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CYFIP2 Gene

protein-coding GIFtS: 62

GC05P151780

cytoplasmic FMR1 interacting protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
cytoplasmic FMR1 interacting protein 2¹ ²
PIR121¹ ² ³
p53-inducible protein 121² ³
cytoplasmic FMR1-interacting protein 2²
p53 inducible protein²
KIAA1168³

External Ids:	HGNC: 13760¹	Entrez Gene: 26999²	Ensembl: ENSG00000055163⁷	UniProtKB: Q96F07³

Export aliases for CYFIP2 gene to outside databases

Previous GC identifers: GC05P156742 GC05P157244 GC05P156628 GC05P156673 GC05P156674

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Function: Involved in T-cell adhesion and TP53/p53-dependent induction of apoptosis. Does not bind RNA

Gene Wiki entry for CYFIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYFIP2 gene promoter:
         TBP   E47   RORalpha2   FAC1   FOXC1   STAT5B   Sox9   C/EBPalpha   p53   C/EBPbeta
         Other transcription factors

Search SABiosciences Chromatin IP Primers for CYFIP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CYFIP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q34

CYFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYFIP2 gene location

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P151780: view genomic region (about GC identifiers)

Start:	151,780,753 bp from pter
End:	151,910,647 bp from pter
Size:	129,895 bases
Orientation:	plus strand

1 alternative location:

Chr5+ 156,693,089-156,822,606

RefSeq DNA sequence:

NC_000005.9 NT_023133.13

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07 (See protein sequence)

Recommended Name: Cytoplasmic FMR1-interacting protein 2

Size: 1278 amino acids; 148399 Da

Subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300,

NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated

WASF1. The complex can also be activated by NCK1

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly

expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to

the nucleus

Rna editing: Modified_positions=320; Note=Partially edited. Editing appears to be brain-specific

Sequence caution: Sequence=BAA86482.2; Type=Erroneous initiation; Sequence=BAD97324.1; Type=Erroneous initiation;

Secondary accessions: A6NLT2 Q53EN5 Q9NTK4 Q9ULQ2 Q9UN29

Alternative splicing: 2 isoforms: Q96F07-1 Q96F07-2

Explore the universe of human proteins at neXtProt for CYFIP2: NX_Q96F07

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001032409.2 NP_001032410.1 NP_055191.2

ENSEMBL proteins:

ENSP00000325817 ENSP00000430904 ENSP00000390948 ENSP00000428655 ENSP00000428520 ENSP00000430930

ENSP00000428009 ENSP00000427933 ENSP00000429846 ENSP00000428946 ENSP00000428022 ENSP00000366799

ENSP00000313567 ENSP00000428156 ENSP00000429135 ENSP00000428079 ENSP00000381303 ENSP00000428645

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for CYFIP2
	Novus Biologicals Proteins for CYFIP2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005737	cytoplasm	IDA	11438699
GO:0019717	synaptosome	IDA	11438699
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

About this table

CYFIP2 for ontologies About GeneDecksing

Antibodies for CYFIP2:

	Millipore Mono- and Polyclonal Antibodies for the study of CYFIP2
	Sigma-Aldrich Antibodies for CYFIP2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for CYFIP2
	Novus Biologicals Antibodies for CYFIP2
	Epitomics antibodies for CYFIP2

Assays for CYFIP2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYFIP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYFIP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYFIP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR008081 Cytoplasmic_FMR1-int

IPR016536 Cytoplasmic_FMR1-int_sub

Graphical View of Domain Structure for InterPro Entry Q96F07

ProtoNet protein and cluster: Q96F07

1 Blocks protein family: IPB008081 Cytoplasmic fragile X mental retardation protein interacting protein signature

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Similarity: Belongs to the CYFIP family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Function: Involved in T-cell adhesion and TP53/p53-dependent induction of apoptosis. Does not bind RNA

