Aliases &
Descriptions
for DGAT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| diacylglycerol O-acyltransferase 11 2 | | acyl coenzyme A:cholesterol acyltransferase related gene 12 | | DGAT1 2 3 | | diacylglycerol O-acyltransferase homolog 12 | | ARGP11 2 5 | | ACAT related gene product 12 | | Diglyceride acyltransferase2 3 | | EC 2.3.1.203 | | ACAT-related gene product 12 3 | | AGRP13 | | diacylglycerol O-acyltransferase homolog 1 (mouse)1 | | |
Export aliases for DGAT1 gene to outside databasesPrevious GC identifers: GC08M143202 GC08U900023 GC08M145142 GC08M145544 GC08M145510 |
Summaries
for DGAT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DGAT1:
The enzyme encoded by this gene utilizes diacylglycerol and fatty acyl CoA as substrates in order to catalyze the finalstage of triacylglycerol synthesis. It is also involved in cellular as well as physiological metabolic processes.(provided by RefSeq)
UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fattyacyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very lowdensity lipoprotein) assembly
|
Genomic Views
for DGAT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DGAT1 gene promoter:
CREB deltaCREB NRSF form 1 NRSF form 2 PPAR-gamma1 PPAR-gamma2 GCNF-1 GCNF-2 MEF-2A Pax-6
Other transcription factors
Search SABiosciences Chromatin IP Primers for DGAT1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DGAT1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3DGAT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M140652: view genomic region
(about GC identifiers)
Start:
|
140,652,766 bp from pter |
End:
|
140,665,066 bp from pter |
Size:
|
12,301 bases |
Orientation:
|
minus strand |
2 alternative locations:
| Chr8-,PATCHES 145,454,727-145,467,047 | Chr8- 145,538,252-145,550,567 |
RefSeq DNA sequence:- NC_000008.10 NT_037704.5
|
Proteins
for DGAT1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907 (See
protein sequence)Recommended Name: Diacylglycerol O-acyltransferase 1 Size: 488 amino acids; 55278 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: B2RWQ2 Q96BB8Explore the universe of human proteins at neXtProt for DGAT1: NX_O75907
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036211.2
ENSEMBL proteins: ENSP00000332258
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
DGAT1 for ontologies About GeneDecksing
Antibodies for DGAT1:
Assays for DGAT1: |
Protein
Domains/
Families
for DGAT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DGAT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O75907ProtoNet protein and cluster: O75907 1 Blocks protein family: IPB004299 Membrane bound O-acyl transferase
UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907Similarity: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily |
Gene Function
for DGAT1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907Function: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fattyacyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very lowdensity lipoprotein) assemblyCatalytic activity: Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerolEnzyme Number (IUBMB): EC 2.3.1.20
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
DGAT1 for ontologies About GeneDecksing
Animal Models: 9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Dgat1):
DGAT1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DGAT1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
DGAT1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for DGAT1
3  Kegg Pathways (Kegg details for DGAT1):
UniProtKB/Swiss-Prot: DGAT1_HUMAN, O75907Pathway: Lipid metabolism; glycerolipid metabolism SABiosciences Custom Pathway-Focused PCR Arrays for DGAT1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DGAT1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DGAT1
5/22 Interacting proteins for DGAT1 (ENSP000003322583) via UniProtKB, MINT, and/or STRING (see all 22) About this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
DGAT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DGAT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
DGAT1 for compounds About GeneDecksing
 Compounds for DGAT1 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| A 922500 | Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor | [959122-11-3] |
About this table
10/16  Novoseek chemical compound relationships for DGAT1 gene (see all 16)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| triacylglycerol |
85.4 |
47 |
14557275 (4), 18768481 (3), 16864897 (2), 15500922 (2) (see all 20) |
| monoacylglycerol |
60.6 |
14 |
18768481 (5), 20374941 (1) |
| fatty acid |
59.6 |
18 |
16130466 (2), 12923227 (2), 15500922 (1), 20126314 (1) (see all 12) |
| acyl-coa |
58.8 |
4 |
20374941 (2), 11672446 (1) |
| lipid |
52.8 |
25 |
15669762 (2), 16459663 (1), 19028692 (1), 15500922 (1) (see all 17) |
| palmitate |
45.7 |
4 |
10070036 (2), 15500922 (1) |
| glycerol 3-phosphate |
45.2 |
1 |
