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DHRS13 Gene

protein-coding GIFtS: 41

GC17M023433

dehydrogenase/reductase (SDR family) member 13
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
dehydrogenase/reductase (SDR family) member 13¹ ²		OTTHUMP00000163522²
SDR7C5¹ ²		short chain dehydrogenase/reductase family 7C, member 5²
MGC23280¹ ²		EC 1.1.-.-³
dehydrogenase/reductase SDR family member 13²

External Ids:	HGNC: 28326¹	Entrez Gene: 147015²	Ensembl: ENSG00000167536⁷	UniProtKB: Q6UX07³

Export aliases for DHRS13 gene to outside databases

Previous GC identifers: GC17M024249 GC17M027224

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DHR13_HUMAN, Q6UX07

Function: Putative oxidoreductase (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for DHRS13
Other transcription factors

Search SABiosciences Chromatin IP Primers for DHRS13

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DHRS13

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2

DHRS13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DHRS13 gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M023433: view genomic region (about GC identifiers)

Start:	23,433,016 bp from pter
End:	23,438,305 bp from pter
Size:	5,290 bases
Orientation:	minus strand

1 alternative location:

Chr17- 27,224,799-27,230,089

RefSeq DNA sequence:

NC_000017.10 NT_010799.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: DHR13_HUMAN, Q6UX07 (See protein sequence)

Recommended Name: Dehydrogenase/reductase SDR family member 13 precursor

Size: 377 amino acids; 40849 Da

Subcellular location: Secreted (Potential)

Secondary accessions: Q96BH7

Alternative splicing: 2 isoforms: Q6UX07-1 Q6UX07-2

Explore the universe of human proteins at neXtProt for DHRS13: NX_Q6UX07

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity)¹

REFSEQ proteins: NP_653284.2

ENSEMBL proteins:

ENSP00000378361 ENSP00000412826 ENSP00000368173

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

About this table

DHRS13 for ontologies About GeneDecksing

Antibodies for DHRS13:

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Assays for DHRS13:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DHRS13 for domains About GeneDecksing

3 InterPro domains/families:

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q6UX07

ProtoNet protein and cluster: Q6UX07

2 Blocks protein families:

IPB002198 Short-chain dehydrogenase/reductase SDR

IPB002347 Glucose/ribitol dehydrogenase family signature

UniProtKB/Swiss-Prot: DHR13_HUMAN, Q6UX07

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: DHR13_HUMAN, Q6UX07

Function: Putative oxidoreductase (Potential)

Enzyme Number (IUBMB): EC 1.1.-.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DHRS13 Sigma-Aldrich shRNA for DHRS13
		OriGene 29mer shRNA kits in GFP-retroviral vector: DHRS13 OriGene shRNA RFP: DHRS13 OriGene basic RS shRNA: DHRS13 OriGene siRNA: DHRS13
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miRNA:		Sigma-Aldrich microRNA Mimics for DHRS13 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DHRS13
		Search SABiosciences for Assays for microRNAs that regulate DHRS13

Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: DHRS13 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DHRS13 OriGene untagged cDNA clones in CMV expression vector (see all 3): DHRS13 OriGene 3'-UTR clone: DHRS13 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for DHRS13
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for DHRS13

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005488	binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0050662	coenzyme binding	--	--

About this table

DHRS13 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

DHRS13 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for DHRS13

Inositol Metabolism

SABiosciences Custom Pathway-Focused PCR Arrays for DHRS13

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for DHRS13

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DHRS13

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	--	--
GO:0044237	cellular metabolic process	--	--
GO:0055114	oxidation-reduction process	IEA	--

About this table

DHRS13 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DHRS13

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for DHRS13 Sigma-Aldrich shRNA for DHRS13
		OriGene 29mer shRNA kits in GFP-retroviral vector: DHRS13 OriGene shRNA RFP: DHRS13 OriGene basic RS shRNA: DHRS13 OriGene siRNA: DHRS13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DHRS13

miRNA:		Sigma-Aldrich microRNA Mimics for DHRS13 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DHRS13
		Search SABiosciences for Assays for microRNAs that regulate DHRS13

