Aliases &
Descriptions
for CYP3A43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cytochrome P450, family 3, subfamily A, polypeptide 431 2 | | cytochrome P450 3A432 | | cytochrome P450, subfamily IIIA, polypeptide 431 2 | | cytochrome P450 polypeptide 432 | | OTTHUMP000002099892 | | MGC1193162 | | MGC1193152 | | EC 1.14.14.13 |
Export aliases for CYP3A43 gene to outside databasesPrevious GC identifers: GC07P097960 GC07P099023 GC07P099037 GC07P099070 GC07P099263 GC07P099426 |
Summaries
for CYP3A43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP3A43:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to somedrug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. Thisgene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results inthree transcript variants encoding different isoforms. (provided by RefSeq)
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55Function: Exhibits low testosterone 6-beta-hydroxylase activity
|
Genomic Views
for CYP3A43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP3A43 gene promoter:
GATA-1 C/EBPalpha CHOP-10 PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP3A43
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21.1CYP3A43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P094062: view genomic region
(about GC identifiers)
Start:
|
94,061,564 bp from pter |
End:
|
94,100,060 bp from pter |
Size:
|
38,497 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 99,425,636-99,464,173 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079595.2
|
Proteins
for CYP3A43 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55 (See
protein sequence)Recommended Name: Cytochrome P450 3A43 Size: 503 amino acids; 57670 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheralmembrane protein
Secondary accessions: Q9HB52 Q9HB53 Q9HB54 Q9HB57Alternative splicing: 5 isoforms: Q9HB55-1 Q9HB55-2 Q9HB55-3 Q9HB55-4 Q9HB55-5 (Additional isoforms seem to exist)Explore the universe of human proteins at neXtProt for CYP3A43: NX_Q9HB55
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_073731.1 NP_476436.1 NP_476437.1
ENSEMBL proteins: ENSP00000405557 ENSP00000222382 ENSP00000416581 ENSP00000401521 ENSP00000400316 ENSP00000312110 ENSP00000411653 ENSP00000415221 ENSP00000368975 ENSP00000345351 ENSP00000397332 ENSP00000346887
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CYP3A43 for ontologies About GeneDecksing
Antibodies for CYP3A43:
Assays for CYP3A43: |
Protein
Domains/
Families
for CYP3A43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP3A43 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HB55ProtoNet protein and cluster: Q9HB55 2 Blocks protein families: IPB002401 E-class P450 group I signature IPB008072 CYP3A P450 family signature
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55Similarity: Belongs to the cytochrome P450 family |
Gene Function
for CYP3A43 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55Function: Exhibits low testosterone 6-beta-hydroxylase activityCatalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)OInduction: By rifampicinEnzyme Number (IUBMB): EC 1.14.14.1
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
CYP3A43 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP3A43 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CYP3A43 for pathways About GeneDecksing
5  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CYP3A43
5/8  Kegg Pathways (Kegg details for CYP3A43) (see all 8):
SABiosciences Pathway-Focused PCR Array including CYP3A43: PAHS-068A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CYP3A43
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP3A43
5/48 Interacting proteins for CYP3A43 (ENSP000002223823) via UniProtKB, MINT, and/or STRING (see all 48)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006805 | xenobiotic metabolic process |
TAS | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
CYP3A43 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP3A43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CYP3A43
|
Transcripts
for CYP3A43 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CYP3A43 gene (3 alternative transcripts): NM_022820.3 NM_057095.1 NM_057096.2 Additional cDNA sequence: AF280108.1 AF280109.1 AF280110.1 AF280111.1 AF280112.1 AF280113.1 AF319634.1 AF337813.1 AY390423.1 AY390424.1 AY390425.1 AY390426.1 BC100981.3 BC100982.3 3 DOTS entries: DT.104214 DT.100745110 DT.99960925 20 AceView cDNA sequences: NM_057095 AY390423 AF280112 AF280109 AF319634 NM_022820 AY390424 BX092633 AY390425 AF280108 AF280111 NM_057096 AF280113 AY390426 BX951468 AA417369 AF337813 AW662829 AA416822 AF280110
 highest scoring ESTs for CYP3A43:AA417369 AF280108 AF280109 AF280110 AF280111 AF280113 AF319634 AF337813 AY390423 AY390424 Unigene Cluster for CYP3A43: Cytochrome P450, family 3, subfamily A, polypeptide 43 Hs.306220 [show with all ESTs]Unigene Representative Sequence: NM_022820
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP3A43 (see all 6)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for CYP3A43
