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CXADR Gene

protein-coding   GIFtS: 64

GC21P004271
coxsackie virus and adenovirus receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for CXADR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase, and/or 9Nature:405,311-319 and CroW21)
About This Section
Aliases & Descriptions
coxsackie virus and adenovirus receptor1 2     CVB3 binding protein2
CAR1 2 3 5     OTTHUMP000000832332
Coxsackievirus B-adenovirus receptor2 3     coxsackie virus B receptor2
CVB3-binding protein2 3     coxsackievirus and adenovirus receptor2
HCVADR2 3     CAR4/62
46 kD coxsackievirus and adenovirus receptor (CAR) protein2 9     HCAR2
OTTHUMP000000832342     hCAR3

External Ids:    HGNC: 25591   Entrez Gene: 15252   Ensembl: ENSG000001546397   UniProtKB: P783103   

Export aliases for CXADR gene to outside databases

Previous GC identifers: GC21P015549 GC21P017807 GC21P018884


Summaries
for CXADR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CXADR:
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C
adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. (provided by RefSeq)

UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
Function: Component of the epithelial apical junction complex that is essential for the tight junction integrity.
Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably
involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with
AMICA1/JAML located in the plasma membrane of PMN

Gene Wiki entry for CXADR (Coxsackie virus and adenovirus receptor)

Genomic Views
for CXADR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CXADR gene promoter:
         HNF-4alpha2   COUP-TF1   p53   Meis-1   HOXA9B   Sox9   RFX1   GATA-1   Bach1   Pax-6   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for CXADR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CXADR 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q
Nature(405: 311-319) cytogenetic band:   21q21.1
CXADR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CXADR gene location
GeneLoc gene densities for chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P004271:   GeneLoc Nature:405,311-319
Start:
 4,271,134 bp from pter       4,549,799 bp from centromere
End:
 4,325,108 bp from pter 4,603,690 bp from centromere
Size:
 53,975 bases 53,892 bases
Orientation:
 plus strand plus strand

1 alternative location:
Chr21+ 18,884,700-18,965,897     
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  

Whole chromosome sequencing:
cDNA sequence: U90716Y07593
genomic clones: R827P19 R877L16


Proteins
for CXADR gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310 (See protein sequence)
Recommended Name: Coxsackievirus and adenovirus receptor precursor  
Size: 365 amino acids; 40030 Da
Subunit: Monomer. Probably homodimer formed by 2 molecules on adjacent cells. Interacts with LNX, MPDZ, BAIAP1, DLG4,
PRKCABP, TJP1 and CTNNB1. Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of
the receptor. Interacts with DNAJC7. Probably part of a complex containing CXADR, HSP90AA1 and DNAJC7 (By similarity).
Interacts with adenovirus subgroup A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6
capsid proteins and acts as a receptor for these viruses
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Cell junction, adherens junction. Basolateral cell membrane; Single-pass type I membrane protein. Note=In epithelial
cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells
localized to basolateral membrane but not to apical surface
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Cell junction, adherens junction. Basolateral cell membrane; Single-pass membrane protein. Note=In epithelial cells
localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells
localized to basolateral membrane but not to apical surface
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
Subcellular location: Isoform 5: Secreted
PDB structures from and Proteopedia :
1EAJ (3D)    1F5W (3D)    1JEW (3D)    1KAC (3D)    1P69 (3D)    1P6A (3D)    1RSF (3D)    2J12 (3D)    
2J1K (3D)    2NPL (3D)    2W9L (3D)    2WBW (3D)    
Secondary accessions: B2R8V8 O00694 Q8WWT6 Q8WWT7 Q8WWT8 Q9UKV4
Alternative splicing: 5 isoforms:  P78310-1   P78310-2   P78310-3   P78310-4   P78310-5   

Explore the universe of human proteins at neXtProt for CXADR: NX_P78310 

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_001329.1  

    ENSEMBL proteins: 
    ENSP00000303395 ENSP00000383026 ENSP00000284878 ENSP00000383033 ENSP00000383029 ENSP00000348620 
    ENSP00000307152 ENSP00000383030 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for CXADR
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CXADR
    GenScript Custom Purified and Recombinant Proteins Services for CXADR 
    Novus Biologicals Proteins for CXADR
    Novus Biologicals Lysates for CXADR
    Sino Biological Recombinant Protein for CXADR
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0005886 plasma membrane IDA18029348
    GO:0005887 integral to plasma membrane TAS9096397
    About this table

    CXADR for ontologies           About GeneDecksing



    Antibodies for CXADR: 
    Millipore Mono- and Polyclonal Antibodies for the study of CXADR
    Sigma-Aldrich Antibodies for CXADR
    R&D Systems Antibodies for CXADR
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for CXADR 
    Novus Biologicals Antibodies for CXADR
    Browse antibodies at Epitomics

