Aliases &
Descriptions
for CST1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cystatin SN1 2 | | cystatin-SN2 | | Salivary cystatin-SA-12 3 | | cystatin-12 | | cystatin 12 | | cysteine proteinase inhibitor, type 2 family2 | | cystatin SA-I2 | | Cystatin-13 | | cystain-SA-I2 | | Cystain-SA-I3 | | OTTHUMP000001641842 | | |
Export aliases for CST1 gene to outside databasesPrevious GC identifers: GC20M023716 GC20M023676 GC20M023723 |
Summaries
for CST1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CST1:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members areactive cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Thereare three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and thekininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of humanfluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 containsthe majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes acysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. (provided by RefSeq)
UniProtKB/Swiss-Prot: CYTN_HUMAN, P01037Function: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related tocystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5,is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficinequally well
Gene Wiki entry for CST1 |
Genomic Views
for CST1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CST1 gene promoter:
HNF-4alpha2 COUP-TF1 SREBP-1a SREBP-1b SREBP-1c POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CST1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.2CST1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M023687: view genomic region
(about GC identifiers)
Start:
|
23,687,404 bp from pter |
End:
|
23,690,788 bp from pter |
Size:
|
3,385 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr20- 23,728,190-23,731,905 |
RefSeq DNA sequence:- NC_000020.10 NT_011387.8
|
Proteins
for CST1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CYTN_HUMAN, P01037 (See
protein sequence)Recommended Name: Cystatin-SN precursor Size: 141 amino acids; 16388 Da
Subcellular location: Secreted
Mass spectrometry: Mass=14303.1553; Mass_error=0.0675; Method=Electrospray; Range=21-141; Source=PubMed:20189825;
Mass spectrometry: Mass=14319.171; Mass_error=0.0523; Method=Electrospray; Range=21-141; Note=Variant Leu-31;Source=PubMed:20189825;
Secondary accessions: Q96LE6 Q9UCQ6Explore the universe of human proteins at neXtProt for CST1: NX_P01037
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001889.2
ENSEMBL proteins: ENSP00000305731 ENSP00000381439
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
CST1 for ontologies About GeneDecksing
Antibodies for CST1:
Assays for CST1: |
Protein
Domains/
Families
for CST1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CST1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01037ProtoNet protein and cluster: P01037 3 Blocks protein families: IPB000010 Cysteine protease inhibitor IPB001005 Myb DNA-binding domain IPB003243 Proteinase inhibitor I25A and I25B
UniProtKB/Swiss-Prot: CYTN_HUMAN, P01037Similarity: Belongs to the cystatin family |
Gene Function
for CST1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CYTN_HUMAN, P01037Function: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related tocystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5,is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficinequally well
Genatlas biochemistry entry for CST1:cystatin SN,cysteine proteinase inhibitor,type 2 family2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004869 | cysteine-type endopeptidase inhibitor activity |
IEA | -- | | GO:0030414 | peptidase inhibitor activity |
IEA | -- |
About this table
CST1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CST1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CST1 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for CST1):
SABiosciences Custom Pathway-Focused PCR Arrays for CST1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST1
|
Drugs & Compounds
for CST1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CST1 for compounds About GeneDecksing
 Browse Tocris compounds for CST1
3  Novoseek chemical compound relationships for CST1 gene
About this table
|
Transcripts
for CST1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CST1 gene: NM_001898.2 Additional cDNA sequence: BC021225.2 J03870.1 10 DOTS entries: DT.97759874 DT.91721790 DT.100781828 DT.120823084 DT.120823092 DT.120823095 DT.120823099 DT.97759875 DT.99999111 DT.120823070 24/198 AceView cDNA sequences (see all 198): CK429248 CD721927 NM_001898 BX485701 AI648499 BC074952 BC074953 CD721796 NM_001899 CB957526 BP334427 BP334083 BP334853 BP335106 BP334009 BC065714 BP334006 CB985287 AA336824 BP334188 BP334799 CB958788 BP334362 BP334794
 highest scoring ESTs for CST1:BF745588 BQ320681 J03870 AA336824 AA337409 AA337515 AA337959 BC021225 BE091549 BF689725 Unigene Cluster for CST1: Cystatin SN Hs.123114 [show with all ESTs]Unigene Representative Sequence: BU839412
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304749(uc002wtp.2) ENST00000398402
|
Expression
for CST1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CST1 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching CST1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 206224_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
NM_001898 |
0.40 |
0.50 |
0.45 |
1 |
| 206224_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTACACACCC
SOURCE GeneReport for Unigene cluster: Hs.123114
Expression variation in blood from EXPOLDB for CST1 UniProtKB/Swiss-Prot: CYTN_HUMAN, P01037Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).Expressed in saliva, tears, urine and seminal fluid
SABiosciences Custom PCR Arrays for CST1
|
Orthologs
for CST1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CST1 gene from 1 species
About this table Species with no ortholog for CST1
ENSEMBL Gene Tree for CST1 (if available) |
Paralogs
for CST1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CST1 gene
- CST42 CST22 CSTL12 CST82 CST32 CST52 CST112
CST1 for paralogs About GeneDecksing
|
Genomic Variants
for CST1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CST1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CST1
2 CNVs: 7301 50636 | | QIAGEN SeqTarget long-range PCR primers for resequencing CST1 |
|
Disorders & Mutations
for CST1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CST1 for disorders About GeneDecksing
OMIM: 123855
1 Novoseek disease relationship for CST1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
0 |
1 |
17044913 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: CST1 (3 documents)
Export disorders and mutations for CST1 gene to outside databases
|
Medical News
for CST1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CST1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/55 PubMed articles for CST1 gene, integrated from 7 sources (see all 55):
(articles sorted by number of sources associating them with CST1)- Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S. (PubMed id 1778989)1, 2, 7 Isemura S.... Minakata K. (1991)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Newly identified proteins in human nasal lavage fluid from non- smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting. (PubMed id 11788998)1, 2 Ghafouri B.... Lindahl M. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. (PubMed id 3202964)1, 2 Saitoh E.... Maeda N. (1988)
- Purification, molecular cloning, and sequencing of salivary cystatin SA-1. (PubMed id 2837486)1, 2 Al-Hashimi I.... Levine M.J. (1988)
- Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. (PubMed id 3446578)1, 2 Saitoh E.... Maeda N. (1987)
- Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S. (PubMed id 3514272)1, 2 Isemura S.... Sanada K. (1986)
- Upregulation of the cysteine protease inhibitor, cyst atin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer. (PubMed id 19463800)1, 7 Choi E.H....Lee H.G. (2009)
|
External Searches for CST1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CST1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CST1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CST1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CST1 gene:
Search GeneIP for patents involving CST1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CST1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for CST1 |
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 | | | ELISAs and CLIAs for CST1 |
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