Aliases &
Descriptions
for CSPG4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| chondroitin sulfate proteoglycan 41 2 | | chondroitin sulfate proteoglycan 4 (melanoma-associated)1 2 | | MCSP1 2 3 | | HMW-MAA1 2 | | MCSPG1 2 5 | | Chondroitin sulfate proteoglycan NG22 3 | | MSK161 2 5 | | Melanoma-associated chondroitin sulfate proteoglycan2 3 | | NG21 2 5 | | Melanoma chondroitin sulfate proteoglycan2 3 | | MEL-CSPG1 2 | | |
Export aliases for CSPG4 gene to outside databasesPrevious GC identifers: GC15M071843 GC15M069056 GC15M073542 GC15M073682 GC15M073754 GC15M075966 |
Summaries
for CSPG4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CSPG4:
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactionsduring early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integralmembrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (provided by RefSeq)
UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motilityduring microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axonregeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on thatsubstrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating theiractivity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cellsinvasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibitingangiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffoldingand signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation.May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signalingcascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades
Gene Wiki entry for CSPG4 |
Genomic Views
for CSPG4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CSPG4 gene promoter:
AP-4 MEF-2A RSRFC4 TBP Chx10 GR-beta GR-alpha E47 Tal-1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for CSPG4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q24.2CSPG4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M052722: view genomic region
(about GC identifiers)
Start:
|
52,722,948 bp from pter |
End:
|
52,761,468 bp from pter |
Size:
|
38,521 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 75,966,663-76,005,189 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for CSPG4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1 (See
protein sequence)Recommended Name: Chondroitin sulfate proteoglycan 4 precursor Size: 2322 amino acids; 250537 Da
Subunit: Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2.Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternarycomplex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3.Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1.Interacts with MMP16
Subcellular location: Apical cell membrane; Single-pass type I membrane protein; Extracellular side (By similarity).Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side (By similarity).Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation byPRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity)
Miscellaneous: Valuable marker for several incompletely differentiated precursor cells
Secondary accessions: D3DW77 Q92675Explore the universe of human proteins at neXtProt for CSPG4: NX_Q6UVK1
Post-translational modifications:
O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and functionin stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA41
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001888.2
ENSEMBL proteins: ENSP00000312506
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
CSPG4 for ontologies About GeneDecksing
Antibodies for CSPG4:
Assays for CSPG4: |
Protein
Domains/
Families
for CSPG4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CSPG4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UVK1ProtoNet protein and cluster: Q6UVK1 2 Blocks protein families: IPB001791 Laminin G IPB012679 Laminin G
UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1Similarity: Contains 15 CSPG (NG2) repeatsSimilarity: Contains 2 laminin G-like domains |
Gene Function
for CSPG4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motilityduring microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axonregeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on thatsubstrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating theiractivity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cellsinvasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibitingangiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffoldingand signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation.May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signalingcascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004871 | signal transducer activity |
IEA | -- | | GO:0005082 | receptor signaling protein tyrosine phosphatase signaling protein activity |
-- | -- | | GO:0005515 | protein binding |
-- | -- | | GO:0008268 | receptor signaling protein tyrosine kinase signaling protein activity |
-- | -- | | GO:0019901 | protein kinase binding |
IPI | 10587647 |
About this table
CSPG4 for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cspg4):
CSPG4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CSPG4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CSPG4 for pathways About GeneDecksing
1  Millipore Pathway for CSPG4
SABiosciences Custom Pathway-Focused PCR Arrays for CSPG4
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CSPG4
1 Interacting protein for CSPG4 (Q6UVK12) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
CSPG4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CSPG4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CSPG4 for compounds About GeneDecksing