    Assays for CXADR: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CXADR 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CXADR 

    Protein Domains/
    Families
    for CXADR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CXADR for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like
     IPR003599 Ig_sub
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P78310

    ProtoNet protein and cluster: P78310

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
    Domain: The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML
    Domain: The PDZ-binding motif mediates interaction with MPDZ and BAIAP1
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Gene Function
    for CXADR gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
    Function: Component of the epithelial apical junction complex that is essential for the tight junction integrity.
    Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably
    involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with
    AMICA1/JAML located in the plasma membrane of PMN

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CXADR
    Sigma-Aldrich shRNA Panels and shRNA for CXADR
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CXADR
    OriGene shRNA RFP (see all 2): CXADR
    OriGene basic RS shRNA (see all 2): CXADR
    OriGene siRNA: CXADR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CXADR 
    miRNA:Sigma-Aldrich microRNA Mimics for CXADR
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CXADR 
    4 SABiosciences Assays for microRNAs that regulate CXADR:
    hsa-miR-26a hsa-miR-26b hsa-miR-1297 hsa-miR-412

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CXADR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CXADR
    OriGene untagged cDNA clones in CMV expression vector (see all 2): CXADR
    OriGene 3'-UTR clone: CXADR 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CXADR 
    Sino Biological Human cDNA Clone for CXADR

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for CXADR 

    Genatlas biochemistry entry for CXADR:
    coxsackie B and adenovirus (group C) common receptor

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005515 protein binding IEA--
    About this table

    CXADR for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cxadr):

    cardiovascular systemcellularembryogenesishomeostasis/metabolismlethality-prenatal/perinatal
    life span-post-weaning/agingmusclerespiratory system

    CXADR for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CXADR gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    CXADR for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  CXADR
        Virus Entry via Endocytic Pathways

    1 Kegg Pathway  (Kegg details for CXADR):
        hsa05416 Viral myocarditis

        SABiosciences Custom Pathway-Focused PCR Arrays for CXADR 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CXADR
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CXADR

    5/13 Interacting proteins for CXADR (ENSP000002848783 P783102) via UniProtKB, MINT, and/or STRING (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMICA1ENSP000003486353STRING: ENSP00000348635
    CUL4AENSP000003645843STRING: ENSP00000364584
    DNM1ENSP000003620143STRING: ENSP00000362014
    HHLA2ENSP000003504023STRING: ENSP00000350402
    CUX1ENSP000003534013STRING: ENSP00000353401
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007005 mitochondrion organization IEA--
    GO:0007155 cell adhesion IEA--
    GO:0007507 heart development IEA--
    GO:0007596 blood coagulation TAS--
    GO:0044419 interspecies interaction between organisms IEA--
    About this table

    CXADR for ontologies           About GeneDecksing



    Drugs & Compounds
    for CXADR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    CXADR for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CXADR
    10/46 Novoseek chemical compound relationships for CXADR gene (see all 46)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    penton 86.4 9 15483666 (2), 12923563 (1), 15684699 (1), 11884569 (1) (see all 7)
    androstane 83.6 9 19196842 (1), 14567971 (1), 12695351 (1), 14978227 (1) (see all 8)
    citco 82.7 14 15802384 (1), 17585873 (1), 18492798 (1), 19925382 (1)
    cinacalcet 69.5 13 16816924 (2), 18561096 (2), 19765257 (2), 15631545 (1)
    depsipeptide 68 45 16356494 (4), 16951199 (3), 14614025 (2), 17308048 (2) (see all 9)
    ad 11 67.5 1 12915534 (1)
    hexon 58.2 2 15671566 (1), 16956941 (1)
    tcpobop 57.7 2 15802384 (1), 19925382 (1)
    calcium 51 230 15525493 (5), 7835282 (4), 20130845 (4), 9722568 (4) (see all 91)
    spermine 43.8 11 17041782 (2), 8694826 (1), 9677383 (1), 11108243 (1) (see all 8)
    About this table



    Transcripts
    for CXADR gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for CXADR
    Sigma-Aldrich shRNA Panels and shRNA for CXADR
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): CXADR
    OriGene shRNA RFP (see all 2): CXADR
    OriGene basic RS shRNA (see all 2): CXADR
    OriGene siRNA: CXADR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CXADR 
    miRNA: Sigma-Aldrich microRNA Mimics for CXADR
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CXADR 
    4 SABiosciences Assays for microRNAs that regulate CXADR:
    hsa-miR-26a hsa-miR-26b hsa-miR-1297 hsa-miR-412
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: CXADR
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: CXADR
    OriGene untagged cDNA clones in CMV expression vector (see all 2): CXADR
    OriGene 3'-UTR Clone: CXADR 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: CXADR 
    Primers: OriGene genome-wide validated SYBR primer pairs: CXADR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CXADR: PPH00828A

