Aliases &
Descriptions
for CYP4Z1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| cytochrome P450, family 4, subfamily Z, polypeptide 11 2 | | CYP4A201 2 | | CYPIVZ12 3 | | cytochrome P450 4Z12 | | EC 1.14.14.13 |
Export aliases for CYP4Z1 gene to outside databasesPrevious GC identifers: GC01P046923 GC01P046903 GC01P046902 GC01P047245 GC01P047305 GC01P047533 |
Summaries
for CYP4Z1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP4Z1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. (provided by RefSeq)
|
Genomic Views
for CYP4Z1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP4Z1 gene promoter:
NF-Y Chx10 NF-YA CP1A Meis-1 HOXA9B HNF-1A XBP-1 AP-2rep CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP4Z1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33CYP4Z1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P045649: view genomic region
(about GC identifiers)
Start:
|
45,649,119 bp from pter |
End:
|
45,699,646 bp from pter |
Size:
|
50,528 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr1+ 47,533,160-47,583,991 |
RefSeq DNA sequence:- NC_000001.10 NT_032977.9
|
Proteins
for CYP4Z1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10 (See
protein sequence)Recommended Name: Cytochrome P450 4Z1 Size: 505 amino acids; 59086 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane;Single-pass type II membrane protein
Secondary accessions: Q5VVE4Explore the universe of human proteins at neXtProt for CYP4Z1: NX_Q86W10
REFSEQ proteins: NP_835235.1
ENSEMBL proteins: ENSP00000334246
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
CYP4Z1 for ontologies About GeneDecksing
Antibodies for CYP4Z1:
Assays for CYP4Z1: |
Protein
Domains/
Families
for CYP4Z1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP4Z1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86W10ProtoNet protein and cluster: Q86W10 UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10Similarity: Belongs to the cytochrome P450 family |
Gene Function
for CYP4Z1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)OEnzyme Number (IUBMB): EC 1.14.14.1
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
CYP4Z1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CYP4Z1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
CYP4Z1 for pathways About GeneDecksing
5/6  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for CYP4Z1 (see all 6)
SABiosciences Custom Pathway-Focused PCR Arrays for CYP4Z1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for CYP4Z1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP4Z1
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
CYP4Z1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP4Z1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for CYP4Z1
|
Transcripts
for CYP4Z1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for CYP4Z1 gene: NM_178134.2 Additional cDNA sequence: AK292175.1 AY262056.1 AY358631.1 2 DOTS entries: DT.100742965 DT.106617 22 AceView cDNA sequences: AY358631 NM_178134 BG218514 BG193485 AY262056 BX094680 BG210988 H21976 AI733538 BG201072 AI668594 AV700083 AV689946 BG219391 H25577 BG212152 AI668602 AW472756 BG192933 AI820775 BG204180 H25624
 highest scoring ESTs for CYP4Z1:AI668602 AY262056 AY358631 AI668594 AI733538 AI820775 AV700083 AW472756 BG192933 BG193485 Unigene Cluster for CYP4Z1: Cytochrome P450, family 4, subfamily Z, polypeptide 1 Hs.176588 [show with all ESTs]Unigene Representative Sequence: AY358631
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334194(uc001cqu.1) ENST00000471598
|
Expression
for CYP4Z1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| CYP4Z1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching CYP4Z1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 59570_at2, 3
|
U95-B |
2 |
0.94 |
0.97 |
1.00 |
1.00 |
AI668602 |
0.80 |
1.00 |
0.91 |
1 |
| 237395_at2, 3
|
U133-B |
2 |
1.00 |
0.95 |
-- |
-- |
AV700083 |
0.60 |
1.00 |
0.82 |
1 |
| 237395_at2
|
U133Plus2 |
2 |
1.00 |
0.95 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
CYP4Z1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATAGCTTTAT
SOURCE GeneReport for Unigene cluster: Hs.176588
UniProtKB/Swiss-Prot: CP4Z1_HUMAN, Q86W10Tissue specificity: Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginalexpression is found in all other tested tissues
SABiosciences Custom PCR Arrays for CYP4Z1
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Orthologs
for CYP4Z1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CYP4Z1 gene from 3 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
African clawed frog
(Xenopus laevis) |
AB022671.12 |
-- |
-- |
73.56(n) |
AB022671.1 |
thale cress
(Arabidopsis thaliana) |
BAS1/CYP734A11 |
-- |
BAS1/CYP734A1 (PHYB ACTIVATION TAGGED SUPPRESSOR 1); more |
44.55(n)
33.65(a) |
817212 NM_128228.2 NP_180239.1 |
rice
(Oryza sativa) |
Os06g06004001 |
-- |
hypothetical protein |
42.5(n)
30.17(a) |
4341450 NM_001064535.1 NP_001058000.1 |
About this table Species with no ortholog for CYP4Z1
ENSEMBL Gene Tree for CYP4Z1 (if available) |
Paralogs
for CYP4Z1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for CYP4Z1 gene
- CYP4B12 CYP4A112 CYP4X12 CYP4A222
CYP4Z1 for paralogs About GeneDecksing
|
Genomic Variants
for CYP4Z1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for CYP4Z1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP4Z1
1 CNV: 68525 | | QIAGEN SeqTarget long-range PCR primers for resequencing CYP4Z1 |
|
Disorders & Mutations
for CYP4Z1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for CYP4Z1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for CYP4Z1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for CYP4Z1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with CYP4Z1)- Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma. (PubMed id 15059886)1, 2, 3, 7 Rieger M.A.... Weigle B. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Conditional regulation of the human CYP4X1 and CYP4Z1 genes. (PubMed id 15797250)1, 7 Savas U....Johnson E.F. (2005)
- Identification of genes associated with non-small-cel l lung cancer promotion and progression. (PubMed id 19473719)1 Bankovic J....Tanic N. (2010)
- Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid. (PubMed id 19090726)1 ZAPllner A....Bureik M. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
- The cytochrome P450 4 (CYP4) family. (PubMed id 9068972)1 Simpson A.E. (1997)
- Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells. (PubMed id 16527260)7 Thomas R.D....Runge-Morris M. (2006)
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External Searches for CYP4Z1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CYP4Z1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP4Z1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP4Z1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CYP4Z1 gene:
Search GeneIP for patents involving CYP4Z1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP4Z1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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