gene

protein-coding   GIFtS: 60

GC01M073305
crystallin, zeta (quinone reductase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
crystallin, zeta (quinone reductase)1 2     OTTHUMP000000112112
NADPH:quinone reductase2 3     OTTHUMP000000112122
DKFZp779E08342     FLJ414752
quinone oxidoreductase2     Zeta-crystallin3
zeta-crystallin2     EC 1.6.5.53

External Ids:    HGNC: 24191   Entrez Gene: 14292   Ensembl: ENSG000001167917   UniProtKB: Q082573   

Export aliases for CRYZ gene to outside databases

Previous GC identifers: GC01M075290 GC01M074149 GC01M074533 GC01M074541 GC01M074883 GC01M074943 GC01M075171


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CRYZ:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the
major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former
class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein
which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol
dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase
family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. One pseudogene is known to exist. (provided by RefSeq)

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.
Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in
the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.
Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding

Gene Wiki entry for CRYZ

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CRYZ gene promoter:
         RP58   RFX1   HNF-1A   CREB   deltaCREB   FOXO4   POU2F2C   POU2F2B   POU2F2 (Oct-2.1)   POU2F2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CRYZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31-p22   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31-p22

CRYZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CRYZ gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M073305:  view genomic region     (about GC identifiers)

Start:
73,305,573 bp from pter
End:
73,333,498 bp from pter
Size:
27,926 bases
Orientation:
minus strand

1 alternative location:
Chr1- 75,171,170-75,199,092     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257 (See protein sequence)
Recommended Name: Quinone oxidoreductase  
Size: 329 amino acids; 35207 Da
Subunit: Homotetramer
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1YB5 (3D)    
Secondary accessions: Q53FT0 Q59EU7 Q6NSK9

Explore the universe of human proteins at neXtProt for CRYZ: NX_Q08257 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001123514.1  NP_001123515.1  NP_001128231.1  NP_001880.2  


    ENSEMBL proteins: 
    ENSP00000339399 ENSP00000359909 ENSP00000378494 ENSP00000404289 ENSP00000359907 ENSP00000399805 
    ENSP00000359908 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for CRYZ 
    Novus Biologicals Proteins for CRYZ
    Novus Biologicals Lysate for CRYZ
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625 soluble fraction IEA--
    GO:0005737 cytoplasm IDA18029348
    GO:0005794 Golgi apparatus IDA18029348
    GO:0005829 cytosol IDA17497241
    GO:0043231 intracellular membrane-bounded organelle IDA18029348
    About this table

    CRYZ for ontologies           About GeneDecksing



    Antibodies for CRYZ: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CRYZ
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CRYZ 
    Novus Biologicals Antibodies for CRYZ
    Browse antibodies at Epitomics

    Assays for CRYZ: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CRYZ 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CRYZ for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013149 ADH_C
     IPR011032 GroES-like
     IPR016040 NAD(P)-bd_dom
     IPR013154 ADH_GroES-like
     IPR002364 Quin_OxRdtase/zeta-crystal_CS

    Graphical View of Domain Structure for InterPro Entry Q08257

    ProtoNet protein and cluster: Q08257

    2 Blocks protein families:
    IPB002364 Quinone oxidoreductase/zeta-crystallin
    IPB013154 Alcohol dehydrogenase GroES-like


    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process.
    Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in
    the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species.
    Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding
    Catalytic activity: NADPH + 2 quinone = NADP(+) + 2 semiquinone
    Enzyme Number (IUBMB): EC 1.6.5.5 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRYZ
    Sigma-Aldrich shRNA for CRYZ
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): CRYZ
    OriGene shRNA RFP (see all 4): CRYZ
    OriGene basic RS shRNA (see all 4): CRYZ
    OriGene siRNA (see all 4): CRYZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRYZ 
    miRNA:Sigma-Aldrich microRNA Mimics for CRYZ
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRYZ 
    Search SABiosciences for Assays for microRNAs that regulate CRYZ

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CRYZ
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CRYZ
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CRYZ
    OriGene 3'-UTR clone (see all 4): CRYZ 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CRYZ 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CRYZ 

    Genatlas biochemistry entry for CRYZ:
    crystallin,zeta polypeptide (quinone reductase)

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0003730 mRNA 3'-UTR binding IDA17497241
    GO:0003960 NADPH:quinone reductase activity IDA17497241
    GO:0005488 binding IEA--
    GO:0008270 zinc ion binding IEA--
    About this table

