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CSH1 Gene

protein-coding GIFtS: 60

GC17M057339

chorionic somatomammotropin hormone 1 (placental lactogen)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
chorionic somatomammotropin hormone 1 (placental lactogen)¹ ²		chorionic somatomammotropin hormone²
PL¹ ² ³ ⁵		CS-1²
CSA¹ ² ⁵		chorionic somatomammotropin A²
CSMT¹ ²		lactogen²
hCS-A¹ ²		choriomammotropin²
FLJ75407¹ ²		Lactogen³
Placental lactogen² ³		Choriomammotropin³
CSH2²

External Ids:	HGNC: 2440¹	Entrez Gene: 1442²	Ensembl: ENSG00000136488⁷	UniProtKB: P01243³

Export aliases for CSH1 gene to outside databases

Previous GC identifers: GC17U990017 GC17M064398 GC17M062291 GC17M062422 GC17M062445 GC17M059326 GC17M059307 GC17M061972

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CSH1:

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important

role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related

genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene

duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed

selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth

hormones, leading to further diversity and potential for specialization. This particular family member is expressed

mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature

proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1

to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome.

(provided by RefSeq)

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243

Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does

not interact with GHR but only activates PRLR through zinc-induced dimerization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CSH1 gene promoter:
         CUTL1   SREBP-1a   SREBP-1b   SREBP-1c   STAT5B   PPAR-gamma1   PPAR-gamma2   FOXF2   POU3F2   POU3F2 (N-Oct-5b)
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CSH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q22-q24

CSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CSH1 gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M057339: view genomic region (about GC identifiers)

Start:	57,339,949 bp from pter
End:	57,341,663 bp from pter
Size:	1,715 bases
Orientation:	minus strand

1 alternative location:

Chr17- 61,972,273-61,974,013

RefSeq DNA sequence:

NC_000017.10 NT_010783.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243 (See protein sequence)

Recommended Name: Chorionic somatomammotropin hormone precursor

Size: 217 amino acids; 25020 Da

Subcellular location: Secreted

Miscellaneous: The sequence of CSH1 is shown

PDB structures from and Proteopedia :

1Z7C (3D)

Secondary accessions: Q0VDB1 Q14407

Explore the universe of human proteins at neXtProt for CSH1: NX_P01243

REFSEQ proteins (3 alternative transcripts):

NP_001308.1 NP_072166.1 NP_072167.1

ENSEMBL proteins:

ENSP00000402517 ENSP00000259003 ENSP00000333268 ENSP00000316416

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CSH1
	R&D Systems Recombinant & Natural Proteins for CSH1 (Placental Lactogen/CSH1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): CSH1
	GenScript Custom Purified and Recombinant Proteins Services for CSH1
	Novus Biologicals Proteins for CSH1
	Novus Biologicals Lysate for CSH1
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CSH1

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

About this table

CSH1 for ontologies About GeneDecksing

Antibodies for CSH1:

	Millipore Mono- and Polyclonal Antibodies for the study of CSH1
	Sigma-Aldrich Antibodies for CSH1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CSH1
	Novus Biologicals Antibodies for CSH1
	Browse antibodies at Epitomics

Assays for CSH1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CSH1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CSH1 for domains About GeneDecksing

4 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR018116 Somatotropin_CS

IPR012351 4_helix_cytokine_core

IPR001400 Somatotropin

Graphical View of Domain Structure for InterPro Entry P01243

ProtoNet protein and cluster: P01243

1 Blocks protein family: IPB001400 Somatotropin hormone

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243

Similarity: Belongs to the somatotropin/prolactin family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CSH_HUMAN, P01243

Function: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does

not interact with GHR but only activates PRLR through zinc-induced dimerization

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CSH1 Sigma-Aldrich shRNA for CSH1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): CSH1 OriGene shRNA RFP (see all 4): CSH1 OriGene basic RS shRNA (see all 4): CSH1 OriGene siRNA (see all 4): CSH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CSH1

miRNA:		Sigma-Aldrich microRNA Mimics for CSH1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CSH1
		Search SABiosciences for Assays for microRNAs that regulate CSH1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene untagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene 3'-UTR clone (see all 3): CSH1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): CSH1
		Sino Biological Human cDNA Clone for CSH1