18 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495115 ENST00000463915 ENST00000444905 ENST00000222382 ENST00000417625
ENST00000415413 ENST00000433277 ENST00000312017 ENST00000434806 ENST00000491648
ENST00000472352 ENST00000436834 ENST00000379654(uc003urx.1 uc003ury.1 uc003urz.1 uc003usa.1 uc010lgi.1)
ENST00000481362 ENST00000342499(uc003usb.1) ENST00000477658 ENST00000421837
ENST00000354829
|
Expression
for CYP3A43 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CYP3A43 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching CYP3A43 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 207773_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_022820 |
0.60 |
1.00 |
0.82 |
1 |
| 211440_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF280110 |
0.80 |
1.00 |
0.91 |
1 |
| 211442_x_at2, 3
|
U133-A |
4 |
1.00 |
0.93 |
-- |
-- |
AF280111 |
0.80 |
1.00 |
0.91 |
1 |
| 211441_x_at2, 3
|
U133-A |
4 |
0.91 |
0.93 |
-- |
-- |
AF280113 |
0.80 |
1.00 |
0.91 |
1 |
| 207773_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211440_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211442_x_at2
|
U133Plus2 |
4 |
1.00 |
0.93 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211441_x_at2
|
U133Plus2 |
4 |
0.91 |
0.93 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTCCATTTGT
SOURCE GeneReport for Unigene cluster: Hs.306220
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55Tissue specificity: Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver andfetal skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including CYP3A43: PAHS-068A
|
Orthologs
for CYP3A43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CYP3A43 gene from 5/7 species (see all 7)
About this table Species with no ortholog for CYP3A43
ENSEMBL Gene Tree for CYP3A43 (if available) |
Paralogs
for CYP3A43 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CYP3A43 gene
- TBXAS12 CYP3A52 CYP46A12 CYP3A42 CYP3A72
CYP3A43 for paralogs About GeneDecksing
|
Genomic Variants
for CYP3A43 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
UniProtKB/Swiss-Prot: CP343_HUMAN, Q9HB55Polymorphism: At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is thatof CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CYP3A43 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CYP3A43
4 CNVs: 94732 64899 82103 94733 |
Disorders & Mutations
for CYP3A43 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP3A43 for disorders About GeneDecksing
OMIM: 606534
Locus Specific Mutation Databases (LSDB): CYP3A43
Human Gene Mutation Database (HGMD): CYP3A43
Genetic Association Database (GAD): CYP3A43
Human Genome Epidemiology (HuGE) Navigator: CYP3A43 (10 documents)
Export disorders and mutations for CYP3A43 gene to outside databases
|
Medical News
for CYP3A43 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CYP3A43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/22 PubMed articles for CYP3A43 gene, integrated from 7 sources (see all 22):
(articles sorted by number of sources associating them with CYP3A43)- cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. (PubMed id 11160876)1, 2, 3, 7 Domanski T.L.... Zaphiropoulos P.G. (2001)
- First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant. (PubMed id 14695544)1, 2, 4, 7 Cauffiez C.... Broly F. (2004)
- Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. (PubMed id 11266076)1, 2, 3, 7 Gellner K....Wojnowski L. (2001)
- CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians. (PubMed id 15894682)1, 4 Stone A....Lang N.P. (2005)
- CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. (PubMed id 15548719)1, 4 Zeigler-Johnson C....Rebbeck T.R. (2004)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Intergenic mRNA molecules resulting from trans-splicing. (PubMed id 11726664)1, 2 Finta C. and Zaphiropoulos P.G. (2002)
- Cloning and tissue distribution of a novel human cytochrome P450 of the CYP3A subfamily, CYP3A43. (PubMed id 11243885)1, 2 Westlind A.... Oscarson M. (2001)
- Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia. (PubMed id 16848237)1, 7 Shchepotina E.G....Lyakhovich V.V. (2005)
- Evaluation of candidate genes for cholinesterase acti vity in farmworkers exposed to organophosphorus pesticides: association of sing le nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (2010)
|
External Searches for CYP3A43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP3A43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP3A43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP3A43 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Cytochrome P450 Allele Nomenclature Committee | http://www.cypalleles.ki.se/cyp3a43.htm |
|
| | |
About This Section
| Patent Information for CYP3A43 gene:
Search GeneIP for patents involving CYP3A43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP3A43 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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