Aliases &
Descriptions
for CYP26C1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cytochrome P450, family 26, subfamily C, polypeptide 11 2 | | cytochrome P450 26C12 | | FLJ453012 | | EC 1.14.-.-3 |
Export aliases for CYP26C1 gene to outside databasesPrevious GC identifers: GC10P094952 GC10P094485 GC10P094811 |
Summaries
for CYP26C1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP26C1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes tothe regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome10q23.33. (provided by RefSeq)
UniProtKB/Swiss-Prot: CP26C_HUMAN, Q6V0L0Function: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and itsstereoisomer 9-cis-RA (preferred substrate)
 summary
for CYP26C1: Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.
|
Genomic Views
for CYP26C1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP26C1 gene promoter:
Egr-1 Cart-1 NRSF form 2 NRSF form 1 Cdc5 HOXA9B Meis-1 FOXI1 FAC1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP26C1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for CYP26C1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.33 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23.33CYP26C1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P088448: view genomic region
(about GC identifiers)
Start:
|
88,448,547 bp from pter |
End:
|
88,455,975 bp from pter |
Size:
|
7,429 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 94,820,565-94,829,293 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for CYP26C1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CP26C_HUMAN, Q6V0L0 (See
protein sequence)Recommended Name: Cytochrome P450 26C1 Size: 522 amino acids; 57111 Da
Cofactor: Heme group (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q5VXH6Explore the universe of human proteins at neXtProt for CYP26C1: NX_Q6V0L0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_899230.2
ENSEMBL proteins: ENSP00000285949 ENSP00000413120
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CYP26C1 for ontologies About GeneDecksing
Antibodies for CYP26C1:
Assays for CYP26C1: |
Protein
Domains/
Families
for CYP26C1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP26C1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6V0L0ProtoNet protein and cluster: Q6V0L0 1 Blocks protein family: IPB002403 E-class P450 group IV signature
UniProtKB/Swiss-Prot: CP26C_HUMAN, Q6V0L0Similarity: Belongs to the cytochrome P450 family |
Gene Function
for CYP26C1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CP26C_HUMAN, Q6V0L0Function: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and itsstereoisomer 9-cis-RA (preferred substrate)Induction: By retinoic acidEnzyme Number (IUBMB): EC 1.14.-.-
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
CYP26C1 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cyp26c1):
CYP26C1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYP26C1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CYP26C1 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for CYP26C1):
SABiosciences Pathway-Focused PCR Array including CYP26C1: PAHS-068A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP26C1
5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8): About this table
CYP26C1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP26C1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for CYP26C1 available from Tocris Bioscience
About this table
|
Transcripts
for CYP26C1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CYP26C1 gene: NM_183374.2 Additional cDNA sequence: AK127234.1 AK131099.1 AY356349.1 3 DOTS entries: DT.101980241 DT.101980240 DT.65286830 5 AceView cDNA sequences: AK131099 AK127234 AY356349 NM_183374 BI043270
 highest scoring ESTs for CYP26C1:AK131099 AY356349 AK127234 NM_183374 BI043270 AI828091 AI884778 DA314034 DA811474 DW412517 Unigene Cluster for CYP26C1: Cytochrome P450, family 26, subfamily C, polypeptide 1 Hs.369993 [show with all ESTs]Unigene Representative Sequence: AK131099
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CYP26C1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CYP26C1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285949(uc010qns.1) ENST00000424745(uc009xud.2)
|
Expression
for CYP26C1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CYP26C1 expression in normal and diseased human tissues
1 / 3 Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.369993
UniProtKB/Swiss-Prot: CP26C_HUMAN, Q6V0L0Tissue specificity: Detected in most tissues at very low level
SABiosciences Expression via Pathway-Focused PCR Array including CYP26C1: PAHS-068A
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Orthologs
for CYP26C1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CYP26C1 gene from 5/6 species (see all 6)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
cow
(Bos taurus) |
LOC5390481 |
-- |
similar to cytochrome P450, family 26, subfamily C, more |
88.44(n)
89.21(a) |
539048 XM_584485.3 XP_584485.3 |
rat
(Rattus norvegicus) |
Cyp26c11 |
-- |
cytochrome P450, family 26, subfamily C, polypeptide more |
84.4(n)
86.8(a) |
308190 XM_217935.3 XP_217935.3 |
mouse
(Mus musculus) |
Cyp26c11 , 5 |
19 (32.36 cM)5
|
cytochrome P450, family 26, subfamily c, polypeptide more1, 5 |
84.56(n)1
87.98(a)1 |
5467261 XM_621503.21 XP_621503.21
BC1510985 BC1511065 |
chicken
(Gallus gallus) |
CYP26C11 |
-- |
cytochrome P450, family 26, subfamily C, polypeptide more |
73.03(n)
73.18(a) |
423806 XM_421678.2 XP_421678.2 |
African clawed frog
(Xenopus laevis) |
Xl.19462 |
-- |
Xenopus laevis transcribed sequence with weak similarity more |
75.4(n) |
BJ065612.1 |
About this table Species with no ortholog for CYP26C1
ENSEMBL Gene Tree for CYP26C1 (if available) |
Paralogs
for CYP26C1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CYP26C1 gene
- CYP51A12 CYP26A12 CYP26B12
CYP26C1 for paralogs About GeneDecksing
|
Genomic Variants
for CYP26C1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CYP26C1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYP26C1
2 CNVs: 75357 85434 | | QIAGEN SeqTarget long-range PCR primers for resequencing CYP26C1 |
|
Disorders & Mutations
for CYP26C1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP26C1 for disorders About GeneDecksing
OMIM: 608428
Human Genome Epidemiology (HuGE) Navigator: CYP26C1 (3 documents)
Export disorders and mutations for CYP26C1 gene to outside databases
|
Medical News
for CYP26C1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CYP26C1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
7 PubMed articles for CYP26C1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CYP26C1)- A novel human cytochrome P450, CYP26C1, involved in metabolism of 9- cis and all-trans isomers of retinoic acid. (PubMed id 14532297)1, 2, 7 Taimi M.... Petkovich M. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Positive association between ALDH1A2 and schizophreni a in the Chinese population. (PubMed id 19703508)1 Wan C....He L. (2009)
- Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. (PubMed id 16933217)1 Rat E....Broly F. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
- Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. (PubMed id 19016711)7 Pavez LoriA" E....Vahlquist A. (2009)
|
External Searches for CYP26C1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP26C1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP26C1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP26C1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CYP26C1 gene:
Search GeneIP for patents involving CYP26C1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP26C1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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