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CTBS Gene

protein-coding GIFtS: 52

GC01M083128

chitobiase, di-N-acetyl-
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CTB)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
chitobiase, di-N-acetyl-¹ ²
CTB² ³ ⁵
OTTHUMP00000011570²
di-N-acetylchitobiase²
EC 3.2.1.-³

External Ids:	HGNC: 2496¹	Entrez Gene: 1486²	Ensembl: ENSG00000117151⁷	UniProtKB: Q01459³

Export aliases for CTBS gene to outside databases

Previous GC identifers: GC01P085516 GC01M084156 GC01M084307 GC01M084442 GC01M084732 GC01M085018

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTBS:

Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins

(Aronson and Kuranda, 1989 (PubMed 2531691)).(supplied by OMIM)

UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459

Function: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine

(1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by

glycosylasparaginase

Gene Wiki entry for CTBS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTBS gene promoter:
         NF-kappaB   NF-kappaB1   LCR-F1   POU3F2   RORalpha1   GCNF-2   GCNF-1   SREBP-1c   SREBP-1b   SREBP-1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CTBS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CTBS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22

CTBS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTBS gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M083128: view genomic region (about GC identifiers)

Start:	83,128,864 bp from pter
End:	83,150,219 bp from pter
Size:	21,356 bases
Orientation:	minus strand

1 alternative location:

Chr1- 85,018,804-85,040,163

RefSeq DNA sequence:

NC_000001.10 NT_032977.9

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459 (See protein sequence)

Recommended Name: Di-N-acetylchitobiase precursor

Size: 385 amino acids; 43760 Da

Subcellular location: Lysosome

Explore the universe of human proteins at neXtProt for CTBS: NX_Q01459

REFSEQ proteins: NP_004379.1

ENSEMBL proteins:

ENSP00000359664 ENSP00000359659

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Custom Purified and Recombinant Proteins Services for CTBS
	Novus Biologicals Protein for CTBS
	Novus Biologicals Lysate for CTBS
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	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IEA	--

About this table

CTBS for ontologies About GeneDecksing

Antibodies for CTBS:

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	Browse antibodies at Epitomics

Assays for CTBS:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CTBS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTBS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTBS for domains About GeneDecksing

5 InterPro domains/families:

IPR001579 Glyco_hydro_18_chit_AS

IPR011583 Chitinase_II

IPR017853 Glyco_hydro_catalytic_core

IPR001223 Glyco_hydro18cat

IPR013781 Glyco_hydro_sg_catalytic

Graphical View of Domain Structure for InterPro Entry Q01459

ProtoNet protein and cluster: Q01459

1 Blocks protein family: IPB001579 Glycoside hydrolase

UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459

Similarity: Belongs to the glycosyl hydrolase 18 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459

Function: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine

(1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by

glycosylasparaginase

Enzyme Number (IUBMB): EC 3.2.1.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CTBS Sigma-Aldrich shRNA for CTBS
		OriGene 29mer shRNA kits in GFP-retroviral vector: CTBS OriGene shRNA RFP: CTBS OriGene basic RS shRNA: CTBS OriGene siRNA: CTBS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CTBS

miRNA:		Sigma-Aldrich microRNA Mimics for CTBS Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CTBS
		Search SABiosciences for Assays for microRNAs that regulate CTBS

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CTBS OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CTBS OriGene untagged cDNA clones in CMV expression vector: CTBS OriGene 3'-UTR clone: CTBS Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CTBS
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CTBS

Genatlas biochemistry entry for CTBS:

lysosomal chitobiase,involved in degradation of asparagine-linked glycoproteins

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	--	--
GO:0004568	chitinase activity	IEA	--
GO:0043169	cation binding	IEA	--

About this table

CTBS for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CTBS for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for CTBS

Aminosugars Metabolism

SABiosciences Custom Pathway-Focused PCR Arrays for CTBS

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CTBS

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CTBS

3 Interacting proteins for CTBS (ENSP00000359664³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HK1	ENSP00000348697³	STRING: ENSP00000348697
HK2	ENSP00000290573³	STRING: ENSP00000290573
HK3	ENSP00000292432³	STRING: ENSP00000292432

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	IEA	--
GO:0006032	chitin catabolic process	IEA	--
GO:0009313	oligosaccharide catabolic process	IEA	--

About this table

CTBS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTBS

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CTBS Sigma-Aldrich shRNA for CTBS
		OriGene 29mer shRNA kits in GFP-retroviral vector: CTBS OriGene shRNA RFP: CTBS OriGene basic RS shRNA: CTBS OriGene siRNA: CTBS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CTBS

miRNA:		Sigma-Aldrich microRNA Mimics for CTBS Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CTBS
		Search SABiosciences for Assays for microRNAs that regulate CTBS

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: CTBS OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CTBS OriGene untagged cDNA clones in CMV expression vector: CTBS OriGene 3'-UTR Clone: CTBS Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CTBS

