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CTPS Gene

protein-coding   GIFtS: 58

GC01P039562
CTP synthase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
CTP synthase1 2     cytidine 5'-triphosphate synthetase2
UTP--ammonia ligase 12 3     cytidine 5-prime triphosphate synthetase2
CTP synthetase 12 3     CTP synthase 12
OTTHUMP000000063232     EC 6.3.4.23

External Ids:    HGNC: 25191   Entrez Gene: 15032   Ensembl: ENSG000001717937   UniProtKB: P178123   

Export aliases for CTPS gene to outside databases

Previous GC identifers: GC01P041479 GC01P040448 GC01P040908 GC01P040858 GC01P041114 GC01P041217


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTPS:
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The
enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth,
development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints
involved in several tumor types (provided by RefSeq)

UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of
nitrogen


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTPS gene promoter:
         GCNF-2   GCNF-1   STAT5B   STAT5A   RORalpha1   Bach1   MEF-2A   HSF1 (long)   NF-YA   NF-Y   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CTPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CTPS 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

CTPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTPS gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P039562:  view genomic region     (about GC identifiers)

Start:
39,562,096 bp from pter
End:
39,595,318 bp from pter
Size:
33,223 bases
Orientation:
plus strand

1 alternative location:
Chr1+ 41,445,007-41,478,235     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812 (See protein sequence)
Recommended Name: CTP synthase 1  
Size: 591 amino acids; 66690 Da
PDB structures from and Proteopedia :
2VO1 (3D)    
Secondary accessions: Q5VW67 Q96GK6

Explore the universe of human proteins at neXtProt for CTPS: NX_P17812 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001896.2  

    ENSEMBL proteins: 
    ENSP00000361699 ENSP00000361704 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CTPS
    OriGene Protein Over-expression Lysate: CTPS
    GenScript Custom Purified and Recombinant Proteins Services for CTPS 
    Novus Biologicals Protein for CTPS
    Novus Biologicals Lysate for CTPS
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575 cellular_component ND--
    GO:0005829 cytosol TAS--
    About this table

    CTPS for ontologies           About GeneDecksing



    Antibodies for CTPS: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CTPS
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CTPS 
    Novus Biologicals Antibodies for CTPS
    Browse antibodies at Epitomics

    Assays for CTPS: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTPS 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CTPS 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CTPS for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000991 GATase_class1_C
     IPR004468 CTP_synthase
     IPR017456 CTP_synthase_N
     IPR017926 GATASE_1

    Graphical View of Domain Structure for InterPro Entry P17812

    ProtoNet protein and cluster: P17812

    1 Blocks protein family: IPB000991 Glutamine amidotransferase class-I

    UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
    Similarity: Belongs to the CTP synthase family
    Similarity: Contains 1 glutamine amidotransferase type-1 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
    Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of
    nitrogen
    Catalytic activity: ATP + UTP + NH(3) = ADP + phosphate + CTP
    Enzyme regulation: Activated by GTP and inhibited by CTP
    Enzyme Number (IUBMB): EC 6.3.4.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CTPS
    Sigma-Aldrich shRNA for CTPS
    OriGene 29mer shRNA kits in GFP-retroviral vector: CTPS
    OriGene shRNA RFP: CTPS
    OriGene basic RS shRNA: CTPS
    OriGene siRNA: CTPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CTPS 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CTPS 
    Search SABiosciences for Assays for microRNAs that regulate CTPS

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CTPS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CTPS
    OriGene untagged cDNA clones in CMV expression vector: CTPS
    OriGene 3'-UTR clone: CTPS 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CTPS 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for CTPS 

    Genatlas biochemistry entry for CTPS:
    cytidine triphosphate (CTP) synthase,pyrimidine biosynthetic pathway

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003824 catalytic activity ----
    GO:0003883 CTP synthase activity TAS--
    GO:0005515 protein binding IPI17353931
    GO:0005524 ATP binding IEA--
    About this table

    CTPS for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CTPS for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  CTPS
        Pyrimidine Metabolism

    2 Kegg Pathways  (Kegg details for CTPS):
        hsa00240 Pyrimidine metabolism
    hsa01100 Metabolic pathways

    UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
    Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2

        SABiosciences Custom Pathway-Focused PCR Arrays for CTPS 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CTPS
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTPS

