Aliases &
Descriptions
for CST5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cystatin D1 2 | | MGC719222 | | cystatin-D2 | | cystatin-52 | | cystatin 52 | | Cystatin-53 | | cysteine-proteinase inhibitor2 | | |
Export aliases for CST5 gene to outside databasesPrevious GC identifers: GC20M023844 GC20M023804 |
Summaries
for CST5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CST5:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members areactive cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. Thereare three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and thekininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of humanfluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes andpseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encodedprotein may play a protective role against proteinases present in the oral cavity. (provided by RefSeq)
UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325Function: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oralcavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B
Gene Wiki entry for CST5 |
Genomic Views
for CST5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CST5 gene promoter:
MyoD TGIF SREBP-1a SREBP-1b SREBP-1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for CST5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p11.21 Ensembl cytogenetic band: 20p11.21 HGNC cytogenetic band: 20p11.21CST5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M023851: view genomic region
(about GC identifiers)
Start:
|
23,813,604 bp from pter |
End:
|
23,817,412 bp from pter |
Size:
|
3,809 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr20- 23,856,572-23,860,387 |
RefSeq DNA sequence:- NC_000020.10 NT_011387.8
|
Proteins
for CST5 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325 (See
protein sequence)Recommended Name: Cystatin-D precursor Size: 142 amino acids; 16080 Da
Subunit: Monomer
Subcellular location: Secreted
Mass spectrometry: Mass=13154.4675; Mass_error=0.0101; Method=Electrospray; Range=29-142; Note=Variant Arg-46;Source=PubMed:20189825;
Mass spectrometry: Mass=13596.7015; Mass_error=0.0049; Method=Electrospray; Range=25-142; Note=Variant Arg-46;Source=PubMed:20189825;
Caution: The truncated forms found may result from N-terminal proteolysis (PubMed:20189825)
PDB structure from  and Proteopedia  :1RN7 (3D)
1ROA (3D)
Secondary accessions: Q5JRF5 Q9UCA0Explore the universe of human proteins at neXtProt for CST5: NX_P28325
REFSEQ proteins: NP_001891.2
ENSEMBL proteins: ENSP00000307132
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
CST5 for ontologies About GeneDecksing
Antibodies for CST5:
Assays for CST5: |
Protein
Domains/
Families
for CST5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CST5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P28325ProtoNet protein and cluster: P28325 2 Blocks protein families: IPB000010 Cysteine protease inhibitor IPB003243 Proteinase inhibitor I25A and I25B
UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325Similarity: Belongs to the cystatin family |
Gene Function
for CST5 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325Function: Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oralcavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin BBiophysicochemical properties: Temperature dependence: Thermostable;
Genatlas biochemistry entry for CST5:cystatin D,cysteine proteinase inhibitor,found at high levels in salviva,tears,seminal plasma,type 2 family3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
CST5 for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cst10):
CST5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CST5 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CST5 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for CST5):
SABiosciences Custom Pathway-Focused PCR Arrays for CST5
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CST5
|
Drugs & Compounds
for CST5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
CST5 for compounds About GeneDecksing
 Browse Tocris compounds for CST5
1  Novoseek chemical compound relationship for CST5 gene
About this table
|
Transcripts
for CST5 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CST5 gene: NM_001900.4 Additional cDNA sequence: BC062678.1 BC069514.1 X70377.1 1 DOTS entry: DT.204835 13 AceView cDNA sequences: BC062678 BC069514 NM_001900 CB957678 BP334786 BP333996 X70377 BP334744 BP334002 BP334304 CB987021 BP333854 CB985957
 highest scoring ESTs for CST5:X70377 BC062678 BC069514 CB957678 CB985957 CB987021 BP333854 BP333996 BP334002 BP334304 Unigene Cluster for CST5: Cystatin D Hs.121489 [show with all ESTs]Unigene Representative Sequence: CB987021
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304710(uc002wtr.1)
|
Expression
for CST5 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CST5 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CST5 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31723_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
X70377 |
1.00 |
1.00 |
1.00 |
1 |
| 207925_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_001900 |
0.60 |
1.00 |
0.82 |
1 |
| 207925_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CST5 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CGCCTGCACC
SOURCE GeneReport for Unigene cluster: Hs.121489
Expression variation in blood from EXPOLDB for CST5 UniProtKB/Swiss-Prot: CYTD_HUMAN, P28325Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level).Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastriccorpus, small intestine, liver, or gall bladder tissue
SABiosciences Custom PCR Arrays for CST5
|
Orthologs
for CST5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CST5 gene from 2 species
About this table Species with no ortholog for CST5
ENSEMBL Gene Tree for CST5 (if available) |
Paralogs
for CST5 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CST5 gene
- CST42 CST22 CSTL12 CST82 CST12 CST32 CST112
CST5 for paralogs About GeneDecksing
|
Genomic Variants
for CST5 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CST5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CST5
1 CNV: 5129 | | QIAGEN SeqTarget long-range PCR primers for resequencing CST5 |
|
Disorders & Mutations
for CST5 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CST5 for disorders About GeneDecksing
OMIM: 123858
Human Genome Epidemiology (HuGE) Navigator: CST5 (1 document)
Export disorders and mutations for CST5 gene to outside databases
|
Medical News
for CST5 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CST5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/29 PubMed articles for CST5 gene, integrated from 7 sources (see all 29):
(articles sorted by number of sources associating them with CST5)- Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. (PubMed id 1939105)1, 2, 3, 7 Freije J.P....Lopez-Otin C. (1991)
- Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. (PubMed id 8083219)1, 2, 7 Balbin M....Abrahamson M. (1994)
- Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile. (PubMed id 15728581)1, 2, 7 Alvarez-Fernandez M.... Su X.D. (2005)
- Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. (PubMed id 8340398)1, 2, 7 Freije J.P.... Lopez-Otin C. (1993)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level. (PubMed id 8444475)1, 2 Balbin M.... Lopez-Otin C. (1993)
- Cystatin D is a candidate tumor suppressor gene induc ed by vitamin D in human colon cancer cells. (PubMed id 19662683)1, 7 Alvarez-DA-az S....MuA+oz A. (2009)
- Localization of the human cystatin D gene (CST5) to chromosome 20p11.21 by in situ hybridization. (PubMed id 8422752)1, 7 Freije J.P....Lopez-Otin C. (1993)
- Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry. (PubMed id 20189825)2, 7 Ryan C.M....Whitelegge J.P. (2010)
|
External Searches for CST5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CST5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CST5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CST5 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CST5 gene:
Search GeneIP for patents involving CST5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CST5 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for CST5 |
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 | | | ELISAs and CLIAs for CST5 |
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