Aliases &
Descriptions
for DHRS7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| dehydrogenase/reductase (SDR family) member 71 2 | | short chain dehydrogenase/reductase family 34C, member 12 | | retDSR41 2 | | dehydrogenase/reductase SDR family member 72 | | SDR34C11 2 | | 2310016E22Rik2 | | Retinal short-chain dehydrogenase/reductase 42 3 | | DHRS7A3 | | retSDR42 3 | | EC 1.1.-.-3 | | RETSDR43 5 | | |
Export aliases for DHRS7 gene to outside databasesPrevious GC identifers: GC14M058602 GC14M058603 GC14M059681 GC14M060610 |
Summaries
for DHRS7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DHRS7:
Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range ofsubstrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 (PubMed 10800688)).(supplied by OMIM)
|
Genomic Views
for DHRS7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DHRS7 gene promoter:
POU2F1 AP-4 CUTL1 MEF-2A AP-2rep NF-E2 p45 NF-E2 FOXJ2 (long isoform) YY1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for DHRS7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23.1 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q23.1DHRS7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M040775: view genomic region
(about GC identifiers)
Start:
|
40,775,646 bp from pter |
End:
|
40,796,362 bp from pter |
Size:
|
20,717 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr14- 60,610,838-60,632,147 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for DHRS7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: DHRS7_HUMAN, Q9Y394 (See
protein sequence)Recommended Name: Dehydrogenase/reductase SDR family member 7 precursor Size: 339 amino acids; 38299 Da
Secondary accessions: B2R896 Q9UKU2Alternative splicing: 2 isoforms: Q9Y394-1 Q9Y394-2 Explore the universe of human proteins at neXtProt for DHRS7: NX_Q9Y394
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057113.1
ENSEMBL proteins: ENSP00000353759 ENSP00000216500
Human Recombinant Proteins
Antibodies for DHRS7:
Assays for DHRS7: |
Protein
Domains/
Families
for DHRS7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DHRS7 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y394ProtoNet protein and cluster: Q9Y394 1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR
UniProtKB/Swiss-Prot: DHRS7_HUMAN, Q9Y394Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family |
Gene Function
for DHRS7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
About this table
DHRS7 for ontologies About GeneDecksing
|
Pathways & Interactions
for DHRS7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for DHRS7
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DHRS7
5/17 Interacting proteins for DHRS7 (ENSP000003537593) via UniProtKB, MINT, and/or STRING (see all 17)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
-- | -- | | GO:0055114 | oxidation-reduction process |
IEA | -- |
About this table
DHRS7 for ontologies About GeneDecksing
|
Drugs & Compounds
for DHRS7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DHRS7
|
Transcripts
for DHRS7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for DHRS7 gene: NM_016029.2 Additional cDNA sequence: AF126782.1 AF151844.1 AK313285.1 AL117420.1 AY359031.1 BC000637.2 BC007337.2 CR616087.1 CR624637.1 11 DOTS entries: DT.456185 DT.100807010 DT.95186383 DT.120745789 DT.75142986 DT.120745862 DT.95186386 DT.75157387 DT.95186380 DT.86854156 DT.120745766 24/386 AceView cDNA sequences (see all 386): AA017652 AI074309 AI332904 BX110473 AA610853 N93481 BU688509 BM843298 BM466818 AI758165 BQ674782 AI824932 AI433414 AI082464 AF151844 BQ187291 AL599496 BM449453 BQ276464 BC000637 AI244824 CB135529 AI697738 BQ640424
 highest scoring ESTs for DHRS7:AA012823 AA017512 AA227942 AA370002 AA393693 AA471171 AA587128 AA916783 AA922690 AA932059 Unigene Cluster for DHRS7: Dehydrogenase/reductase (SDR family) member 7 Hs.59719 [show with all ESTs]Unigene Representative Sequence: BU541074
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7 (see all 6)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for DHRS7
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360557(uc001xes.2 uc001xeu.2) ENST00000216500(uc001xet.2)
|
Expression
for DHRS7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| DHRS7 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching DHRS7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39814_s_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI052724 |
0.80 |
1.00 |
0.91 |
1 |
| 210788_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AF126782 |
0.80 |
1.00 |
0.91 |
1 |
| 236332_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AI823497 |
0.60 |
1.00 |
0.82 |
1 |
| 210788_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 236332_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
DHRS7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AATCTTGCAA
SOURCE GeneReport for Unigene cluster: Hs.59719
Expression variation in blood from EXPOLDB for DHRS7 SABiosciences Custom PCR Arrays for DHRS7
|
Orthologs
for DHRS7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DHRS7 gene from 5/14 species (see all 14)
About this table Species with no ortholog for DHRS7
ENSEMBL Gene Tree for DHRS7 (if available) |
Paralogs
for DHRS7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DHRS7 gene
- DHRS7B2 KDSR2 DHRS7C2
DHRS7 for paralogs About GeneDecksing
|
Genomic Variants
for DHRS7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing DHRS7 |
|
Disorders & Mutations
for DHRS7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DHRS7 for disorders About GeneDecksing
OMIM: 612833
Export disorders and mutations for DHRS7 gene to outside databases
|
Medical News
for DHRS7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DHRS7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for DHRS7 gene integrated from 7 sources:
(articles sorted by number of sources associating them with DHRS7)- Short-chain dehydrogenases/reductases in retina. (PubMed id 10800688)1, 2, 3 Haeseleer F. and Palczewski K. (2000)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DHRS7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DHRS7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DHRS7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DHRS7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DHRS7 gene:
Search GeneIP for patents involving DHRS7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DHRS7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for DHRS7 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for DHRS7 |
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