Aliases &
Descriptions
for CYBASC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cytochrome b, ascorbate dependent 31 2 | | FLJ397242 | | Lysosomal cytochrome b2 3 | | cytochrome b ascorbate-dependent protein 32 | | LCYTB2 3 | | EC 1.-.-.-3 | | MGC204462 | | LCytb3 |
Export aliases for CYBASC3 gene to outside databasesPrevious GC identifers: GC00U913227 GC11M060873 GC11M061116 |
Summaries
for CYBASC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CYAC3_HUMAN, Q8NBI2Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to thecytoplasm. Probably uses ascorbate as electron donor (By similarity)
|
Genomic Views
for CYBASC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYBASC3 gene promoter:
GR-alpha Nkx2-2 CHOP-10 C/EBPalpha HSF1 (long) PPAR-gamma2 PPAR-gamma1 STAT1alpha STAT1 STAT1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYBASC3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CYBASC3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2CYBASC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M057443: view genomic region
(about GC identifiers)
Start:
|
57,443,700 bp from pter |
End:
|
57,457,361 bp from pter |
Size:
|
13,662 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr11- 61,116,280-61,129,729 |
RefSeq DNA sequence:- NC_000011.9 NT_167190.1
|
Proteins
for CYBASC3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CYAC3_HUMAN, Q8NBI2 (See
protein sequence)Recommended Name: Cytochrome b ascorbate-dependent protein 3 Size: 242 amino acids; 27214 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subcellular location: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;Multi-pass membrane protein
Secondary accessions: B3KPU2 Q6PK96Explore the universe of human proteins at neXtProt for CYBASC3: NX_Q8NBI2
Post-translational modifications:
N-glycosylated (By similarity)1
REFSEQ proteins (3 alternative transcripts):
NP_001154924.1 NP_001154926.1 NP_705839.3
ENSEMBL proteins: ENSP00000398979 ENSP00000389745 ENSP00000294072
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CYBASC3 for ontologies About GeneDecksing
Antibodies for CYBASC3:
Assays for CYBASC3: |
Protein
Domains/
Families
for CYBASC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYBASC3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NBI2ProtoNet protein and cluster: Q8NBI2 1 Blocks protein family: IPB006593 Cytochrome b561 / ferric reductase transmembrane
UniProtKB/Swiss-Prot: CYAC3_HUMAN, Q8NBI2Similarity: Contains 1 cytochrome b561 domain |
Gene Function
for CYBASC3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CYAC3_HUMAN, Q8NBI2Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to thecytoplasm. Probably uses ascorbate as electron donor (By similarity)Enzyme Number (IUBMB): EC 1.-.-.-
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
About this table
CYBASC3 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYBASC3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for CYBASC3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYBASC3
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- | | GO:0022900 | electron transport chain |
IEA | -- |
About this table
CYBASC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYBASC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CYBASC3
|
Transcripts
for CYBASC3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CYBASC3 gene (3 alternative transcripts): NM_001161452.1 NM_001161454.1 NM_153611.4 Additional cDNA sequence: AK024953.1 AK025870.1 AK056751.1 AK075559.1 AK097043.1 AK225754.1 AK297063.1 AK297084.1 AK310167.1 AK310976.1 AL833374.1 BC004391.1 BC014045.2 BC047710.1 CR600742.1 CR607104.1 CR609780.1 CR614872.1 CR619941.1 24/35 DOTS entries (see all 35): DT.453250 DT.120694196 DT.102839520 DT.100686561 DT.100879131 DT.100805287 DT.95268138 DT.100758991 DT.97860343 DT.120694362 DT.120694278 DT.120694268 DT.97860342 DT.120694260 DT.120694379 DT.418132 DT.92446415 DT.100879115 DT.120694243 DT.100038865 DT.120694386 DT.120694361 DT.91905992 DT.92446413 24/437 AceView cDNA sequences (see all 437): BE260535 AL698734 BC004391 BU541030 BE740840 BQ944694 BE513856 BE383145 BQ681151 BQ642016 BQ073585 CR609780 BU195916 AA297912 BI770223 BQ057596 NM_153611 AW408467 BQ430448 CB159684 BG761406 AL833374 BU856564 BE741474
 highest scoring ESTs for CYBASC3:AK056751 AK075559 AL554239 AL560803 AL698734 AL703008 AV710096 AW583799 BC004391 BC014045 Unigene Cluster for CYBASC3: Cytochrome b, ascorbate dependent 3 Hs.22546 [show with all ESTs]Unigene Representative Sequence: NM_001161454
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CYBASC3 (see all 13)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | - | | | |
About this scheme
ECgene alternative splicing isoforms for CYBASC3
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426130 ENST00000447532 ENST00000294072(uc001nrf.3 uc009yno.2 uc001nrk.2 uc010rlh.1 uc001nrg.2 uc009ynn.2 uc001nrh.2 uc001nri.2)
|
Expression
for CYBASC3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CYBASC3 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CYBASC3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 65774_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI556963 |
0.40 |
1.00 |
0.76 |
1 |
| 224735_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AA683481 |
0.60 |
1.00 |
0.82 |
1 |
| 224735_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CYBASC3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACCAGCTCCC
SOURCE GeneReport for Unigene cluster: Hs.22546
SABiosciences Custom PCR Arrays for CYBASC3
|
Orthologs
for CYBASC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CYBASC3 gene from 5/8 species (see all 8)
About this table Species with no ortholog for CYBASC3
ENSEMBL Gene Tree for CYBASC3 (if available) |
Paralogs
for CYBASC3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CYBASC3 gene
- CYBRD12 CYB5612
CYBASC3 for paralogs About GeneDecksing
|
Genomic Variants
for CYBASC3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CYBASC3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYBASC3
1 CNV: 4748 | | QIAGEN SeqTarget long-range PCR primers for resequencing CYBASC3 |
|
Disorders & Mutations
for CYBASC3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for CYBASC3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CYBASC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for CYBASC3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CYBASC3)- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Integral and associated lysosomal membrane proteins. (PubMed id 17897319)2 Schroeder B.... Hasilik A. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)1 Suzuki Y.... Sugano S. (1997)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
|
External Searches for CYBASC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYBASC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYBASC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYBASC3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CYBASC3 gene:
Search GeneIP for patents involving CYBASC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYBASC3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for CYBASC3 |
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