Aliases &
Descriptions
for DAAM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| dishevelled associated activator of morphogenesis 21 2 | | KIAA03811 2 3 5 | | MGC905152 | | dishevelled-associated activator of morphogenesis 22 | | dJ90A20A.12 | | disheveled-associated activator of morphogenesis 22 |
Export aliases for DAAM2 gene to outside databasesPrevious GC identifers: GC06P039837 GC06P039807 GC06P039868 |
Summaries
for DAAM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DAAM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DAAM2 gene promoter:
MRF-2 FAC1 ATF-2 c-Jun CREB deltaCREB POU2F1 POU3F2 MEF-2A IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DAAM2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.1DAAM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P039535: view genomic region
(about GC identifiers)
Start:
|
39,535,788 bp from pter |
End:
|
39,590,458 bp from pter |
Size:
|
54,671 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+ 39,760,142-39,872,644 |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15
|
Proteins
for DAAM2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65 (See
protein sequence)Recommended Name: Disheveled-associated activator of morphogenesis 2 Size: 1068 amino acids; 123499 Da
Sequence caution: Sequence=BAA20835.2; Type=Erroneous initiation;
Secondary accessions: Q5T4T8 Q5T4U0 Q9NQI5 Q9Y4G0Explore the universe of human proteins at neXtProt for DAAM2: NX_Q86T65
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056160.2
ENSEMBL proteins: ENSP00000381876 ENSP00000384637 ENSP00000274867
Human Recombinant Proteins
Antibodies for DAAM2:
Assays for DAAM2: |
Protein
Domains/
Families
for DAAM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DAAM2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q86T65ProtoNet protein and cluster: Q86T65 2 Blocks protein families: IPB003104 Actin-binding FH2 IPB010472 Diaphanous FH3
UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65Similarity: Belongs to the formin homology familySimilarity: Contains 1 DAD (diaphanous autoregulatory) domainSimilarity: Contains 1 FH1 (formin homology 1) domainSimilarity: Contains 1 FH2 (formin homology 2) domainSimilarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain |
Gene Function
for DAAM2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
DAAM2 for ontologies About GeneDecksing
|
Pathways & Interactions
for DAAM2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DAAM2 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for DAAM2):
SABiosciences Custom Pathway-Focused PCR Arrays for DAAM2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAAM2
5 Interacting proteins for DAAM2 (ENSP000002748673) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016043 | cellular component organization |
IEA | -- | | GO:0030036 | actin cytoskeleton organization |
IEA | -- |
About this table
DAAM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DAAM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DAAM2
|
Transcripts
for DAAM2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DAAM2 gene: NM_015345.2 Additional cDNA sequence: AB002379.2 AK127022.1 AK310111.1 AK310941.1 AL833083.2 BC014275.2 BC047555.1 BC078153.1 BC128388.1 17 DOTS entries: DT.101983952 DT.91744099 DT.100048626 DT.95174580 DT.91715233 DT.101972336 DT.100694454 DT.100000228 DT.100025782 DT.100638231 DT.91712887 DT.95174584 DT.97843321 DT.121366769 DT.40265466 DT.75146294 DT.91814233 24/155 AceView cDNA sequences (see all 155): AI695717 BF197174 CD674696 BM702131 AA351772 BM998829 BG765111 BM974490 BQ672979 BM664836 AI375627 Z40552 AA642518 BG770201 BM722673 BC014275 AW513907 AI572246 CF130640 AI366006 BF594052 BG761505 AL121065 BU681846
 highest scoring ESTs for DAAM2:AB002379 AA346905 AA348768 AI140880 AI252798 AI572246 AL039871 AL596694 AL596702 AL833083 Unigene Cluster for DAAM2: Dishevelled associated activator of morphogenesis 2 Hs.357128 [show with all ESTs]Unigene Representative Sequence: AL833083
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 (see all 17)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DAAM2
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398904(uc003oox.2) ENST00000494405 ENST00000475489(uc003ooy.3)
ENST00000405961(uc003oov.3) ENST00000274867(uc010jxc.2 uc003oow.2)
ENST00000496787 ENST00000491083
|
Expression
for DAAM2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DAAM2 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching DAAM2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 41098_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
1.00 |
1.00 |
AB002379 |
1.00 |
1.00 |
1.00 |
1 |
| 212793_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
BF513244 |
0.80 |
1.00 |
0.91 |
1 |
| 212793_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DAAM2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCTCCCCAC
SOURCE GeneReport for Unigene cluster: Hs.357128
Expression variation in blood from EXPOLDB for DAAM2 UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65Tissue specificity: Expressed in most tissues examined
SABiosciences Custom PCR Arrays for DAAM2
|
Orthologs
for DAAM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAAM2 gene from 5/8 species (see all 8)
About this table Species with no ortholog for DAAM2
ENSEMBL Gene Tree for DAAM2 (if available) |
Paralogs
for DAAM2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DAAM2 gene
- DAAM12 FHDC12
DAAM2 for paralogs About GeneDecksing
|
Genomic Variants
for DAAM2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DAAM2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DAAM2
1 CNV: 93690 | | QIAGEN SeqTarget long-range PCR primers for resequencing DAAM2 |
|
Disorders & Mutations
for DAAM2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DAAM2 for disorders About GeneDecksing
OMIM: 606627
Human Genome Epidemiology (HuGE) Navigator: DAAM2 (1 document)
Export disorders and mutations for DAAM2 gene to outside databases
|
Medical News
for DAAM2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DAAM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for DAAM2 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with DAAM2)- Identification and characterization of human DAAM2 gene in silico. (PubMed id 12632087)1, 3, 7 Katoh M. and Katoh M. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PubMed id 11779461)1, 3 Habas R.... He X. (2001)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
- Genome-wide association study identifies five loci as sociated with lung function. (PubMed id 20010834)1 Repapi E....Rudnicka A.R. (2010)
- Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1 Hirata H....Dahiya R. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Sequence identification of 2,375 human brain genes. (PubMed id 1538749)1 Adams M.D.... Venter J.C. (1992)
- WNT/PCP signaling pathway and human cancer (review). (PubMed id 16273260)7 Katoh M. (2005)
|
External Searches for DAAM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DAAM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DAAM2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DAAM2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DAAM2 gene:
Search GeneIP for patents involving DAAM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DAAM2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for DAAM2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DAAM2 |
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