    REFSEQ mRNAs for CXADR gene: 

    NM_001338.3  

    Additional cDNA sequence: 

    AF124598.1 AK313526.1 AY072910.1 AY072911.1 AY072912.1 BC003684.1 BC010536.1 BT019876.1 
    CR617256.1 GU474812.1 U90716.1 Y07593.1 

    10 DOTS entries:

    DT.95369288  DT.100778374  DT.100814204  DT.100778367  DT.100757082  DT.95072828  DT.315373  DT.215678 
    DT.95369281  DT.75171993 

    24/152 AceView cDNA sequences (see all 152):

    AA977172 AI290221 AI538104 CR617256 BC003684 AA128200 AA176652 BC010536 
    Y07593 BF062895 AA676233 AA176808 AW628404 BF476200 AI686754 BI754365 
    AL521066 AA128199 BE503229 AI718484 BP372920 AI336853 AA954469 AF124598 

    highest scoring ESTs for CXADR:

    Y07593 AA089566 AA100291 AA102279 AA847725 AA977172 AF124598 AI024837 AI218013 AI378896 

    Unigene Cluster for CXADR:

    Coxsackie virus and adenovirus receptor
    Hs.634837  [show with all ESTs]
    Unigene Representative Sequence: BC003684


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CXADR

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                -                                                   
    SP2:                                -                       -     -                     
    SP3:                                -           -     -     -     -                     
    SP4:        -     -     -           -                                                   
    SP5:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for CXADR
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306618 ENST00000400162 ENST00000284878(uc002ykh.1 uc010gld.1 uc010gle.1 uc002yki.2)
    ENST00000400169(uc002ykj.1) ENST00000400165 ENST00000356275 ENST00000346439
    ENST00000400166

    Expression
    for CXADR gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    CXADR expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching CXADR gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37534_at2, 3 U95-A 1 1.00 1.00 0.87 0.53 Y07593 1.00 1.00 1.00 1
    47068_at2, 3 U95-B 1 0.38 1.00 0.95 1.40 AA173992 0.20 1.00 0.72 1
    46439_r_at2, 3 U95-B 1 0.31 1.00 0.99 1.12 AI921735 0.40 0.67 0.55 1
    203917_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001338 0.60 1.00 0.82 1
    226374_at2, 3 U133-B 1 0.55 1.00 -- -- BG260087 0.20 1.00 0.72 1
    203917_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555716_a_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    226374_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    CXADR for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    CXADR gene expression
    CXADR gene electronic northern expression
    CXADR gene sage expression
    About these images

    CGAP SAGE TAG: TCTCTGTGTA

    SOURCE GeneReport for Unigene cluster: Hs.634837

    Expression variation in blood from EXPOLDB for CXADR

    UniProtKB/Swiss-Prot: CXAR_HUMAN, P78310
    Tissue specificity: Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in
    liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal
    muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle,
    isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel
    wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy

    Primers: OriGene genome-wide validated SYBR primer pairs: CXADR
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for CXADR: PPH00828A
        SABiosciences Custom PCR Arrays for CXADR 


    Orthologs
    for CXADR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CXADR gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CXADR1   -- coxsackie virus and adenovirus receptor 90.39(n)
    89.49(a)    		 403772  XM_535566.2  XP_535566.2 
    chimpanzee
    (Pan troglodytes)    		 CXADR1   -- coxsackie virus and adenovirus receptor 99.45(n)
    100(a)    		 473920  XM_001156087.1  XP_001156087.1 
    cow
    (Bos taurus)    		 CXADR1   -- coxsackie virus and adenovirus receptor 88.58(n)
    90.96(a)    		 281733  NM_174298.3  NP_776723.1 
    rat
    (Rattus norvegicus)    		 Cxadr1   -- coxsackie virus and adenovirus receptor 84.66(n)
    90.56(a)    		 89843  NM_053570.1  NP_446022.1 
    mouse
    (Mus musculus)    		 Cxadr1 , 5 16 (45.28 cM)5
    		 coxsackie virus and adenovirus receptor1, 5 83.56(n)1
    89.86(a)1    		 130521  NM_001025192.21  NP_001020363.11 
     AA1170595  AA4741275  (see all 34)
    About this table        Species with no ortholog for CXADR

    ENSEMBL Gene Tree for CXADR (if available)

    Paralogs
    for CXADR gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for CXADR gene
    C1orf2042  VSIG82  ASAM2  