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: DHRS13 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: DHRS13 OriGene untagged cDNA clones in CMV expression vector (see all 3): DHRS13 OriGene 3'-UTR Clone: DHRS13 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for DHRS13

Primers:		OriGene genome-wide validated SYBR primer pairs: DHRS13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for DHRS13: PPH07307A

REFSEQ mRNAs for DHRS13 gene:

NM_144683.3

Additional cDNA sequence:

AK296017.1 AY358566.1 BC015582.2 CR591219.1 CR595762.1 CR597091.1 CR598291.1 CR617686.1

6 DOTS entries:

DT.100031389 DT.100688342 DT.427158 DT.100681024 DT.87015758 DT.91750784

24/565 AceView cDNA sequences (see all 565):

CB117585 AI076063 BM725631 BM708733 AY358566 BQ438316 BM917108 AL563747

CA455346 NM_144683 CA448508 BM693331 BU163696 BI222336 BM914621 BU688770

AI305836 BI818509 CR541784 BX097334 BM917069 BQ878546 AI741599 BQ217852

highest scoring ESTs for DHRS13:

AY358566 BC015582 BE019444 BG490069 BG826818 BM722228 BU501749 CB991212 AL560611 AW014279

Unigene Cluster for DHRS13:

Dehydrogenase/reductase (SDR family) member 13

Hs.631760 [show with all ESTs]

Unigene Representative Sequence: BC015582

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS13

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for DHRS13
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394901(uc002hdd.3 uc002hde.3 uc010wba.1) ENST00000426464

ENST00000378895

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

DHRS13 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching DHRS13 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52561_s_at²^{, 3}	U95-B	1	1.00	1.00	0.98	0.95	N69449	0.60	0.83	0.73	1
64430_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.06	AI076793	0.60	0.83	0.73	1
226121_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI076793	0.60	0.83	0.73	1
226121_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

DHRS13 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

DHRS13 gene electronic northern expression

About these images

CGAP SAGE TAG: GGAGTAAGGG

SOURCE GeneReport for Unigene cluster: Hs.631760

Primers:		OriGene genome-wide validated SYBR primer pairs: DHRS13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for DHRS13: PPH07307A

SABiosciences Custom PCR Arrays for DHRS13

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DHRS13 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DHRS13¹	--	dehydrogenase/reductase (SDR family) member 13	89.54(n) 89.28(a)	491173 XM_548293.2 XP_548293.2
chimpanzee (Pan troglodytes)	DHRS13¹	--	dehydrogenase/reductase (SDR family) member 13	99.66(n) 100(a)	736545 XM_001136514.1 XP_001136514.1
cow (Bos taurus)	DHRS13¹	--	dehydrogenase/reductase (SDR family) member 13	87.2(n) 89.07(a)	514903 NM_001075687.1 NP_001069155.1
mouse (Mus musculus)	Dhrs13^{1 , 5}	11 (46.74 cM)⁵	dehydrogenase/reductase (SDR family) member 13^{1, 5}	84.5(n)¹ 85.22(a)¹	70451¹ NM_183286.2¹ NP_899109.2¹ AI849398⁵ AK011939⁵ (see all 9)
zebrafish (Danio rerio)	zgc:101719¹	--	zgc:101719	55.81(n) 54.82(a)	492783 NM_001007424.1 NP_001007425.1

About this table Species with no ortholog for DHRS13

ENSEMBL Gene Tree for DHRS13 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DHRS13 gene

