Aliases &
Descriptions
for DDX52 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 521 2 | | HUSSY192 5 | | ROK11 2 3 5 | | probable ATP-dependent RNA helicase DDX522 | | ATP-dependent RNA helicase ROK1-like2 3 | | EC 3.6.4.133 | | DEAD box protein 522 3 | | |
Export aliases for DDX52 gene to outside databasesPrevious GC identifers: GC17M035703 GC17M036168 GC17M036167 GC17M033047 GC17M035969 |
Summaries
for DDX52 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for DDX52 |
Genomic Views
for DDX52 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX52 gene promoter:
PPAR-gamma1 PPAR-gamma2 COUP-TF1 HNF-4alpha2 IRF-7A POU3F2 (N-Oct-5a) POU3F2 POU3F2 (N-Oct-5b) XBP-1 NF-E2 p45
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX52
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DDX52  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1DDX52 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M031909: view genomic region
(about GC identifiers)
Start:
|
31,909,833 bp from pter |
End:
|
31,940,863 bp from pter |
Size:
|
31,031 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 35,969,826-36,003,493 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for DDX52 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DDX52_HUMAN, Q9Y2R4 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX52 Size: 599 amino acids; 67498 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAD27766.1; Type=Frameshift; Positions=324, 350, 365, 377; Sequence=AK093661;Type=Miscellaneous discrepancy; Note=Several sequencing problems; Sequence=BAA91812.1; Type=Miscellaneous discrepancy;Note=Several sequencing problems; Sequence=CAA09374.1; Type=Frameshift; Positions=355, 377;
PDB structures from  and Proteopedia  :3DKP (3D)
Secondary accessions: Q86YG1 Q8N213 Q9NVE0 Q9Y482Explore the universe of human proteins at neXtProt for DDX52: NX_Q9Y2R4
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_008941.2 NP_689513.2
ENSEMBL proteins: ENSP00000268854 ENSP00000409531 ENSP00000377893
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
DDX52 for ontologies About GeneDecksing
Antibodies for DDX52:
Assays for DDX52: |
Protein
Domains/
Families
for DDX52 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX52 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2R4ProtoNet protein and cluster: Q9Y2R4 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX52_HUMAN, Q9Y2R4Similarity: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Gene Function
for DDX52 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DDX52_HUMAN, Q9Y2R4Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.13
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
DDX52 for ontologies About GeneDecksing
|
Pathways & Interactions
for DDX52 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for DDX52
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX52
5/7 Interacting proteins for DDX52 (ENSP000002688543) via UniProtKB, MINT, and/or STRING (see all 7)About this table
|
Drugs & Compounds
for DDX52 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DDX52
|
Transcripts
for DDX52 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DDX52 gene (2 alternative transcripts): NM_007010.3 NM_152300.2 Additional cDNA sequence: AB208938.1 AF077033.1 AJ010840.1 AK001245.1 AK001652.1 AK025721.1 AK027425.1 AK093661.1 BC006489.2 BC012557.1 BC041785.1 CR613865.1 9 DOTS entries: DT.113614 DT.95270618 DT.120918398 DT.100778682 DT.422496 DT.120918407 DT.40131436 DT.100778684 DT.100778686 24/207 AceView cDNA sequences (see all 207): AI201605 AI015962 AI161405 AA313565 BG286433 AI619442 CF129871 AA909896 AA193611 AA563590 AA460140 BU931079 BQ233081 BG743345 AA947786 AK025721 AL703638 BM550361 AJ709778 BE349995 AI811496 AA010769 BM466048 N20812
 highest scoring ESTs for DDX52:AA774659 AF077033 AJ010840 AK001652 AK093661 AL600602 AL601112 AL698536 AL711165 AL711282 Unigene Cluster for DDX52: DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 Hs.590937 [show with all ESTs]Unigene Representative Sequence: NM_152300
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DDX52 (see all 7)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DDX52
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000349699(uc002hoh.1 uc002hoi.1) ENST00000488402 ENST00000460080
ENST00000491963(uc002hoj.1) ENST00000437041 ENST00000394367
|
Expression
for DDX52 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DDX52 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching DDX52 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38358_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.69 |
0.88 |
AJ010840 |
0.80 |
1.00 |
0.91 |
1 |
| 46725_at2, 3
|
U95-B |
1 |
0.69 |
1.00 |
0.38 |
1.12 |
W73792 |
0.20 |
1.00 |
0.72 |
1 |
| 40187_at2
|
U95-A |
1 |
0.62 |
1.00 |
0.30 |
0.26 |
-- |
-- |
-- |
-- |
-- |
| 210320_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF077033 |
0.80 |
1.00 |
0.91 |
1 |
| 212834_at2
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213637_at2
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 210320_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212834_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213637_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1570415_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DDX52 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTCTTTCCTG
SOURCE GeneReport for Unigene cluster: Hs.590937
Expression variation in blood from EXPOLDB for DDX52 SABiosciences Custom PCR Arrays for DDX52
|
Orthologs
for DDX52 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DDX52 gene from 5/17 species (see all 17)
About this table Species with no ortholog for DDX52
ENSEMBL Gene Tree for DDX52 (if available) |
Paralogs
for DDX52 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for DDX52 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for DDX52 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DDX52
1 Inversion: 37189 | | QIAGEN SeqTarget long-range PCR primers for resequencing DDX52 |
|
Disorders & Mutations
for DDX52 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX52 for disorders About GeneDecksing
OMIM: 612500
Export disorders and mutations for DDX52 gene to outside databases
|
Medical News
for DDX52 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DDX52 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for DDX52 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with DDX52)- Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
|
External Searches for DDX52 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDX52 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX52 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX52 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DDX52 gene:
Search GeneIP for patents involving DDX52
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX52 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for DDX52 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DDX52 |
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