    CXADR for paralogs           About GeneDecksing


    Pseudogenes
    2 related pseudogenes



    Genomic Variants
    for CXADR gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/772 NCBI SNPs in CXADR are shown (see all 772)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 21 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs1698361,2
    		C,18893371(-) CTTTAC/TACAGA 1 -- int111Minor allele frequency- T:0.00MN NS EA NA WA 546
    rs1824151,2
    		C,F,A,18893097(-) CAGACA/GTCAGG 1 -- int18Minor allele frequency- G:0.47MN NS EA NA WA 696
    rs1824161,2
    		--18932181(+) ttgtaA/Gacatg 1 -- int10--------
    rs1833211,2
    		--18932132(+) gctgaA/Gactac 1 -- int10--------
    rs1841611,2
    		--18886668(+) GCAAGA/TCTAAT 1 -- int10--------
    rs2119511,2
    		C,18887678(+) ggaggA/Tttgcc 1 -- int110Minor allele frequency- T:0.00NS EA NA WA 428
    rs2119521,2
    		C,F,18888782(+) TCCAGG/TGCTTG 1 -- int14Minor allele frequency- T:0.10NA EA WA 212
    rs2119531,2
    		C,F18890217(+) GACTAG/AGTAAG 1 -- int19Minor allele frequency- A:0.10NS EA 526
    rs2119541,2
    		C,H,18890584(+) CAAACA/CAAAAA 1 -- int14Minor allele frequency- C:0.00NA WA 10
    rs2119551,2
    		C,18891210(+) TTGTCG/ATCAGC 1 -- int11Minor allele frequency- A:0.50NA 2
    About this table

    HapMap Linkage Disequilibrium images for CXADR (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CXADR: --

    QIAGEN SeqTarget long-range PCR primers for resequencing CXADR 

    Disorders & Mutations
    for CXADR gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CXADR for disorders           About GeneDecksing

    OMIM: 602621

    10/79 Novoseek disease relationships for CXADR gene (see all 79)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenovirus infections 84.2 23 11972385 (2), 11207218 (2), 11522619 (1), 14614025 (1) (see all 19)
    nshpt 74.1 7 7717399 (2), 16509534 (2), 7593455 (1), 9769711 (1)
    coxsackie virus 66.9 8 16014330 (2), 12753648 (1), 12923563 (1), 14978758 (1) (see all 7)
    hyperparathyroidism secondary 57.4 3 15466262 (1), 16816924 (1), 19303957 (1)
    hypocalcemia, autosomal dominant 57 3 9769711 (2), 15591042 (1)
    epidemic keratoconjunctivitis 55 1 12429514 (1)
    hypercalcemia 54.7 16 12970167 (2), 9769711 (2), 8636323 (1), 11323743 (1) (see all 11)
    swine vesicular disease 52.8 2 10814575 (2)
    parathyroid adenoma 48 9 10024390 (2), 7759551 (2), 9854589 (1), 10352095 (1) (see all 7)
    urogenital cancer 45.5 6 14695181 (4)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: CXADR (4 documents)

    Export disorders and mutations for CXADR gene to outside databases

    Medical News
    for CXADR gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for CXADR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/428 PubMed articles for CXADR gene, integrated from 7 sources (see all 428):
    (articles sorted by number of sources associating them with CXADR)
    1. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. (PubMed id 9036860)1, 2, 3 Bergelson J.M.... Finberg R.W. (1997)
    2. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. (PubMed id 9096397)1, 2, 3 Tomko R.P.... Philipson L. (1997)
    3. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. (PubMed id 11457744)1, 2, 7 Noutsias M.... Poller W. (2001)
    4. Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs. (PubMed id 15533241)1, 2, 7 Shaw C.A.... Nalbantoglu J. (2004)
    5. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. (PubMed id 14978041)1, 2, 7 Doerner A.... Knowlton K.U. (2004)
    6. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. (PubMed id 15304526)1, 2, 7 Ashbourne-Excoffon K.J.D....Zabner J. (2004)
    7. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. (PubMed id 11734628)1, 2, 7 Cohen C.J....Bergelson J.M. (2001)
    8. Fatty acid modification of the coxsackievirus and adenovirus receptor. (PubMed id 12021372)1, 2, 7 van't Hof W. and Crystal R.G. (2002)
    9. Expression of Coxsackie-adenovirus-receptor and alpha v-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. (PubMed id 10490761)1, 2, 7 Fechner H.... Poller W. (1999)
    10. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PubMed id 15800062)1, 2 Zen K....Parkos C.A. (2005)

    External Searches for CXADR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CXADR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1525 HGNC: 2559 AceView: CXADR Ensembl:ENSG00000154639 euGenes: HUgn1525
    ECgene: CXADR Kegg: 1525 H-InvDB: CXADR

    Other Databases showing CXADR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CXADR gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for CXADR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for CXADR gene:
    Search GeneIP for patents involving CXADR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CXADR gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Regulatory tfbs in CXADR promoter
     Search Chromatin IP Primers for CXADR
     RT2 qPCR Primer Assay for CXADR
     GNC Network for CXADR
     Assays for microRNAs that regulate CXADR
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     Proteins and Antibodies for CXADR
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     ELISAs and CLIAs for CXADR
           

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