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CSH1

Genatlas biochemistry entry for CSH1:

chorionic somatomammotropin hormone 1 (see GH@)

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

CSH1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CSH1 for pathways About GeneDecksing

1 Millipore Pathway for CSH1

Development Prolactin receptor signaling

2 Kegg Pathways (Kegg details for CSH1):

	hsa04080 Neuroactive ligand-receptor interaction
	hsa04630 Jak-STAT signaling pathway

SABiosciences Custom Pathway-Focused PCR Arrays for CSH1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CSH1

4 Interacting proteins for CSH1 (P01243²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN12	Q05209²	MINT-61776
SMAD2	Q15796²	MINT-60918
SMAD4	Q13485²	MINT-61946
SMAD9	O15198²	MINT-62064

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	1378436
GO:0007565	female pregnancy	TAS	1378436

About this table

CSH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CSH1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CSH1 Sigma-Aldrich shRNA for CSH1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): CSH1 OriGene shRNA RFP (see all 4): CSH1 OriGene basic RS shRNA (see all 4): CSH1 OriGene siRNA (see all 4): CSH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CSH1

miRNA:		Sigma-Aldrich microRNA Mimics for CSH1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CSH1
		Search SABiosciences for Assays for microRNAs that regulate CSH1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene untagged cDNA clones in CMV expression vector (see all 3): CSH1 OriGene 3'-UTR Clone (see all 3): CSH1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): CSH1

Primers:		OriGene genome-wide validated SYBR primer pairs: CSH1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for CSH1

REFSEQ mRNAs for CSH1 gene (3 alternative transcripts):

NM_001317.3 NM_022640.2 NM_022641.2

Additional cDNA sequence:

AK291587.1 BC002717.2 BC005921.1 BC020756.1 BC057768.1 BC062775.1 BT006926.1 CR589999.1

CR590057.1 CR590060.1 CR590382.1 CR590494.1 CR590503.1 CR590588.1 CR590632.1 CR590715.1

CR590740.1 CR590802.1 CR590972.1 CR591160.1 CR591321.1 CR591340.1 CR591417.1 CR591525.1

CR591705.1 CR591739.1 CR592017.1 CR592104.1 CR592334.1 CR592481.1 CR592486.1 CR592502.1

CR592728.1 CR592879.1 CR592885.1 CR592981.1 CR592996.1 CR593277.1 CR593393.1 CR593413.1

CR593469.1 CR593660.1 CR593959.1 CR594027.1 CR594159.1 CR594237.1 CR594291.1 CR594302.1

CR594342.1 CR594377.1 CR594515.1 CR594577.1 CR594619.1 CR594776.1 CR594778.1 CR594835.1

CR594864.1 CR594905.1 CR595279.1 CR595296.1 CR595351.1 CR595662.1 CR595678.1 CR595713.1

CR595921.1 CR596026.1 CR596027.1 CR596250.1 CR596365.1 CR596447.1 CR596504.1 CR596539.1

CR596602.1 CR596625.1 CR596910.1 CR596940.1 CR597231.1 CR597430.1 CR597599.1 CR597646.1

CR597749.1 CR597767.1 CR598212.1 CR598220.1 CR598246.1 CR598293.1 CR598407.1 CR598419.1

CR598457.1 CR598505.1 CR598579.1 CR598783.1 CR598863.1 CR598937.1 CR599098.1 CR599161.1

CR599408.1 CR599528.1 CR599531.1 CR599591.1 CR599639.1 CR599883.1 CR599897.1 CR599911.1

CR600155.1 CR600410.1 CR600413.1 CR600635.1 CR600641.1 CR600736.1 CR600909.1 CR601031.1

CR601066.1 CR601165.1 CR601307.1 CR601342.1 CR601370.1 CR601491.1 CR601644.1 CR601677.1

CR602006.1 CR602268.1 CR602514.1 CR602518.1 CR602672.1 CR602737.1 CR602849.1 CR602888.1

CR603173.1 CR603324.1 CR603406.1 CR603528.1 CR603719.1 CR603759.1 CR603809.1 CR603820.1

CR603907.1 CR604049.1 CR604195.1 CR604276.1 CR604462.1 CR604805.1 CR604889.1 CR604939.1

CR604979.1 CR605026.1 CR605118.1 CR605365.1 CR605382.1 CR605508.1 CR605609.1 CR605692.1

CR605776.1 CR605778.1 CR605784.1 CR606041.1 CR606093.1 CR606289.1 CR606291.1 CR606466.1

CR606591.1 CR606598.1 CR606712.1 CR606743.1 CR606840.1 CR606854.1 CR606994.1 CR607050.1

CR607091.1 CR607149.1 CR607428.1 CR607493.1 CR607531.1 CR607572.1 CR607763.1 CR607823.1

CR607891.1 CR607961.1 CR608146.1 CR608401.1 CR608457.1 CR608724.1 CR608744.1 CR608751.1

CR609023.1 CR609208.1 CR609245.1 CR609286.1 CR609350.1 CR609419.1 CR609620.1 CR609656.1

CR609696.1 CR610209.1 CR610224.1 CR610286.1 CR610355.1 CR610435.1 CR610446.1 CR610498.1

CR610642.1 CR610745.1 CR610814.1 CR610828.1 CR610932.1 CR610940.1 CR611027.1 CR611038.1

CR611412.1 CR611453.1 CR611498.1 CR611505.1 CR611694.1 CR611962.1 CR612166.1 CR612322.1

CR612383.1 CR612411.1 CR612449.1 CR612546.1 CR613125.1 CR613313.1 CR613375.1 CR613416.1

CR613452.1 CR613646.1 CR613660.1 CR613696.1 CR613721.1 CR613771.1 CR614095.1 CR614101.1

CR614158.1 CR614306.1 CR614423.1 CR614693.1 CR614793.1 CR614858.1 CR615097.1 CR615133.1

CR615316.1 CR615426.1 CR615728.1 CR615810.1 CR615867.1 CR615975.1 CR615978.1 CR616170.1

CR616422.1 CR616436.1 CR616611.1 CR616660.1 CR616752.1 CR616833.1 CR616852.1 CR617071.1

CR617072.1 CR617110.1 CR617241.1 CR617268.1 CR617369.1 CR617479.1 CR617499.1 CR617529.1

CR617668.1 CR617983.1 CR618004.1 CR618078.1 CR618132.1 CR618200.1 CR618470.1 CR618593.1

CR618653.1 CR618703.1 CR618773.1 CR618794.1 CR618933.1 CR618986.1 CR618992.1 CR619044.1

CR619094.1 CR619097.1 CR619103.1 CR619105.1 CR619286.1 CR619316.1 CR619357.1 CR619425.1

CR619564.1 CR619594.1 CR619645.1 CR619648.1 CR619674.1 CR619799.1 CR619934.1 CR619986.1

CR620014.1 CR620049.1 CR620140.1 CR620157.1 CR620169.1 CR620524.1 CR620822.1 CR620891.1

CR620937.1 CR621002.1 CR621021.1 CR621080.1 CR621181.1 CR621648.1 CR621851.1 CR621891.1

CR621919.1 CR621954.1 CR622008.1 CR622059.1 CR622127.1 CR622152.1 CR622231.1 CR622470.1

CR622602.1 CR622748.1 CR622910.1 CR622947.1 CR623229.1 CR623264.1 CR623276.1 CR623287.1

CR623298.1 CR623401.1 CR623417.1 CR623451.1 CR623469.1 CR623542.1 CR623570.1 CR624074.1

CR624109.1 CR624178.1 CR624232.1 CR624472.1 CR624505.1 CR624534.1 CR624647.1 CR624985.1

CR625026.1 CR625043.1 CR625104.1 CR625149.1 CR625374.1 CR625582.1 CR625774.1 CR625838.1

CR625867.1 CR626011.1 CR626031.1 CR626130.1 CR626176.1 CR626221.1 CR626395.1 CR626454.1

CR626463.1 CR626639.1 CR626704.1 CR626712.1 J00118.1 M25118.1 M35419.1 V00593.1

24/122 DOTS entries (see all 122):