    CRYZ for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for CRYZ 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CRYZ

    5/21 Interacting proteins for CRYZ (ENSP000003393993) via UniProtKB, MINT, and/or STRING (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKR7A2ENSP000002358353STRING: ENSP00000235835
    FOSENSP000003062453STRING: ENSP00000306245
    FXYD2ENSP000003145283STRING: ENSP00000314528
    HMOX1ENSP000002161173STRING: ENSP00000216117
    HMOX2ENSP000002197003STRING: ENSP00000219700
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601 visual perception TAS7835889
    GO:0042178 xenobiotic catabolic process IDA17497241
    GO:0051289 protein homotetramerization IPI17497241
    GO:0055114 oxidation-reduction process IEA--
    About this table

    CRYZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CRYZ for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CRYZ
    2 PharmGKB drug compound relationships for CRYZ gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurinePD  FA  GN  12704389
    methotrexatePD  FA  GN  12704389
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CRYZ
    Sigma-Aldrich shRNA for CRYZ
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): CRYZ
    OriGene shRNA RFP (see all 4): CRYZ
    OriGene basic RS shRNA (see all 4): CRYZ
    OriGene siRNA (see all 4): CRYZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CRYZ 
    miRNA: Sigma-Aldrich microRNA Mimics for CRYZ
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CRYZ 
    Search SABiosciences for Assays for microRNAs that regulate CRYZ
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CRYZ
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): CRYZ
    OriGene untagged cDNA clones in CMV expression vector (see all 3): CRYZ
    OriGene 3'-UTR Clone (see all 4): CRYZ 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CRYZ 
    Primers: OriGene genome-wide validated SYBR primer pairs: CRYZ
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CRYZ: PPH01733A

    REFSEQ mRNAs for CRYZ gene (4 alternative transcripts): 

    NM_001130042.1  NM_001130043.1  NM_001134759.1  NM_001889.3  

    Additional cDNA sequence: 

    AB209714.1 AK123469.1 AK128794.1 AK223150.1 AK223201.1 AK314813.1 BC039578.1 BC070058.1 
    BX647883.1 BX649061.1 CR594192.1 CR595439.1 CR614503.1 CR620400.1 L13278.1 

    21 DOTS entries:

    DT.317064  DT.91958776  DT.451787  DT.40197655  DT.100795962  DT.121406059  DT.100795957  DT.121406041 
    DT.91760330  DT.100809052  DT.121406021  DT.121406038  DT.121406042  DT.121406070  DT.91760318  DT.91760321 
    DT.91760322  DT.91760323  DT.95170655  DT.95170662  DT.97813930 

    24/243 AceView cDNA sequences (see all 243):

    BM315099 BC039578 AW013953 BP362209 BQ772916 BE336715 CA446797 BX097794 
    BX445370 T28683 CA445304 CA430131 BG391747 BQ225733 BM315014 AA035180 
    CR594192 BM314808 AI978806 CA395829 BQ011562 AA948647 CR614503 CR620400 

    highest scoring ESTs for CRYZ:

    AU100059 BM752407 AA442104 AK128794 AL535974 AU137029 AV645524 AV645598 AV655112 AV683636 

    Unigene Cluster for CRYZ:

    Crystallin, zeta (quinone reductase)
    Hs.83114  [show with all ESTs]
    Unigene Representative Sequence: BX649061


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CRYZ (see all 13)

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                    -     -     -     -     -                                                                 -                                 
    SP2:                                      -     -                                                                 -                                 
    SP3:                    -     -     -     -     -                                                           -     -                                 
    SP4:                                      -     -                             -     -                                                               
    SP5:                    -     -     -     -     -     -     -                 -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for CRYZ
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340866 ENST00000370872 ENST00000395054 ENST00000441120 ENST00000370870
    ENST00000417775(uc001dgk.2 uc001dgj.2 uc001dgl.2 uc001dgm.2)
    ENST00000370871 ENST00000492102

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CRYZ expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching CRYZ gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37902_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 L13278 0.80 0.80 0.80 1
    202950_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001889 0.60 1.00 0.82 1
    202950_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    CRYZ for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CRYZ gene expression
    CRYZ gene electronic northern expression
    CRYZ gene sage expression
    About these images

    CGAP SAGE TAG: ACTGTATTGG

    SOURCE GeneReport for Unigene cluster: Hs.83114

    Expression variation in blood from EXPOLDB for CRYZ

    UniProtKB/Swiss-Prot: QOR_HUMAN, Q08257
    Tissue specificity: Only very low amounts in the lens