Induction: By TP53/p53

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CYFIP2 Sigma-Aldrich shRNA for CYFIP2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CYFIP2 OriGene shRNA RFP (see all 5): CYFIP2 OriGene basic RS shRNA (see all 5): CYFIP2 OriGene siRNA (see all 3): CYFIP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CYFIP2

miRNA:		Sigma-Aldrich microRNA Mimics for CYFIP2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CYFIP2
		7 SABiosciences Assays for microRNAs that regulate CYFIP2:
		hsa-miR-153 hsa-miR-513b hsa-miR-146b-3p hsa-miR-655 hsa-miR-514 hsa-miR-1207-3p hsa-miR-1826

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CYFIP2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CYFIP2 OriGene untagged cDNA clones in CMV expression vector (see all 4): CYFIP2 OriGene 3'-UTR clone (see all 3): CYFIP2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CYFIP2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for CYFIP2

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15048733
GO:0008009	chemokine activity	--	--

About this table

CYFIP2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

CYFIP2 for pathways About GeneDecksing

1 Millipore Pathway for CYFIP2

G-protein signaling RAC1 in cellular process

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CYFIP2

	Rac Signaling
	Actin Cytoskeleton Signaling

1 Kegg Pathway (Kegg details for CYFIP2):

hsa04810 Regulation of actin cytoskeleton

SABiosciences Pathway-Focused PCR Arrays including CYFIP2: PAHS-022A PAHS-088A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CYFIP2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYFIP2

5/17 Interacting proteins for CYFIP2 (Q96F07² ENSP00000366799³) via UniProtKB, MINT, and/or STRING (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FMR1	Q06787², ENSP00000359506³	MINT-15317 MINT-15318 STRING: ENSP00000359506
WASF1	Q92558², ENSP00000352425³	MINT-14901 STRING: ENSP00000352425
ABI3	Q9P2A4²	MINT-3390361
FXR1	P51114²	MINT-16283
FXR2	P51116²	MINT-17596

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IDA	10449408
GO:0006955	immune response	--	--
GO:0016337	cell-cell adhesion	IDA	15048733

About this table

CYFIP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYFIP2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for CYFIP2 Sigma-Aldrich shRNA for CYFIP2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): CYFIP2 OriGene shRNA RFP (see all 5): CYFIP2 OriGene basic RS shRNA (see all 5): CYFIP2 OriGene siRNA (see all 3): CYFIP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of CYFIP2

miRNA:		Sigma-Aldrich microRNA Mimics for CYFIP2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of CYFIP2
		7 SABiosciences Assays for microRNAs that regulate CYFIP2:
		hsa-miR-153 hsa-miR-513b hsa-miR-146b-3p hsa-miR-655 hsa-miR-514 hsa-miR-1207-3p hsa-miR-1826

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): CYFIP2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): CYFIP2 OriGene untagged cDNA clones in CMV expression vector (see all 4): CYFIP2 OriGene 3'-UTR Clone (see all 3): CYFIP2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for CYFIP2

Primers:		OriGene genome-wide validated SYBR primer pairs: CYFIP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CYFIP2: PPH14474A

REFSEQ mRNAs for CYFIP2 gene (3 alternative transcripts):

NM_001037332.2 NM_001037333.1 NM_014376.2

Additional cDNA sequence:

AB032994.2 AF132197.1 AF160973.1 AK172724.1 AK223604.1 AK294220.1 AK295865.1 AK297401.1

AK303702.1 AK312157.1 AL136549.1 AL161999.1 BC011762.1 BC021008.1 BC026892.2 BC066933.1

CR596909.1 CR607036.1 L47738.1

24 DOTS entries:

DT.91879845 DT.100655783 DT.454661 DT.444880 DT.100655781 DT.100862470 DT.95214650 DT.100738555

DT.101955204 DT.40252820 DT.100655782 DT.120837307 DT.95262088 DT.95339040 DT.416237 DT.100655785

DT.100803745 DT.120837343 DT.120837362 DT.120837395 DT.86838971 DT.97777401 DT.100722385 DT.97821880

24/380 AceView cDNA sequences (see all 380):

