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CT45A3 Gene

protein-coding   GIFtS: 34

GC0XP134869
cancer/testis antigen family 45, member A3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
cancer/testis antigen family 45, member A31 2     OTTHUMP000000240832
CT45-31 2 3     RP13-36C9.12
CT45.31 2 5     OTTHUMP000002217612
Cancer/testis antigen 45-32 3     cancer/testis antigen family 45 member A32
Cancer/testis antigen 45A32 3     OTTHUMP000002217602
cancer/testis antigen CT45-32     

External Ids:    HGNC: 332681   Entrez Gene: 4415192   Ensembl: ENSG000002324177   UniProtKB: Q8NHU03   

Export aliases for CT45A3 gene to outside databases

Previous GC identifer: GC0XP134712


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CT45A3
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CT45A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

CT45A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CT45A3 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP134869:  view genomic region     (about GC identifiers)

Start:
134,869,956 bp from pter
End:
134,893,393 bp from pter
Size:
23,438 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0 (See protein sequence)
Recommended Name: Cancer/testis antigen family 45 member A3  
Size: 189 amino acids; 21331 Da
Secondary accessions: B2RU20 B7ZMC9

Explore the universe of human proteins at neXtProt for CT45A3: NX_Q8NHU0 

REFSEQ proteins: NP_001017435.1  

ENSEMBL proteins: 
ENSP00000421659 ENSP00000359769 ENSP00000426216 ENSP00000411223 ENSP00000394635 


Human Recombinant Proteins 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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CT45A3 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR011051 Cupin_RmlC_type

Graphical View of Domain Structure for InterPro Entry Q8NHU0

ProtoNet protein and cluster: Q8NHU0


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for CT45A3
Sigma-Aldrich shRNA for CT45A3
OriGene 29mer shRNA kits in GFP-retroviral vector: CT45A3
OriGene shRNA RFP: CT45A3
OriGene basic RS shRNA: CT45A3
OriGene siRNA: CT45A3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CT45A3 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CT45A3 
Search SABiosciences for Assays for microRNAs that regulate CT45A3

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: CT45A3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CT45A3
OriGene untagged cDNA clones in CMV expression vector: CT45A3
Browse 3'-UTR reporter clones for miRNA target validation 
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Cell
Lines:
  
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(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for CT45A3 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CT45A3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CT45A3


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for CT45A3
Sigma-Aldrich shRNA for CT45A3
OriGene 29mer shRNA kits in GFP-retroviral vector: CT45A3
OriGene shRNA RFP: CT45A3
OriGene basic RS shRNA: CT45A3
OriGene siRNA: CT45A3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CT45A3 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CT45A3 
Search SABiosciences for Assays for microRNAs that regulate CT45A3
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: CT45A3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CT45A3
OriGene untagged cDNA clones in CMV expression vector: CT45A3
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: CT45A3 
Primers: OriGene genome-wide validated SYBR primer pairs: CT45A3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CT45A3: PPH66853A

REFSEQ mRNAs for CT45A3 gene: 

NM_001017435.1  

Additional cDNA sequence: 

AY743711.1 BC028711.2 BC140735.1 BC140926.1 BC144437.1 

6 DOTS entries:

DT.95369049  DT.121288022  DT.103147  DT.121278210  DT.121278213  DT.121307899 

Unigene Cluster for CT45A3:

Cancer/testis antigen family 45, member A3
Hs.535080  [show with all ESTs]
Unigene Representative Sequence: BC028711


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000485366 ENST00000370734(uc004ezc.2) ENST00000461216 ENST00000455625
ENST00000443882

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CT45A3 expression in normal and diseased human tissues

1  / 2

4 probe-sets matching CT45A3 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
77230_at2 U95-D 7 0.94 0.29 1.00 1.00 -- -- -- -- --
235700_at2 U133-B 7 0.91 0.21 -- -- -- -- -- -- --
1567912_s_at2 U133Plus2 6 1.00 0.20 -- -- -- -- -- -- --
235700_at2 U133Plus2 7 0.91 0.21 -- -- -- -- -- -- --
About this table

CT45A3 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
CT45A3 gene expression
CT45A3 gene electronic northern expression
CT45A3 gene sage expression
About these images

CGAP SAGE TAG: CTATTCCACC

SOURCE GeneReport for Unigene cluster: Hs.535080

UniProtKB/Swiss-Prot: CT453_HUMAN, Q8NHU0
Tissue specificity: Testis specific. Expressed in cancer cell lines

Primers: OriGene genome-wide validated SYBR primer pairs: CT45A3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for CT45A3: PPH66853A
    SABiosciences Custom PCR Arrays for CT45A3 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
ENSEMBL Gene Tree for CT45A3 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for CT45A3 gene
XX-FW88277B6.1  RP13-36C9.1  CT45-4  CT45-6  CT45A22  INTS62  CT45A52  CT45A12  
CT45A42  SAGE12  CT45A62  DDX26B2  

CT45A3 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for CT45A3
     14 CNVs: 31563 33178 74057 37000 0669 83765 96995 4174 74056 83764 52935 74058 3256 96994
     1 Inversion: 37350
Search QIAGEN SeqTarget long-range PCR primers for resequencing for CT45A3 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CT45A3 for disorders           About GeneDecksing

OMIM: 300794


Export disorders and mutations for CT45A3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

6 PubMed articles for CT45A3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CT45A3)
  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  3. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
  4. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 441519 HGNC: 33268 Ensembl:ENSG00000232417 euGenes: HUgn441519 ECgene: CT45A3
H-InvDB: CT45A3

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for CT45A3 gene:
Search GeneIP for patents involving CT45A3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CT45A3
 Search QIAGEN SeqTarget long-range PCR primers for resequencing for CT45A3
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CT45A3
 GenScript Custom Purified and Recombinant Proteins Services for CT45A3 GenScript cDNA clones with any tag delivered in your preferred vector for CT45A3
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