    Primers: OriGene genome-wide validated SYBR primer pairs: CRYZ
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CRYZ: PPH01733A
        SABiosciences Custom PCR Arrays for CRYZ 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CRYZ gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6114311   -- similar to crystallin, zeta 86.32(n)
    86.63(a)
    611431  XM_848704.1  XP_853797.1 
    chimpanzee
    (Pan troglodytes)
    CRYZ1   -- crystallin, zeta (quinone reductase) 98.38(n)
    99.09(a)
    456952  XM_001167460.1  XP_001167460.1 
    cow
    (Bos taurus)
    CRYZ1   -- crystallin, zeta (quinone reductase) 88.35(n)
    87.54(a)
    281093  NM_174025.3  NP_776450.2 
    rat
    (Rattus norvegicus)
    Cryz1   -- crystallin, zeta 78.12(n)
    80.85(a)
    362061  NM_001012183.1  NP_001012183.1 
    mouse
    (Mus musculus)
    Cryz1 , 5 3 (79.25 cM)5
    crystallin, zeta1, 5 79.03(n)1
    81.16(a)1
    129721  NM_009968.11  NP_034098.11 
     AI3235545  AK0903885  (see all 19)
    About this table        Species with no ortholog for CRYZ

    ENSEMBL Gene Tree for CRYZ (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CRYZ gene
    VAT12  ZADH22  VAT1L2  TP53I32  

    CRYZ for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/267 NCBI SNPs in CRYZ are shown (see all 267)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs66731,2
    C,F,A,H,75171211(-) TGTCTC/G/TGTAAC 2 -- ut31 ese38EA NA MN 1210
    rs174591,2
    C,F,A,75171751(+) ACATGC/TTATTT 2 -- ut3115Minor allele frequency- T:0.30MN NA NS EA WA 942
    rs1906841,2
    --75192326(+) acttaA/Ggcaag 2 -- int10--------
    rs2773821,2
    C,75192253(+) aaaggT/Cctctg 2 -- int17Minor allele frequency- C:0.00NA WA 14
    rs2773831,2
    C,75192845(+) catttT/Gcaggt 2 -- int12Minor allele frequency- G:0.00NA WA 4
    rs2774011,2
    C,75189770(+) GAAGTC/ATTAAG 2 -- int17Minor allele frequency- A:0.00NA WA 14
    rs2774021,2
    C,A,75188321(+) atCCTG/AAGCAT 2 -- int15Minor allele frequency- A:0.15NA EA WA 214
    rs2774031,2
    C,75186806(+) TGCCAC/TGAAAT 2 -- int17Minor allele frequency- T:0.00NA WA 16
    rs4193681,2
    --75193127(-) gtaaaA/Gatggg 2 -- int10--------
    rs4436391,2
    --75193129(-) tagtaA/Gaaatg 2 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for CRYZ (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CRYZ
         1 Indel: 68852

    QIAGEN SeqTarget long-range PCR primers for resequencing CRYZ 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CRYZ for disorders           About GeneDecksing

    OMIM: 123691

    1 PharmGKB disease relationship for CRYZ gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    About this table

    Genetic Association Database (GAD): CRYZ
    Human Genome Epidemiology (HuGE) Navigator: CRYZ (1 document)

    Export disorders and mutations for CRYZ gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for CRYZ gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with CRYZ)
    1. Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). (PubMed id 8088825)1, 2, 7 Gonzalez P.... Zigler J.S. Jr. (1994)
    2. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PubMed id 20103721)1, 2 Lapucci A.... Capaccioli S. (2010)
    3. Human and yeast zeta-crystallins bind AU-rich elements in RNA. (PubMed id 17497241)1, 2 Fernandez M.R.... Pares X. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase gene in Parkinson's disease] (PubMed id 11295131)1, 4 Shao M....Chen B. (2001)
    6. Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. (PubMed id 8466529)1, 2 Gonzalez P.... Zigler J.S. Jr. (1993)
    7. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. (PubMed id 7835889)1, 7 Heinzmann C....Bateman J.B. (1994)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1429 HGNC: 2419 AceView: CRYZ Ensembl:ENSG00000116791 euGenes: HUgn1429
    ECgene: CRYZ H-InvDB: CRYZ

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for CRYZ gene:
    Search GeneIP for patents involving CRYZ

    GeneCards and IP:
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