AA309733 BQ721622 BM802750 BC021008 BX364037 AA351287 BQ212237 BU154305

AA034345 BQ049658 BQ181756 CA390055 BE396592 AW468488 AL547269 CA441485

AW500506 AI954773 BQ058650 BM691201 BQ052799 AI223790 AW501520 BQ277880

highest scoring ESTs for CYFIP2:

L47738 AA027332 AA033638 AA228447 AA324178 AA351287 AA356055 AA364516 AA383780 AA609256

Unigene Cluster for CYFIP2:

Cytoplasmic FMR1 interacting protein 2

Hs.519702 [show with all ESTs]

Unigene Representative Sequence: NM_001037332

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP2 (see all 16)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:																	-
SP2:					-		-		-								-																																		-
SP3:																	-																																		-
SP4:					-		-		-								-												-
SP5:					-		-		-						-		-		-		-

ExUns:	20	^	21	^	22	^	23	^	24a	·	24b	·	24c	^	25a	·	25b	^	26a	·	26b	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34	^	35a	·	35b	·	35c	^
SP1:			-						-																								-						-				-		-				-		-
SP2:			-						-																								-						-				-		-				-		-
SP3:			-						-																								-						-				-		-				-		-
SP4:
SP5:

ExUns:	36a	·	36b	^	37a	·	37b	·	37c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CYFIP2
18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000318218(uc003lwq.2 uc011ddn.1 uc011ddo.1 uc003lwt.2 uc011ddp.1 uc003lwv.2)

ENST00000518555 ENST00000521420 ENST00000442283(uc003lwp.2) ENST00000517753

ENST00000519252 ENST00000522892 ENST00000519002 ENST00000522463 ENST00000523119

ENST00000523383 ENST00000519663 ENST00000522775 ENST00000523969 ENST00000519153

ENST00000520419 ENST00000377576(uc003lws.2) ENST00000520424

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

CYFIP2 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching CYFIP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
60441_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.08	AI422235	0.80	1.00	0.91	1
37579_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.93	L47738	1.00	0.90	0.95	1
74135_r_at²^{, 3}	U95-D	1	0.38	1.00	-0.08	1.01	AI927912	0.60	1.00	0.82	1
215785_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL161999	0.80	0.88	0.84	1
220999_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
215785_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
220999_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

CYFIP2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

CYFIP2 gene electronic northern expression

About these images

CGAP SAGE TAG: CTGGTTTCTC

SOURCE GeneReport for Unigene cluster: Hs.519702

Expression variation in blood from EXPOLDB for CYFIP2

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Tissue specificity: Expressed in T-cells. Increased expression is observed in CD4(+) T lymphocytes from patients with

multiple sclerosis (at protein level)

Primers:		OriGene genome-wide validated SYBR primer pairs: CYFIP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for CYFIP2: PPH14474A

SABiosciences Expression via Pathway-Focused PCR Arrays including CYFIP2: PAHS-022A PAHS-088A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CYFIP2 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CYFIP2¹	--	cytoplasmic FMR1 interacting protein 2	93.03(n) 99.92(a)	479317 XM_536455.2 XP_536455.2
chimpanzee (Pan troglodytes)	CYFIP2¹	--	cytoplasmic FMR1 interacting protein 2	99.65(n) 100(a)	462221 XM_001137120.1 XP_001137120.1
cow (Bos taurus)	CYFIP2¹	--	cytoplasmic FMR1 interacting protein 2	92.36(n) 99.84(a)	518833 XM_597034.3 XP_597034.3
mouse (Mus musculus)	Cyfip2^{1 , 5}	11 (27.61 cM)⁵	cytoplasmic FMR1 interacting protein 2^{1, 5}	90.9(n)¹ 99.92(a)¹	76884¹ NM_133769.2¹ NP_598530.2¹ AA930218⁵ AB093288⁵ (see all 27)
chicken (Gallus gallus)	CYFIP2¹	--	cytoplasmic FMR1 interacting protein 2	86.19(n) 99.84(a)	416246 XM_414567.2 XP_414567.2