DHRS12² WWOX² DHRSX²

DHRS13 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2277666^1,2	C	27228118(+)	`CCTGCC/TGCCAG`	2	Q R	mis¹ ref¹ ese³		4		NS EA	416
rs4795474^1,2	C,F,A,	27228198(+)	`ACCACG/ACGGCT`	2	/R	ref¹ syn¹ ese³		7		NS EA NA WA	424
rs28523716^1,2	C,F,	27227605(+)	`GTCTTT/AGTTTT`	1	--	int¹		1		WA	50
rs34200761^1,2	C,F,	27228294(+)	`GCCTCA/GCGGGT`	2	R	syn¹ ref¹		1		NA	58
rs34370083^1,2	--	27227314(+)	`GTGCT-/GGGGAT`	1	--	int¹		0	--	--	--	--
rs34380186^1,2	C,F,	27230679(+)	`CTTTCC/TTTCCT`	1	--	ng5¹		4		NA EA WA	164
rs34651323^1,2	--	27231755(+)	`TCTAT-/CCCTAA`	1	--	ng5¹		0	--	--	--	--
rs35777851^1,2	--	27226802(+)	`TTACT-/GGGCAA`	1	--	int¹		0	--	--	--	--
rs61744798^1,2	--	27228056(+)	`GTTGGC/GGAGCT`	2	P A	mis¹ ref¹		0	--	--	--	--
rs67465968^1,2	C,F,	27226818(+)	`ACCTCT/CAGGTT`	1	--	int¹		6		NA WA	82

About this table

HapMap Linkage Disequilibrium images for DHRS13 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DHRS13: --

QIAGEN SeqTarget long-range PCR primers for resequencing DHRS13

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

4 PubMed articles for DHRS13 gene integrated from 7 sources:
(articles sorted by number of sources associating them with DHRS13)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 147015	HGNC: 28326	AceView: FLOT2andMGC23280	Ensembl:ENSG00000167536	euGenes: HUgn147015
ECgene: DHRS13	H-InvDB: DHRS13

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for DHRS13 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for DHRS13 gene:
Search GeneIP for patents involving DHRS13

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of DHRS13
	SeqTarget long-range PCR primers for resequencing DHRS13
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for DHRS13
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of DHRS13

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DHRS13 Gene

protein-coding GIFtS: 41

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DHRS13 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor DHRS13 gene

Summariesfor DHRS13 gene

Genomic Viewsfor DHRS13 gene

Proteinsfor DHRS13 gene

Protein Domains/Familiesfor DHRS13 gene

Gene Functionfor DHRS13 gene

Pathways & Interactionsfor DHRS13 gene

Drugs & Compoundsfor DHRS13 gene

Transcriptsfor DHRS13 gene

Expression for DHRS13 gene

Orthologsfor DHRS13 gene

Paralogsfor DHRS13 gene

Genomic Variantsfor DHRS13 gene

Disorders & Mutationsfor DHRS13 gene

Medical Newsfor DHRS13 gene

Publicationsfor DHRS13 gene

External Searches for DHRS13 gene

Genome Databases showing DHRS13 gene

Other Databases showing DHRS13 gene

Specialized Databases showing DHRS13 gene

Intellectual Propertyfor DHRS13 gene

Productsfor DHRS13 gene

View Random Gene

Aliases &
Descriptions
for DHRS13 gene

Summaries
for DHRS13 gene

Genomic Views
for DHRS13 gene

Proteins
for DHRS13 gene

Protein Domains/
Families
for DHRS13 gene

Gene Function
for DHRS13 gene

Pathways & Interactions
for DHRS13 gene

Drugs & Compounds
for DHRS13 gene

Transcripts
for DHRS13 gene

Expression
for DHRS13 gene

Orthologs
for DHRS13 gene

Paralogs
for DHRS13 gene

Genomic Variants
for DHRS13 gene

Disorders & Mutations
for DHRS13 gene

Medical News
for DHRS13 gene

Publications
for DHRS13 gene

Intellectual Property
for DHRS13 gene

Products
for DHRS13 gene