 Browse Tocris compounds for CSPG4
3  Novoseek chemical compound relationships for CSPG4 gene
About this table
|
Transcripts
for CSPG4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CSPG4 gene: NM_001897.4 Additional cDNA sequence: AY359468.1 BC033194.1 BC128110.1 X96753.1 7 DOTS entries: DT.213407 DT.121052811 DT.95165668 DT.100028178 DT.121052879 DT.70104223 DT.95165669 24/117 AceView cDNA sequences (see all 117): AI423029 BU190456 CF272486 NM_001897 AY359468 AI452449 CA417234 BU167327 BG015442 AI802991 AI276983 AW082096 BQ680275 AI337443 BQ677440 BP362998 BF062585 CA428796 AI366351 BG259493 BF530254 BG762021 AL138007 BG476684
 highest scoring ESTs for CSPG4:X96753 AY359468 CB044012 AA433835 AA937420 AI127907 AI276983 AI337443 AI366351 AI423029 Unigene Cluster for CSPG4: Chondroitin sulfate proteoglycan 4 Hs.513044 [show with all ESTs]Unigene Representative Sequence: NM_001897
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000308508(uc002baw.2)
|
Expression
for CSPG4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CSPG4 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching CSPG4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38004_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.86 |
0.89 |
X96753 |
1.00 |
1.00 |
1.00 |
1 |
| 110_at2, 3
|
U95-A |
1 |
0.62 |
1.00 |
0.45 |
1.15 |
X96753 |
1.00 |
1.00 |
1.00 |
1 |
| 204736_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_001897 |
0.60 |
1.00 |
0.82 |
1 |
| 214297_at2, 3
|
U133-A |
1 |
0.27 |
1.00 |
-- |
-- |
BE857703 |
0.60 |
1.00 |
0.82 |
1 |
| 204736_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 214297_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CSPG4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGCCTGGAT
SOURCE GeneReport for Unigene cluster: Hs.513044
Expression variation in blood from EXPOLDB for CSPG4 UniProtKB/Swiss-Prot: CSPG4_HUMAN, Q6UVK1Tissue specificity: Detected only in malignant melanoma cells
SABiosciences Custom PCR Arrays for CSPG4
|
Orthologs
for CSPG4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CSPG4 gene from 5/7 species (see all 7)
About this table Species with no ortholog for CSPG4
ENSEMBL Gene Tree for CSPG4 (if available) |
Paralogs
for CSPG4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CSPG4 gene
- ENSG000002052732 CSPG4P52 FREM22 LOC7281212 ENSG000002052722 ENSG000001887922 FREM32 FREM12
- FRAS12
CSPG4 for paralogs About GeneDecksing
|
Genomic Variants
for CSPG4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CSPG4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CSPG4
1 CNV: 77008 | | QIAGEN SeqTarget long-range PCR primers for resequencing CSPG4 |
|
Disorders & Mutations
for CSPG4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CSPG4 for disorders About GeneDecksing
OMIM: 601172
9 Novoseek disease relationships for CSPG4 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glioma |
43.7 |
14 |
10571405 (4), 9281375 (3), 11919162 (2), 16365873 (1) (see all 6) |
| melanoma |
36.2 |
10 |
17217338 (3), 16365873 (1), 8523067 (1), 20309546 (1) (see all 7) |
| demyelinating diseases |
33.3 |
1 |
15949494 (1) |
| minimal residual disease |
33.1 |
1 |
12886247 (1) |
| demyelination |
22.2 |
1 |
16753227 (1) |
| neovascularization |
18.6 |
2 |
11919162 (1), 15181153 (1) |
| multiple sclerosis |
13 |
2 |
15949494 (1), 16753227 (1) |
| tumors |
5.34 |
14 |
11919162 (4), 10383148 (2), 19618851 (1), 12220645 (1) (see all 6) |
| leukemia |
0 |
3 |
16643437 (1), 12886247 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: CSPG4 (2 documents)
Export disorders and mutations for CSPG4 gene to outside databases
|
Medical News
for CSPG4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CSPG4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/90 PubMed articles for CSPG4 gene, integrated from 7 sources (see all 90):
(articles sorted by number of sources associating them with CSPG4)- Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. (PubMed id 8790396)1, 2, 3 Pluschke G.... Reisfeld R.A. (1996)
- NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PubMed id 15181153)1, 2, 7 Fukushi J.... Stallcup W.B. (2004)
- A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family. (PubMed id 12220645)1, 2, 7 Staub E.... Rosenthal A. (2002)
- Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. (PubMed id 16407841)1, 3 Luo W....Ferrone S. (2006)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. (PubMed id 15210734)1, 2 Yang J.... McCarthy J.B. (2004)
- Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. (PubMed id 11278606)1, 2 Iida J....McCarthy J.B. (2001)
- Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. (PubMed id 10587647)1, 2 Eisenmann K.M.... Iida J. (1999)
- A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PubMed id 9488735)1, 2 Iida J.... McCarthy J.B. (1998)
- The expression of NG2 proteoglycan in the human intervertebral disc. (PubMed id 17268261)1, 7 Akeda K....Masuda K. (2007)
|
External Searches for CSPG4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CSPG4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CSPG4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CSPG4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CSPG4 gene:
Search GeneIP for patents involving CSPG4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CSPG4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for CSPG4 (NG2) |
| | | | Search Tocris compounds for CSPG4 |
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