DT.92434084 DT.95278368 DT.100715479 DT.100715496 DT.92061817 DT.91766654 DT.100715602 DT.100715588

DT.100838861 DT.100715551 DT.100862539 DT.95092424 DT.92434082 DT.97868481 DT.100715584 DT.100862608

DT.100715495 DT.100715566 DT.100059909 DT.100715568 DT.92455957 DT.92434087 DT.95222130 DT.91840785

24/442 AceView cDNA sequences (see all 442):

CR612166 CR626176 CR594342 CR596027 CR614101 CR613557 CR613721 CR623287

CR618200 CR623417 CR594237 CR607531 CR623264 CR596625 CR591417 CR590057

CR599883 CR603907 CR594027 CR590503 CR622127 CR599098 CR601165 CR596250

highest scoring ESTs for CSH1:

AL541171 AL541620 AL542999 AL543048 AL543080 AL543091 AL543590 AL543624 AL543634 AL543638

Unigene Cluster for CSH1:

Chorionic somatomammotropin hormone 1 (placental lactogen)

Hs.654390 [show with all ESTs]

Unigene Representative Sequence: CR610932

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CSH1 (see all 8)

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14
SP1:
SP2:
SP3:																			-		-		-		-		-		-		-
SP4:																	-		-		-		-		-		-		-		-		-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for CSH1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000453363 ENST00000259003(uc002jcq.1) ENST00000329882(uc002jcp.1 uc002jcr.1 uc002jcs.1 uc002jct.1 uc002jcu.1 uc002jcv.1 uc002jcw.2 uc002jcy.2)

ENST00000316193

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CSH1 expression in normal and diseased human tissues

¹ / ² / ³

15 probe-sets matching CSH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31493_s_at²^{, 3}	U95-A	3	1.00	0.49	1.00	1.00	J03071	0.20	0.33	0.27	1
208357_x_at²^{, 3}	U133-A	5	1.00	0.53	--	--	NM_022641	0.40	0.42	0.41	1
208356_x_at²	U133-A	5	1.00	0.53	--	--	--	--	--	--	--
211739_x_at²^{, 3}	U133-A	5	1.00	0.47	--	--	BC005921	0.60	0.56	0.58	1
202493_x_at²^{, 3}	U133-A	5	0.91	0.49	--	--	NM_001317	0.40	0.42	0.41	1
203807_x_at²^{, 3}	U133-A	5	0.91	0.34	--	--	NM_020991	0.40	0.42	0.41	1
208342_x_at²^{, 3}	U133-A	5	0.82	0.30	--	--	NM_022645	0.40	0.42	0.41	1
206475_x_at²^{, 3}	U133-A	5	0.64	0.47	--	--	NM_022640	0.40	0.42	0.41	1
208357_x_at²	U133Plus2	5	1.00	0.53	--	--	--	--	--	--	--
208356_x_at²	U133Plus2	5	1.00	0.53	--	--	--	--	--	--	--
211739_x_at²	U133Plus2	5	1.00	0.47	--	--	--	--	--	--	--
202493_x_at²	U133Plus2	5	0.91	0.49	--	--	--	--	--	--	--
203807_x_at²	U133Plus2	5	0.91	0.34	--	--	--	--	--	--	--
208342_x_at²	U133Plus2	5	0.82	0.30	--	--	--	--	--	--	--
206475_x_at²	U133Plus2	5	0.64	0.47	--	--	--	--	--	--	--

About this table

CSH1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CSH1 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGCAGTGCC

SOURCE GeneReport for Unigene cluster: Hs.654390

Expression variation in blood from EXPOLDB for CSH1

Primers:		OriGene genome-wide validated SYBR primer pairs: CSH1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for CSH1

SABiosciences Custom PCR Arrays for CSH1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CSH1 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC454774¹	--	similar to growth hormone variant	98.62(n) 98.62(a)	454774 XM_001158844.1 XP_001158844.1