16864897 (1) |
| oleic acid |
42.6 |
4 |
18278045 (1), 15308631 (1) |
| acetyl-coa |
35.9 |
1 |
12888629 (1) |
| phosphatidylcholine |
26.3 |
4 |
14557275 (2) |
About this table
|
Transcripts
for DGAT1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DGAT1 gene: NM_012079.4 Additional cDNA sequence: AB057815.1 AF059202.1 BC006263.2 BC015762.1 BC023565.1 BC106084.1 BC150649.1 CR619886.1 CR622706.1 CR624618.1 CR625143.1 12 DOTS entries: DT.415463 DT.100780987 DT.121492236 DT.411156 DT.86840605 DT.97848211 DT.100688235 DT.100780988 DT.40291106 DT.100028131 DT.95195890 DT.100812890 24/208 AceView cDNA sequences (see all 208): BE271571 CR619886 BC015762 BM739011 BU180661 AA769695 BM755533 CR625143 BM476315 BX099763 BQ058342 AA430536 BM857224 BQ083910 BM851470 AI472888 BF345504 BM769358 BU680970 BI907285 CK825344 CR624618 BM743182 CR622706
 highest scoring ESTs for DGAT1:AF059202 AB057815 BC015762 BC023565 BI907285 BM543662 BM764060 BM764193 BM854896 BM926071 Unigene Cluster for DGAT1: Diacylglycerol O-acyltransferase 1 Hs.521954 [show with all ESTs]Unigene Representative Sequence: NM_012079
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DGAT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DGAT1
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332324(uc003zbv.3 uc010mfv.2)
|
Expression
for DGAT1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DGAT1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching DGAT1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 34255_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AF059202 |
1.00 |
0.90 |
0.95 |
1 |
| 203669_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_012079 |
0.60 |
1.00 |
0.82 |
1 |
| 203669_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DGAT1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TACGTCCACG
SOURCE GeneReport for Unigene cluster: Hs.521954
Expression variation in blood from EXPOLDB for DGAT1 SABiosciences Custom PCR Arrays for DGAT1
|
Orthologs
for DGAT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DGAT1 gene from 5/14 species (see all 14)
About this table Species with no ortholog for DGAT1
ENSEMBL Gene Tree for DGAT1 (if available) |
Paralogs
for DGAT1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DGAT1 gene
- LOC727765 SOAT12 SOAT22
DGAT1 for paralogs About GeneDecksing
|
Genomic Variants
for DGAT1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DGAT1
3 CNVs: 3752 31457 30306 | | QIAGEN SeqTarget long-range PCR primers for resequencing DGAT1 |
|
Disorders & Mutations
for DGAT1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DGAT1 for disorders About GeneDecksing
OMIM: 604900
4 Novoseek disease relationships for DGAT1 gene
About this table
Human Gene Mutation Database (HGMD): DGAT1
Genetic Association Database (GAD): DGAT1
Human Genome Epidemiology (HuGE) Navigator: DGAT1 (3 documents)
Export disorders and mutations for DGAT1 gene to outside databases
|
Medical News
for DGAT1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DGAT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/103 PubMed articles for DGAT1 gene, integrated from 7 sources (see all 103):
(articles sorted by number of sources associating them with DGAT1)- Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. (PubMed id 9756920)1, 2, 3 Oelkers P.... Sturley S.L. (1998)
- Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. (PubMed id 14569040)1, 4, 7 Coudreau S.K....Clement K. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. (PubMed id 12123490)1, 4 Ludwig E.H....Farese R.V. (2002)
- Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. (PubMed id 18768481)1, 7 Cheng D....Hussain M.M. (2008)
- Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. (PubMed id 14557275)1, 7 Bagnato C. and Igal R.A. (2003)
- DGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins. (PubMed id 20167659)1, 7 Krapivner S....van't Hooft F.M. (2010)
- Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. (PubMed id 15258194)1, 7 Ganji S.H....Kashyap M.L. (2004)
- Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein. (PubMed id 11672446)1, 7 Cheng D....Young P.R. (2001)
- Visceral and subcutaneous adipose tissue diacylglycer ol acyltransferase activity in humans. (PubMed id 19197254)1, 7 Hou X.G....Jensen M.D. (2009)
|
External Searches for DGAT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DGAT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DGAT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DGAT1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DGAT1 gene:
Search GeneIP for patents involving DGAT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DGAT1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
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 |  |  |  | |
| |  | Tocris compounds for DGAT1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DGAT1 |
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