Primers:		OriGene genome-wide validated SYBR primer pairs: CTBS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CTBS: PPH12323A

REFSEQ mRNAs for CTBS gene:

NM_004388.2

Additional cDNA sequence:

AK075423.1 AK298703.1 AK314640.1 BC024007.2 BC065191.1 BC096752.1 BC126333.1 BC126335.1

CR590327.1 CR595959.1 CR602282.1 CR615615.1 M95767.1

8 DOTS entries:

DT.95172057 DT.410826 DT.95297552 DT.121427673 DT.92443352 DT.100782215 DT.121427721 DT.97795709

24/423 AceView cDNA sequences (see all 423):

AI911433 BX956979 AW340694 H15938 BI467209 AI368858 BG008942 M95767

CA425643 AA974553 BX109756 AI499049 AI346848 BM826029 CB121330 BT006823

AA923637 AI601142 AA878529 CR590327 AA167380 AA371357 CR615615 BF109470

highest scoring ESTs for CTBS:

M95767 AI269096 AI547276 AK075423 AL530653 BC024007 BC065191 BG703950 BG704290 BG719820

Unigene Cluster for CTBS:

Chitobiase, di-N-acetyl-

Hs.513557 [show with all ESTs]

Unigene Representative Sequence: NM_004388

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CTBS

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c
SP1:			-
SP2:
SP3:			-				-
SP4:							-

About this scheme

ECgene alternative splicing isoforms for CTBS
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477677(uc001dkd.2 uc001dkb.2) ENST00000465118 ENST00000370630(uc001dkc.2 uc001dka.2)

ENST00000370625

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CTBS expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching CTBS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37855_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.97	M95767	1.00	0.90	0.95	1
61307_at²^{, 3}	U95-C	1	0.88	1.00	0.98	1.03	AI547276	0.80	0.88	0.84	1
218923_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW304174	0.60	0.83	0.73	1
218924_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_004388	0.60	0.83	0.73	1
218923_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218924_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

CTBS for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CTBS gene electronic northern expression

About these images

CGAP SAGE TAG: GAAAGTGGAG

SOURCE GeneReport for Unigene cluster: Hs.513557

Expression variation in blood from EXPOLDB for CTBS

Primers:		OriGene genome-wide validated SYBR primer pairs: CTBS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CTBS: PPH12323A

SABiosciences Custom PCR Arrays for CTBS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTBS gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CTBS¹	--	chitobiase, di-N-acetyl-	84.7(n) 77.31(a)	490188 XM_547309.2 XP_547309.2
chimpanzee (Pan troglodytes)	CTBS¹	--	chitobiase, di-N-acetyl-	99.21(n) 98.95(a)	456978 XM_513520.2 XP_513520.1
cow (Bos taurus)	CTBS¹	--	chitobiase, di-N-acetyl-	82.05(n) 71.35(a)	524503 XM_602828.3 XP_602828.3
rat (Rattus norvegicus)	Ctbs¹	--	chitobiase, di-N-acetyl-	82.45(n) 81.89(a)	81652 NM_031023.1 NP_112285.1
mouse (Mus musculus)	Ctbs^{1 , 5}	3 (71.26 cM)⁵	chitobiase, di-N-acetyl-^{1, 5}	86.58(n)¹ 86.04(a)¹	74245¹ NM_028836.2¹ NP_083112.1¹ AK008791⁵ AV029632⁵ (see all 9)

About this table Species with no ortholog for CTBS

ENSEMBL Gene Tree for CTBS (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs15911^1,2	C,F,	85029077(+)	`AGGGAC/TTTTTG`	2	I V	mis¹ ref¹		18	MN NA EA NS WA	1408
rs1043493^1,2	C,F,A,H,	85020649(-)	`AGAAAG/AATGAT`	1	--	ut3¹		10	MN NA NS EA WA	788
rs1517602^1,2	C,F,O,	85021557(+)	`CCTCTA/GAAACC`	1	--	int¹		13	NA NS EA WA	722
rs1803276^1,2	C,F,A,	85020496(-)	`CATAAA/TGGCAA`	1	--	ut3¹ ese³		6	NS EA WA	470
rs1891126^1,2	C,F,	85036538(-)	`TGGGAC/ACCCTA`	1	--	int¹		6	NS EA NA WA	526
rs2303306^1,2	C,F,O,A,	85036239(+)	`TGCTGC/GACACA`	1	--	int¹		14	EA NA NS WA	2252
rs2303307^1,2	C,F,	85039955(+)	`CGGCAG/AAGCTC`	2	/L	ref¹ syn¹ ese³		8	EA NS NA	2040
rs2911584^1,2	C,A,	85030359(+)	`GTCTTT/GCCTGA`	1	--	int¹		6	WA NA	60
rs2911587^1,2	F,	85032069(+)	`TAAAAG/TAATTC`	1	--	int¹		4	NS EA	406
rs2911588^1,2	C,F,O,A,	85034024(+)	`AGGAGG/AAGAAG`	1	--	int¹ trp³		8	NA EA WA	284