About this table Species with no ortholog for CSH1

ENSEMBL Gene Tree for CSH1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CSH1 gene

CSH2¹ ² GH2² GH1² CSHL1²

CSH1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
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SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1050840^1,2	F	61972403(-)	`TCTGTG/AGAGGG`	4	/V	syn¹ ref¹ ese³		2		MN	366
rs1050850^1,2	C,F	61972397(-)	`GAGGGC/TAGCTG`	4	G	ref¹ syn¹ ese³		4		MN EU WA EA	332
rs1050857^1,2	F	61972374(-)	`GCCCGA/CGTAGC`	2	--	ut3¹ ese³		2		MN	368
rs1050899^1,2	C,F	61972310(-)	`GCCCAC/TCAGCC`	2	--	ut3¹		3		EU WA EA	148
rs2009894^1,2	--	61975752(-)	`ctctaC/Tttaaa`	2	--	ng5¹		0	--	--	--	--
rs2665812^1,2	C,A,	61971957(+)	`TTCTTC/TCCGCT`	2	--	ng3¹		0	--	--	--	--
rs2665813^1,2	--	61972149(+)	`AACCTC/TTTATA`	2	--	ng3¹		0	--	--	--	--
rs2727341^1,2	C,F,H	61974575(+)	`GGGGAT/CGAATA`	2	--	ng5¹ tfbs³		4		EA NA	1472
rs2727342^1,2	C,H	61975532(+)	`tctctC/Ttcttt`	2	--	ng5¹ trp³		0	--	--	--	--
rs2727353^1,2	--	61972008(+)	`AGGAAA/GAAATG`	2	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for CSH1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CSH1
1 CNV: 49909

QIAGEN SeqTarget long-range PCR primers for resequencing CSH1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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CSH1 for disorders About GeneDecksing

OMIM: 150200

1 Novoseek disease relationship for CSH1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma	75.4	5	1708334 (1), 12573257 (1), 15457851 (1), 8472847 (1)

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Genatlas disease: CSH1

placental lactogen deficiency (CSH1 deficiency),with deletion encompassing CSH1,GHV,CSH2

Human Gene Mutation Database (HGMD): CSH1
Genetic Association Database (GAD): CSH1
Human Genome Epidemiology (HuGE) Navigator: CSH1 (4 documents)

Export disorders and mutations for CSH1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/101 PubMed articles for CSH1 gene, integrated from 7 sources (see all 101):
(articles sorted by number of sources associating them with CSH1)

Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements. (PubMed id 6208192)^{1, 2, 3} Selby M.J.... Eberhardt N.L. (1984)
Crystal structure and site 1 binding energetics of human placental lactogen. (PubMed id 16546209)^{1, 2} Walsh S.T. and Kossiakoff A.A. (2006)
Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. (PubMed id 15531513)^{1, 4} Day I.N....Phillips D.I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human growth hormone locus: nucleotide sequence, biology, and evolution. (PubMed id 2744760)^{1, 2} Chen E.Y....Seeburg P.H. (1989)
The human growth hormone gene locus: structure, evolution, and allelic variations. (PubMed id 3030680)^{1, 2} Hirt H.... Barta A. (1987)
Two structurally different genes produce the same secreted human placental lactogen hormone. (PubMed id 6300056)^{1, 2} Barrera-Saldana H.A.... Saunders G.F. (1983)
The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone. (PubMed id 7169009)^{1, 2} Seeburg P.H. (1982)
Identification of the interchain disulfide bonds of dimeric human placental lactogen. (PubMed id 438159)^{1, 2} Schneider A.B.... Sherwood L.M. (1979)
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. (PubMed id 593368)^{1, 2} Shine J.... Goodman H.M. (1977)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1442	HGNC: 2440	AceView: CSH1andGH2andCSH2	Ensembl:ENSG00000136488	euGenes: HUgn1442
ECgene: CSH1	Kegg: 1442	H-InvDB: CSH1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for CSH1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for CSH1 gene:
Search GeneIP for patents involving CSH1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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