About this table Species with no ortholog for CYFIP2

ENSEMBL Gene Tree for CYFIP2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CYFIP2 gene

CYFIP1²

CYFIP2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1247^1,2	C,F,	156761605(-)	`caataA/Gtatgt`	3	--	int¹		8	NS EA NA WA	526
rs1248^1,2	C,A,H,	156761617(-)	`aTATGT/Atgata`	3	--	int¹		9	MN NA EA WA	404
rs1249^1,2	C,A,	156761590(-)	`ctggtA/Gatatt`	3	--	int¹		9	MN NA EA WA	404
rs70529^1,2	C,A,H,	156734310(+)	`AGGAGC/TAGCCC`	3	--	int¹		7	MN NA WA	314
rs163406^1,2	C,A,	156692057(+)	`cggcgG/Ccagga`	2	--	ng5¹		2	NA	4
rs187458^1,2	C,F,A,	156693562(+)	`GGCCGG/CGAGCC`	2	--	ut5¹ int¹		2	MN NA	186
rs364479^1,2	C,A,H	156732618(+)	`ggctcG/Aagcga`	3	--	int¹		4	NA WA	8
rs369890^1,2	C,A,H,	156731773(+)	`AAATCG/TTtttt`	3	--	int¹ trp³		6	NA WA	130
rs373619^1,2	C,F,	156739876(+)	`taaaaT/Attttt`	3	--	int¹		3	NA EA WA	210
rs374411^1,2	C,F,	156734001(+)	`atggaA/Gagaag`	3	--	int¹		10	NS EA NA WA	626

About this table

HapMap Linkage Disequilibrium images for CYFIP2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYFIP2
1 CNV: 51598

QIAGEN SeqTarget long-range PCR primers for resequencing CYFIP2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYFIP2 for disorders About GeneDecksing

OMIM: 606323

Human Genome Epidemiology (HuGE) Navigator: CYFIP2 (3 documents)

Export disorders and mutations for CYFIP2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/34 PubMed articles for CYFIP2 gene, integrated from 7 sources (see all 34):
(articles sorted by number of sources associating them with CYFIP2)

CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. (PubMed id 15048733)^{1, 2, 7} Mayne M.... Melanson M. (2004)
CYFIP2, a direct p53 target, is leptomycin-B sensitive. (PubMed id 17245118)^{1, 2} Jackson R.S. II... Liang P. (2007)
Evolutionarily conserved human targets of adenosine to inosine RNA editing. (PubMed id 15731336)^{1, 2} Levanon E.Y.... Eisenberg E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PubMed id 11438699)^{1, 3} Schenck A....Mandel J.L. (2001)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{1, 2} Hirosawa M.... Ohara O. (1999)
Increased apoptosis induction by 121F mutant p53. (PubMed id 10449408)^{1, 2} Saller E....Iggo R. (1999)
Evaluation of candidate genes in a genome-wide associ ation study of childhood asthma in Mexicans. (PubMed id 19910030)^{1, 7} Wu H....London S.J. (2010)
Protein complexes containing CYFIP/Sra/PIR121 coordin ate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. (PubMed id 20228810)¹ Anitei M....Hoflack B. (2010)

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Entrez Gene: 26999	HGNC: 13760	AceView: CYFIP2	Ensembl:ENSG00000055163	euGenes: HUgn26999
ECgene: CYFIP2	Kegg: 26999	H-InvDB: CYFIP2

(According to HUGE)
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HUGE: KIAA1168

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