Aliases &
Descriptions
for DAZAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| DAZ associated protein 11 2 | | MGC199071 2 | | Deleted in azoospermia-associated protein 12 3 | | deleted in azoospermia associated protein 12 | | DAZ-associated protein 12 |
Export aliases for DAZAP1 gene to outside databasesPrevious GC identifers: GC19P001465 GC19P001347 GC19P001359 GC19P001360 GC19P001361 |
Summaries
for DAZAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DAZAP1:
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. Ahigh percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted inazoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severelyoligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning ofthe ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes aRNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factorsDAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5Function: RNA-binding protein, which may be required during spermatogenesis
Gene Wiki entry for DAZAP1 (DAZ associated protein 1) |
Genomic Views
for DAZAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DAZAP1 gene promoter:
PPAR-gamma2 PPAR-gamma1 Pax-6 YY1 E2F-1 E2F E2F-2 E2F-3a E2F-5 E2F-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for DAZAP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DAZAP1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3DAZAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001170: view genomic region
(about GC identifiers)
Start:
|
1,170,341 bp from pter |
End:
|
1,210,179 bp from pter |
Size:
|
39,839 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 1,407,584-1,435,683 |
RefSeq DNA sequence:- NC_000019.9 NT_011255.14
|
Proteins
for DAZAP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 (See
protein sequence)Recommended Name: DAZ-associated protein 1 Size: 407 amino acids; 43383 Da
Subunit: Interacts with DAZ and DAZL
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (Bysimilarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized inboth the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizesmainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity)
Sequence caution: Sequence=BAB71295.1; Type=Erroneous initiation;
PDB structure from  and Proteopedia  :2DGS (3D)
2DH8 (3D)
Secondary accessions: Q96MJ3 Q9NRR9Alternative splicing: 2 isoforms: Q96EP5-1 Q96EP5-2 Explore the universe of human proteins at neXtProt for DAZAP1: NX_Q96EP5
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_061832.2 NP_733829.1
ENSEMBL proteins: ENSP00000233078 ENSP00000378904 ENSP00000337132
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
DAZAP1 for ontologies About GeneDecksing
Antibodies for DAZAP1:
Assays for DAZAP1: |
Protein
Domains/
Families
for DAZAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DAZAP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96EP5ProtoNet protein and cluster: Q96EP5 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5Similarity: Contains 2 RRM (RNA recognition motif) domains |
Gene Function
for DAZAP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5Function: RNA-binding protein, which may be required during spermatogenesis
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
DAZAP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DAZAP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for DAZAP1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAZAP1
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
About this table
DAZAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DAZAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DAZAP1
|
Transcripts
for DAZAP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DAZAP1 gene (2 alternative transcripts): NM_018959.2 NM_170711.1 Additional cDNA sequence: AF181719.1 AK056850.1 AK124583.1 AK125032.1 AK128682.1 AL360261.1 BC012062.1 CR601549.1 CR608914.1 CR619052.1 CR626076.1 24/30 DOTS entries (see all 30): DT.100690251 DT.100824328 DT.97859319 DT.97786432 DT.456067 DT.91862508 DT.121495017 DT.100824333 DT.100824337 DT.40113747 DT.40278462 DT.92034325 DT.100824334 DT.95201609 DT.121495005 DT.100824338 DT.40278443 DT.65287030 DT.92427967 DT.95111539 DT.95201593 DT.95229276 DT.100824327 DT.100824331 24/1397 AceView cDNA sequences (see all 1397): CR608914 AI290933 AI707933 BM910580 BU579796 BE901680 BE383224 BQ674967 AJ708622 CD106986 CF129091 BG388078 AI669716 BF685471 BM856496 BU726264 BU539823 CD385238 BU075869 BE793105 BM559229 BU507059 BQ430302 CA434031
 highest scoring ESTs for DAZAP1:AA523424 AI951998 AI675162 AA046936 AA046956 AA278780 AA419178 AA626856 AA628585 AA643519 Unigene Cluster for DAZAP1: DAZ associated protein 1 Hs.222510 [show with all ESTs]Unigene Representative Sequence: AK124583
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP1 (see all 10)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DAZAP1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000233078 ENST00000395533 ENST00000336761(uc002lsm.2 uc002lsn.2 uc002lso.2 uc002lsl.1)
|
Expression
for DAZAP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DAZAP1 expression in normal and diseased human tissues
1 / 2 / 3 13 probe-sets matching DAZAP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 75641_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.84 |
0.57 |
AA046956 |
0.80 |
1.00 |
0.91 |
1 |
| 65586_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.86 |
1.06 |
AI951998 |
1.00 |
1.00 |
1.00 |
1 |
| 52558_s_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.95 |
1.03 |
AI675162 |
1.00 |
0.90 |
0.95 |
1 |
| 45513_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.96 |
1.05 |
AA478830 |
0.60 |
0.83 |
0.73 |
1 |
| 52559_r_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.35 |
1.39 |
AI675162 |
1.00 |
0.90 |
0.95 |
1 |
| 62527_r_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.30 |
0.70 |
AA523424 |
1.00 |
1.00 |
1.00 |
1 |
| 50940_at2, 3
|
U95-C |
1 |
0.81 |
1.00 |
0.79 |
1.21 |
AI992237 |
0.60 |
1.00 |
0.82 |
1 |
| 218443_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018959 |
0.60 |
1.00 |
0.82 |
1 |
| 226620_x_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI951998 |
1.00 |
1.00 |
1.00 |
1 |
| 229813_x_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
BF512907 |
0.40 |
1.00 |
0.76 |
1 |
| 218443_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226620_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 229813_x_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DAZAP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGCAAGCCCC
SOURCE GeneReport for Unigene cluster: Hs.222510
UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5Tissue specificity: Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart,liver, brain, placenta, lung, skeletal muscle, kidney and pancreas
SABiosciences Custom PCR Arrays for DAZAP1
|
Orthologs
for DAZAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAZAP1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for DAZAP1
ENSEMBL Gene Tree for DAZAP1 (if available) |
Paralogs
for DAZAP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DAZAP1 gene
- HNRNPD2 HNRNPA02 MSI22 HNRNPAB2 MSI12 HNRPDL2
DAZAP1 for paralogs About GeneDecksing
|
Genomic Variants
for DAZAP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DAZAP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DAZAP1
3 CNVs: 7191 4066 5066 | | QIAGEN SeqTarget long-range PCR primers for resequencing DAZAP1 |
|
Disorders & Mutations
for DAZAP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DAZAP1 for disorders About GeneDecksing
OMIM: 607430
1  Novoseek disease relationship for DAZAP1 gene
About this table
Export disorders and mutations for DAZAP1 gene to outside databases
|
Medical News
for DAZAP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DAZAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/17 PubMed articles for DAZAP1 gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with DAZAP1)- Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 3 Tsui S.... Yen P.H. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. (PubMed id 11604102)1, 7 Dai T....Yen P.H. (2001)
- Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. (PubMed id 16209998)1, 7 Pan H.A....Kuo P.L. (2005)
- Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. (PubMed id 15744350)1, 7 Prima V.... Hunger S.P. (2005)
- DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. (PubMed id 19285026)1, 7 Yang H.T....Rousseau S. (2009)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. (PubMed id 18391021)1 Goina E....Pagani F. (2008)
|
External Searches for DAZAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DAZAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DAZAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAZAP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DAZAP1 gene:
Search GeneIP for patents involving DAZAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DAZAP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for DAZAP1 |
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