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DCLK1 Gene

protein-coding   GIFtS: 56

GC13M017156
doublecortin-like kinase 1
(Previous name: doublecortin and CaM kinase-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DCAMKL1)
Products    

Aliases &
Descriptions
for DCLK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
doublecortin-like kinase 11 2 3     Doublecortin-like and CAM kinase-like 12 3
KIAA03691 2 3 5     CLICK12 5
DCDC3A1 2 3     CL12 5
DCAMKL12 3 5     serine/threonine-protein kinase DCLK12
DCLK1 2     OTTHUMP000000182522
doublecortin and CaM kinase-like 11 2     EC 2.7.11.13
Doublecortin domain-containing protein 3A2 3     

External Ids:    HGNC: 27001   Entrez Gene: 92012   Ensembl: ENSG000001330837   UniProtKB: O150753   

Export aliases for DCLK1 gene to outside databases

Previous GC identifers: GC13M035244 GC13M036343


Summaries
for DCLK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DCLK1:
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this
gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a
C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent
protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which
mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is
independent of its protein kinase activity. The encoded protein is involved in several different cellular processes,
including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by
brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript
variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length
nature and biological validity of some variants have not been defined. These variants encode different isoforms, which
are differentially expressed and have different kinase activities.

UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the
developing brain. May also participate in functions of the mature nervous system

Gene Wiki entry for DCLK1

Genomic Views
for DCLK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DCLK1
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for DCLK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

DCLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCLK1 gene location

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M017156:  view genomic region     (about GC identifiers)

Start:
 17,156,433 bp from pter
End:
 17,334,638 bp from pter
Size:
 178,206 bases
Orientation:
 minus strand

1 alternative location:
Chr13- 36,343,122-36,705,443     
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  

Proteins
for DCLK1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase DCLK1  
Size: 740 amino acids; 82224 Da
Sequence caution: Sequence=BAA20824.2; Type=Erroneous initiation;
PDB structures from and Proteopedia :
1MFW (3D)    1MG4 (3D)    1UF0 (3D)    
Secondary accessions: B7Z3E9 Q5VZY8 Q5VZZ0 Q5VZZ1
Alternative splicing: 4 isoforms:  O15075-1   O15075-2   O15075-3   O15075-4   (Additional isoforms seem to exist. Type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain. An alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms)

Explore the universe of human proteins at neXtProt for DCLK1: NX_O15075 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001182344.1  NP_001182345.1  NP_001182359.1  NP_004725.1  


    ENSEMBL proteins: 
    ENSP00000255448 ENSP00000369223 ENSP00000353846 ENSP00000369222 ENSP00000382257 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for DCLK1 
    Novus Biologicals Protein for DCLK1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887 integral to plasma membrane TAS10036192
    About this table

    DCLK1 for ontologies           About GeneDecksing



    Antibodies for DCLK1: 
    Millipore Mono- and Polyclonal Antibodies for the study of DCLK1
    Sigma-Aldrich Antibodies for DCLK1
    Browse R&D Systems for Antibodies
    OriGene Antibodies: DCLK1
    GenScript Custom Superior Antibodies Services for DCLK1 
    Novus Biologicals Antibodies for DCLK1
    Browse antibodies at Epitomics

    Assays for DCLK1: 
    Millipore Kits and Assays for the Analysis of DCLK1
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCLK1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DCLK1 

    Protein Domains/
    Families
    for DCLK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCLK1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR003533 Doublecortin_dom
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR017442 Se/Thr_prot_kinase-like_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry O15075

    ProtoNet protein and cluster: O15075

    1 Blocks protein family: IPB003533 Doublecortin

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 2 doublecortin domains
    Similarity: Contains 1 protein kinase domain


    Gene Function
    for DCLK1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the
    developing brain. May also participate in functions of the mature nervous system
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:            		Millipore RNAi Products for the Analysis of DCLK1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for DCLK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DCLK1
    Sigma-Aldrich shRNA Panels and shRNA for DCLK1
    OriGene 29mer shRNA kits in GFP-retroviral vector: DCLK1
    OriGene shRNA RFP: DCLK1
    OriGene basic RS shRNA: DCLK1
    OriGene siRNA: DCLK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DCLK1 
    miRNA:Sigma-Aldrich microRNA Mimics for DCLK1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DCLK1 
    8/27 SABiosciences Assays for microRNAs that regulate DCLK1 (see all 27):
    hsa-miR-623 hsa-miR-181c hsa-miR-15a hsa-miR-509-5p hsa-miR-767-5p hsa-miR-503 hsa-miR-501-3p hsa-miR-218

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DCLK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DCLK1
    OriGene untagged cDNA clones in CMV expression vector: DCLK1
    OriGene 3'-UTR clone: DCLK1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DCLK1 
    Sino Biological Human cDNA Clone for DCLK1

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for DCLK1 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity TAS9747029
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0005057 receptor signaling protein activity TAS10036192
    GO:0005524 ATP binding IEA--
    About this table