    5/38 Interacting proteins for CTPS (ENSP000003616993 P178121, 2) via UniProtKB, MINT, and/or STRING (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K31EBI-1042983,EBI-359276
    YWHAZP631042MINT-3296359
    NME2P1ENSP000002426303STRING: ENSP00000242630
    POLR1AENSP000002638573STRING: ENSP00000263857
    POLR1BENSP000002633313STRING: ENSP00000263331
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process TAS2113467
    GO:0006221 pyrimidine nucleotide biosynthetic process IEA--
    GO:0006241 CTP biosynthetic process IDA16179339
    GO:0006541 glutamine metabolic process IEA--
    GO:0015949 nucleobase, nucleoside and nucleotide interconversion TAS--
    About this table

    CTPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CTPS for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTPS
    6 Novoseek chemical compound relationships for CTPS gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclopentenylcytosine 92.6 5 7554044 (3), 7694793 (1), 9220496 (1)
    ctp 90.6 36 10064135 (6), 15158730 (5), 7554044 (3), 7694793 (2) (see all 12)
    carbamoyl phosphate 68.5 2 8532677 (1), 2347042 (1)
    glutamine 56.2 6 15158730 (4), 2229235 (1), 2347042 (1)
    guanylate 44.8 2 8532677 (1), 2347042 (1)
    atp 11.2 1 2229235 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for CTPS
    Sigma-Aldrich shRNA for CTPS
    OriGene 29mer shRNA kits in GFP-retroviral vector: CTPS
    OriGene shRNA RFP: CTPS
    OriGene basic RS shRNA: CTPS
    OriGene siRNA: CTPS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CTPS 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CTPS 
    Search SABiosciences for Assays for microRNAs that regulate CTPS
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CTPS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CTPS
    OriGene untagged cDNA clones in CMV expression vector: CTPS
    OriGene 3'-UTR Clone: CTPS 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for CTPS 
    Primers: OriGene genome-wide validated SYBR primer pairs: CTPS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CTPS: PPH15117A

    REFSEQ mRNAs for CTPS gene: 

    NM_001905.2  

    Additional cDNA sequence: 

    AK130549.1 AK225899.1 AK297386.1 AK299122.1 AK303797.1 AK304817.1 BC009408.1 CR599441.1 
    CR602579.1 CR608005.1 X52142.1 

    22 DOTS entries:

    DT.318826  DT.121329011  DT.101980098  DT.100780851  DT.92439909  DT.92408218  DT.92439924  DT.100721542 
    DT.100028838  DT.100745700  DT.100780850  DT.121329054  DT.92439910  DT.100734930  DT.121329029  DT.121329048 
    DT.40117440  DT.86836834  DT.95098942  DT.95250054  DT.99989428  DT.95341460 

    24/284 AceView cDNA sequences (see all 284):

    BX402445 BE797529 BU501830 AI950210 BX095044 AU132845 AU143659 AI703490 
    AU137720 BC009408 AI989584 CR599441 BU151411 BQ678001 AL521717 AK130549 
    BU178343 AL041570 BU169128 BE328358 AA653125 BQ581680 BF448288 T28502 

    highest scoring ESTs for CTPS:

    X52142 AA055002 AA132742 AA135134 AA136515 AA191481 AA196826 AA196899 AA476603 AA632297 

    Unigene Cluster for CTPS:

    CTP synthase
    Hs.473087  [show with all ESTs]
    Unigene Representative Sequence: NM_001905


    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CTPS (see all 13)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^
    SP1:                    -     -     -     -                             -                                         -           -                 -               
    SP2:                                                                    -                                         -           -                 -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -           -                                 
    SP5:                                                                                                                                            -               

    ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d
    SP1:                                -                                             
    SP2:                                -                                             
    SP3:                                -                                             
    SP4:                                                                              
    SP5:                                                                              

    About this scheme

    ECgene alternative splicing isoforms for CTPS
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480420 ENST00000497210 ENST00000464283 ENST00000463423 ENST00000479480
    ENST00000372616 ENST00000470271 ENST00000475060 ENST00000463285 ENST00000484267
    ENST00000372621(uc010ojp.1 uc001cgk.3 uc010ojo.1 uc001cgl.3 uc010ojq.1 uc009vwe.2)
    ENST00000498694 ENST00000486889

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CTPS expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching CTPS gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32441_at2, 3 U95-A 1 0.69 1.00 1.00 1.00 X52142 1.00 1.00 1.00 1
    202613_at2, 3 U133-A 1 0.82 1.00 -- -- NM_001905 0.60 1.00 0.82 1
    202613_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    CTPS for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CTPS gene expression
    CTPS gene electronic northern expression
    CTPS gene sage expression
    About these images

