Aliases &
Descriptions
for DDAH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| dimethylarginine dimethylaminohydrolase 21 2 3 | | OTTHUMP000001744882 | | Protein G6a2 3 | | OTTHUMP000000293102 | | DDAHII2 3 | | N(G),N(G)-dimethylarginine dimethylaminohydrolase 22 | | DDAH2 3 | | OTTHUMP000001744892 | | DDAH-22 3 | | dimethylargininase-22 | | NG302 3 | | alternative name: NG30, G6a2 | | S-phase protein2 3 | | G6a2 | | dimethylarginine dimethylaminohydrolase II2 | | Dimethylargininase-23 | | OTTHUMP000000293072 | | G6A3 | | NG-dimethylarginine dimethylamino hydrolase homolog2 | | EC 3.5.3.183 |
Export aliases for DDAH2 gene to outside databasesPrevious GC identifers: GC06M031758 GC06M031465 GC06M031799 GC06M031803 GC06M031694 |
Summaries
for DDAH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDAH2:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role innitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxidesynthase activity. (provided by RefSeq)
UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitorsof NOS. Has therefore a role in the regulation of nitric oxide generation
|
Genomic Views
for DDAH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDAH2 gene promoter:
Sp1 HNF-1A Fra-1 c-Fos AP-1 JunD c-Jun JunB Bach2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDAH2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DDAH2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21DDAH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031481: view genomic region
(about GC identifiers)
Start:
|
31,481,041 bp from pter |
End:
|
31,484,263 bp from pter |
Size:
|
3,223 bases |
Orientation:
|
minus strand |
6 alternative locations:
| Chr6-,ALT_REF_LOCI_2 31,682,228-31,724,640 | Chr6-,ALT_REF_LOCI_3 31,676,987-31,691,249 | Chr6-,ALT_REF_LOCI_4 31,657,366-31,660,588 | | Chr6-,ALT_REF_LOCI_6 31,685,048-31,723,853 | Chr6-,ALT_REF_LOCI_7 31,615,099-31,618,321 | Chr6-,ALT_REF_LOCI_5 31,685,923-31,689,145 | |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1 NT_167249.1
|
Proteins
for DDAH2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865 (See
protein sequence)Recommended Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Size: 285 amino acids; 29644 Da
Secondary accessions: A2BEZ7Explore the universe of human proteins at neXtProt for DDAH2: NX_O95865
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_039268.1
ENSEMBL proteins: ENSP00000364949 ENSP00000364945 ENSP00000413164 ENSP00000395759 ENSP00000397466 ENSP00000364943 ENSP00000415881
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
About this table
DDAH2 for ontologies About GeneDecksing
Antibodies for DDAH2:
Assays for DDAH2: |
Protein
Domains/
Families
for DDAH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDAH2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95865ProtoNet protein and cluster: O95865 1 Blocks protein family: IPB003198 Amidinotransferase
UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865Similarity: Belongs to the DDAH family |
Gene Function
for DDAH2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitorsof NOS. Has therefore a role in the regulation of nitric oxide generationCatalytic activity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrullineEnzyme Number (IUBMB): EC 3.5.3.18
Genatlas biochemistry entry for DDAH2:N-omega,N-omega dimethylarginine dimethylaminohydrolase,endogenous inhibitor of nitric oxide synthesis,encoded byG6A,member of MHC35/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
DDAH2 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Ddah2):
DDAH2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DDAH2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Arrays including DDAH2: PAHS-062A PAHS-3012A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDAH2
1 Interacting protein for DDAH2 (O958651, 2) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
DDAH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDAH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
DDAH2 for compounds About GeneDecksing
 Browse Tocris compounds for DDAH2
10/26  Novoseek chemical compound relationships for DDAH2 gene (see all 26)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adma |
97.5 |
272 |
20209122 (8), 17141242 (6), 18342305 (6), 16897158 (5) (see all 91) |
| demethylbellidifolin |
85.3 |
2 |
15234768 (1) |
| n(g),n(g)-dimethylarginine |
84.8 |
3 |
16472125 (1), 8982498 (1), 19682580 (1) |
| dimethylamine |
82.8 |
7 |
19682581 (1), 16702618 (1), 14664899 (1), 11168975 (1) (see all 7) |
| citrulline |
80.8 |
18 |
17205823 (2), 17653133 (2), 10377069 (1), 8982498 (1) (see all 15) |
| nitric oxide |
77.8 |
91 |
18167189 (6), 12370443 (6), 18342305 (5), 17097077 (3) (see all 34) |
| arginine |
74 |
26 |
17075694 (2), 11473257 (2), 16897158 (1), 16358064 (1) (see all 19) |
| 2,4-dichlorophenoxyacetic acid |
73 |
10 |
18292189 (2), 17977009 (1), 19178698 (1), 14664899 (1) (see all 6) |
| xanthone |
63.2 |
3 |
14604680 (2) |
| lysophosphatidylcholine |
53.7 |
15 |
18342305 (4), 16309971 (3), 16897158 (1), 12750878 (1) |
About this table
|
Transcripts