    DCLK1 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dclk1):

    lethality-postnatalnervous systemno phenotypic analysisreproductive system

    DCLK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCLK1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for DCLK1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCLK1

    5/15 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 15):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764 neuron migration IEA--
    GO:0006468 protein phosphorylation IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0007399 nervous system development TAS10036192
    GO:0007409 axonogenesis ----
    About this table

    DCLK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCLK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    DCLK1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCLK1
    1 Novoseek chemical compound relationship for DCLK1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 4 14741399 (1), 10550327 (1), 11473121 (1)
    About this table



    Transcripts
    for DCLK1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Millipore RNAi Products for the Analysis of DCLK1 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for DCLK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DCLK1
    Sigma-Aldrich shRNA Panels and shRNA for DCLK1
    OriGene 29mer shRNA kits in GFP-retroviral vector: DCLK1
    OriGene shRNA RFP: DCLK1
    OriGene basic RS shRNA: DCLK1
    OriGene siRNA: DCLK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DCLK1 
    miRNA: Sigma-Aldrich microRNA Mimics for DCLK1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DCLK1 
    8/27 SABiosciences Assays for microRNAs that regulate DCLK1 (see all 27):
    hsa-miR-623 hsa-miR-181c hsa-miR-15a hsa-miR-509-5p hsa-miR-767-5p hsa-miR-503 hsa-miR-501-3p hsa-miR-218
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: DCLK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DCLK1
    OriGene untagged cDNA clones in CMV expression vector: DCLK1
    OriGene 3'-UTR Clone: DCLK1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for DCLK1 
    Primers: OriGene genome-wide validated SYBR primer pairs: DCLK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DCLK1: PPH08313A

    REFSEQ mRNAs for DCLK1 gene (4 alternative transcripts): 

    NM_001195415.1  NM_001195416.1  NM_001195430.1  NM_004734.4  

    Additional cDNA sequence: 

    AB002367.1 AF052152.1 AF070534.1 AK123427.1 AK295777.1 AK299059.1 AK299829.1 AK308925.1 
    AK311183.1 AK311195.1 AK311434.1 AK311438.1 AK311459.1 BC152456.1 CR618189.1 CR627093.1 

    6 DOTS entries:

    DT.212699  DT.105227  DT.97793316  DT.100729376  DT.91686214  DT.120769111 

    24/111 AceView cDNA sequences (see all 111):

    AL157657 AL157652 BX451944 BU147508 AB002367 BQ719452 NM_004734 BM729248 
    AI359804 AW264475 AI656707 AA829556 AA033625 CR618189 AA360492 AI419597 
    AL710910 BU733351 CB269320 AU128204 AI363348 CD250954 AI860075 AA984223 

    Unigene Cluster for DCLK1:

    Doublecortin-like kinase 1
    Hs.507755  [show with all ESTs]
    Unigene Representative Sequence: NM_004734


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                -           -                                                                                 
    SP2:                                                                                                                              
    SP3:                                                                                                              -               

    About this scheme

    ECgene alternative splicing isoforms for DCLK1
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255448 ENST00000477664 ENST00000379893 ENST00000360631 ENST00000379892
    ENST00000460982(uc001uvg.2 uc001uvh.3) ENST00000399319(uc001uve.3 uc010teh.1 uc010abk.2 uc001uvf.2)
    ENST00000486239

    Expression
    for DCLK1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    DCLK1 expression in normal and diseased human tissues

    1  / 2

    9 probe-sets matching DCLK1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38957_at2 U95-A 1 1.00 1.00 0.98 1.20 -- -- -- -- --
    35400_at2 U95-A 1 0.38 1.00 0.85 0.53 -- -- -- -- --
    45660_at*2 U95-B 1 0.38 1.00 0.88 1.32 -- -- -- -- --
    205399_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    215303_at2 U133-A 1 0.55 1.00 -- -- -- -- -- -- --
    229800_at2 U133-B 1 0.36 1.00 -- -- -- -- -- -- --
    205399_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    215303_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    229800_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    DCLK1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    DCLK1 gene expression
    DCLK1 gene electronic northern expression
    DCLK1 gene sage expression
    About these images

    CGAP SAGE TAG: TTATTCCTCT

    SOURCE GeneReport for Unigene cluster: Hs.507755

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In
    adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis,
    ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B
    isoforms are expressed abundantly in both fetal and adult brain

    Primers: OriGene genome-wide validated SYBR primer pairs: DCLK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for DCLK1: PPH08313A
        SABiosciences Custom PCR Arrays for DCLK1 