    CGAP SAGE TAG: CCTGTGGCTG

    SOURCE GeneReport for Unigene cluster: Hs.473087

    Expression variation in blood from EXPOLDB for CTPS

    Primers: OriGene genome-wide validated SYBR primer pairs: CTPS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CTPS: PPH15117A
        SABiosciences Custom PCR Arrays for CTPS 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for CTPS gene from 5/17 species (see all 17)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    CTPS1   -- CTP synthase 99.72(n)
    99.66(a)
    469296  XM_524681.2  XP_524681.2 
    cow
    (Bos taurus)
    CTPS1   -- CTP synthase 91.6(n)
    97.97(a)
    506131  XM_001253201.1  XP_001253202.1 
    rat
    (Rattus norvegicus)
    Ctps1   -- CTP synthase 90.3(n)
    97.46(a)
    313560  XM_233467.4  XP_233467.4 
    mouse
    (Mus musculus)
    Ctps1 , 5 4 (56.52 cM)5
    cytidine 5'-triphosphate synthase1, 5 90.02(n)1
    97.12(a)1
    517971  NM_016748.11  NP_058028.11 
     AK1464765  AK1482595  (see all 12)
    zebrafish
    (Danio rerio)
    NM_199211.12   --   -- 75.58(n) 322089  NM_199211.1 
    About this table        Species with no ortholog for CTPS

    ENSEMBL Gene Tree for CTPS (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CTPS gene
    CTPS22  

    CTPS for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/303 NCBI SNPs in CTPS are shown (see all 303)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs18925531,2
    C,41443980(+) AAAGAA/GAAGCC 1 -- ng51 trp37Minor allele frequency- G:0.00MN NA WA 196
    rs28972301,2
    C,F,A,H,41444545(+) gaactT/Gttggg 1 -- ng514Minor allele frequency- G:0.50NA EA WA 166
    rs28972311,2
    C,F,A,H,41444603(+) TTGCCG/ATCTAC 1 -- ng5111Minor allele frequency- A:0.41NS EA MN NA WA 1832
    rs39226761,2
    C,F,41472153(-) ATGAAT/CTAATA 1 -- int13Minor allele frequency- C:0.05NA 140
    rs39358711,2
    A,H41478285(-) TCAGAC/TGCTTC 1 -- ng313Minor allele frequency- T:0.00EA NS 298
    rs41308281,2
    --41476122(-) TGGAGA/GAAGGG 1 -- int1 trp30--------
    rs41324381,2
    C,F,A,H,41449795(-) TCCTGA/TTGCCA 1 -- int113Minor allele frequency- N:0.00EA NA WA 412
    rs41324391,2
    C,F,A,41449574(-) GCAGTC/TGGGCA 1 -- int15Minor allele frequency- T:0.20NA EA WA 214
    rs41324401,2
    C,F,A,H,41449629(-) CACAGT/CTGTAT 1 -- int112Minor allele frequency- C:0.28NS EA NA WA 482
    rs43634141,2
    C,F,A41476117(+) GGCAGC/TCCTTC 1 -- int1 trp37Minor allele frequency- T:0.00NS EA NA 554
    About this table

    HapMap Linkage Disequilibrium images for CTPS (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CTPS
         1 CNV: 34824

    QIAGEN SeqTarget long-range PCR primers for resequencing CTPS 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CTPS for disorders           About GeneDecksing

    OMIM: 123860


    Export disorders and mutations for CTPS gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/41 PubMed articles for CTPS gene, integrated from 7 sources (see all 41):
    (articles sorted by number of sources associating them with CTPS)
    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)1, 2 Gevaert K.... Vandekerckhove J. (2005)
    4. Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. (PubMed id 16179339)1, 2 Han G.-S.... Carman G.M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    7. Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS). (PubMed id 1783378)1, 3 Yamauchi M....Meuth M. (1991)
    8. Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes. (PubMed id 2113467)1, 2 Yamauchi M.... Meuth M. (1990)
    9. Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells. (PubMed id 10064135)1, 7 Verschuur A.C....Van Kuilenburg A.B. (1999)
    10. Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. (PubMed id 20739275)1 Kassel K.M....Graves L.M. (2010 Oct 29)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1503 HGNC: 2519 AceView: CTPS Ensembl:ENSG00000171793 euGenes: HUgn1503
    ECgene: CTPS Kegg: 1503 H-InvDB: CTPS

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CTPS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for CTPS gene:
    Search GeneIP for patents involving CTPS

    GeneCards and IP:
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     ELISAs and CLIAs for CTPS
           

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