for DDAH2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DDAH2 gene: NM_013974.1 Additional cDNA sequence: AF070667.1 AF087894.1 AK026191.1 AK098671.1 AK310024.1 BC001435.2 CR596804.1 CR597156.1 CR607100.1 CR616443.1 13 DOTS entries: DT.100820948 DT.100820945 DT.448917 DT.100820947 DT.102841783 DT.97768715 DT.95153733 DT.100820952 DT.121408303 DT.91769251 DT.121408228 DT.91769254 DT.91769255 24/1684 AceView cDNA sequences (see all 1684): BU690082 CR597156 CR624716 BM423696 BQ219183 AI523300 CN478474 CF528144 BX104760 CF128398 BM785317 BM554940 BM811078 BI828473 BQ683391 BM911574 CB109855 AI927258 CA420656 BM795129 BE264424 AA716568 CN484077 BF796054
 highest scoring ESTs for DDAH2:AA088769 AA297508 AA297871 AA298022 AF070667 AF087894 AK098671 AL521126 AL701729 AU099204 Unigene Cluster for DDAH2: Dimethylarginine dimethylaminohydrolase 2 Hs.247362 [show with all ESTs]Unigene Representative Sequence: BM460795
GeneLoc Exon Structure
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000488119 ENST00000375792(uc003nwq.2) ENST00000375789(uc003nwp.2)
ENST00000437288 ENST00000436437 ENST00000416410 ENST00000483792 ENST00000480913
ENST00000469963 ENST00000375787 ENST00000444662
|
Expression
for DDAH2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DDAH2 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching DDAH2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38621_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AJ012008 |
0.20 |
0.25 |
0.23 |
1 |
| 214909_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AK026191 |
0.60 |
0.83 |
0.73 |
1 |
| 215537_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AJ012008 |
0.20 |
0.25 |
0.23 |
1 |
| 202262_x_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_013974 |
0.60 |
0.83 |
0.73 |
1 |
| 214909_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 215537_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202262_x_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DDAH2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGGGGACCTC
SOURCE GeneReport for Unigene cluster: Hs.247362
Expression variation in blood from EXPOLDB for DDAH2 UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865Tissue specificity: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very lowlevels in brain
SABiosciences Expression via Pathway-Focused PCR Arrays including DDAH2: PAHS-062A PAHS-3012A
|
Orthologs
for DDAH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DDAH2 gene from 5/7 species (see all 7)
About this table Species with no ortholog for DDAH2
ENSEMBL Gene Tree for DDAH2 (if available) |
Paralogs
for DDAH2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DDAH2 gene
- DDAH12
DDAH2 for paralogs About GeneDecksing
|
Genomic Variants
for DDAH2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DDAH2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DDAH2
2 Indels: 12829 12828 | | QIAGEN SeqTarget long-range PCR primers for resequencing DDAH2 |
|
Disorders & Mutations
for DDAH2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDAH2 for disorders About GeneDecksing
OMIM: 604744
10/11 Novoseek disease relationships for DDAH2 gene (see all 11)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cardiovascular diseases |
51.6 |
2 |
14550280 (1), 20219849 (1) |
| atherosclerosis |
41 |
2 |
17293168 (1), 18991678 (1), 17368960 (1) |
| preeclampsia |
35.6 |
11 |
18251679 (3), 19570459 (2), 15501905 (1), 16508323 (1) |
| renal failure chronic |
33.3 |
1 |
16932427 (1) |
| diabetes mellitus |
18.4 |
3 |
19775692 (2) |
| necrosis |
18.2 |
4 |
10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1) |
| hypercholesterolemia |
11.5 |
2 |
10377069 (1), 17293168 (1) |
| stroke |
0 |
1 |
19250061 (1) |
| hypertension pulmonary |
0 |
2 |
12615801 (1), 15827267 (1) |
| tumors |
0 |
4 |
10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1) |
About this table
Human Gene Mutation Database (HGMD): DDAH2
Human Genome Epidemiology (HuGE) Navigator: DDAH2 (12 documents)
Export disorders and mutations for DDAH2 gene to outside databases
|
Medical News
for DDAH2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DDAH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/133 PubMed articles for DDAH2 gene, integrated from 7 sources (see all 133):
(articles sorted by number of sources associating them with DDAH2)- Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. (PubMed id 10493931)1, 2, 3, 7 Leiper J.M.... Vallance P. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. (PubMed id 10384126)1, 2 Ribas G.... Campbell R.D. (1999)
- Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PubMed id 10950934)1, 7 Tran C.T....Leiper J.M. (2000)
- Gene transfer of dimethylarginine dimethylaminohydrolase-2 improves the impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells induced by lysophosphatidylcholine. (PubMed id 18342305)1, 7 Feng M....Xiong Y. (2008)
- Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China. (PubMed id 19250061)1, 7 Bai Y....Hui R. (2009)
- Sequence variation in DDAH1 and DDAH2 genes is strong ly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PubMed id 20209122)1, 7 Abhary S....Craig J.E. (2010)
|
External Searches for DDAH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDAH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDAH2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDAH2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DDAH2 gene:
Search GeneIP for patents involving DDAH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDAH2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for DDAH2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DDAH2 |
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