    Orthologs
    for DCLK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DCLK1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 DCLK11   -- doublecortin-like kinase 1 93.73(n)
    99.85(a)    		 477304  XM_844031.1  XP_849124.1 
    chimpanzee
    (Pan troglodytes)    		 DCLK11   -- doublecortin-like kinase 1 99.73(n)
    100(a)    		 467259  XM_522657.2  XP_522657.2 
    mouse
    (Mus musculus)    		 Dclk11 , 5 3 (26.53 cM)5
    		 doublecortin-like kinase 11, 5 89.89(n)1
    98.4(a)1    		 131751  NM_019978.21  NP_064362.11 
     AA1167875  AB0739695  (see all 44)
    chicken
    (Gallus gallus)    		 DCLK11   -- doublecortin-like kinase 1 85.5(n)
    96.22(a)    		 418903  XM_417099.2  XP_417099.2 
    zebrafish
    (Danio rerio)    		 LOC5659571   -- similar to Serine/threonine-protein kinase DCLK1 (Doublecortin-like more 74.5(n)
    84.05(a)    		 565957  XM_001920710.1  XP_001920745.1 
    About this table        Species with no ortholog for DCLK1

    ENSEMBL Gene Tree for DCLK1 (if available)

    Paralogs
    for DCLK1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for DCLK1 gene
    DCLK32  DCX2  STK332  PRKD22  DCLK22  PRKD32  PRKD12  

    DCLK1 for paralogs           About GeneDecksing



    Genomic Variants
    for DCLK1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/3701 NCBI SNPs in DCLK1 are shown (see all 3701)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 13 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs7289851,2
    		C,F,A,H,36552205(-) AATTTG/ATAATG 1 -- int114Minor allele frequency- A:0.49NA EA NS WA 614
    rs7309041,2
    		C,F,A,H,36657594(-) TATCAT/CTGGGT 1 -- int111Minor allele frequency- C:0.30NA EA WA 470
    rs7441901,2
    		C,F,O,A,36656872(+) CACTAA/GAAGTT 1 -- int116Minor allele frequency- G:0.29NS EA NA WA 998
    rs7441911,2
    		F,A,H36656973(+) ACTTTA/GTCTTC 1 -- int15Minor allele frequency- G:0.01NA NS EA 496
    rs7445231,2
    		C,F,A,H,36657591(-) CATTGG/TGTAGT 1 -- int19Minor allele frequency- T:0.28NA EA WA 224
    rs7469031,2
    		C,A,36564927(+) GCCAAC/TGTGGG 1 -- int14Minor allele frequency- T:0.06EA NA WA 94
    rs7469041,2
    		C,A,36564951(+) GTGAGA/GTATTT 1 -- int15Minor allele frequency- G:0.31NA EA WA 166
    rs8751101,2
    		C,F,A,36681102(-) GGTCTT/CTATTT 1 -- int17Minor allele frequency- C:0.36NA EA WA 218
    rs9130711,2
    		C,F,A,36553105(-) GTAGAG/ACACTT 1 -- int112Minor allele frequency- A:0.41NS EA NA WA 522
    rs9130721,2
    		C,36680799(+) ACAGAA/GAAGTT 1 -- int17Minor allele frequency- G:0.45NA EA WA 218
    About this table

    HapMap Linkage Disequilibrium images for DCLK1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for DCLK1
         5 CNVs: 86785 86786 66418 86784 66419
         5 Indels: 42842 39968 101704 41260 11666

    QIAGEN SeqTarget long-range PCR primers for resequencing DCLK1 

    Disorders & Mutations
    for DCLK1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCLK1 for disorders           About GeneDecksing

    OMIM: 604742

    Human Gene Mutation Database (HGMD): DCLK1
    Human Genome Epidemiology (HuGE) Navigator: DCLK1 (2 documents)

    Export disorders and mutations for DCLK1 gene to outside databases

    Medical News
    for DCLK1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for DCLK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/53 PubMed articles for DCLK1 gene, integrated from 7 sources (see all 53):
    (articles sorted by number of sources associating them with DCLK1)
    1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PubMed id 9747029)1, 2, 3, 7 Omori Y....Fujiwara T. (1998)
    2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PubMed id 10036192)1, 2, 3 Sossey-Alaoui K. and Srivastava A.K. (1999)
    3. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    4. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). (PubMed id 10051403)1, 2 Matsumoto N.... Ledbetter D.H. (1999)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    6. Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain. (PubMed id 11473121)1, 7 Burgess H.A. and Reiner O. (2001)
    7. Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities. (PubMed id 11884394)1, 7 Burgess H.A. and Reiner O. (2002)
    8. Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase. (PubMed id 12595708)1, 7 Kim M.H....Derewenda Z.S. (2003)
    9. The DCX-domain tandems of doublecortin and doublecortin-like kinase. (PubMed id 12692530)1, 7 Kim M.H....Derewenda Z.S. (2003)
    10. Functional differences between two DCLK splice variants. (PubMed id 14741399)1, 7 Engels B.M....Vreugdenhil E. (2004)

    External Searches for DCLK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DCLK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9201 HGNC: 2700 AceView: DCAMKL1 Ensembl:ENSG00000133083 euGenes: HUgn9201
    ECgene: DCLK1 H-InvDB: DCLK1

    Other Databases showing DCLK1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0369

    Specialized Databases showing DCLK1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for DCLK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for DCLK1 gene:
    Search GeneIP for patents involving DCLK1

    GeneCards and IP:
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