About this table

HapMap Linkage Disequilibrium images for CTBS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTBS: --

QIAGEN SeqTarget long-range PCR primers for resequencing CTBS

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTBS for disorders About GeneDecksing

OMIM: 600873

Export disorders and mutations for CTBS gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/11 PubMed articles for CTBS gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with CTBS)

Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PubMed id 7606925)^{1, 3, 7} Ahmad W....Aronson N.N. (1995)
Structure of the human gene for lysosomal di-N-acetylchitobiase. (PubMed id 10336991)^{1, 2} Liu B.... Aronson N.N. Jr. (1999)
Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5). (PubMed id 1549114)^{1, 3} Fisher K.J. and Aronson N.N. (1992)
Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase. (PubMed id 1527079)^{1, 2} Fisher K.J. and Aronson N.N. Jr. (1992)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase. (PubMed id 16794344)¹ Aronson N.N. and Halloran B.A. (2006)
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. (PubMed id 15252009)¹ Kamioka Y....Mochizuki N. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor. (PubMed id 11907625)¹ Hutchinson T....Pereira B.M. (2002)
Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins. (PubMed id 2751306)¹ Aronson N.N....Kuranda M.J. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1486	HGNC: 2496	AceView: CTBSandGNG5	Ensembl:ENSG00000117151	euGenes: HUgn1486
ECgene: CTBS	H-InvDB: CTBS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for CTBS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for CTBS gene:
Search GeneIP for patents involving CTBS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTBS		Antibodies for CTBS
	Super-pooled esiRNAs for CTBS		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CTBS		microRNA Mimics for CTBS
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for CTBS (Chitobiase/CTBS)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
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	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CTBS
	SeqTarget long-range PCR primers for resequencing CTBS
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CTBS
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CTBS

	GenScript Custom Purified and Recombinant Proteins Services for CTBS		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CTBS
	GenScript Custom Assay Services for CTBS		GenScript Custom Superior Antibodies Services for CTBS
	GenScript Custom overexpressing Cell Line Services for CTBS		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CTBS promoter
	Search Chromatin IP Primers for CTBS
	RT² qPCR Primer Assay for CTBS
	Search GNC Networks for CTBS
	Search for Assays for microRNAs that regulate CTBS
	SABiosciences Custom PCR Arrays for CTBS

Search Tocris compounds for CTBS

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for CTBS
	Proteins for CTBS
	Lysates for CTBS

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for CTBS

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

CTBS gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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CTBS Gene

protein-coding GIFtS: 52

Aliases &
Descriptions
for CTBS gene

Summaries
for CTBS gene

Genomic Views
for CTBS gene

Proteins
for CTBS gene

Protein Domains/
Families
for CTBS gene

Gene Function
for CTBS gene

Pathways & Interactions
for CTBS gene

Drugs & Compounds
for CTBS gene

Transcripts
for CTBS gene

Expression
for CTBS gene

Orthologs
for CTBS gene

Paralogs
for CTBS gene

Genomic Variants
for CTBS gene

Disorders & Mutations
for CTBS gene

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for CTBS gene

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for CTBS gene

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Genome Databases showing CTBS gene

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Intellectual Property
for CTBS gene

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View Random Gene

Advanced Search

Export list of displayed genes

CTBS Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor CTBS gene

Summariesfor CTBS gene

Genomic Viewsfor CTBS gene

Proteinsfor CTBS gene

Protein Domains/Familiesfor CTBS gene

Gene Functionfor CTBS gene

Pathways & Interactionsfor CTBS gene

Drugs & Compoundsfor CTBS gene

Transcriptsfor CTBS gene

Expression for CTBS gene

Orthologsfor CTBS gene

Paralogsfor CTBS gene

Genomic Variantsfor CTBS gene

Disorders & Mutationsfor CTBS gene

Medical Newsfor CTBS gene

Publicationsfor CTBS gene

External Searches for CTBS gene

Genome Databases showing CTBS gene

Other Databases showing CTBS gene

Specialized Databases showing CTBS gene

Intellectual Propertyfor CTBS gene

Productsfor CTBS gene

View Random Gene

Aliases &
Descriptions
for CTBS gene

Summaries
for CTBS gene

Genomic Views
for CTBS gene

Proteins
for CTBS gene

Protein Domains/
Families
for CTBS gene

Gene Function
for CTBS gene

Pathways & Interactions
for CTBS gene

Drugs & Compounds
for CTBS gene

Transcripts
for CTBS gene

Expression
for CTBS gene

Orthologs
for CTBS gene

Paralogs
for CTBS gene

Genomic Variants
for CTBS gene

Disorders & Mutations
for CTBS gene

Medical News
for CTBS gene

Publications
for CTBS gene

Intellectual Property
for CTBS gene

Products
for CTBS gene